S. Betz

发表

Disulfide bonds and the stability of globular proteins

S. Betz, 1993, Protein science : a publication of the Protein Society.

Native-like and structurally characterized designed α-helical bundles

W. DeGrado, S. Betz, J. Bryson, 1995 .

De novo protein design: from molten globules to native-like states

Stephen F. Betz, William F. DeGrado, D. Raleigh, 1993 .

Protein Design: A Hierarchic Approach

W. DeGrado, S. Betz, J. Bryson, 1995, Science.

Non-peptidic small molecule inhibitors of XIAP.

Chaohong Sun, R. Meadows, E. Olejniczak, 2005, Bioorganic & medicinal chemistry letters.

Discovery of potent inhibitors of dihydroneopterin aldolase using CrystaLEAD high-throughput X-ray crystallographic screening and structure-directed lead optimization.

Jean M. Severin, Rolf Wagner, Vincent S Stoll, 2004, Journal of medicinal chemistry.

Overlapping, nonidentical binding sites of different classes of nonpeptide antagonists for the human gonadotropin-releasing hormone receptor.

S. Betz, Chen Chen, Greg J. Reinhart, 2006, Journal of medicinal chemistry.

Identification of 2-(4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-ethylamine derivatives as novel GnRH receptor antagonists.

Zhiqian Guo, S. Betz, Xin-jun Liu, 2007, Bioorganic & medicinal chemistry letters.

Discovery of nonpeptide 3,4-dihydroquinazoline-4-carboxamides as potent and selective sst2 agonists.

S. Betz, S. H. Kim, Yun-fei Zhu, 2020, Bioorganic & medicinal chemistry letters.

The crystal structure of a quercetin 2,3-dioxygenase from Bacillus subtilis suggests modulation of enzyme activity by a change in the metal ion at the active site(s).

S. Betz, A. Kossiakoff, B. Gopal, 2005, Biochemistry.

Somatostatin receptors in congenital hyperinsulinism: Biology to bedside

S. Betz, K. Mohnike, M. Dunne, 2022, Frontiers in Endocrinology.

1H, 13C and 15N resonance assignments and secondary structure of the human protein tyrosine phosphatase, PRL-2.

P. Domaille, J. Fetrow, S. Betz, 2003, Journal of biomolecular NMR.

Determination of the binding mode of thienopyrimidinedione antagonists to the human gonadotropin releasing hormone receptor using structure-activity relationships, site-directed mutagenesis, and homology modeling.

Zhiqian Guo, S. Betz, M. Mesleh, 2006, Journal of medicinal chemistry.

Discovery of 4-(3-aminopyrrolidinyl)-3-aryl-5-(benzimidazol-2-yl)-pyridines as potent and selective SST5 agonists for the treatment of congenital hyperinsulinism.

S. Betz, Melissa A. Fowler, E. Sturchler, 2022, Bioorganic & medicinal chemistry letters.

Introduction of a disulfide bond into cytochrome c stabilizes a compact denatured state.

S. Betz, G. Pielak, 1992, Biochemistry.

Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties.

Zhiqian Guo, S. Betz, Chen Chen, 2008, Bioorganic & medicinal chemistry letters.

Non-peptide gonadotropin-releasing hormone receptor antagonists.

S. Betz, Chen Chen, Yun-fei Zhu, 2008, Journal of medicinal chemistry.

Single amino acid residue determinants of non-peptide antagonist binding to the corticotropin-releasing factor1 (CRF1) receptor.

S. Betz, Brock T Brown, D. Grigoriadis, 2006, Biochemical pharmacology.

NMR studies of the anti-apoptotic protein Bcl-xL in micelles.

E. Olejniczak, S. Fesik, S. Betz, 2000, Biochemistry.

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

Stephen F. Betz, Stephen W. Fesik, Edward T. Olejniczak, 2000, Nature.

Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.

Saul H Rosenberg, Chaohong Sun, R. Meadows, 2004, Journal of medicinal chemistry.

Solution structure of the cytohesin-1 (B2-1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1.

R. Meadows, E. Olejniczak, S. Fesik, 1998, Proceedings of the National Academy of Sciences of the United States of America.

From Bacterial Genomes to Novel Antibacterial Agents: Discovery, Characterization, and Antibacterial Activity of Compounds that Bind to HI0065 (YjeE) from Haemophilus influenzae

P. Hajduk, K. Comess, Liping Yu, 2007, Chemical biology & drug design.

Paltusotine, a novel oral once-daily nonpeptide SST2 receptor agonist, suppresses GH and IGF-1 in healthy volunteers

S. Betz, S. Markison, R. Struthers, 2022, Pituitary.

Discovery of substituted 3H-pyrido[2,3-d]pyrimidin-4-ones as potent, biased, and orally bioavailable sst2 agonist.

S. Betz, Yun-fei Zhu, E. Rico-Bautista, 2020, Bioorganic & medicinal chemistry letters.

MON-176 Discovery and Identification of Late Stage Selective Nonpeptide ACTH Antagonists for the Treatment of Cushing’s Disease, Ectopic ACTH Secreting Tumors, and Congenital Adrenal Hyperplasia

S. Betz, S. H. Kim, Melissa A. Fowler, 2020, Journal of the Endocrine Society.

OR19-03 Effects of Nonpeptide Orally Bioavailable ACTH Antagonists on Adrenal Gland Size and Function in Rats

S. Betz, Melissa A. Fowler, S. Markison, 2020, Journal of the Endocrine Society.

Unusual effects of an engineered disulfide on global and local protein stability.

S. Betz, G. Pielak, D. Doyle, 1996, Biochemistry.

De novo design of native proteins: characterization of proteins intended to fold into antiparallel, rop-like, four-helix bundles.

W. DeGrado, S. Betz, P. Liebman, 1997, Biochemistry.

SAT-429 Final Results from the First in Man Phase 1 Clinical Trial of CRN00808, an Orally Bioavailable sst2-Selective, Nonpeptide Somatostatin Biased Agonist, for the Treatment of Acromegaly: Safety, Pharmacokinetics, Pharmacodynamics, and Midazolam Drug Interaction in Healthy Volunteers

S. Betz, T. Oltersdorf, S. Markison, 2019, Journal of the Endocrine Society.

Hydrophobic core malleability of a de novo designed three-helix bundle protein.

W. DeGrado, S. Betz, S. Walsh, 2001, Journal of molecular biology.

Changes in global stability and local structure of cytochrome c upon substituting phenylalanine-82 with tyrosine.

D. Auld, S. Betz, G. Pielak, 1993, Journal of inorganic biochemistry.

Amide proton exchange rates of oxidized and reduced saccharomyces cerevisiae iso‐1‐cytochrome c

D. Auld, S. Betz, G. Pielak, 1993, Protein science : a publication of the Protein Society.

A Strategy for High-Throughput Assay Development Using Leads Derived from Nuclear Magnetic Resonance-Based Screening

P. Hajduk, Xiaoan Ruan, S. Fesik, 2002, Journal of biomolecular screening.

Function first: a powerful approach to post-genomic drug discovery.

Jacquelyn S Fetrow, J. Fetrow, S. Betz, 2002, Drug discovery today.

PSUN304 CRN04777 an Oral, Nonpeptide SST5-selective Somatostatin Agonist Dose Dependently Suppresses Basal and Stimulated Insulin Secretion

Yang Wang, T. Heise, S. Betz, 2022, Journal of the Endocrine Society.

Selective Somatostatin 5 (SST5) and Somatostatin 2 (SST2) Nonpeptide Agonists Potently Suppress Glucose- and Tolbutamide-Stimulated Dynamic Insulin Secretion From Isolated Human Islets

S. Betz, Yun-fei Zhu, Mi Chen, 2021, Journal of the Endocrine Society.

LBSAT142 Discovery And Characterization Of A Potent And Orally Bioavailable Parathyroid Hormone Receptor Type-1 (PTHR1) Antagonist For The Treatment Of Hypercalcemia

S. Betz, Beth A. Fleck, P. Arroyo, 2022, Journal of the Endocrine Society.

A de Novo Designed Protein Mimics the Native State of Natural Proteins

D. Raleigh, W. DeGrado, S. Betz, 1995 .

Native-like and structurally characterized designed alpha-helical bundles.

W. DeGrado, S. Betz, J. Bryson, 1995, Current opinion in structural biology.

Controlling topology and native-like behavior of de novo-designed peptides: design and characterization of antiparallel four-stranded coiled coils.

W. DeGrado, S. Betz, Stephen F. Betz, 1996, Biochemistry.

Design of two-stranded and three-stranded coiled-coil peptides.

W. DeGrado, R. Fairman, S. Betz, 1995, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Design and characterization of an engineered gp41 protein from human immunodeficiency virus-1 as a tool for drug discovery

Kevin Harris, Kent D. Stewart, Kevin Steffy, 2007, J. Comput. Aided Mol. Des..

Probing weakly polar interactions in cytochrome c

D. Auld, S. Betz, G. Pielak, 1993, Protein science : a publication of the Protein Society.

Resonance-Based Screening A Strategy for High-Throughput Assay Development Using Leads Derived from Nuclear Magnetic

P. Hajduk, Xiaoan Ruan, S. Fesik, 2013 .