BinQing Wei

发表

Lead discovery using molecular docking.

J. Irwin, B. Shoichet, S. McGovern, 2002, Current opinion in chemical biology.

A model binding site for testing scoring functions in molecular docking.

B. Matthews, B. Shoichet, W. Baase, 2002, Journal of molecular biology.

Soft docking and multiple receptor conformations in virtual screening.

B. Shoichet, A. Ferrari, BinQing Wei, 2004, Journal of medicinal chemistry.

Testing a flexible-receptor docking algorithm in a model binding site.

Brian K Shoichet, Brian W Matthews, B. Matthews, 2004, Journal of molecular biology.

Discovery and optimization of a novel spiropyrrolidine inhibitor of β-secretase (BACE1) through fragment-based drug design.

M. Mansour, J. Pandit, BinQing Wei, 2012, Journal of medicinal chemistry.

Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα).

C. Li, R. Rowntree, BinQing Wei, 2019, Bioorganic & medicinal chemistry letters.

Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity.

Steve Price, E. Bradley, BinQing Wei, 2013, Journal of medicinal chemistry.

Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer.

BinQing Wei, D. Sutherlin, L. Friedman, 2011, Journal of medicinal chemistry.

High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers.

Athena W Wong, BinQing Wei, P. Polakis, 2018, Bioconjugate chemistry.

Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers.

Jeffrey T. Lau, BinQing Wei, S. Spencer, 2017, Journal of medicinal chemistry.

Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo.

Jeffrey T. Lau, R. Rowntree, B. Vollmar, 2019, Bioconjugate chemistry.

Potent and selective inhibitors of PI3Kδ: obtaining isoform selectivity from the affinity pocket and tryptophan shelf.

Steve Price, A. Nadin, BinQing Wei, 2013, Bioorganic & medicinal chemistry letters.

Cis-amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase.

E. Bradley, BinQing Wei, J. Lesnick, 2013, Bioorganic & medicinal chemistry letters.

Rational design of phosphoinositide 3-kinase α inhibitors that exhibit selectivity over the phosphoinositide 3-kinase β isoform.

BinQing Wei, D. Sutherlin, J. Lesnick, 2011, Journal of medicinal chemistry.

Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development.

Adam R. Johnson, BinQing Wei, C. Eigenbrot, 2018, Journal of medicinal chemistry.

A Novel Depurination Methodology to Assess DNA Alkylation of Chloro-Bis-Seco-Cyclopropylbenzoindoles Allowed for Comparison of Minor-Groove Reactivity

BinQing Wei, P. Dragovich, C. Khojasteh, 2019, Drug Metabolism and Disposition.

Simple methodology to estimate bioavailability in early clinical studies: theory and reality

BinQing Wei, Xingrong Liu, Lichuan Liu, 2017 .

Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice.

Marie Evangelista, BinQing Wei, M. Ultsch, 2016, ACS medicinal chemistry letters.

Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase.

BinQing Wei, M. Ultsch, C. Eigenbrot, 2014, Bioorganic & medicinal chemistry letters.

Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates.

Keyang Xu, Donglu Zhang, Tao Wang, 2016, Nature chemistry.

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition.

M. Belvin, A. Daemen, BinQing Wei, 2016, Nature chemical biology.

Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.

BinQing Wei, M. Ultsch, C. Eigenbrot, 2015, Bioorganic & medicinal chemistry letters.

Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.

BinQing Wei, M. Ultsch, C. Eigenbrot, 2014, Bioorganic & medicinal chemistry letters.

Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase.

BinQing Wei, M. Ultsch, C. Eigenbrot, 2013, Bioorganic & medicinal chemistry letters.

The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).

S. Steinbacher, Steve Price, E. Gancia, 2016, Journal of medicinal chemistry.

Discovery of novel PI3-kinase δ specific inhibitors for the treatment of rheumatoid arthritis: taming CYP3A4 time-dependent inhibition.

P. Savy, Steve Price, A. Nadin, 2012, Journal of medicinal chemistry.

Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase.

BinQing Wei, M. Ultsch, C. Eigenbrot, 2013, Bioorganic & medicinal chemistry letters.

Attachment Site Cysteine Thiol pKa Is a Key Driver for Site-Dependent Stability of THIOMAB Antibody-Drug Conjugates.

G. A. Lazar, Genee Y. Lee, B. Vollmar, 2017, Bioconjugate chemistry.

Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity.

S. Steinbacher, BinQing Wei, C. Eigenbrot, 2017, Journal of medicinal chemistry.

Structure-based Inhibitor Discovery against Adenylyl Cyclase Toxins from Pathogenic Bacteria That Cause Anthrax and Whooping Cough*

Brian K. Shoichet, Milan Mrksich, Yuequan Shen, 2003, Journal of Biological Chemistry.

Systematic Variation of Pyrrolobenzodiazepine (PBD)-dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates.

R. Rowntree, BinQing Wei, P. Dragovich, 2020, Journal of medicinal chemistry.

Structure-based Optimization of Hydroxylactam as Potent, Cell-Active Inhibitors of Lactate Dehydrogenase.

BinQing Wei, M. Ultsch, C. Eigenbrot, 2022, Bioorganic & medicinal chemistry letters.

Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties.

Melinda M. Mulvihill, Karen E Gascoigne, R. Rowntree, 2021, Journal of medicinal chemistry.

Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles.

A. K. Forrest, BinQing Wei, M. Ultsch, 2017, ACS medicinal chemistry letters.

Identification of GNE-293, a potent and selective PI3Kδ inhibitor: navigating in vitro genotoxicity while improving potency and selectivity.

Steve Price, BinQing Wei, D. Sutherlin, 2013, Bioorganic & medicinal chemistry letters.

Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase β isoform.

Steve Price, M. Belvin, BinQing Wei, 2013, Bioorganic & medicinal chemistry letters.

Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads.

B. Vollmar, BinQing Wei, P. Dragovich, 2018, Bioconjugate chemistry.

Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy.

Melinda M. Mulvihill, R. Rowntree, Wentao Wei, 2021, Journal of medicinal chemistry.

Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer.

BinQing Wei, Y. Franke, E. Day, 2019, Structure.

Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).

Hoai An Le Thi, E. Gancia, BinQing Wei, 2021, ACS medicinal chemistry letters.