P. Lam

发表

GPCR 3 D homology models for ligand screening : Lessons learned from blind predictions of adenosine A 2 a receptor complex

R. Abagyan, M. Yeager, V. Katritch, 2009 .

Triazole-linked reduced amide isosteres: an approach for the fragment-based drug discovery of anti-Alzheimer's BACE1 inhibitors.

M. Totrov, P. Lam, Christopher J. Monceaux, 2011, Bioorganic & medicinal chemistry letters.

Molecular Basis of Secretin Docking to Its Intact Receptor Using Multiple Photolabile Probes Distributed throughout the Pharmacophore*

Ruben Abagyan, Laurence J Miller, Patrick M Sexton, 2011, The Journal of Biological Chemistry.

GPCR 3D homology models for ligand screening: Lessons learned from blind predictions of adenosine A2a receptor complex

Ruben Abagyan, Vsevolod Katritch, Mark Yeager, 2010, Proteins.

Experimental and Computational Studies in Bioorganic and Synthetic Organic Chemistry

P. Lam, 2004 .

Neurotoxicology of bis(n)-tacrines on Blattella germanica and Drosophila melanogaster acetylcholinesterase.

J. Bloomquist, M. Totrov, P. Lam, 2013, Archives of insect biochemistry and physiology.

Crystal structure of acetylcholinesterase catalytic subunits of the malaria vector Anopheles gambiae

M. Totrov, P. Lam, P. Carlier, 2018, Insect science.

Molecular Basis of Action of a Small-Molecule Positive Allosteric Modulator Agonist at the Type 1 Cholecystokinin Holoreceptor

R. Abagyan, P. Sexton, A. Christopoulos, 2019, Molecular Pharmacology.

Complete mapping of the stereochemical course of retentive deprotonation/alkylation of 1H-benzo[e][1,4]diazepin-2(3H)-ones.

P. Lam, P. Carlier, C. Slebodnick, 2009, Journal of the American Chemical Society.

Select Small Core Structure Carbamates Exhibit High Contact Toxicity to “Carbamate-Resistant” Strain Malaria Mosquitoes, Anopheles gambiae (Akron)

J. Bloomquist, M. Totrov, P. Lam, 2012, PloS one.

Memory of chirality trapping of low inversion barrier 1,4-benzodiazepin-2-one enolates

P. Lam, P. Carlier, Hong‐Wu Zhao, 2005 .

3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae.

J. Bloomquist, M. Totrov, P. Lam, 2015, Bioorganic & medicinal chemistry.

Experimental and computational studies of ring inversion of 1,4-benzodiazepin-2-ones: implications for memory of chirality transformations.

P. Lam, P. Carlier, 2005, The Journal of organic chemistry.

Enantioselective synthesis of "quaternary" 1,4-benzodiazepin-2-one scaffolds via memory of chirality.

P. Lam, P. Carlier, Hong‐Wu Zhao, 2003, Journal of the American Chemical Society.

Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase.

J. Bloomquist, M. Totrov, P. Lam, 2012, Bioorganic & medicinal chemistry letters.

Elucidation of the molecular basis of cholecystokinin Peptide docking to its receptor using site-specific intrinsic photoaffinity labeling and molecular modeling.

Ruben Abagyan, Laurence J Miller, Maoqing Dong, 2009, Biochemistry.

Role of lysine187 within the second extracellular loop of the type A cholecystokinin receptor in agonist-induced activation. Use of complementary charge-reversal mutagenesis to define a functionally important interdomain interaction.

R. Abagyan, P. Lam, L. Miller, 2007, Biochemistry.

Inhibitor profile of bis(n)-tacrines and N-methylcarbamates on acetylcholinesterase from Rhipicephalus (Boophilus) microplus and Phlebotomus papatasi.

Fan Tong, J. Bloomquist, M. Totrov, 2013, Pesticide biochemistry and physiology.

Catalytic asymmetric synthesis of protected tryptophan regioisomers.

P. Lam, P. Carlier, D. M. Wong, 2002, The Journal of organic chemistry.

Towards a species-selective acetylcholinesterase inhibitor to control the mosquito vector of malaria, Anopheles gambiae.

J. Bloomquist, M. Totrov, P. Lam, 2008, Chemico-biological interactions.

Aryl methylcarbamates: potency and selectivity towards wild-type and carbamate-insensitive (G119S) Anopheles gambiae acetylcholinesterase, and toxicity to G3 strain An. gambiae.

J. Bloomquist, M. Totrov, P. Lam, 2013, Chemico-biological interactions.

Molecular Mechanism of Action of Triazolobenzodiazepinone Agonists of the Type 1 Cholecystokinin Receptor. Possible Cooperativity across the Receptor Homodimeric Complex.

R. Abagyan, P. Sexton, A. Christopoulos, 2015, Journal of medicinal chemistry.

Refinement of Glucagon-like Peptide 1 Docking to Its Intact Receptor Using Mid-region Photolabile Probes and Molecular Modeling*

Ruben Abagyan, Laurence J Miller, Patrick M Sexton, 2011, The Journal of Biological Chemistry.

Development of a Highly Selective Allosteric Antagonist Radioligand for the Type 1 Cholecystokinin Receptor and Elucidation of Its Molecular Basis of Binding

R. Abagyan, P. Sexton, A. Christopoulos, 2015, Molecular Pharmacology.

Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping

Ruben Abagyan, Laurence J Miller, Patrick M Sexton, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Identification of a New Class of FtsZ Inhibitors by Structure-Based Design and in Vitro Screening

Ning Sun, Ruben Abagyan, Dik-Lung Ma, 2013, J. Chem. Inf. Model..

Macrocycle modeling in ICM: benchmarking and evaluation in D3R Grand Challenge 4

Ruben Abagyan, Maxim Totrov, Polo C.-H. Lam, 2019, Journal of Computer-Aided Molecular Design.

Homology modeling of GPCRs.

Ruben Abagyan, Arthur Christopoulos, John Simms, 2009, Methods in molecular biology.

Molecular Basis for Benzodiazepine Agonist Action at the Type 1 Cholecystokinin Receptor*

R. Abagyan, P. Sexton, A. Christopoulos, 2013, The Journal of Biological Chemistry.

Molecular Basis for Binding and Subtype Selectivity of 1,4-Benzodiazepine Antagonist Ligands of the Cholecystokinin Receptor*

R. Abagyan, P. Sexton, P. Lam, 2012, The Journal of Biological Chemistry.

Hybrid receptor structure/ligand-based docking and activity prediction in ICM: development and evaluation in D3R Grand Challenge 3

Ruben Abagyan, Maxim Totrov, Polo Chun-Hung Lam, 2018, Journal of Computer-Aided Molecular Design.

Spatial Approximation between Secretin Residue Five and the Third Extracellular Loop of Its Receptor Provides New Insight into the Molecular Basis of Natural Agonist Binding

R. Abagyan, P. Sexton, P. Lam, 2008, Molecular Pharmacology.

Fluorescence Resonance Energy Transfer Analysis of Secretin Docking to Its Receptor

R. Abagyan, P. Sexton, P. Lam, 2007, Journal of Biological Chemistry.

Ligand-biased ensemble receptor docking (LigBEnD): a hybrid ligand/receptor structure-based approach

Ruben Abagyan, Maxim Totrov, Polo Chun-Hung Lam, 2017, Journal of Computer-Aided Molecular Design.

Functional Importance of a Structurally Distinct Homodimeric Complex of the Family B G Protein-Coupled Secretin Receptor

Ruben Abagyan, Arthur Christopoulos, Laurence J Miller, 2009, Molecular Pharmacology.

Use of Cysteine Trapping to Map Spatial Approximations between Residues Contributing to the Helix N-capping Motif of Secretin and Distinct Residues within Each of the Extracellular Loops of Its Receptor*

R. Abagyan, P. Sexton, A. Christopoulos, 2016, The Journal of Biological Chemistry.

Secretin Occupies a Single Protomer of the Homodimeric Secretin Receptor Complex

R. Abagyan, P. Sexton, P. Lam, 2010, The Journal of Biological Chemistry.

Molecular Approximations between Residues 21 and 23 of Secretin and Its Receptor: Development of a Model for Peptide Docking with the Amino Terminus of the Secretin Receptor

R. Abagyan, P. Sexton, P. Lam, 2007, Molecular Pharmacology.

Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008

Charles L. Brooks, Adrian W. R. Serohijos, John Moult, 2009, Nature Reviews Drug Discovery.

Bivalent Carbamates as Novel Control Agents of the Malaria Mosquito, Anopheles gambiae.

J. Bloomquist, M. Totrov, P. Lam, 2016, Chimia.

Molecular Basis of Secretin Docking to Its Intact Receptor Using Multiple Photolabile Probes Distributed throughout the Pharmacophore*

R. Abagyan, P. Sexton, P. Lam, 2011, The Journal of Biological Chemistry.