G. Trainor

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A system for rapid DNA sequencing with fluorescent chain-terminating dideoxynucleotides.

J. M. Prober, G. Trainor, R. J. Dam, 1987, Science.

Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1).

S. Pang, G. Trainor, M. Poss, 2009, Bioorganic & medicinal chemistry letters.

Benzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)--Hit to Lead studies.

S. Pang, G. Trainor, M. Poss, 2009, Bioorganic & medicinal chemistry letters.

Potent antisense oligonucleotides to the human multidrug resistance-1 mRNA are rationally selected by mapping RNA-accessible sites with oligonucleotide libraries.

G. Trainor, F. Hobbs, B. Stone, 1996, Nucleic acids research.

MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products.

J. Wityak, G. Trainor, F. Hobbs, 1998, Bioorganic & medicinal chemistry letters.

Matrix metalloproteinase–activated doxorubicin prodrugs inhibit HT1080 xenograft growth better than doxorubicin with less toxicity

G. Trainor, R. Copeland, S. P. Seitz, 2005, Molecular Cancer Therapeutics.

Quinazolines as cyclin dependent kinase inhibitors.

G L Trainor, C. Chang, G. Trainor, 2001, Bioorganic & medicinal chemistry letters.

Chapter 31 Plasma Protein Binding and the Free Drug Principle: Recent Developments and Applications

G. Trainor, 2007 .

Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor.

Punit Marathe, Ravindra Tejwani, Arvind Mathur, 2008, Bioorganic & medicinal chemistry letters.

Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development.

G. Trainor, A. Mathur, D. Langley, 2009, Journal of medicinal chemistry.

Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one.

G. Trainor, M. Gottardis, A. Greer, 2010, Bioorganic & medicinal chemistry letters.

Discovery of BMS-641988, a Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer.

S. Spergel, G. Trainor, L. Schweizer, 2015, ACS medicinal chemistry letters.

The discovery of 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1 ,5-a]-pyrimidine: a corticotropin-releasing factor (hCRF1) antagonist.

G. Trainor, A. Cocuzza, D. Robertson, 2000, Bioorganic & medicinal chemistry.

9H-Carbazole-1-carboxamides as potent and selective JAK2 inhibitors.

J. Tokarski, G. Trainor, J. Sack, 2015, Bioorganic & medicinal chemistry letters.

Evidence for the general base mechanism in carboxypeptidase A-catalyzed reactions: partitioning studies on nucleophiles and H2(18)O kinetic isotope effects.

D. Hilvert, G. Trainor, R. Breslow, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Identification of selective inhibitors of cyclin dependent kinase 4.

G. Trainor, S. Cox, S. P. Seitz, 2001, Bioorganic & medicinal chemistry letters.

Discovery of CC chemokine receptor-3 (CCR3) antagonists with picomolar potency.

G. Trainor, M. Covington, C. Decicco, 2005, Journal of medicinal chemistry.

Biochemical and transcriptional profiling to triage additional activities in a series of IGF-1R/IR inhibitors.

P. Ross-Macdonald, H. de Silva, Isaac Neuhaus, 2012, Bioorganic & Medicinal Chemistry.

Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors.

A. Good, J. Macor, J. Marcinkeviciene, 2011, Bioorganic & medicinal chemistry letters.

Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors.

J. Fargnoli, J. Tokarski, G. Trainor, 2010, Bioorganic & medicinal chemistry letters.

The Preparation of O-Trifluoromethyl Carbohydrates

G. Trainor, 1985 .

Dihydropyridopyrazinones and dihydropteridinones as corticotropin-releasing factor-1 receptor antagonists: structure-activity relationships and computational modeling.

G. Trainor, T. Molski, M. Rafalski, 2007, Journal of medicinal chemistry.

Preclinical antitumor activity of XK469 (NSC 656889)

G. Trainor, R. Parchment, C. Behrens, 1998, Investigational New Drugs.

Preclinical antitumor efficacy of analogs of XK469: sodium-(2-[4-(7-chloro-2-quinoxalinyloxy)phenoxy]propionate

P. LoRusso, G. Trainor, L. Heilbrun, 2004, Investigational New Drugs.

CCR3 antagonists: a potential new therapy for the treatment of asthma. Discovery and structure-activity relationships.

G. Trainor, M. Covington, C. Decicco, 2002, Bioorganic & medicinal chemistry letters.

4-(1,3-Dimethoxyprop-2-ylamino)-2,7-dimethyl-8-(2, 4-dichlorophenyl)pyrazolo[1,5-a]-1,3,5-triazine: a potent, orally bioavailable CRF(1) receptor antagonist.

S. Shelton, G. Trainor, P. Hartig, 2000, Journal of medicinal chemistry.

The Ca V 1.2 L-type calcium channel regulates bone homeostasis in the middle and inner ear

R. Rodriguiz, M. Greenblatt, G. Trainor, 2019 .

Discovery of matrix metalloproteases selective and activated peptide-doxorubicin prodrugs as anti-tumor agents.

G. Trainor, S. P. Seitz, C. Albright, 2010, Bioorganic & medicinal chemistry letters.

Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer.

A. Doweyko, G. Trainor, A. Fura, 2016, ACS medicinal chemistry letters.

Receptor Occupancy of Nonpeptide Corticotropin-Releasing Factor 1 Antagonist DMP696: Correlation with Drug Exposure and Anxiolytic Efficacy

G. Trainor, R. Taub, H. Wong, 2003, Journal of Pharmacology and Experimental Therapeutics.

2,4-Disubstituted piperidines as selective CC chemokine receptor 3 (CCR3) antagonists: synthesis and selectivity.

G. Trainor, M. Covington, C. Decicco, 2006, Bioorganic & medicinal chemistry letters.

Discovery of N-propylurea 3-benzylpiperidines as selective CC chemokine receptor-3 (CCR3) antagonists.

G. Trainor, M. Covington, C. Decicco, 2004, Bioorganic & medicinal chemistry letters.

Receptor Occupancy of Non-Peptide CRF 1 Antagonist DMP 696 : Correlation with Drug Exposure and Anxiolytic Efficacy

G. Trainor, R. Taub, S. Grossman, 2002 .

Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2

P. Ross-Macdonald, K. McIntyre, G. Trainor, 2012, Leukemia.

Synthesis and evaluation of benzoxazinones as HIV-1 reverse transcriptase inhibitors. Analogs of Efavirenz (SUSTIVATM)

G. Trainor, R. Klabe, S. Erickson-Viitanen, 1999 .

Genetic Bit Analysis: a solid phase method for typing single nucleotide polymorphisms.

Y. Rogers, G. Trainor, M. Kotewicz, 1994, Nucleic acids research.

Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily.

J. Fargnoli, J. Tokarski, G. Trainor, 2009, Journal of medicinal chemistry.

Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors.

S Diamond, S S Ko, G L Trainor, 2000, Journal of medicinal chemistry.

Synthesis and evaluation of analogs of Efavirenz (SUSTIVATM) as HIV-1 reverse transcriptase inhibitors

G. Trainor, S. P. Seitz, A. Srivastava, 1999 .

Discovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: synthesis, X-ray crystallographic analysis, and biological activities.

J. Fargnoli, J. Tokarski, D. Xie, 2008, Journal of medicinal chemistry.

Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an orally efficacious inhibitor of insulin-like growth factor-1 receptor kinase with broad spectrum in vivo antitumor activ

Zheng Yang, Sean Kim, Praveen Balimane, 2008, Journal of medicinal chemistry.

Design, Synthesis, and Biological Evaluation of 1,2,3,7-Tetrahydro-6H-purin-6-one and 3,7-Dihydro-1H-purine-2,6-dione Derivatives as Corticotropin-Releasing Factor1 Receptor Antagonists

Vijay T. Ahuja, K. K. Nanda, G. Trainor, 2004 .

Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 3. Structure activity relationships at C3

Angela Smallwood, Chong-Hwan Chang, Steven P. Seitz, 2002 .

Synthesis and evaluation of 2-anilino-3-phenylsulfonyl-6-methylpyridines as corticotropin-releasing factor1 receptor ligands.

G. Trainor, D. Langley, H. Wong, 2006, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of efavirenz (Sustiva) analogues as HIV-1 reverse transcriptase inhibitors: replacement of the cyclopropylacetylene side chain.

L. Bacheler, G. Trainor, A. Cocuzza, 2001, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of cyclin-dependent kinases.

Chong-Hwan Chang, Chong-Hwan Chang, G. Trainor, 2004, Journal of medicinal chemistry.

Synthesis and evaluation of quinoxalinones as HIV-1 reverse transcriptase inhibitors.

G. Trainor, R. Klabe, J. Rodgers, 2000, Bioorganic & medicinal chemistry letters.

Nonsymmetric P2/P2' cyclic urea HIV protease inhibitors. Structure-activity relationship, bioavailability, and resistance profile of monoindazole-substituted P2 analogues.

L. Bacheler, G. Trainor, R. Klabe, 1998, Journal of medicinal chemistry.

Cyclin-dependent kinase inhibitors: useful targets in cell cycle regulation.

G L Trainor, G. Trainor, J. Boylan, 2000, Journal of medicinal chemistry.

Functionalized porous silica microspheres as scavengers in parallel synthesis.

G. Trainor, J. Kirkland, L. Thompsona, 2000, Combinatorial chemistry & high throughput screening.

Expanded-Spectrum Nonnucleoside Reverse Transcriptase Inhibitors Inhibit Clinically Relevant Mutant Variants of Human Immunodeficiency Virus Type 1

Ronald M. Klabe, L. Bacheler, P. Anderson, 1999, Antimicrobial Agents and Chemotherapy.

Parallel synthesis of potent, pyrazole-based inhibitors of Helicobacter pylori dihydroorotate dehydrogenase.

J. Marcinkeviciene, G. Trainor, F. Hobbs, 2002, Journal of medicinal chemistry.

Purin-8-ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists.

G. Trainor, L. Fitzgerald, R. Zaczek, 1999, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones as corticotropin-releasing factor-1 receptor antagonists.

J. Macor, G. Trainor, H. Wong, 2012, Bioorganic & medicinal chemistry letters.

The synthesis and antitumor evaluation of unsymmetrical bis-imides

G. Trainor, S. P. Seitz, C. Behrens, 1997 .

Drug design with a new transition state analog of the hydrated carbonyl: silicon-based inhibitors of the HIV protease.

S. Sieburth, G. Trainor, R. Klabe, 2001, Chemistry & biology.

Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors.

K. Kish, G. Trainor, N. Meanwell, 2020, Journal of medicinal chemistry.

Influence of the Heterocyclic Base-component on the Reaction of Enamines with Allylic Halides

G. Trainor, A. Bose, U. Pandit, 1973 .

Lamivudine-Resistant Viral Variants Activity against Zidovudine- and DPC 817: a Cytidine Nucleoside Analog with

M. Otto, M. Rayner, J. Mellors, 2014 .

Synthesis and evaluation of quinoxalinones as HIV-1 reverse transcriptase inhibitors.

G. Trainor, R. Klabe, J. Rodgers, 2000, Bioorganic & medicinal chemistry letters.

An organotransition metal based approach to the synthesis of C-glycosides

G. Trainor, P. DeShong, G. Slough, 1985 .

PREPARATION OF A STABLE (GLUCOPYRANOSYL)IRON COMPOUND

G. Trainor, B. Smart, 1983 .

High acylation rates and enantioselectivity with cyclodextrin complexes of rigid substrates

G. Trainor, R. Breslow, 1981 .

Effect of pressure on two cyclodextrin-promoted ester hydrolyses

W. L. Noble, G. Trainor, R. Breslow, 1983 .

Optimization of metallocene substrates for .beta.-cyclodextrin reactions

G. Trainor, R. Breslow, A. Ueno, 1983 .

DNA sequencing, automation, and the human genome.

G L Trainor, G. Trainor, 1990, Analytical chemistry.

Selective inhibition of bacterial dihydroorotate dehydrogenases by thiadiazolidinediones.

T. Chung, J. Marcinkeviciene, G. Trainor, 2000, Biochemical pharmacology.

BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR

Zheng Yang, G. Trainor, F. Lee, 2009, Molecular Cancer Therapeutics.

The importance of plasma protein binding in drug discovery

G. Trainor, George L Trainor, 2007, Expert opinion on drug discovery.

Discovery of N-propylurea 3-benzylpiperidines as selective CC chemokine receptor-3 (CCR3) antagonists.

G. Trainor, M. Covington, C. Decicco, 2004, Bioorganic & medicinal chemistry letters.

BMS-871: a novel orally active pan-Notch inhibitor as an anticancer agent.

Derek J. Norris, D. Shen, G. Trainor, 2015, Bioorganic & medicinal chemistry letters.

Biodistribution and metabolism of internally 3H-labeled oligonucleotides. I. Comparison of a phosphodiester and a phosphorothioate.

G. Trainor, F. Hobbs, A. Cocuzza, 1994, Molecular pharmacology.

Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists.

G. Trainor, M. Covington, C. Decicco, 2002, Journal of medicinal chemistry.

DNA recognition of base analogue and chemically modified substrates by the TaqI restriction endonuclease.

F. Barany, G. Trainor, J. Zebala, 1992, Journal of Biological Chemistry.

Oligonucleotides with a nuclease-resistant sulfur-based linkage

G. Trainor, E. Huie, M. Kirshenbaum, 1992 .

Oligonucleotides with a Nuclease‐Resistant Sulfur‐Based Linkage.

G. Trainor, E. Huie, M. Kirshenbaum, 1993 .

Inhibitors of human mitotic kinesin Eg5: characterization of the 4-phenyl-tetrahydroisoquinoline lead series.

Wayne Vaccaro, Steven Sheriff, Neil Burford, 2006, Bioorganic & medicinal chemistry letters.

Helicobacter pylori-selective Antibacterials Based on Inhibition of Pyrimidine Biosynthesis*

J. Marcinkeviciene, G. Trainor, F. Hobbs, 2000, The Journal of Biological Chemistry.

Anxiolytic-Like Effects of the Corticotropin-Releasing Factor1 (CRF1) Antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] Administered Acutely or Chronically at Doses Occupying Central CRF1 Receptors in Rats

S. Arneric, G. Trainor, R. Taub, 2004, Journal of Pharmacology and Experimental Therapeutics.

Anxiolytic-Like Effects of the Corticotropin-Releasing Factor 1 ( CRF 1 ) Antagonist DMP 904 [ 4-( 3-pentylamino )-2 , 7-dimethyl-8-( 2-methyl-4-methoxyphenyl )-pyrazolo-[ 1 , 5-a ]-pyrimidine ] Administered Acutely or Chronically at Doses Occupying Central CRF 1 Receptors in Rats

S. Arneric, G. Trainor, R. Taub, 2004 .

Identification and optimization of small molecule antagonists of vasoactive intestinal peptide receptor-1 (VIPR1).

David S. Nirschl, David S Nirschl, G. Trainor, 2012, Bioorganic & medicinal chemistry letters.

OPTIMIZATION OF METALLOCENE SUBSTRATES FOR β-CYCLODEXTRIN REACTIONS

G. Trainor, R. Breslow, A. Ueno, 1983 .

Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3.

Chong-Hwan Chang, G. Trainor, S. Cox, 2004, Bioorganic & medicinal chemistry letters.

[2.2.1]-Bicyclic sultams as potent androgen receptor antagonists.

Michael A. Galella, G. Trainor, Weifang Shan, 2016, Bioorganic & medicinal chemistry letters.

Trends in kinase selectivity: insights for target class-focused library screening.

Stephen R. Johnson, Stephen R Johnson, Wayne Vaccaro, 2011, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of 8-(pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: potent, orally bioavailable corticotropin releasing factor receptor-1 (CRF1) antagonists.

S. Arneric, G. Trainor, H. Wong, 2009, Journal of medicinal chemistry.

DNA sequencing technology.

M A Kashdan, G L Trainor, G. Trainor, 1988, Basic life sciences.

Pyrrolo[1,2-f]triazines as JAK2 inhibitors: achieving potency and selectivity for JAK2 over JAK3.

Jonathan Lippy, John S Tokarski, David S Nirschl, 2011, Bioorganic & medicinal chemistry letters.

Beyond U0126. Dianion chemistry leading to the rapid synthesis of a series of potent MEK inhibitors.

J. Wityak, G. Trainor, R. Copeland, 2004, Bioorganic & medicinal chemistry letters.

Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5-d]pyrrolo[2,3-b]pyridine Inhibitors.

J. Tokarski, G. Trainor, J. Sack, 2015, ACS medicinal chemistry letters.

Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms.

J. Tokarski, G. Trainor, A. Mathur, 2015, ACS medicinal chemistry letters.

Identification of 2-amino-5-(thioaryl)thiazoles as inhibitors of nerve growth factor receptor TrkA.

Ping Chen, R. Moquin, J. Tokarski, 2008, Bioorganic & medicinal chemistry letters.

Regulated Expression of the Escherichia coli lepB Gene as a Tool for Cellular Testing of Antimicrobial Compounds That Inhibit Signal Peptidase I In Vitro

David L. Pompliano, Jay A. Markwalder, Joseph A. DeVito, 2002, Antimicrobial Agents and Chemotherapy.

Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors.

Derek J. Norris, D. Shen, G. Trainor, 2015, ACS medicinal chemistry letters.

8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists.

Lawrence Fitzgerald, Ge Zhang, Harvey Wong, 2009, Journal of medicinal chemistry.

Synthesis, antiviral activity and pharmacokinetics of P1/P1' substituted 3-aminoindazole cyclic urea HIV protease inhibitors.

L. Bacheler, G. Trainor, R. Klabe, 2003, Bioorganic & medicinal chemistry letters.

NUCLEAR MAGNETIC RESONANCE SPECTRAL STUDIES PART 8, TITANIUM TETRACHLORIDE AS A SHIFT REAGENT

G. Trainor, P. R. Srinivasan, A. Bose, 1974 .

Nuclear magnetic resonance spectral studies. VIII. Titanium tetrachloride as a shift reagent

G. Trainor, P. R. Srinivasan, A. Bose, 1974 .

Improvements in the chain-termination method of DNA sequencing through the use of 7-deaza-2'-deoxyadenosine.

E. Chen, G. Trainor, R. Zagursky, 1991, DNA sequence : the journal of DNA sequencing and mapping.

A procedure for the preparation of fluorescence-labeled DNA with terminal deoxynucleotidyl transferase.

G. Trainor, M. Jensen, 1988, Nucleic acids research.

Synthesis and evaluation of benzoxazinones as HIV-1 reverse transcriptase inhibitors. Analogs of Efavirenz (SUSTIVA).

G. Trainor, R. Klabe, S. Erickson-Viitanen, 1999, Bioorganic & medicinal chemistry letters.

Modulation of cofilin phosphorylation by inhibition of the Lim family kinases.

J. Tokarski, G. Trainor, M. Poss, 2012, Bioorganic & medicinal chemistry letters.

J. Fargnoli, J. Tokarski, G. Trainor, 2009, Journal of medicinal chemistry.

J. Fargnoli, G. Derbin, J. Barrish, 2008, Bioorganic & medicinal chemistry letters.