Wen-Ching Wang

发表

Structure-based inhibitor discovery of Helicobacter pylori dehydroquinate synthase.

Jai-Shin Liu, W. Cheng, Hung-Jung Wang, 2008, Biochemical and biophysical research communications.

Structure-stability-activity relationship in covalently cross-linked N-carbamoyl D-amino acid amidohydrolase and N-acylamino acid racemase.

Jenn-Kang Hwang, Wei-Chun Chiu, Jenn-Kang Hwang, 2006, Journal of molecular biology.

Time-Averaged Photoelastic Stress Analysis of the Ultrasonic Wave in a Strip

Wen-Ching Wang, Ying-Huang Tsai, W. Wang, 2006 .

A Heparan Sulfate-Binding Cell Penetrating Peptide for Tumor Targeting and Migration Inhibition

Wen-Ching Wang, M. D. Chang, Y. Chuang, 2015, BioMed research international.

Lower Prevalence of Helicobacter pylori Infection with vacAs1a, cagA‐Positive, and babA2‐Positive Genotype in Erosive Reflux Esophagitis Disease

Wen-Ching Wang, Chi-Sen Chang, Chih-Ho Lai, 2005, Helicobacter.

Glutamic acid 219 is critical for the thermostability of a truncated α-amylase from alkaliphilic and thermophilic Bacillus sp. strain TS-23

Jai-Shin Liu, Wen-Ching Wang, Long-Liu Lin, 2008 .

Identification of Glutamate Residues Important for Catalytic Activity or Thermostability of a Truncated Bacillus sp. Strain TS-23 α-amylase by Site-directed Mutagenesis

Jai-Shin Liu, Wen-Ching Wang, Long-Liu Lin, 2006, The protein journal.

Helicobacter pylori CagA-mediated IL-8 induction in gastric epithelial cells is cholesterol-dependent and requires the C-terminal tyrosine phosphorylation-containing domain.

Hung-Jung Wang, Wen-Ching Wang, J. Sheu, 2011, FEMS microbiology letters.

The CrdRS two‐component system in Helicobacter pylori responds to nitrosative stress

Wen-Ching Wang, Z. Tsai, Huai-Kuang Tsai, 2015, Molecular microbiology.

Characterization and identification of essential residues of the glycoside hydrolase family 64 laminaripentaose-producing-β-1, 3-glucanase.

Wen-Ching Wang, Yaw-Kuen Li, Chin-Ping Huang, 2011, Protein engineering, design & selection : PEDS.

Structures of Helicobacter pylori Shikimate Kinase Reveal a Selective Inhibitor-Induced-Fit Mechanism

W. Cheng, Hung-Jung Wang, Wen-Ching Wang, 2012, PloS one.

KDM4A Coactivates E2F1 to Regulate the PDK-Dependent Metabolic Switch between Mitochondrial Oxidation and Glycolysis.

Yun-Ru Chen, H. Kung, D. Ann, 2016, Cell reports.

Crystal Structure of Helicobacter pylori Formamidase AmiF Reveals a Cysteine-Glutamate-Lysine Catalytic Triad*

Jenn-Kang Hwang, Wen-Ching Wang, Shao-Wei Huang, 2007, Journal of Biological Chemistry.

Increased numbers of Foxp3-positive regulatory T cells in gastritis, peptic ulcer and gastric adenocarcinoma.

Hung-Jung Wang, Wen-Ching Wang, Hsiao‐Bai Yang, 2012, World journal of gastroenterology.

Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer

H. Hsieh, H. Kung, Jai-Shin Liu, 2022, Journal of biomedical science.

High Prevalence of cagA- and babA2-Positive Helicobacter pylori Clinical Isolates in Taiwan

Wen-Ching Wang, Chi-Sen Chang, Chih-Ho Lai, 2002, Journal of Clinical Microbiology.

Engineering of the critical residues at the stereochemistry-gate loops of Brevibacillus agri dihydropyrimidinase for the production of l-homophenylalanine

Wen-Ching Wang, W. Hsu, Long-Liu Lin, 2009 .

Characterization of nitrophenols in river, lake, and field water samples using dispersive liquid–liquid microextraction

Wen-Ching Wang, P.-S. Chen, S.-D. Huang, 2019, International Journal of Environmental Science and Technology.

Significance of the Conserved Tyr352 and Asp380 Residues in the Catalytic Activity of Bacillus stearothermophilus Aminopeptidase II as Evaluated by Site-directed Mutagenesis

Wen-Ching Wang, Long-Liu Lin, Y. Hua, 2008, The protein journal.

KDM4B is a coactivator of c-Jun and involved in gastric carcinogenesis

H. Kung, S. Chien, Wen-Ching Wang, 2019, Cell Death & Disease.

Manipulation of host cholesterol by Helicobacter pylori for their beneficial ecological niche

Hung-Jung Wang, Wen-Ching Wang, Chih-Ho Lai, 2013 .

Expression and Binding Analysis of GST-VacA Fusions Reveals That the C-Terminal ∼100-Residue Segment of Exotoxin Is Crucial for Binding in HeLa Cells

Hung-Jung Wang, Wen-Ching Wang, Hung‐Jung Wang, 2000 .

Cholesterol Depletion Reduces Helicobacter pylori CagA Translocation and CagA-Induced Responses in AGS Cells

Hui-Hao Lin, Hung-Jung Wang, Wen-Ching Wang, 2008, Infection and Immunity.

Association of antibiotic resistance and higher internalization activity in resistant Helicobacter pylori isolates.

Wen-Ching Wang, Chi-Sen Chang, Chih-Ho Lai, 2006, The Journal of antimicrobial chemotherapy.

Helicobacter pylori cholesterol glucosylation modulates autophagy for increasing intracellular survival in macrophages

Jai-Shin Liu, Hung-Jung Wang, Wen-Ching Wang, 2018, Cellular microbiology.

Caffeic acid phenethyl ester suppresses androgen receptor signaling and stability via inhibition of phosphorylation on Ser81 and Ser213

Jai-Shin Liu, Wen-Ching Wang, Chih-Pin Chuu, 2019, Cell Communication and Signaling.

Redox-proteomic analysis of doxorubicin resistance-induced altered thiol activity in uterine carcinoma.

P. Lyu, Shing-Jyh Chang, Wen-Ching Wang, 2013, Journal of pharmaceutical and biomedical analysis.

SiMMap: a web server for inferring site-moiety map to recognize interaction preferences between protein pockets and compound moieties

Kai-Cheng Hsu, Jinn-Moon Yang, Yu-Chi Huang, 2010, Nucleic Acids Res..

Cholesterol Depletion Reduces Entry of Campylobacter jejuni Cytolethal Distending Toxin and Attenuates Intoxication of Host Cells

Wen-Ching Wang, Yu-Hsin Lin, J. Hsieh, 2011, Infection and Immunity.

Proteomic analysis of proteins responsible for the development of doxorubicin resistance in human uterine cancer cells.

P. Lyu, Shing-Jyh Chang, Wen-Ching Wang, 2012, Journal of proteomics.

Cross-Linked Hyaluronic acid can Prevent the Capsular Contracture Formation

Wen-Ching Wang, I. Jou, C. Hung, 2017 .

Hepatitis B virus PreS2-mutant large surface antigen activates store-operated calcium entry and promotes chromosome instability

Linyi Chen, Wen-Ching Wang, M. D. Chang, 2016, Oncotarget.

Sgo1 is a potential therapeutic target for hepatocellular carcinoma

Wen-Ching Wang, C. Yen, Tian-Neng Li, 2015, Oncotarget.

Prevalence of antimicrobial resistance in Helicobacter pylori isolates in Taiwan in relation to consumption of antimicrobial agents.

Hung-Jung Wang, Wen-Ching Wang, Chi-Sen Chang, 2009, International journal of antimicrobial agents.

Inhibition of Helicobacter pylori-induced inflammation in human gastric epithelial AGS cells by Phyllanthus urinaria extracts.

Y. Tzeng, Ying Lin, Wen-Ching Wang, 2008, Journal of ethnopharmacology.

Multicentric primary intestinal EBV-positive diffuse large B cell lymphoma of the elderly presenting with perforation

Wen-Ching Wang, Shu-Hui Lin, R. Ichinohasama, 2010, International journal of hematology.

Purification, characterization, and genetic analysis of a leucine aminopeptidase from Aspergillus sojae.

Wen-Ching Wang, W. Hsu, Long-Liu Lin, 2002, Biochimica et biophysica acta.

Helicobacter pylori cholesteryl glucosides interfere with host membrane phase and affect type IV secretion system function during infection in AGS cells

W. Cheng, Hung-Jung Wang, Wen-Ching Wang, 2012, Molecular microbiology.

Structure-guided design of Serratia marcescens short-chain dehydrogenase/reductase for stereoselective synthesis of (R)-phenylephrine

Jai-Shin Liu, Wen-Ching Wang, W. Hsu, 2018, Scientific Reports.

Cellular evasion strategies of Helicobacter pylori in regulating its intracellular fate

Wen-Ching Wang, Yu-An Chen, Chih-Ho Lai, 2020, Seminars in Cell & Developmental Biology.

Epigenetic Switch Driven by DNA Inversions Dictates Phase Variation in Streptococcus pneumoniae

Xuegong Zhang, R. Sebra, Guilin Wang, 2016, PLoS pathogens.

JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α–mediated glucose metabolism

H. Kung, W. Cheng, Wen-Ching Wang, 2013, Proceedings of the National Academy of Sciences.

Targeting KDM4B that coactivates c-Myc-regulated metabolism to suppress tumor growth in castration-resistant prostate cancer

H. Kung, Wen-Ching Wang, Chih-Jung Chen, 2021, Theranostics.

Inhibition of KDM4C/c‐Myc/LDHA signalling axis suppresses prostate cancer metastasis via interference of glycolytic metabolism

C. Yuh, Kelvin K. Tsai, H. Kung, 2022, Clinical and translational medicine.

Pathway-based Screening Strategy for Multitarget Inhibitors of Diverse Proteins in Metabolic Pathways

Kai-Cheng Hsu, Jinn-Moon Yang, Wen-Chi Cheng, 2013, PLoS Comput. Biol..

KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC

C. Tepper, H. Kung, Cheng-Ying Chu, 2018, Oncogene.

Crystal Structures of Lysine-Preferred Racemases, the Non-Antibiotic Selectable Markers for Transgenic Plants

Wen-Ching Wang, W. Hsu, Chia-Han Chu, 2012, PloS one.

Upregulation of LGALS1 is associated with oral cancer metastasis

Wen-Ching Wang, W. Kuo, Chi-Chen Lin, 2018, Therapeutic advances in medical oncology.

siMMP-13 downregulated the invasion ability of oral cancer cells in transwell invasion and migration assays

P. Lyu, H. Kung, Wen-Ching Wang, 2016 .

Retraction: MMP-13 is involved in oral cancer cell metastasis

P. Lyu, H. Kung, Wen-Ching Wang, 2016, Oncotarget.

Whole-Exome Sequencing to Identify a Novel LMNA Gene Mutation Associated with Inherited Cardiac Conduction Disease

C. Tang, L. Hsu, Wen-Ching Wang, 2013, PloS one.

Sequence Elements Upstream of the Core Promoter Are Necessary for Full Transcription of the Capsule Gene Operon in Streptococcus pneumoniae Strain D39

Wen-Ching Wang, Z. Wen, Jing-Ren Zhang, 2015, Infection and Immunity.

Interleukin‐1β and ‐10 polymorphisms influence erosive reflux esophagitis and gastritis in Taiwanese patients

Wen-Ching Wang, Chi-Sen Chang, Hsin‐Hung Cheng, 2010, Journal of gastroenterology and hepatology.

Residues threonine 346 and leucine 352 are critical for the proper function of Bacillus kaustophilus leucine aminopeptidase.

Jai-Shin Liu, Wen-Ching Wang, Long-Liu Lin, 2006, FEMS microbiology letters.

Histone Demethylase KDM4C Stimulates the Proliferation of Prostate Cancer Cells via Activation of AKT and c-Myc

C. Yuh, Kelvin K. Tsai, H. Kung, 2019, Cancers.

KDM4B as a Target for Prostate Cancer: Structural Analysis and Selective Inhibition by a Novel Inhibitor

Kai-Cheng Hsu, Ruiwu Liu, Chia-Han Chu, 2014, Journal of medicinal chemistry.

Prognostic Significance of O-GlcNAc and PKM2 in Hormone Receptor-Positive and HER2-Nonenriched Breast Cancer

H. Kung, Wen-Ching Wang, Chih-Jung Chen, 2021, Diagnostics.

The central cavity from the (alpha/alpha)6 barrel structure of Anabaena sp. CH1 N-acetyl-D-glucosamine 2-epimerase contains two key histidine residues for reversible conversion.

Wen-Ching Wang, W. Hsu, Yen-Chung Lee, 2007, Journal of molecular biology.

Binding and internalization of Helicobacter pylori VacA via cellular lipid rafts in epithelial cells.

Wen-Ching Wang, C. Kuo, 2003, Biochemical and biophysical research communications.

Biochemical characterization of two thymidylate synthases in Corynebacterium glutamicum NCHU 87078.

Jai-Shin Liu, Wen-Ching Wang, W. Hsu, 2010, Biochimica et biophysica acta.

Enhancing oxidative resistance of Agrobacterium radiobacter N-carbamoyl D-amino acid amidohydrolase by engineering solvent-accessible methionine residues.

Wen-Ching Wang, W. Hsu, Chuan-Long Hsu, 2002, Biochemical and biophysical research communications.

Site-directed mutagenesis of the conserved Ala348 and Gly350 residues at the putative active site of Bacillus kaustophilus leucine aminopeptidase.

Jai-Shin Liu, Wen-Ching Wang, Long-Liu Lin, 2008, Biochimie.

Monocytes secrete CXCL7 to promote breast cancer progression

Wen-Ching Wang, W. Kuo, Lu‐Hai Wang, 2021, Cell Death & Disease.

The chromatin modification by SUMO-2/3 but not SUMO-1 prevents the epigenetic activation of key immune-related genes during Kaposi’s sarcoma associated herpesvirus reactivation

Mel Campbell, Wen-Ping Hsieh, Chia-Han Chu, 2013, BMC Genomics.

Cholesterol glucosylation by Helicobacter pylori delays internalization and arrests phagosome maturation in macrophages.

Wen-Ching Wang, L. Wang, S. Du, 2016, Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.

Structural Basis for Shikimate-Binding Specificity of Helicobacter pylori Shikimate Kinase

W. Cheng, Wen-Ching Wang, Yu-Ning Chang, 2005, Journal of bacteriology.

Synchronous primary gastric cancer and renal cell carcinoma: A case report and literatures review

Wen-Ching Wang, K. Shen, W. Lai, 2012 .

Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation

H. Kung, Jai-Shin Liu, Wen-Ching Wang, 2019, Communications Biology.

Caffeic acid phenethyl ester suppresses androgen receptor signaling and stability via inhibition of phosphorylation on Ser81 and Ser213

Jai-Shin Liu, Wen-Ching Wang, Chih-Pin Chuu, 2019, Cell Communication and Signaling.

A conserved aspartate is essential for FAD binding and catalysis in the d‐amino acid oxidase from Trigonopsis variabilis

Wen-Ching Wang, W. Hsu, Long-Liu Lin, 1998, FEBS letters.

Structural basis for catalytic racemization and substrate specificity of an N-acylamino acid racemase homologue from Deinococcus radiodurans.

Jai-Shin Liu, Wen-Ching Wang, W. Chiu, 2004, Journal of molecular biology.

An improved ChIP-seq peak detection system for simultaneously identifying post-translational modified transcription factors by combinatorial fusion, using SUMOylation as an example

Chung Yi Tang, H. Kung, Wen-Ching Wang, 2014, BMC Genomics.

Engineering Streptomyces clavuligerus Deacetoxycephalosporin C Synthase for Optimal Ring Expansion Activity toward Penicillin G

Wen-Ching Wang, Y. Tsai, Yunn-Bor Yang, 2003, Applied and Environmental Microbiology.

Penicillin G Optimal Ring Expansion Activity toward Deacetoxycephalosporin C Synthase for Streptomyces clavuligerus Engineering

Wen-Ching Wang, Y. Tsai, G. Wei, 2003 .

Mapping band alignment across complex oxide heterointerfaces.

Wen-Ching Wang, Y. Chu, Po‐Cheng Huang, 2012, Physical review letters.

Core Site-Moiety Maps Reveal Inhibitors and Binding Mechanisms of Orthologous Proteins by Screening Compound Libraries

Kai-Cheng Hsu, Hung-Jung Wang, Yen-Fu Chen, 2012, PloS one.

KDM4B is a coactivator of c-Jun and involved in gastric carcinogenesis

H. Kung, S. Chien, Wen-Ching Wang, 2019, Cell Death and Disease.

Targeting the histone demethylase PHF8-mediated PKCα-Src-PTEN axis in HER2-negative gastric cancer

C. Yuh, H. Kung, Wen-Ching Wang, 2020, Proceedings of the National Academy of Sciences.

Structure, Mechanistic Action, and Essential Residues of a GH-64 Enzyme, Laminaripentaose-producing β-1,3-Glucanase*

W. Cheng, Wen-Ching Wang, Yaw-Kuen Li, 2009, The Journal of Biological Chemistry.

Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation

H. Kung, Jai-Shin Liu, Wen-Ching Wang, 2019, Communications Biology.

Structural Basis for Catalysis and Substrate Specificity of Agrobacterium radiobacter N-Carbamoyl-D-amino Acid Amidohydrolase*

Jai-Shin Liu, Wen-Ching Wang, W. Chiu, 2003, Journal of Biological Chemistry.

Enantioselective synthesis of (R)-phenylephrine by Serratia marcescens BCRC10948 cells that homologously express SM_SDR.

Wen-Ching Wang, Ming-Te Yang, Yue-Bin Xu, 2018, Enzyme and microbial technology.

A local average distance descriptor for flexible protein structure comparison

Tun-Wen Pai, Wen-Ching Wang, Chia-Han Chu, 2014, BMC Bioinformatics.

Crystal structure and site-directed mutagenesis studies of N-carbamoyl-D-amino-acid amidohydrolase from Agrobacterium radiobacter reveals a homotetramer and insight into a catalytic cleft.

Wen-Ching Wang, W. Hsu, W. C. Wang, 2001, Journal of molecular biology.

Two distinctive cell binding patterns by vacuolating toxin fused with glutathione S-transferase: one high-affinity m1-specific binding and the other lower-affinity binding for variant m forms.

Wen-Ching Wang, W. C. Wang, H. J. Wang, 2001, Biochemistry.

Interleukin‐1β and ‐10 polymorphisms influence erosive reflux esophagitis and gastritis in Taiwanese patients

Wen-Ching Wang, Chi-Sen Chang, Hsin‐Hung Cheng, 2010, Journal of gastroenterology and hepatology.

MMP-13 is involved in oral cancer cell metastasis

P. Lyu, H. Kung, Wen-Ching Wang, 2016, Oncotarget.

Broad-specificity amino acid racemase, a novel non-antibiotic selectable marker for transgenic plants

Wen-Ching Wang, Tsan-Jan Chen, Wen-Ching Wang, 2018, Plant Biotechnology Reports.

A local average distance descriptor for flexible protein structure comparison

Tun-Wen Pai, Hsin-Wei Wang, Chia-Han Chu, 2014, BMC Bioinformatics.