D. Mackenna

发表

Measurement of strain and analysis of stress in resting rat left ventricular myocardium.

A. McCulloch, J. Omens, D. Mackenna, 1993, Journal of biomechanics.

Extracellular signal-regulated kinase and c-Jun NH2-terminal kinase activation by mechanical stretch is integrin-dependent and matrix-specific in rat cardiac fibroblasts.

E Ruoslahti, E. Ruoslahti, D. Mackenna, 1998, The Journal of clinical investigation.

Role of mechanical factors in modulating cardiac fibroblast function and extracellular matrix synthesis.

D. Mackenna, F. Villarreal, S. R. Summerour, 2000, Cardiovascular research.

Delivery of high levels of anti-proliferative nucleoside triphosphates to CYP3A-expressing cells as a potential treatment for hepatocellular carcinoma

M. Erion, D. Mackenna, D. Linemeyer, 2009, Cancer Chemotherapy and Pharmacology.

Lysyl oxidase like-2 contributes to renal fibrosis in Col4α3/Alport mice.

D. Mackenna, M. Gratton, D. Meehan, 2018, Kidney international.

Thyroid hormone β receptor activation has additive cholesterol lowering activity in combination with atorvastatin in rabbits, dogs and monkeys

M. Erion, P. D. van Poelje, D. Mackenna, 2009, British journal of pharmacology.

Immobilization of the knee joint alters the mechanical and ultrastructural properties of the rabbit anterior cruciate ligament

S. Woo, W. Akeson, D. Mackenna, 1995, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Liver-Targeted Drug Delivery Using HepDirect1 Prodrugs

M. Erion, P. D. van Poelje, D. Mackenna, 2005, Journal of Pharmacology and Experimental Therapeutics.

rg-101, a Galnac-conjugated anti-mir employing a unique mechanism of action by targeting host factor microrna-122 (mir-122), demonstrates potent activity and reduction of Hcv in preclinical studies : lb-28

D. Mackenna, J. Tay, Daniel J Hogan, 2013 .

MicroRNA-21 Promotes Fibrosis of the Kidney by Silencing Metabolic Pathways

Aaron N. Chang, S. Orkin, Jochen C. Hartner, 2012, Science Translational Medicine.

Polysome shift assay for direct measurement of miRNA inhibition by anti-miRNA drugs

D. Mackenna, V. Kaimal, Xueqing Liu, 2015, Nucleic acids research.

Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways.

Naoki Nakagawa, Jonathan Himmelfarb, D. Mackenna, 2015, The Journal of clinical investigation.

Fibronectin Matrix Regulates Activation of RHO and CDC42 GTPases and Cell Cycle Progression

Erkki Ruoslahti, Renata Pasqualini, E. Ruoslahti, 1998, The Journal of cell biology.

Biomechanics and Morphology of the Medial Collateral and Anterior Cruciate Ligaments

J. Weiss, S. Woo, D. Mackenna, 1990 .

A comparative evaluation of the mechanical properties of the rabbit medial collateral and anterior cruciate ligaments.

S L Woo, S. Woo, D. Mackenna, 1992, Journal of biomechanics.

Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy.

E. Masliah, T. Gaasterland, D. Mackenna, 2014, Cell metabolism.

An equibiaxial strain system for cultured cells.

T Delhaas, A D McCulloch, L K Waldman, 1996, The American journal of physiology.

Contribution of collagen matrix to passive left ventricular mechanics in isolated rat hearts.

A. McCulloch, J. Omens, J. Covell, 1994, The American journal of physiology.

Dysregulated Expression of microRNA-21 and Disease-Related Genes in Human Patients and in a Mouse Model of Alport Syndrome.

Jie Ding, Yanqin Zhang, Su-xia Wang, 2019, Human gene therapy.

A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis.

M. Erion, Q. Dang, P. D. van Poelje, 2010, ACS medicinal chemistry letters.

Hit-to-Lead Optimization and Discovery of 5-((5-([1,1'-Biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic Acid (MK-3903): A Novel Class of Benzimidazole-Based Activators of AMP-Activated Protein Kinase.

Margaret S. Wu, Q. Dang, D. Mackenna, 2017, Journal of medicinal chemistry.

Myocardial remodeling in hypertensive Ren-2 transgenic rats.

J. Omens, D. Mackenna, F. Villarreal, 1995, Hypertension.

Therapeutic modulation of microRNAs

D. Mackenna, N. Gibson, S. Neben, 2013 .

Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2).

Jilly F. Evans, Andiliy G. Lai, D. Mackenna, 2017, Journal of medicinal chemistry.

Synthesis and Characterization of a Novel Liver-Targeted Prodrug of Cytosine-1-β-d-arabinofuranoside Monophosphate for the Treatment of Hepatocellular Carcinoma

M. Erion, D. Mackenna, K. R. Reddy, 2006 .

Left ventricular perimysial collagen fibers uncoil rather than stretch during diastolic filling

J. Omens, J. Covell, D. Mackenna, 1996, Basic Research in Cardiology.

Anti-microRNA21 as a strategy to treat progressive kidney disease (abstract) ☆

D. Mackenna, J. Duffield, Ivan G. Gomez, 2016 .