S. Wetzel

发表

Charting biologically relevant chemical space: a structural classification of natural products (SCONP).

A. Schuffenhauer, P. Ertl, M. A. Koch, 2005, Proceedings of the National Academy of Sciences of the United States of America.

High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions.

John A. Tallarico, Jeffrey A. Porter, Mathias Frederiksen, 2014, Microbiological research.

Biology-oriented synthesis.

Stefan Wetzel, Herbert Waldmann, S. Wetzel, 2011, Angewandte Chemie.

Biology-inspired synthesis of compound libraries

S. Wetzel, H. Waldmann, M. Kaiser, 2008, Cellular and Molecular Life Sciences.

Bioactivity-guided mapping and navigation of chemical space.

Stefan Wetzel, Tudor I. Oprea, Herbert Waldmann, 2009, Nature chemical biology.

Biologie‐orientierte Synthese (BIOS)

S. Wetzel, H. Waldmann, R. Bon, 2011 .

Protein structure similarity clustering: dynamic treatment of PDB structures facilitates clustering.

Stefan Wetzel, Herbert Waldmann, Richard G Macdonald, 2006, Angewandte Chemie.

Interactive exploration of chemical space with Scaffold Hunter.

Stefan Wetzel, Tudor I. Oprea, Herbert Waldmann, 2009, Nature chemical biology.

Small-molecule inhibition of APT1 affects Ras localization and signaling.

Stefan Wetzel, Herbert Waldmann, Daniel Rauh, 2010, Nature chemical biology.

S. Wetzel, H. Waldmann, 2009 .

Biology Oriented Synthesis and Diversity Oriented Synthesis in Compound Collection Development

S. Wetzel, H. Waldmann, Kamal Kumar, 2008 .

A scaffold-tree-merging strategy for prospective bioactivity annotation of gamma-pyrones.

Stefan Wetzel, Tudor I. Oprea, Herbert Waldmann, 2010, Angewandte Chemie.

Impairment of prostate cancer cell growth by a selective and reversible lysine‐specific demethylase 1 inhibitor

S. Wetzel, H. Waldmann, R. Schüle, 2012, International journal of cancer.

3.02 – Natural Products as Lead Sources for Drug Development

S. Wetzel, H. Waldmann, Hugo Lachance, 2010 .

Natural-product-derived fragments for fragment-based ligand discovery

Stefan Wetzel, Herbert Waldmann, Daniel Rauh, 2012, Nature Chemistry.

Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase.

R. Goody, S. Wetzel, H. Waldmann, 2012, Journal of the American Chemical Society.

Structure-guided development of selective RabGGTase inhibitors.

R. Goody, S. Wetzel, H. Waldmann, 2011, Angewandte Chemie.

Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex.

R. Goody, S. Wetzel, H. Waldmann, 2008, Angewandte Chemie.

Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design.

P. Bastiaens, S. Renner, S. Wetzel, 2011, Angewandte Chemie.

Charting, navigating, and populating natural product chemical space for drug discovery.

Stefan Wetzel, Kamal Kumar, Herbert Waldmann, 2012, Journal of medicinal chemistry.

Synthesis and conformational analysis of stevastelin C3 analogues and their activity against the dual-specific vaccina H1-related phosphatase.

S. Wetzel, H. Waldmann, H. Arndt, 2008, Chemistry.

Cheminformatic Analysis of Natural Products and their Chemical Space

Stefan Wetzel, Herbert Waldmann, Peter Ertl, 2007 .

Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors.

R. Goody, S. Wetzel, H. Waldmann, 2009, Journal of medicinal chemistry.

Role of Natural Products in Drug Discovery

Stefan Wetzel, Herbert Waldmann, S. Wetzel, 2010 .

Biology-Oriented Synthesis

Stefan Wetzel, Herbert Waldmann, S. Wetzel, 2012 .

Corrigendum: Interactive exploration of chemical space with Scaffold Hunter

Stefan Wetzel, Tudor I. Oprea, Herbert Waldmann, 2009 .

The Scaffold Tree - Visualization of the Scaffold Universe by Hierarchical Scaffold Classification

Stefan Wetzel, Herbert Waldmann, Peter Ertl, 2007, J. Chem. Inf. Model..

ATP competitive inhibitors of D-alanine-D-alanine ligase based on protein kinase inhibitor scaffolds.

Stefan Wetzel, Herbert Waldmann, Daniel Rauh, 2009, Bioorganic & medicinal chemistry.

A microarray strategy for mapping the substrate specificity of protein tyrosine phosphatase.

S. Wetzel, H. Waldmann, H. Schroeder, 2007, Angewandte Chemie.

Protein structure similarity clustering: dynamic treatment of PDB structures facilitates clustering.

S. Wetzel, H. Waldmann, D. Berkowitz, 2006, Angewandte Chemie.