J. Warmus

发表

A novel nonpeptide HIV-1 protease inhibitor: elucidation of the binding mode and its application in the design of related analogs.

C. Humblet, E. Lunney, S. Hagen, 1994, Journal of medicinal chemistry.

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.

A. Doherty, J. Warmus, A. Bridges, 2008, Bioorganic & medicinal chemistry letters.

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

J. Warmus, J. Sebolt-Leopold, Chunhong Yan, 2004, Nature Structural &Molecular Biology.

Synthesis and transannular diels-alder reactions of (E,E,E)-cyclotetradeca-2,8,10-trienones

J. Warmus, W. Roush, Andrea B. Works, 1993 .

Utility of the carboxylesterase inhibitor bis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor

J. Bauman, A. Kalgutkar, Y. Chen, 2010, Xenobiotica; the fate of foreign compounds in biological systems.

Inhibition of interleukin-1beta converting enzyme (ICE or caspase 1) by aspartyl acyloxyalkyl ketones and aspartyl amidooxyalkyl ketones.

E. Lunney, D. Downing, J. Warmus, 2010, Bioorganic & medicinal chemistry letters.

Identification of Tetrahydropyrido[4,3-d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists.

A. Kalgutkar, J. Warmus, D. Hepworth, 2013, ACS medicinal chemistry letters.

4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.

Daniel F Ortwine, J. A. Spicer, W. Denny, 2007, Journal of medicinal chemistry.

2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase).

J. Warmus, A. Bridges, W. Leopold, 2008, Bioorganic & medicinal chemistry letters.

Corrigendum: Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

J. Warmus, J. Sebolt-Leopold, Chunhong Yan, 2005, Nature Structural &Molecular Biology.

Design and development of histone deacetylase (HDAC) chemical probes for cell-based profiling.

R. Grimley, J. Warmus, E. Tate, 2016, Molecular bioSystems.

The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain.

A. Brown, E. Stevens, J. Warmus, 2019, Bioorganic & medicinal chemistry.

Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases.

A. Kalgutkar, T. Maurer, J. Warmus, 2015, Journal of medicinal chemistry.

Rapid optimization of an ICE inhibitor synthesis using multiple reaction conditions in a parallel array.

J. Warmus, R. Kennedy, J. C. Hodges, 1998, Bioorganic & medicinal chemistry letters.

Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents.

Jeffrey R. Chabot, J. Cate, J. Warmus, 2018, Journal of medicinal chemistry.

Identification of a novel BODIPY minihepcidin tool for the high content analysis of ferroportin (SLC40A1) pharmacology

C. C. Jorgensen, Rita R. Ferreira, J. Warmus, 2016 .

The discovery of a potent Nav1.3 inhibitor with good oral pharmacokinetics.

J. Warmus, P. Cox, C. Markworth, 2017, MedChemComm.

Characterization of the Antiviral Activity of Highly Substituted Pyrroles: A Novel Class of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor

J. Warmus, J. C. Hodges, T. Antonucci, 1995 .

Synthesis of Small 3-Fluoro- and 3,3-Difluoropyrrolidines Using Azomethine Ylide Chemistry.

M. Tran-Dube, J. Warmus, M. Collins, 2015, The Journal of organic chemistry.

One-Pot Synthesis of α-Branched N-Acylamines via Titanium-Mediated Condensation of Amides, Aldehydes, and Organometallics.

Chan Woo Huh, J. Warmus, D. Blakemore, 2017, Organic letters.

Synthesis and Diels-Alder reactions of 2-alkyl-5-methylene-1,3-dioxolan-4-ones and 2-alkyl-3-acyl-5-methylene-1,3-oxazolidin-4-ones: Highly exo and diastereoface selective chiral ketene equivalents

J. Warmus, W. Roush, Bradley B. Brown, 1989 .

A reinvestigation of the reported synthesis of the spirobenzyl isoquinoline alkaloid, iso-ochotensine

Michael A. Gonzalez, J. Warmus, A. Meyers, 1997 .

Enantioselective synthesis of the bottom half of chlorothricolide. 3. Studies of the steric directing group strategy for stereocontrol in intramolecular Diels-Alder reactions

J. Warmus, W. Roush, R. Riva, 1991 .

Diastereoselective synthesis of β-heteroaryl syn-α-methyl-β-amino acid derivatives via a double chiral auxiliary approach.

J. Warmus, D. Blakemore, J. Bian, 2013, Organic letters.

Chiral lithio formamidines : are they configurationally stable ?

Michael A. Gonzalez, J. Warmus, A. Meyers, 1991 .

Kinetic isotope effects in the deprotonation of chiral formamidines

J. Warmus, R. Barkley, A. Meyers, 1993 .

Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC.

J. Warmus, J. Bronstein, S. Murphy, 2012, Bioorganic & medicinal chemistry letters.

Development of a scalable synthetic route towards a 2,2,6-trisubstituted chiral morpholine via stereoselective hydroalkoxylation

Chan Woo Huh, J. Warmus, B. M. Bechle, 2018 .

Synthesis and Diels-Alder Reactions of 2-Alkyl-5-methylene-1,3-dioxolan-4-ones (Va), (Vb) and 2-Alkyl-3-acyl-5-methylene-1,3-oxazolidin-4-ones (Vc): Highly Exo and Diastereoface Selective Chiral Ketene Equivalents.

J. Warmus, W. Roush, Bradley B. Brown, 1990 .

Effect of dienophile activating group on the stereoselectivity of the intramolecular diels-alder reaction

J. Warmus, W. Roush, A. Essenfeld, 1987 .

An improved amide coupling procedure for the synthesis of N-(pyridin-2-yl)amides

J. Warmus, Xiaojing Yang, G. Storer, 2009 .

Potent inhibitors of LpxC for the treatment of Gram-negative infections.

V. Shanmugasundaram, J. Warmus, K. Leach, 2012, Journal of medicinal chemistry.

Discovery and SAR of benzyl phenyl ethers as inhibitors of bacterial phenylalanyl-tRNA synthetase.

J. Warmus, P. Toogood, Y. Smith, 2009, Bioorganic & medicinal chemistry letters.

Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs

J. Warmus, Hao Sun, A. Vaz, 2018, PloS one.

The Discovery of the Benzhydroxamate MEK Inhibitors CI‐1040 and PD 0325901.

J. Warmus, Joseph S. Warmus, 2009 .

Design and Identification of a Novel, Functionally Subtype Selective GABAA Positive Allosteric Modulator (PF-06372865).

R. M. Owen, Chan Woo Huh, Lishuang Cao, 2019, Journal of medicinal chemistry.

Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain.

Gareth J Waldron, R. Grimley, M. Andrews, 2018, Journal of medicinal chemistry.

Discovery of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as potent agonists of TGR5 via sequential combinatorial libraries.

J. Warmus, M. Boehm, K. Futatsugi, 2013, Bioorganic & medicinal chemistry letters.

Optimization of triazole -based TGR5 agonists towards orally available agents

Bryan M. Li, J. Warmus, D. Hepworth, 2013 .

Discovery and optimisation of potent and highly subtype selective Nav1.8 inhibitors with reduced cardiovascular liabilities

Tanya L Hay, A. Brown, E. Stevens, 2016 .

Chiral formamidines. The mechanism of mono- and di-alkylation leading to chiral, non-racemic tetrahydroisoquinolines.

Michael A. Gonzalez, J. Warmus, A. Meyers, 1991 .

Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors.

R. Grimley, J. Bilsland, J. Cui, 2019, Journal of medicinal chemistry.

Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes.

Brian E Marron, Neil A Castle, Rubben Torella, 2017, Bioorganic & medicinal chemistry letters.

Chiral formamidines. Asymmetric synthesis of 1,1-disubstituted tetrahydroisoquinolines.

Michael A. Gonzalez, J. Warmus, A. Meyers, 1991 .

A modified procedure for the preparation of 2,5-dihydropyrrole (3-pyrroline)

J. Warmus, A. Meyers, G. J. Dilley, 1993 .

Discovery of a Series of Indazole TRPA1 Antagonists.

J. Warmus, P. Cox, K. Omoto, 2017, ACS medicinal chemistry letters.

The discovery of a potent series of carboxamide TRPA1 antagonists

J. Warmus, T. Ryckmans, P. Cox, 2016 .

A Modified Procedure for the Preparation of 2,5-Dihydropyrrole (3- Pyrroline).

J. Warmus, A. Meyers, G. J. Dilley, 1993 .

Design and development of histone deacetylase (HDAC) chemical probes for cell-based profiling.

J. Warmus, James A Clulow, Jianmin Sun, 2016, Molecular Biosystems.

The enantioselective synthesis of (R)- and (S)-3-amino-3,4-dihydro-1H-[1,8]naphthyridin-2-one

J. Warmus, David J. Bernhardson, Xiaojing Yang, 2010 .

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.

J. Warmus, J. Sebolt-Leopold, A. Saltiel, 2008, Bioorganic & medicinal chemistry letters.