Matthew Zatzman

发表

Comprehensive Analysis of Hypermutation in Human Cancer

K. Cole, P. Raman, C. Hawkins, 2017, Cell.

Mutations in the RAS/MAPK pathway drive replication repair deficient hypermutated tumors and confer sensitivity to MEK inhibition.

Trevor J Pugh, T. Pugh, C. Hawkins, 2021, Cancer discovery.

Widespread hypertranscription in aggressive human cancers

F. Notta, S. Gallinger, M. Hellmann, 2022, Science advances.

DNA polymerase and mismatch repair exert distinct microsatellite instability signatures in normal and malignant human cells.

G. Getz, K. Cole, T. Kunkel, 2020, Cancer discovery.

Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival

J. D. Thompson, J. Thompson, D. Durocher, 2021, Nature communications.

Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency

Trevor J Pugh, K. Cole, T. Pugh, 2022, Nature Medicine.

Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival

J. D. Thompson, J. Thompson, D. Durocher, 2021, Nature Communications.

Germline TP53 mutations undergo copy number gain years prior to tumor diagnosis

V. Rotter, M. Gerstung, L. Alexandrov, 2023, Nature Communications.

Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency

Trevor J Pugh, K. Cole, T. Pugh, 2022, Nature medicine.