B. O’Rourke

发表

An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics.

R. Winslow, S. Cortassa, M. Aon, 2003, Biophysical journal.

Dynamics of matrix-free Ca2+ in cardiac mitochondria: two components of Ca2+ uptake and role of phosphate buffering

R. Winslow, B. O’Rourke, An-Chi Wei, 2012, The Journal of general physiology.

Is There a Mitochondrial Clock

S. Cortassa, M. Aon, B. O’Rourke, 2008 .

Compartment-specific Control of Reactive Oxygen Species Scavenging by Antioxidant Pathway Enzymes*

B. O’Rourke, Swati Dey, Agnieszka Sidor, 2016, The Journal of Biological Chemistry.

The role of stochastic and modal gating of cardiac L-type Ca2+ channels on early after-depolarizations.

Joseph L Greenstein, Raimond L Winslow, Brian O'Rourke, 2005, Biophysical journal.

Optical Imaging of the Heart

G. Salama, I. Efimov, B. O’Rourke, 2004, Circulation research.

Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies.

R. Winslow, J. Rice, E. Marbán, 1999, Circulation research.

Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop Sudden Cardiac Death Prediction and Prevention: Report From a National

N. Trayanova, C. Albert, X. Jouven, 2010 .

Sudden Cardiac Death Prediction and Prevention

Mark E. Anderson, N. Trayanova, J. Nerbonne, 2010 .

Sudden Cardiac Death Prediction and Prevention: Report From a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop

Mark E. Anderson, N. Trayanova, J. Nerbonne, 2010, Circulation.

Percolation and criticality in a mitochondrial network.

S. Cortassa, M. Aon, B. O’Rourke, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Parallel Proteomics to Improve Coverage and Confidence in the Partially Annotated Oryctolagus cuniculus Mitochondrial Proteome*

Simon C. F. Sheng, Melanie Y. White, R. Cole, 2010, Molecular & Cellular Proteomics.

Metabolism leaves its mark on the powerhouse: recent progress in post-translational modifications of lysine in mitochondria

B. O’Rourke, Kyriakos N. Papanicolaou, D. B. Foster, 2014, Front. Physiol..

Glutathione oxidation as a trigger of mitochondrial depolarization and oscillation in intact hearts.

M. Aon, B. O’Rourke, M. Slodzinski, 2008, Journal of molecular and cellular cardiology.

Redox-optimized ROS balance: a unifying hypothesis.

S. Cortassa, M. Aon, B. O’Rourke, 2010, Biochimica et biophysica acta.

Mitochondrial Ca2+ influx and efflux rates in guinea pig cardiac mitochondria: low and high affinity effects of cyclosporine A.

R. Winslow, S. Cortassa, B. O’Rourke, 2011, Biochimica et biophysica acta.

Functional Impairment of Human Resident Cardiac Stem Cells by the Cardiotoxic Antineoplastic Agent Trastuzumab

A. Wolff, E. Marbán, B. O’Rourke, 2012, Stem cells translational medicine.

Action potential variation in canine ventricle: a modeling study

R. Winslow, G. Tomaselli, E. Marbán, 1996, Computers in Cardiology 1996.

An integrated mitochondrial ROS production and scavenging model: implications for heart failure.

R. Winslow, J. Greenstein, B. O’Rourke, 2013, Biophysical journal.

Mitochondrial protein phosphorylation as a regulatory modality: implications for mitochondrial dysfunction in heart failure.

B. O’Rourke, J. V. Van Eyk, D. B. Foster, 2011, Congestive heart failure.

Effects of Regional Mitochondrial Depolarization on Electrical Propagation: Implications for Arrhythmogenesis

G. Plank, N. Trayanova, S. Cortassa, 2014, Circulation. Arrhythmia and electrophysiology.

Molecular correlates of altered expression of potassium currents in failing rabbit myocardium.

Jochen Rose, Antonis A Armoundas, Brian O'Rourke, 2005, American journal of physiology. Heart and circulatory physiology.

Role of Sodium-Calcium Exchanger in Modulating the Action Potential of Ventricular Myocytes From Normal and Failing Hearts

Antonis A Armoundas, Raimond L Winslow, Brian O'Rourke, 2003, Circulation research.

Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure.

D. Kass, G. Tomaselli, E. Marbán, 1996, Circulation research.

Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I: experimental studies.

D. Kass, R. Tunin, G. Tomaselli, 1999, Circulation research.

What yeast and cardiomyocytes share: ultradian oscillatory redox mechanisms of cellular coherence and survival.

Brian O'Rourke, David Lloyd, Sonia Cortassa, 2012, Integrative biology : quantitative biosciences from nano to macro.

Integrated Omic Analysis of a Guinea Pig Model of Heart Failure and Sudden Cardiac Death.

R. Cole, B. O’Rourke, Ting Liu, 2016, Journal of proteome research.

Functional Implications of Cardiac Mitochondria Clustering.

A. A. Armoundas, M. Aon, B. O’Rourke, 2017, Advances in experimental medicine and biology.

Mitochondrial networks in cardiac myocytes reveal dynamic coupling behavior.

Antonis A Armoundas, Brian O'Rourke, A. A. Armoundas, 2015, Biophysical journal.

Cardiac mitochondria exhibit dynamic functional clustering

A. A. Armoundas, M. Aon, B. O’Rourke, 2014, Front. Physiol..

Single-channel analysis of inactivation-defective rat skeletal muscle sodium channels containing the F1304Q mutation.

J. Balser, G. Tomaselli, E. Marbán, 1996, Biophysical journal.

Energetic performance is improved by specific activation of K+ fluxes through K(Ca) channels in heart mitochondria.

S. Cortassa, M. Aon, B. O’Rourke, 2009, Biochimica et biophysica acta.

Energetic Performance is Improved by Specific Activation of K+ Fluxes through KCa Channels in Heart Mitochondria

S. Cortassa, M. Aon, B. O’Rourke, 2009 .

Effects of Adrenoceptor Blockade on Cardiac Hypertrophy and Myocardial Phospholipids

B. O’Rourke, D. Reibel, Diane K. Reibel, 1992, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop

G. Dorn, P. Ping, R. Weiss, 2019, Circulation.

The ins and outs of calcium in heart failure.

B. O’Rourke, 2008, Circulation research.

Hibernating Squirrels: SIRTin Clues for Organ Protection after Ischemia-Reperfusion.

B. O’Rourke, C. Steenbergen, D. Berkowitz, 2016, Anesthesiology.

Mitochondrial K(ATP) channels in cell survival and death.

B. O’Rourke, H. Ardehali, 2005, Journal of molecular and cellular cardiology.

Cell-type specificity of preconditioning in an in vitro model

E. Marbán, B. O’Rourke, Y. Liu, 1996, Basic Research in Cardiology.

Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels.

Yongge Liu, E. Marbán, B. O’Rourke, 2001, Molecular pharmacology.

Mitochondrial ATP-Sensitive Potassium Channels Attenuate Matrix Ca2+ Overload During Simulated Ischemia and Reperfusion

E. Marbán, B. O’Rourke, M. Murata, 2001 .

Opening of mitochondrial K(ATP) channels triggers cardioprotection. Are reactive oxygen species involved?

B. O’Rourke, Y. Liu, 2001, Circulation research.

Selective pharmacological agents implicate mitochondrial but not sarcolemmal K(ATP) channels in ischemic cardioprotection.

E. Marbán, B. O’Rourke, Toshiaki Sato, 2000, Circulation.

Nicorandil

E. Marbán, B. O’Rourke, Toshiaki Sato, 2024, Reactions Weekly.

Pharmacological and histochemical distinctions between molecularly defined sarcolemmal KATP channels and native cardiac mitochondrial KATP channels.

Yongge Liu, E. Marbán, B. O’Rourke, 1999, Molecular pharmacology.

Mitochondrial ATP‐Dependent Potassium Channels: Viable Candidate Effectors of Ischemic Preconditioning a

A. Szewczyk, Yongge Liu, E. Marbán, 1999, Annals of the New York Academy of Sciences.

Modulation of mitochondrial ATP-dependent K+ channels by protein kinase C.

E. Marbán, B. O’Rourke, Toshiaki Sato, 1998, Circulation research.

Suppression of KATP currents by gene transfer of a dominant negative Kir6.2 construct

Yongge Liu, E. Marbán, B. O’Rourke, 1998, Pflügers Archiv.

Priming effect of adenosine on KATP currents in intact ventricular myocytes: implications for preconditioning.

Yongge Liu, E. Marbán, B. O’Rourke, 1997, American journal of physiology. Heart and circulatory physiology.

Synergistic modulation of ATP-sensitive K+ currents by protein kinase C and adenosine. Implications for ischemic preconditioning.

E. Marbán, B. O’Rourke, Y. Liu, 1996, Circulation research.

GSH or Palmitate Preserves Mitochondrial Energetic/Redox Balance, Preventing Mechanical Dysfunction in Metabolically Challenged Myocytes/Hearts From Type 2 Diabetic Mice

S. Cortassa, M. Aon, B. O’Rourke, 2012, Diabetes.

Blood-derived mitochondrial DNA copy number is associated with gene expression across multiple tissues and is predictive for incident neurodegenerative disease

D. Arking, E. Guallar, B. O’Rourke, 2020, bioRxiv.

Nuclear-mitochondrial communication involving miR-181c plays an important role in cardiac dysfunction during obesity.

B. O’Rourke, C. Steenbergen, Samarjit Das, 2020, Journal of molecular and cellular cardiology.

Differential Actions of Cardioprotective Agents on the Mitochondrial Death Pathway

Steven P Jones, E. Marbán, B. O’Rourke, 2003, Circulation research.

Subcellular metabolic transients and mitochondrial redox waves in heart cells.

E. Marbán, B. O’Rourke, B O'Rourke, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Hydrogen peroxide diffusion and scavenging shapes mitochondrial network instability and failure by sensitizing ROS-induced ROS release

N. Trayanova, B. O’Rourke, Brent Millare, 2020, Scientific Reports.

Cardiac mitochondrial network excitability: insights from computational analysis.

B. O’Rourke, Lufang Zhou, 2012, American journal of physiology. Heart and circulatory physiology.

Mitochondria are sources of metabolic sink and arrhythmias.

B. O’Rourke, F. Akar, 2011, Pharmacology & therapeutics.

Cardiac mitochondria and arrhythmias.

B. O’Rourke, David A. Brown, 2010, Cardiovascular research.

Mitochondrial ion channels in cardiac function and dysfunction.

S. Cortassa, M. Aon, B. O’Rourke, 2007, Novartis Foundation symposium.

Molecular composition of mitochondrial ATP-sensitive potassium channels probed by viral Kir gene transfer.

E. Marbán, B. O’Rourke, D. Johns, 2000, Journal of molecular and cellular cardiology.

Activation of mitochondrial ATP-dependent potassium channels by nitric oxide.

E. Marbán, B. O’Rourke, Toshiaki Sato, 2000, Circulation.

Rekindling the Mitochondrial Fire

B. O’Rourke, 1999 .

Apoptosis: rekindling the mitochondrial fire.

B. O’Rourke, 1999, Circulation research.

Regulation of mitochondrial Ca2+ and its effects on energetics and redox balance in normal and failing heart

B. O’Rourke, Ting Liu, 2009, Journal of bioenergetics and biomembranes.

Assessing Spatiotemporal and Functional Organization of Mitochondrial Networks.

A. A. Armoundas, M. Aon, B. O’Rourke, 2018, Methods in molecular biology.

Role of mitochondrial dysfunction in cardiac glycoside toxicity.

B. O’Rourke, Ting Liu, David A. Brown, 2010, Journal of molecular and cellular cardiology.

Vascular endothelial growth factor regulation of Weibel-Palade-body exocytosis.

M. Yamakuchi, C. Lowenstein, B. O’Rourke, 2005, Blood.

Combined effects of aging and inflammation on renin-angiotensin system mediate mitochondrial dysfunction and phenotypic changes in cardiomyopathies

D. Kass, B. O’Rourke, J. Walston, 2015, Oncotarget.

Dynamic modulation of Ca2+ sparks by mitochondrial oscillations in isolated guinea pig cardiomyocytes under oxidative stress.

M. Aon, B. O’Rourke, Ting Liu, 2011, Journal of molecular and cellular cardiology.

Hypoxic tumor microenvironments reduce collagen I fiber density.

Brian O'Rourke, Meiyappan Solaiyappan, Ellen Ackerstaff, 2010, Neoplasia.

Mitochondrial energetics, pH regulation, and ion dynamics: a computational-experimental approach.

R. Winslow, S. Cortassa, M. Aon, 2011, Biophysical journal.

A computational model of reactive oxygen species and redox balance in cardiac mitochondria.

R. Winslow, J. Greenstein, S. Cortassa, 2013, Biophysical journal.

Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative.

N. Trayanova, P. Ping, J. Weiss, 2015, Circulation research.

Mss51 deletion enhances muscle metabolism and glucose homeostasis in mice.

B. O’Rourke, Ting Liu, Jason K. Kim, 2019, JCI insight.

Integrated Omic Analysis of a Guinea Pig Model of Heart Failure and Sudden Cardiac Death.

R. Cole, B. O’Rourke, Ting Liu, 2015, Journal of proteome research.

Anti-hypertrophic and anti-oxidant effect of beta3-adrenergic stimulation in myocytes requires differential neuronal NOS phosphorylation.

D. Kass, B. O’Rourke, L. Barouch, 2013, Journal of molecular and cellular cardiology.

MCU Overexpression Rescues Inotropy and Reverses Heart Failure by Reducing SR Ca2+ Leak.

B. O’Rourke, Ting Liu, Agnieszka Sidor, 2021, Circulation research.

Inhibiting Mitochondrial Na+/Ca2+ Exchange Prevents Sudden Death in a Guinea Pig Model of Heart Failure

T. Abraham, V. Dimaano, B. O’Rourke, 2014, Circulation research.

Cytosolic free magnesium modulates Na/Ca exchange currents in pig myocytes.

B. O’Rourke, M. Haigney, Shao-kui Wei, 2002, Cardiovascular research.

Mitochondrial Creatine Kinase Attenuates Pathologic Remodeling in Heart Failure

S. Lai, M. Schär, P. Bottomley, 2022, Circulation research.

Impaired mitochondrial network excitability in failing guinea-pig cardiomyocytes.

B. O’Rourke, Ting Liu, L. Dell’Italia, 2016, Cardiovascular research.

Presynaptic modulation of cortical synaptic activity by calcineurin.

E. Marbán, B. O’Rourke, R. Victor, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms.

Joao A. C. Lima, B. O’Rourke, Paul L Huang, 2002 .

Alpha-adrenergic modification of the Ca2+ transient and contraction in single rat cardiomyocytes.

B. O’Rourke, A. Thomas, D. Reibel, 1992, Journal of molecular and cellular cardiology.

Identification and characterization of a functional mitochondrial angiotensin system

B. O’Rourke, R. Cohn, R. Carey, 2011, Proceedings of the National Academy of Sciences.

HNO enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization.

Dong I. Lee, D. Kass, G. M. Wilson, 2013, Antioxidants & redox signaling.

Differential Actions of Cardioprotective Agents : mitoKATP Channel Opener and PTP Blockers

Steven P Jones, E. Marbán, B. O’Rourke, 2003 .

Mechanistically Distinct Steps in the Mitochondrial Death Pathway Triggered by Oxidative Stress in Cardiac Myocytes

E. Marbán, B. O’Rourke, M. Akao, 2003, Circulation research.

Effect of Isoflurane on Myocardial Energetic and Oxidative Stress in Cardiac Muscle from Zucker Diabetic Fatty Rat

S. Cortassa, M. Aon, B. O’Rourke, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Myocardial BDNF regulates cardiac bioenergetics through the transcription factor Yin Yang 1

D. Kass, B. O’Rourke, An-Chi Wei, 2021, bioRxiv.

Deranged sodium to sudden death

B. Fermini, J. Weiss, Z. Qu, 2015, The Journal of physiology.

Disruption of sodium homeostasis in cardiac disease In the session on ‘ Disruption of Na + homeostasis

B. Fermini, J. Weiss, Z. Qu, 2015 .

The mitochondrial regulator PGC1α is induced by cGMP–PKG signaling and mediates the protective effects of phosphodiesterase 5 inhibition in heart failure

D. Kass, R. Karas, B. O’Rourke, 2021, FEBS letters.

Impaired mitochondrial energy supply coupled to increased H2O2 emission under energy/redox stress leads to myocardial dysfunction during Type I diabetes.

S. Cortassa, M. Aon, B. O’Rourke, 2015, Clinical science.

Effects of 4'-chlorodiazepam on cellular excitation-contraction coupling and ischaemia-reperfusion injury in rabbit heart.

M. Aon, B. O’Rourke, Ting Liu, 2008, Cardiovascular research.

Cardiac arrhythmias induced by glutathione oxidation can be inhibited by preventing mitochondrial depolarization.

M. Aon, B. O’Rourke, E. Anderson, 2010, Journal of molecular and cellular cardiology.

Enhancing Mitochondrial Ca2+ Uptake in Myocytes From Failing Hearts Restores Energy Supply and Demand Matching

B. O’Rourke, Ting Liu, 2008, Circulation research.

PDE9 Inhibition Activates PPARα to Stimulate Mitochondrial Fat Metabolism and Reduce Cardiometabolic Syndrome

Dorothy D. Sears, D. Kass, B. O’Rourke, 2021, bioRxiv.

Inhibition of phosphodiesterase type 9 reduces obesity and cardiometabolic syndrome in mice.

Dorothy D. Sears, B. O’Rourke, D. Sears, 2021, The Journal of clinical investigation.

A Mighty Small Heart: The Cardiac Proteome of Adult Drosophila melanogaster

Ermir Qeli, Christian H. Ahrens, Rolf Bodmer, 2011, PloS one.

The Mitochondrial ROMK Channel is a Molecular Component of MitoK ATP

B. O’Rourke, Agnieszka Sidor, D. B. Foster, 2012 .

Understanding the Cytosolic Modulators of the Exchanger Is

B. O’Rourke, M. Haigney, Shao-kui Wei, 2022 .

Mitochondrial transplantation in humans: “magical” cure or cause for concern?

B. O’Rourke, C. Maack, E. Bertero, 2018, The Journal of clinical investigation.

Insulin Effects on Cardiac Na+/Ca2+ Exchanger Activity

B. O’Rourke, Agnieszka Sidor, M. C. Villa-Abrille, 2008, Journal of Biological Chemistry.

Altered phospholipid metabolism in pressure-overload hypertrophied hearts.

B. O’Rourke, H. Hutchinson, R. Kent, 1986, The American journal of physiology.

Hydropersulfides (RSSH) Outperform Post-Conditioning and Other Reactive Sulfur Species in Limiting Ischemia–Reperfusion Injury in the Isolated Mouse Heart

B. O’Rourke, Ting Liu, N. Paolocci, 2022, Antioxidants.

Cardiac Sodium-Calcium Exchanger Is Regulated by Allosteric Calcium and Exchanger Inhibitory Peptide at Distinct Sites

B. O’Rourke, C. Maack, Agnieszka Sidor, 2004, Circulation research.

Manipulation of Cellular Excitability by Cell Fusion Effects of Rapid Introduction of Transient Outward K (cid:49) Current on the Guinea Pig Action Potential Rapid Communication

E. Marbán, B. O’Rourke, D. Johns, 1999 .

From Bioblasts to Mitochondria: Ever Expanding Roles of Mitochondria in Cell Physiology

B. O’Rourke, 2010, Front. Physiology.

Redox Regulation of Mitochondrial ATP SynthaseNovelty and Significance

D. Kass, B. O’Rourke, D. B. Foster, 2011 .

Enhancing Mitochondrial Ca 2 (cid:1) Uptake in Myocytes From Failing Hearts Restores Energy Supply and Demand Matching

B. O’Rourke, Ting Liu, 2008 .

Single-Channel Properties of the ROMK-Pore-Forming Subunit of the Mitochondrial ATP-Sensitive Potassium Channel

M. Laskowski, A. Szewczyk, B. O’Rourke, 2019, International journal of molecular sciences.

Phosphorylation-independent modulation of L-type calcium channels by magnesium-nucleotide complexes.

E. Marbán, B. O’Rourke, P. Backx, 1992, Science.

Diabetes Increases the Vulnerability of the Cardiac Mitochondrial Network to Criticality

A. A. Armoundas, S. Cortassa, M. Aon, 2020, Frontiers in Physiology.

MCC-134, a Single Pharmacophore, Opens Surface ATP–Sensitive Potassium Channels, Blocks Mitochondrial ATP–Sensitive Potassium Channels, and Suppresses Preconditioning

E. Marbán, B. O’Rourke, R. Bolli, 2003, Circulation.

Evidence against Functional Heteromultimerization of theK ATP Channel Subunits Kir6.1 and Kir6.2*

E. Marbán, B. O’Rourke, D. Johns, 2000, The Journal of Biological Chemistry.

Global knockout of ROMK potassium channel worsens cardiac ischemia-reperfusion injury but cardiomyocyte-specific knockout does not: Implications for the identity of mitoKATP.

B. O’Rourke, Ting Liu, D. Lefer, 2020, Journal of molecular and cellular cardiology.

Cardioprotective Role of the Mitochondrial ATP-Binding Cassette Protein 1

E. Marbán, B. O’Rourke, H. Ardehali, 2005, Circulation research.

Response by Bertero et al to Letter Regarding Article, "Mitochondria Do Not Survive Calcium Overload".

B. O’Rourke, C. Maack, E. Bertero, 2020, Circulation research.

Dual Effect of Phosphate Transport on Mitochondrial Ca2+ Dynamics*

B. O’Rourke, An-Chi Wei, Ting Liu, 2015, The Journal of Biological Chemistry.

Dual Effect of Phosphate Transport on Mitochondrial Ca 2 (cid:2) Dynamics

B. O’Rourke, An-Chi Wei, Ting Liu, 2015 .

Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms

Joao A. C. Lima, B. O’Rourke, Paul L Huang, 2002, Nature.

Mitochondrial ATP-Sensitive Potassium Channels Inhibit Apoptosis Induced by Oxidative Stress in Cardiac Cells

E. Marbán, B. O’Rourke, M. Akao, 2001, Circulation research.

Mitochondrial ATP-dependent potassium channels: novel effectors of cardioprotection?

Yongge Liu, E. Marbán, B. O’Rourke, 1998, Circulation.

Priming effect of adenosine on K(ATP) currents in intact ventricular myocytes: implications for preconditioning.

E. Marbán, B. O’Rourke, Y. Liu, 1997, The American journal of physiology.

Precisely Control Mitochondria with Light to Manipulate Cell Fate Decision.

Jianyi(Jay) Zhang, B. O’Rourke, M. Goldberg, 2019, Biophysical journal.

Precisely control mitochondrial membrane potential with light to manipulate cell fate decisions

Jianyi(Jay) Zhang, B. O’Rourke, M. Goldberg, 2018 .

Mitochondrial Ca2+ uptake: tortoise or hare?

B. O’Rourke, L. Blatter, 2009, Journal of molecular and cellular cardiology.

(cid:1) -Adrenergic Stimulation of L-type Ca 2 (cid:2) Channels in Cardiac Myocytes Requires the Distal Carboxyl Terminus of (cid:3) 1C but Not Serine 1928

B. O’Rourke, D. Johns, C. Maack, 2006 .

On the Network Properties of Mitochondria

S. Cortassa, M. Aon, B. O’Rourke, 2007 .

Nitric Oxide Regulates Exocytosis by S-Nitrosylation of N-ethylmaleimide-Sensitive Factor

M. Yamakuchi, C. Lowenstein, D. Wagner, 2003, Cell.

Oscillations of membrane current and excitability driven by metabolic oscillations in heart cells.

E. Marbán, B. O’Rourke, B O'Rourke, 1994, Science.

Ion channels as sensors of cellular energy. Mechanisms for modulation by magnesium and nucleotides.

B. O’Rourke, Brian O'Rourke, 1993, Biochemical pharmacology.

Flash photolysis of magnesium-DM-nitrophen in heart cells. A novel approach to probe magnesium- and ATP-dependent regulation of calcium channels.

E. Marbán, B. O’Rourke, P. Backx, 1991, American journal of hypertension.

Mechanism of Ca2+-dependent Inactivation of L-type Ca2+ Channels in GH3 Cells: Direct Evidence Against Dephosphorylation by Calcineurin

E. Marbán, B. O’Rourke, F. Rusnak, 1997, The Journal of Membrane Biology.

Elevated Cytosolic Na+ Increases Mitochondrial Formation of Reactive Oxygen Species in Failing Cardiac Myocytes

B. O’Rourke, Ting Liu, M. Kohlhaas, 2010, Circulation.

Elevated Cytosolic Na+ Decreases Mitochondrial Ca2+ Uptake During Excitation–Contraction Coupling and Impairs Energetic Adaptation in Cardiac Myocytes

Brian O'Rourke, Sonia Cortassa, Miguel A Aon, 2006, Circulation research.

Partial Inhibition of Sodium/Calcium Exchange Restores Cellular Calcium Handling in Canine Heart Failure

B. O’Rourke, C. Maack, I. Hobai, 2004, Circulation research.

Diallyl disulphide depletes glutathione in Candida albicans: oxidative stress‐mediated cell death studied by two‐photon microscopy

Brian O'Rourke, David Lloyd, Sonia Cortassa, 2007, Yeast.

Allyl alcohol and garlic (Allium sativum) extract produce oxidative stress in Candida albicans.

Brian O'Rourke, David Lloyd, Sonia Cortassa, 2005, Microbiology.

Integrating mitochondrial energetics, redox and ROS metabolic networks: a two-compartment model.

R. Winslow, S. Cortassa, M. Aon, 2013, Biophysical journal.

Mitochondrial ion channels.

B. O’Rourke, 2007, Annual review of physiology.

Mitochondrial ion channels: gatekeepers of life and death.

S. Cortassa, M. Aon, B. O’Rourke, 2005, Physiology.

Cytoprotective Role of Ca2+- Activated K+ Channels in the Cardiac Inner Mitochondrial Membrane

Yongge Liu, B. O’Rourke, J. V. Van Eyk, 2002, Science.

Mitochondrial ROMK Channel Is a Molecular Component of MitoKATP

B. O’Rourke, Agnieszka Sidor, D. B. Foster, 2012, Circulation research.

Redox signaling and protein phosphorylation in mitochondria: progress and prospects

E. Marbán, B. O’Rourke, J. V. Van Eyk, 2009, Journal of bioenergetics and biomembranes.

Pathophysiological and protective roles of mitochondrial ion channels

B. O’Rourke, B O'Rourke, 2000, The Journal of physiology.

Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy

Matthew Miyamoto, Chulan Kwon, H. Calkins, 2021, Science Translational Medicine.

Bax regulates primary necrosis through mitochondrial dynamics

G. Dorn, S. Jha, M. Crow, 2012, Proceedings of the National Academy of Sciences.

Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart Failure

B. O’Rourke, Swati Dey, Agnieszka Sidor, 2018, Circulation research.

Mitochondrial oscillations in physiology and pathophysiology.

Brian O'Rourke, Sonia Cortassa, Miguel A Aon, 2008, Advances in experimental medicine and biology.

A mitochondrial oscillator dependent on reactive oxygen species.

Raimond L Winslow, Brian O'Rourke, Sonia Cortassa, 2004, Biophysical journal.

Synchronized Whole Cell Oscillations in Mitochondrial Metabolism Triggered by a Local Release of Reactive Oxygen Species in Cardiac Myocytes*

Brian O'Rourke, Sonia Cortassa, Eduardo Marbán, 2003, Journal of Biological Chemistry.

Comparative Proteomics Reveals Dysregulated Mitochondrial O-GlcNAcylation in Diabetic Hearts.

Junfeng Ma, G. Hart, B. O’Rourke, 2016, Journal of proteome research.

Mitochondria-derived ROS bursts disturb Ca²⁺ cycling and induce abnormal automaticity in guinea pig cardiomyocytes: a theoretical study.

Qince Li, S. Pogwizd, B. O’Rourke, 2015, American journal of physiology. Heart and circulatory physiology.

Mitochondrial Ca2+ in heart failure: Not enough or too much?

B. O’Rourke, Ting Liu, D. Ashok, 2020, Journal of molecular and cellular cardiology.

From metabolomics to fluxomics: a computational procedure to translate metabolite profiles into metabolic fluxes.

Sonia Cortassa, Miguel A. Aon, S. Cortassa, 2015, Biophysical journal.

The role of Na dysregulation in cardiac disease and how it impacts electrophysiology.

B. O’Rourke, C. Maack, 2007, Drug discovery today. Disease models.

Excitation-contraction coupling and mitochondrial energetics

B. O’Rourke, C. Maack, B. O'Rourke, 2007, Basic Research in Cardiology.

Modeling cardiac action potential shortening driven by oxidative stress-induced mitochondrial oscillations in guinea pig cardiomyocytes.

R. Winslow, S. Cortassa, M. Aon, 2009, Biophysical journal.

Evidence for Mitochondrial K Channels and Their Role in Cardioprotection

B. O’Rourke, Brian O’Rourke, 2004 .

Mitochondria Do Not Survive Calcium Overload During Transplantation.

B. O’Rourke, C. Maack, E. Bertero, 2020, Circulation research.

What can mitochondrial proteomics tell us about cardioprotection afforded by preconditioning?

B. O’Rourke, J. V. Van Eyk, D. B. Foster, 2008, Expert review of proteomics.

Conservation of cardiac L-type Ca2+ channels and their regulation in Drosophila: A novel genetically-pliable channelopathic model.

B. O’Rourke, A. Cammarato, D. T. Yue, 2018, Journal of molecular and cellular cardiology.

Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs

J. Bressler, M. Fornage, J. Pankow, 2020, Genome Medicine.

Functional consequences of sulfhydryl modification in the pore-forming subunits of cardiovascular Ca2+ and Na+ channels.

F. Hofmann, E. Marbán, B. O’Rourke, 1995, Circulation research.

Use of Chimeric Fluorescent Proteins and Fluorescence Resonance Energy Transfer to Monitor Cellular Responses

M. Zaccolo, B. O’Rourke, Manuela Zaccolo, 2004, Circulation research.

Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential

L. Kaczmarek, P. Pedersen, M. Aon, 2011, The Journal of cell biology.

Altered carnitine metabolism in spontaneously hypertensive rats.

B. O’Rourke, K. Foster, D. Reibel, 1985, The American journal of physiology.

Inducible Genetic Suppression of Neuronal Excitability

R. Mains, E. Marbán, B. O’Rourke, 1999, The Journal of Neuroscience.

Enhanced tissue production through redox control in stem cell-laden hydrogels.

B. Reid, J. Elisseeff, B. O’Rourke, 2013, Tissue engineering. Part A.

Myocardial K(ATP) channels in preconditioning.

B. O’Rourke, 2000, Circulation research.

Myocardial KATP Channels in Preconditioning

B. O’Rourke, 2000 .

Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy.

Dong I. Lee, Hideki Uosaki, D. Kass, 2017, Cell reports.

The Cardiac Acetyl-Lysine Proteome

R. Cole, B. O’Rourke, Ting Liu, 2013, PloS one.

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK

F. Wondisford, S. Radovick, B. O’Rourke, 2019, Cell reports.

Control and Regulation of Integrated Mitochondrial Function in Metabolic and Transport Networks

Raimond L. Winslow, Sonia Cortassa, Miguel A. Aon, 2009, International journal of molecular sciences.

The mitochondrial origin of postischemic arrhythmias.

Brian O'Rourke, Miguel A Aon, G. Tomaselli, 2005, The Journal of clinical investigation.

Mitochondrial DNA copy number and incident atrial fibrillation

Henry J. Lin, D. Arking, J. Rotter, 2019, bioRxiv.

Cardiac retinoic acid levels decline in heart failure

Jace W. Jones, B. O’Rourke, M. Kane, 2021, JCI insight.

Myocardial oxidative stress correlates with left ventricular dysfunction on strain echocardiography in a rodent model of sepsis

T. Abraham, B. O’Rourke, D. Hackam, 2017, Intensive Care Medicine Experimental.

Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/β-catenin signaling

Dong I. Lee, G. Tomaselli, B. O’Rourke, 2017, Proceedings of the National Academy of Sciences.

Redox-optimized ROS balance and the relationship between mitochondrial respiration and ROS.

S. Cortassa, M. Aon, B. O’Rourke, 2014, Biochimica et biophysica acta.

Redox Regulation of Mitochondrial ATP Synthase: Implications for Cardiac Resynchronization Therapy

Brian O'Rourke, David A. Kass, Jennifer E. Van Eyk, 2011, Circulation Research.

Glutathione/thioredoxin systems modulate mitochondrial H2O2 emission: An experimental-computational study

Brian O'Rourke, Miguel Antonio Aon, Sonia Cortassa, 2012, The Journal of general physiology.

Metabolic oscillations in heart cells.

E. Marbán, B. O’Rourke, B O'Rourke, 1995, Advances in experimental medicine and biology.

Sequential Opening of Mitochondrial Ion Channels as a Function of Glutathione Redox Thiol Status*

S. Cortassa, M. Aon, B. O’Rourke, 2007, Journal of Biological Chemistry.

Potassium channel overexpression

E. Marbán, B. O’Rourke, D. Johns, 2000 .

The fractal architecture of cytoplasmic organization: Scaling, kinetics and emergence in metabolic networks

Brian O'Rourke, Miguel Antonio Aon, Sonia Cortassa, 2004, Molecular and Cellular Biochemistry.

The potential of Na+/Ca2+ exchange blockers in the treatment of cardiac disease

B. O’Rourke, I. Hobai, 2004, Expert opinion on investigational drugs.

Mss51 deletion increases endurance and ameliorates histopathology in the mdx mouse model of Duchenne muscular dystrophy

B. O’Rourke, Ting Liu, R. Lovering, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Two‐Photon Excitation of Quantum‐Dot‐Based Fluorescence Resonance Energy Transfer and Its Applications

Igor L. Medintz, J. Melinger, H. Mattoussi, 2007 .

Mitochondrial criticality: a new concept at the turning point of life or death.

S. Cortassa, M. Aon, B. O’Rourke, 2006, Biochimica et biophysica acta.

A “Minimal” Sodium Channel Construct Consisting of Ligated S5-P-S6 Segments Forms a Toxin-activatable Ionophore*

Brian O'Rourke, G. Tomaselli, E. Marbán, 2002, The Journal of Biological Chemistry.

Differential modulation of cortical synaptic activity by calcineurin (phosphatase 2B) versus phosphatases 1 and 2A

E. Marbán, B. O’Rourke, F. Rusnak, 1997, Brain Research.

Metabolism: Beyond the power of mitochondria

B. O’Rourke, 2016, Nature Reviews Cardiology.

A computational model integrating electrophysiology, contraction, and mitochondrial bioenergetics in the ventricular myocyte.

Raimond L Winslow, Brian O'Rourke, Sonia Cortassa, 2006, Biophysical journal.

Two-Photon Laser Scanning Microscopy of the Transverse-Axial Tubule System in Ventricular Cardiomyocytes from Failing and Non-Failing Human Hearts

S. Houser, G. Tomaselli, B. O’Rourke, 2010, Cardiology research and practice.

Two-Photon Microscopy of Cells and Tissue

B. O’Rourke, Brian O’Rourke, 2004 .

A Reaction-Diffusion Model of ROS-Induced ROS Release in a Mitochondrial Network

Raimond L. Winslow, Lufang Zhou, Brian O'Rourke, 2010, PLoS Comput. Biol..

Inhibiting O-GlcNAcylation impacts p38 and Erk1/2 signaling and perturbs cardiomyocyte hypertrophy

B. O’Rourke, N. Zachara, Kyriakos N. Papanicolaou, 2023, The Journal of biological chemistry.

Cellular Bioenergetics Is an Important Determinant of the Molecular Imaging Signal Derived From Luciferase and the Sodium-Iodide Symporter

R. Wahl, B. Tsui, M. Pomper, 2013, Circulation research.

miR‐181c Activates Mitochondrial Calcium Uptake by Regulating MICU1 in the Heart

B. O’Rourke, E. Murphy, Soroosh Solhjoo, 2019, Journal of the American Heart Association.

ATP-Sensitive Potassium Channels

E. Marbán, B. O’Rourke, N. Sasaki, 2021, Encyclopedia of Molecular Pharmacology.

Chapter 24 Subcellular Heterogeneity of Energy Metabolism and KATP Current Oscillation in Cardiac Myocytes

E. Marbán, B. O’Rourke, D. N. Romashko, 1999 .

Growth Differentiation Factor‐15 Predicts Mortality and Heart Failure Exacerbation But Not Ventricular Arrhythmias in Patients With Cardiomyopathy

H. Calkins, L. Yanek, G. Tomaselli, 2023, Journal of the American Heart Association.

Hyaluronic acid-human blood hydrogels for stem cell transplantation.

R. Wahl, J. Elisseeff, T. Abraham, 2012, Biomaterials.

Cardiac resynchronization therapy restores sympathovagal balance in the failing heart by differential remodeling of cholinergic signaling.

D. Kass, G. Tomaselli, B. O’Rourke, 2015, Circulation research.

Protein S-Nitrosylation Controls Glycogen Synthase Kinase 3&bgr; Function Independent of Its Phosphorylation State

Brian O'Rourke, Jennifer E Van Eyk, Vidya Venkatraman, 2018, Circulation research.

Spatio-temporal oscillations of individual mitochondria in cardiac myocytes reveal modulation of synchronized mitochondrial clusters

Antonis A Armoundas, Brian O'Rourke, A. A. Armoundas, 2010, Proceedings of the National Academy of Sciences.

Enhanced Ca2+-Activated Na+-Ca2+ Exchange Activity in Canine Pacing-Induced Heart Failure

Brian O'Rourke, B. O’Rourke, Ion A. Hobai, 2000 .

Integrative modeling of the cardiac ventricular myocyte

John Jeremy Rice, Joseph L Greenstein, Raimond L Winslow, 2011, Wiley interdisciplinary reviews. Systems biology and medicine.

Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes.

G. Tomaselli, B. O’Rourke, G. Hesketh, 2010, Cardiovascular research.

Enhanced Ca-Activated Na-Ca Exchange Activity in Canine Pacing-Induced Heart Failure

B. O’Rourke, I. Hobai, 2000 .

Electrophysiological Consequences of Dyssynchronous Heart Failure and Its Restoration by Resynchronization Therapy

Brian O'Rourke, David A. Kass, Takeshi Aiba, 2009, Circulation.

Mitochondrial instability during regional ischemia-reperfusion underlies arrhythmias in monolayers of cardiomyocytes.

B. O’Rourke, Soroosh Solhjoo, S. Solhjoo, 2015, Journal of molecular and cellular cardiology.

Cellular and molecular determinants of altered Ca2+ handling in the failing rabbit heart: primary defects in SR Ca2+ uptake and release mechanisms.

A. A. Armoundas, D. Kass, G. Tomaselli, 2007, American journal of physiology. Heart and circulatory physiology.

ATP consumption by uncoupled mitochondria activates sarcolemmal K(ATP) channels in cardiac myocytes.

E. Marbán, B. O’Rourke, B O'Rourke, 2001, American journal of physiology. Heart and circulatory physiology.

&bgr;-Adrenergic Stimulation of L-type Ca2 Channels in Cardiac Myocytes Requires the Distal Carboxyl Terminus of &agr;1C but Not Serine 1928

B. O’Rourke, D. Johns, C. Maack, 2006, Circulation research.

Expression, activity, and pro-hypertrophic effects of PDE5A in cardiac myocytes.

D. Kass, M. Crow, B. O’Rourke, 2008, Cellular signalling.

Wavelet analysis reveals heterogeneous time-dependent oscillations of individual mitochondria.

Antonis A Armoundas, Brian O'Rourke, A. A. Armoundas, 2010, American journal of physiology. Heart and circulatory physiology.

The Scale-Free Dynamics of Eukaryotic Cells

Marc R. Roussel, Brian O'Rourke, David Lloyd, 2008, PloS one.

Myocardial brain-derived neurotrophic factor regulates cardiac bioenergetics through the transcription factor Yin Yang 1.

D. Kass, B. O’Rourke, An-Chi Wei, 2022, Cardiovascular research.

Manipulation of cellular excitability by cell fusion: effects of rapid introduction of transient outward K+ current on the guinea pig action potential.

E. Marbán, B. O’Rourke, D. Johns, 1999, Circulation research.

Muscle Cells Optical Imaging of the Heart Examining Intracellular Organelle Function Using Fluorescent Probes : From Animalcules to Quantum Dots Two-Photon Microscopy of Cells and Tissues

B. O’Rourke, 2004 .

Mitochondrial Origin of Ischemia-Reperfusion Arrhythmias

B. O’Rourke, 2009 .

From mitochondrial dynamics to arrhythmias.

D. Brown, S. Cortassa, M. Aon, 2009, The international journal of biochemistry & cell biology.

Myocardial substrate and route of administration determine acute cardiac retention and lung bio-distribution of cardiosphere-derived cells

R. Wahl, B. Tsui, M. Pomper, 2011, Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.

Cardiosphere-Derived Cells Demonstrate Metabolic Flexibility That Is Influenced by Adhesion Status

R. Wahl, B. Tsui, M. Pomper, 2017, JACC. Basic to translational science.

The fundamental organization of cardiac mitochondria as a network of coupled oscillators.

S. Cortassa, M. Aon, B. O’Rourke, 2006, Biophysical journal.

Allele-specific differences in transcriptome, miRNome, and mitochondrial function in two hypertrophic cardiomyopathy mouse models.

L. Leinwand, T. Abraham, M. Aon, 2018, JCI insight.

Cardiovascular Consequences of Obesity and Type 2 Diabetes Restoring redox balance enhances contractility in heart trabeculae from type 2 diabetic rats exposed to high glucose

S. Cortassa, M. Aon, B. O’Rourke, 2015 .

Mitochondrial membrane potential instability on reperfusion after ischemia does not depend on mitochondrial Ca2+ uptake

B. O’Rourke, Ting Liu, Agnieszka Sidor, 2023, The Journal of biological chemistry.

MitoWave: Spatio-temporal analysis of mitochondrial membrane potential fluctuations during ischemia-reperfusion.

B. O’Rourke, D. Ashok, 2021, Biophysical journal.

MitoWave: Spatio-temporal analysis of mitochondrial membrane potential fluctuations during ischemia-reperfusion

B. O’Rourke, D. Ashok, Brian O'Rourke, 2020, bioRxiv.

Mitochondrial redox and pH signaling occurs in axonal and synaptic organelle clusters

A. A. Armoundas, M. Aon, B. O’Rourke, 2016, Scientific Reports.

Oxidative stress in the mitochondrial matrix underlies ischemia/reperfusion-induced mitochondrial instability

Dong I. Lee, B. O’Rourke, Ting Liu, 2022, The Journal of biological chemistry.

Optical imaging of mitochondrial function uncovers actively propagating waves of mitochondrial membrane potential collapse across intact heart.

M. Aon, B. O’Rourke, A. Lyon, 2010, Journal of molecular and cellular cardiology.

O-GlcNAcomic Profiling Identifies Widespread O-Linked β-N-Acetylglucosamine Modification (O-GlcNAcylation) in Oxidative Phosphorylation System Regulating Cardiac Mitochondrial Function*♦

Junfeng Ma, G. Hart, B. O’Rourke, 2015, The Journal of Biological Chemistry.

TNNT2 mutations in the tropomyosin binding region of TNT1 disrupt its role in contractile inhibition and stimulate cardiac dysfunction

B. O’Rourke, Ting Liu, A. Cammarato, 2020, Proceedings of the National Academy of Sciences.

Enhanced Ca(2+)-activated Na(+)-Ca(2+) exchange activity in canine pacing-induced heart failure.

B. O’Rourke, B O'Rourke, I. Hobai, 2000, Circulation research.

Decreased Sarcoplasmic Reticulum Calcium Content Is Responsible for Defective Excitation-Contraction Coupling in Canine Heart Failure

B. O’Rourke, Brian O’Rourke, Ion A. Hobai, 2001, Circulation.

Structural and functional plasticity in long-term cultures of adult ventricular myocytes.

B. O’Rourke, Ting Liu, D. T. Yue, 2013, Journal of molecular and cellular cardiology.

Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs

J. Bressler, M. Fornage, D. Levy, 2020, Genome medicine.

Computational models of the failing myocyte: relating altered gene expression to cellular function

R. Winslow, J. Greenstein, G. Tomaselli, 2001, Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences.

Reverse engineering the L-type Ca2+ channel alpha1c subunit in adult cardiac myocytes using novel adenoviral vectors.

B. O’Rourke, D. Johns, C. Maack, 2005, Biochemical and biophysical research communications.

Be still, my beating heart: never!

B. O’Rourke, 2010, Circulation research.

Saturday , February 14 Subgroups-Bioenergetics 1-Subg A MITOCHONDRIAL OSCILLATOR TRIGGERED BY OXIDATIVE STRESS IN CARDIAC MYOCYTES

R. Winslow, S. Cortassa, M. Aon, 2007 .

Regulation of the Na+/Ca2+ Exchanger by Pyridine Nucleotide Redox Potential in Ventricular Myocytes*

B. O’Rourke, Ting Liu, 2013, The Journal of Biological Chemistry.

Protein Kinase C and Adenosine Synergistically Activate ATP-Sensitive Potassium Currents: Implications for Ischemic Preconditioning

Yongge Liu, E. Marbán, B. O’Rourke, 1997 .

Kir1.1 and SUR1 are not implicated as subunits of an adenosine triphosphate-sensitive potassium channel involved in diazoxide cardioprotection

B. O’Rourke, Kyriakos N. Papanicolaou, A. Suarez-Pierre, 2023, JTCVS open.

From mitochondrial ion channels to arrhythmias in the heart: computational techniques to bridge the spatio-temporal scales

Gernot Plank, Lufang Zhou, Joseph L Greenstein, 2008, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

Nitroxyl Improves Cellular Heart Function by Directly Enhancing Cardiac Sarcoplasmic Reticulum Ca2+ Cycling

M. Zaccolo, D. Kass, G. M. Wilson, 2007, Circulation research.

Mitochondrial DNA Copy Number (mtDNA-CN) Can Influence Mortality and Cardiovascular Disease via Methylation of Nuclear DNA CpGs

J. Bressler, M. Fornage, D. Levy, 2019, bioRxiv.

Molecular and cellular mechanisms by which cardiac sympathetic denervation prevents heart failure and sudden cardiac arrest

B. O’Rourke, Swati Dey, S. Estes, 2023, bioRxiv.

Control and regulation of mitochondrial energetics in an integrated model of cardiomyocyte function.

Raimond L Winslow, Brian O'Rourke, Sonia Cortassa, 2009, Biophysical journal.

Inward rectifier K+ channel from human heart and brain: cloning and stable expression in a human cell line.

G. Tomaselli, B. O’Rourke, D. Johns, 1995, The American journal of physiology.

Delivering Ion Channels to Mammalian Cells by Membrane Fusion

E. Marbán, B. O’Rourke, D. Johns, 2001 .

Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I: experimental studies.

D. Kass, R. Tunin, G. Tomaselli, 1999, Circulation research.

Antiarrhythmic Engineering of Skeletal Myoblasts for Cardiac Transplantation

C. Henrikson, M. Aon, E. Marbán, 2005, Circulation research.

Dosimetric and technical considerations for interstitial adenoviral gene therapy as applied to prostate cancer.

T. DeWeese, U. Hamper, B. O’Rourke, 2003, International journal of radiation oncology, biology, physics.

diabetic mice excitation-contraction coupling in hearts from type 2 cost of basal metabolism and

S. Cortassa, M. Aon, B. O’Rourke, 2013 .

Seeing the Forest for the Trees.

Brian O'Rourke, B. O’Rourke, Ting Liu, 2016, Circulation research.

Dynamics of early afterdepolarization-mediated triggered activity in cardiac monolayers.

A. Garfinkel, J. Weiss, H. Karagueuzian, 2012, Biophysical journal.

Enhanced Ca 2 1-Activated Na 1-Ca 2 1 Exchange Activity in Canine Pacing-Induced Heart Failure

B. O’Rourke, I. Hobai, 2000 .

Failure Exchange Activity in Canine Pacing-Induced Heart 2 +-Ca +-Activated Na 2 + Enhanced Ca

B. O’Rourke, I. Hobai, 2000 .

Mitochondrial ATP-Sensitive Potassium Channels Inhibit Apoptosis Induced by Oxidative Stress in Cardiac Cells

E. Marbán, B. O’Rourke, M. Akao, 2001, Circulation research.

Inhibiting Mitochondrial Na+/Ca2+ Exchange Prevents Sudden Death in a Guinea Pig Model of Heart Failure

T. Abraham, V. Dimaano, B. O’Rourke, 2014, Circulation research.

Regulation of the Na+/Ca2+ Exchanger by Pyridine Nucleotide Redox Potential in Ventricular Myocytes*

B. O’Rourke, Ting Liu, 2013, The Journal of Biological Chemistry.

Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies.

R. Winslow, E. Marbán, B. O’Rourke, 1999, Circulation research.

Elevated Cytosolic Na+ Increases Mitochondrial Formation of Reactive Oxygen Species in Failing Cardiac Myocytes

B. O’Rourke, Ting Liu, M. Kohlhaas, 2010, Circulation.

Na 1 channel regulation by Ca 2 1 / calmodulin and Ca 2 1 / calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes †

G. Tomaselli, B. O’Rourke, G. Hesketh, 2010 .

Mitochondrial ATP-Sensitive Potassium Channels Attenuate Matrix Ca2+ Overload During Simulated Ischemia and Reperfusion: Possible Mechanism of Cardioprotection

E. Marbán, B. O’Rourke, M. Murata, 2001, Circulation research.

Mitochondrial ion channels: gatekeepers of life and death.

S. Cortassa, M. Aon, B. O’Rourke, 2005, Physiology.

Hyaluronic acid-human blood hydrogels for stem cell transplantation.

B. O’Rourke, T. Higuchi, Patrick A. Armstrong, 2012, Biomaterials.

Cardiac sympathetic denervation prevents sudden cardiac arrest and improves cardiac function by enhancing mitochondrial-antioxidant capacity

B. O’Rourke, Swati Dey, S. Estes, 2023, bioRxiv.

Vascular endothelial growth factor regulation of Weibel-Palade-body exocytosis.

M. Yamakuchi, C. Lowenstein, B. O’Rourke, 2005, Blood.

Distinct Effects of Mitochondrial Na+/Ca2+ Exchanger Inhibition and Ca2+ Uniporter Activation on Ca2+ Sparks and Arrhythmogenesis in Diabetic Rats.

B. O’Rourke, Ting Liu, F. Despa, 2023, Journal of the American Heart Association.

HNO enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization.

Dong I. Lee, D. Kass, G. M. Wilson, 2013, Antioxidants & redox signaling.

What can mitochondrial proteomics tell us about cardioprotection afforded by preconditioning?

B. O’Rourke, J. V. Van Eyk, D. B. Foster, 2008, Expert review of proteomics.

Effects of 4'-chlorodiazepam on cellular excitation-contraction coupling and ischaemia-reperfusion injury in rabbit heart.

M. Aon, B. O’Rourke, Ting Liu, 2008, Cardiovascular Research.

Cardiac mitochondria exhibit dynamic functional clustering

M. Aon, B. O’Rourke, A. Armoundas, 2014, Frontiers in Physiology.

Wavelet analysis reveals heterogeneous time-dependent oscillations of individual mitochondria.

M. Aon, B. O’Rourke, A. Armoundas, 2010, American journal of physiology. Heart and circulatory physiology.

From metabolomics to fluxomics: a computational procedure to translate metabolite profiles into metabolic fluxes.

S. Cortassa, M. Aon, B. O’Rourke, 2015, Biophysical journal.

Role of mitochondrial dysfunction in cardiac glycoside toxicity.

B. O’Rourke, Ting Liu, David A. Brown, 2010, Journal of molecular and cellular cardiology.

A computational model of reactive oxygen species and redox balance in cardiac mitochondria.

R. Winslow, J. Greenstein, S. Cortassa, 2013, Biophysical journal.

Metabolic control analysis applied to mitochondrial networks

Raimond L. Winslow, Sonia Cortassa, Miguel Antonio Aon, 2011, 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.