J. Xu

发表

The role of absorption, distribution, metabolism, excretion and toxicity in drug discovery.

Jing Lin, Diana C Sahakian, S. D. de Morais, 2003, Current topics in medicinal chemistry.

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Adam S. Hayward, C. Meyer, S. Dooley, 2013, Archives of Toxicology.

Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity.

Bracken M. King, D. Lauffenburger, P. Sorger, 2009, Toxicology and applied pharmacology.

8. Hepatic Toxicity

K. Hoffmaster, J. Xu, Jing Xu, 2010 .

Predicting Drug‐Induced Hepatotoxicity: In Vitro, In Silico and In Vivo Approaches

Amit S. Kalgutkar, Jinghai J. Xu, Yvonne Will, 2009 .

Drug efficacy, safety, and biologics discovery : emerging technologies and tools

Sean Ekins, Jinghai J. Xu, S. Ekins, 2009 .

In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone.

J. Xu, L. Marroquin, J. Dykens, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

DIFFERENTIAL INTERACTION OF HMG-CoA REDUCTASE INHIBITORS WITH ABCB1, ABCC2, AND OATP1B1

J. Xu, Cuiping Chen, Jian Lin, 2004 .

Cellular imaging predictions of clinical drug-induced liver injury.

Peter V. Henstock, Peter V Henstock, Jeffrey R. Chabot, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

Applications of cytotoxicity assays and pre-lethal mechanistic assays for assessment of human hepatotoxicity potential.

Dolores Diaz, J. Xu, D. Diaz, 2004, Chemico-biological interactions.

Interaction of porphyrins with human organic anion transporting polypeptide 1B1.

J. Xu, S. Campbell, W. Lau, 2009, Chemico-biological interactions.

Inhibition of human organic anion transporting polypeptide OATP 1B1 as a mechanism of drug-induced hyperbilirubinemia.

S. D. de Morais, J. Xu, Jinghai J Xu, 2004, Chemico-biological interactions.

Adam S. Hayward, C. Meyer, S. Dooley, 2013, Archives of Toxicology.

DIFFERENTIAL INTERACTION OF 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE INHIBITORS WITH ABCB1, ABCC2, AND OATP1B1

J. Xu, T. Smolarek, Jinghai J Xu, 2005, Drug Metabolism and Disposition.

Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714.

Bo Feng, David B Duignan, D. B. Duignan, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

Comparisons between in vitro whole cell imaging and in vivo zebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development

M. Aleo, J. Xu, A. Hill, 2012, Drug metabolism reviews.

Cellular imaging: a key phenotypic screening strategy for predictive toxicology

J. Xu, 2015, Front. Pharmacol..

Multiple effects of acetaminophen and p38 inhibitors: Towards pathway toxicology

B. Hendriks, J. Xu, D. de Graaf, 2008, FEBS letters.

Biochemical and pharmacological characterization of human c-Met neutralizing monoclonal antibody CE-355621

G. Karam, J. Lapointe, J. Xu, 2012, mAbs.

Experimental investigation on the correlation between nano-fluid characteristics and thermal properties of Al2O3 nano-particles dispersed in ethylene glycol–water mixture

J. Xu, D. Jung, K. Bandyopadhyay, 2016 .

Current in vitro Models to Study Drug‐Induced Liver Injury

K. Hoffmaster, J. Xu, J. Davila, 2008 .

Focus on the Fundamentals: Toward Better Therapeutic Index Prediction

J. Xu, Li Yu, 2008 .

Application of an automated natural language processing (NLP) workflow to enable federated search of external biomedical content in drug discovery and development.

Wendy D. Cornell, Sarah McQuay, Jagruti Patel, 2016, Drug discovery today.

A Predictive Ligand-Based Bayesian Model for Human Drug-Induced Liver Injury

Sean Ekins, Jinghai J. Xu, Antony J. Williams, 2010, Drug Metabolism and Disposition.

Developing timely insights into comparative effectiveness research with a text-mining pipeline.

David Milward, Jinghai James Xu, Meiping Chang, 2016, Drug discovery today.

Assessment of hepatotoxicity potential of drug candidate molecules including kinase inhibitors by hepatocyte imaging assay technology and bile flux imaging assay technology.

J. Xu, E. Tien, M. Dunn, 2012, Methods in molecular biology.

A Predictive Ligand-Based Bayesian Model for Human Drug-Induced Liver Injury

Antony J. Williams, S. Ekins, J. Xu, 2010, Drug Metabolism and Disposition.