A. Sharpe

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Targeted reconstruction of T cell receptor sequence from single cell RNA-seq links CDR3 length to T cell differentiation state

P. Klenerman, N. Yosef, D. Douek, 2017, Nucleic acids research.

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

Christopher P. Crum, Arlene H. Sharpe, C. Tabin, 1999, Nature.

Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation.

Michal Sheffer, S. Gygi, Noah Dephoure, 2016, Cell metabolism.

Constitutive Neuronal Expression of the Immune Regulator, Programmed Death 1 (PD-1), Identified During Experimental Autoimmune Uveitis

G. Freeman, A. Sharpe, L. Gordon, 2009, Ocular immunology and inflammation.

PD-1 and its ligands in T-cell immunity.

Loise M. Francisco, A. Sharpe, M. Keir, 2007, Current opinion in immunology.

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.

J. Bluestone, A. Sharpe, D. Lenschow, 2000, Immunity.

The B7–CD28 superfamily

G. Freeman, A. Sharpe, G. Freeman, 2002, Nature Reviews Immunology.

Analysis of the Role of Negative T Cell Costimulatory Pathways in CD4 and CD8 T Cell-Mediated Alloimmune Responses In Vivo1

A. Sharpe, H. Auchincloss, M. Jurewicz, 2005, The Journal of Immunology.

Essential Role of PDL1 Expression on Nonhematopoietic Donor Cells in Acquired Tolerance to Vascularized Cardiac Allografts

A. Sharpe, J. Azzi, M. Sayegh, 2011, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

PD-1 and its ligands in tolerance and immunity.

G. Freeman, A. Sharpe, M. Butte, 2008, Annual review of immunology.

Endothelial Programmed Death-1 Ligand 1 (PD-L1) Regulates CD8+ T-Cell–Mediated Injury in the Heart

G. Freeman, A. Sharpe, Hong-Bo Pang, 2007, Circulation.

Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts.

P. Libby, R. Mitchell, A. Sharpe, 1999, Journal of immunology.

Absence of host B7 expression is sufficient for long-term murine vascularized heart allograft survival.

G. Szot, J. Bluestone, A. Sharpe, 2000, Transplantation.

CD28-independent Costimulation of T Cells in Alloimmune Responses1

A. Sharpe, H. Auchincloss, L. Turka, 2001, The Journal of Immunology.

CTLA-4 regulates induction of anergy in vivo.

A. Sharpe, A. Abbas, V. Boussiotis, 2001, Immunity.

B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4.

R. Mitchell, G. Freeman, A. Sharpe, 2001, Journal of Clinical Investigation.

Rejection of Mouse Cardiac Allografts by Costimulation in trans1

A. Sharpe, H. Auchincloss, M. Sayegh, 2001, The Journal of Immunology.

Negative co-receptors on lymphocytes.

A. Sharpe, R. Greenwald, Y. Latchman, 2002, Current opinion in immunology.

Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses

G. Freeman, A. Sharpe, Y. Latchman, 2003, European journal of immunology.

The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity.

G. Freeman, A. Sharpe, M. Sayegh, 2003, The Journal of clinical investigation.

CD70 Signaling Is Critical for CD28-Independent CD8+ T Cell-Mediated Alloimmune Responses In Vivo1

A. Sharpe, H. Auchincloss, M. Sayegh, 2005, The Journal of Immunology.

Pathogenesis of viral infections. Basic concepts derived from the reovirus model.

A. Sharpe, B. Fields, 1985 .

Lethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF

S. Orkin, A. Sharpe, A. Parkins, 1995, Nature.

Checkpoint Blockade Cancer Immunotherapy Targets Tumour-Specific Mutant Antigens

Maxim N. Artyomov, E. Mardis, R. Aebersold, 2014, Nature.

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

Matheus C. Bürger, Michael Y. Gerner, G. Freeman, 2016, Nature.

Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade.

L. Chin, R. Davis, I. Wistuba, 2016, Cancer discovery.

The PD‐1 pathway in tolerance and autoimmunity

Loise M. Francisco, A. Sharpe, P. Sage, 2010, Immunological reviews.

The ikaros gene is required for the development of all lymphoid lineages

A. Sharpe, K. Georgopoulos, M. Bigby, 1994, Cell.

Restoring function in exhausted CD8 T cells during chronic viral infection

G. Freeman, E. Wherry, R. Ahmed, 2006, Nature.

Auto-antibody production and glomerulonephritis in congenic Slamf1-/- and Slamf2-/- [B6.129] but not in Slamf1-/- and Slamf2-/- [BALB/c.129] mice.

A. Sharpe, D. Brown, V. Vanguri, 2011, International immunology.

CTLA-4 and T cell activation.

A. Sharpe, D. Mandelbrot, R. Greenwald, 1999, Current opinion in immunology.

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

John G. Doench, David E. Root, David E. Fisher, 2017, Nature.

T-cell costimulation--biology, therapeutic potential, and challenges.

A. Sharpe, A. Abbas, 2006, The New England journal of medicine.

Mechanisms of costimulation

A. Sharpe, 2009, Immunological reviews.

T follicular regulatory cells in the regulation of B cell responses.

A. Sharpe, P. Sage, 2015, Trends in immunology.

Role of the B7-CD28/CTLA-4 pathway in autoimmune disease.

V. Kuchroo, A. Sharpe, Tammy T. Chang, 2002, Current directions in autoimmunity.

The role of B7 co‐stimulation in activation and differentiation ofCD4+and CD8+T cells

A. Sharpe, Alexander J. Adam, A. Schweitzer, 1998, Immunological reviews.

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

M. Marín‐Padilla, A. Sharpe, N. Speck, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene

M. Marín‐Padilla, D. Tenen, A. Sharpe, 1997, Nature Genetics.

PD-1 dependent exhaustion of CD8+ T cells drives chronic malaria.

R. Ahmed, C. Poh, L. Rénia, 2013, Cell reports.

Helicobacter pylori cag Pathogenicity Island's Role in B7-H1 Induction and Immune Evasion

B. Rampy, Y. Yamaoka, A. Sharpe, 2015, PloS one.

Understanding adverse events of immunotherapy: A mechanistic perspective

A. Sharpe, D. Vignali, K. Burke, 2020, The Journal of experimental medicine.

PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice.

Scott N. Mueller, R. Ahmed, A. Sharpe, 2010, The Journal of clinical investigation.

Protect the killer: CTLs need defenses against the tumor

G. Freeman, V. Kuchroo, A. Sharpe, 2002, Nature Medicine.

Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma

Ashton C. Berger, D. Neuberg, P. Catalano, 2020, Nature Medicine.

Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1)

G. Freeman, C. Rice, R. Ahmed, 2013, Proceedings of the National Academy of Sciences.

BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes

David E Fisher, Keith T Flaherty, Dennie T Frederick, 2013, Oncoimmunology.

Cutting Edge: IL-27 Induces the Transcription Factor c-Maf, Cytokine IL-21, and the Costimulatory Receptor ICOS that Coordinately Act Together to Promote Differentiation of IL-10-Producing Tr1 Cells1

V. Kuchroo, Hulin Jin, A. Awasthi, 2009, The Journal of Immunology.

SAP controls T cell responses to virus and terminal differentiation of TH2 cells

P. Borrow, A. Sharpe, A. Satoskar, 2001, Nature Immunology.

Generation of pigmented stripes in albino mice by retroviral marking of neural crest melanoblasts.

R. Jaenisch, A. Sharpe, D. Huszar, 1991, Development.

Migration and proliferation of cultured neural crest cells in W mutant neural crest chimeras.

R. Jaenisch, A. Sharpe, D. Huszar, 1991, Development.

Prevention and treatment of factor VIII inhibitors in murine hemophilia AJ. Qian, M. Collins, A.H. Sharpe, et al. Blood 95:1324–1329, 2000

A. Sharpe, M. Collins, L. Hoyer, 2000 .

Taming tissue-specific T cells: CTLA-4 reins in self-reactive T cells

A. Sharpe, A. Paterson, 2010, Nature Immunology.

Syngeneic monoclonal internal image anti-idiotopes as prophylactic vaccines.

A. Sharpe, M. Greene, B. Fields, 1986, Journal of immunology.

CD28 ligation increases macrophage suppression of T-cell proliferation

A. Sharpe, M. Kozlowski, D. Silberman, 2012, Cellular and Molecular Immunology.

Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions.

G. Freeman, A. Sharpe, W. Fanslow, 1999, Immunity.

Role of PD-1 in regulating acute infections.

G. Freeman, E. Wherry, A. Sharpe, 2010, Current opinion in immunology.

Differential Glycosylation of the Cas-Br-E Env Protein Is Associated with Retrovirus-Induced Spongiform Neurodegeneration

A. Sharpe, W. Lynch, 2000, Journal of Virology.

Intrafollicular location of marginal zone/CD1dhi B cells is associated with autoimmune pathology in a mouse model of lupus

A. Sharpe, B. Croker, Biyan Duan, 2008, Laboratory Investigation.

B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation.

E. Simpson, G. Freeman, A. Sharpe, 1997, Immunity.

The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival.

A. Sharpe, M. Sayegh, T. Judge, 1999, Journal of immunology.

B7-1 or B7-2 Is Required to Produce the Lymphoproliferative Phenotype in Mice Lacking Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4)

A. Sharpe, D. Mandelbrot, A. McAdam, 1999, The Journal of experimental medicine.

B7 costimulation in the development of lupus: autoimmunity arises either in the absence of B7.1/B7.2 or in the presence of anti-b7.1/B7.2 blocking antibodies.

A. Sharpe, M. Mamula, M. Kashgarian, 1999, Journal of immunology.

Crucial Role of Granulocytic Myeloid-Derived Suppressor Cells in the Regulation of Central Nervous System Autoimmune Disease

A. Sharpe, J. Matsoukas, D. Boumpas, 2012, The Journal of Immunology.

Regulation of Central Nervous System Myeloid-Derived Suppressor Cells in the Crucial Role of Granulocytic

A. Sharpe, J. Matsoukas, D. Boumpas, 2011 .

Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

Jefte M. Drijvers, S. Gygi, P. Sorger, 2020, Cell.

GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses

A. Sharpe, K. Jeffrey, H. Reinecker, 2013, Nature Immunology.

RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance

Loise M. Francisco, G. Freeman, A. Sharpe, 2014, The Journal of experimental medicine.

Negative Regulation of Humoral Immunity Due to Interplay between the SLAMF1, SLAMF5, and SLAMF6 Receptors

Hui Zhao, A. Sharpe, P. Sage, 2015, Front. Immunol..

Workshop on challenges, insights, and future directions for mouse and humanized models in cancer immunology and immunotherapy: a report from the associated programs of the 2016 annual meeting for the Society for Immunotherapy of cancer

E. Jaffee, Kwok-Kin Wong, L. Coussens, 2017, Journal of Immunotherapy for Cancer.

Hepatic immune regulation by stromal cells.

S. Turley, A. Sharpe, F. Schildberg, 2015, Current opinion in immunology.

PD-L1 – PD-1 interactions limit effector Treg cell populations at homeostasis and during infection

R. de Waal Malefyt, C. Hunter, A. Sharpe, 2020, bioRxiv.

The Role of OX40 Ligand Interactions in the Development of the Th2 Response to the Gastrointestinal Nematode Parasite Heligmosomoides polygyrus1 2

A. Sharpe, W. Gause, J. Urban, 2003, The Journal of Immunology.

Defining ‘T cell exhaustion’

E. Wherry, T. Schumacher, W. Haining, 2019, Nature Reviews Immunology.

Candida Memory-Protective Immunity to T Cells Are Essential Components of the Regulatory + CD 25 + B 7 / CD 28-Dependent CD 4

A. Sharpe, P. Mosci, C. Montagnoli, 2002 .

CD80+Gr-1+ Myeloid Cells Inhibit Development of Antifungal Th1 Immunity in Mice with Candidiasis1

A. Sharpe, A. Mencacci, E. Cenci, 2002, The Journal of Immunology.

Role of costimulators in T cell differentiation: studies using antigen-presenting cells lacking expression of CD80 or CD86.

A. Sharpe, A. Abbas, A. Schweitzer, 1997, Journal of immunology.

A genetic map of reovirus. 1. Correlation of genome RNAs between serotypes 1, 2, and 3.

A. Sharpe, B. Fields, R. F. Ramig, 1978, Virology.

A genetic map of reovirus. III. Assignment of the double-stranded RNA-positive mutant groups A, B, and G to genome segments.

A. Sharpe, B. Fields, R. F. Ramig, 1978, Virology.

Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment

Jacob M. Luber, A. Sharpe, A. Daud, 2020, bioRxiv.

Cutting Edge: A Crucial Role for B7-CD28 in Transmitting T Help from APC to CTL

J. Allison, A. Sharpe, T. Wolfe, 2002, The Journal of Immunology.

Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation

A. Sharpe, Hongzhen He, P. Finn, 2002, European journal of immunology.

PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity

G. Freeman, W. Haining, K. Yates, 2019, Nature Immunology.

Targeted reconstruction of T cell receptor sequence from single cell RNA-sequencing links CDR3 length to T cell differentiation state

P. Klenerman, N. Yosef, D. Douek, 2016, bioRxiv.

Modulation of surgical fibrosis by microbial zwitterionic polysaccharides.

D. Kasper, A. Sharpe, M. Sayegh, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Microfluidic Device Allows Low-Cost Newborn Screening for Severe Combined Immune Deficiency (SCID)

G. Whitesides, A. Sharpe, M. Butte, 2006 .

Distinct Populations of Innate CD8+ T Cells Revealed in a CXCR3 Reporter Mouse

S. Rajagopalan, R. Locksley, A. Sharpe, 2013, The Journal of Immunology.

Glioblastoma Eradication Following Immune Checkpoint Blockade in an Orthotopic, Immunocompetent Model

Kristen L. Jones, A. D. Van den Abbeele, Kristen L Jones, 2015, Cancer Immunology Research.

Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma

P. Sorger, K. Ligon, G. Freeman, 2020, Clinical Cancer Research.

Lack of PD-L1 Expression by iNKT Cells Improves the Course of Influenza A Infection

Anneliese O. Speak, A. Speak, A. Sharpe, 2013, PloS one.

Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection

Scott N. Mueller, G. Freeman, R. Ahmed, 2007, Proceedings of the National Academy of Sciences.

T Follicular Regulatory Cell–Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity

Monika S. Kowalczyk, A. Regev, O. Rozenblatt-Rosen, 2020, The Journal of Immunology.

Inhibitors of the PD-1 Pathway in Tumor Therapy

C. Drake, A. Sharpe, M. LaFleur, 2018, The Journal of Immunology.

CD4 T Cells Promote Rather than Control Tuberculosis in the Absence of PD-1–Mediated Inhibition

A. Sher, A. Sharpe, D. Barber, 2011, The Journal of Immunology.

Mediated Inhibition - Tuberculosis in the Absence of PD-1 CD4 T Cells Promote Rather than Control

A. Sher, A. Sharpe, D. Barber, 2010 .

Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells

Jefte M. Drijvers, I. Harris, A. Sharpe, 2020, Cancer Immunology Research.

Maturation and activation of T cells

L. Galluzzi, A. Sharpe, R. Kitsis, 2021 .

Anti-Programmed Death 1 (PD1)

G. Freeman, A. Sharpe, G. Freeman, 2013 .

Cutting Edge: CTLA-4 (CD152) Differentially Regulates Mitogen-Activated Protein Kinases (Extracellular Signal-Regulated Kinase and c-Jun N-Terminal Kinase) in CD4+ T Cells from Receptor/Ligand-Deficient Mice1

R. Lechler, A. Sharpe, H. Schneider, 2002, The Journal of Immunology.

CTLA‐4 regulates cell cycle progression during a primary immune response

A. Sharpe, V. Boussiotis, D. Mandelbrot, 2002, European journal of immunology.

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

F. Hodi, W. Haining, K. Yates, 2019, Nature Immunology.

Intestinal Tolerance Is Converted to Autoimmune Enteritis upon PD-1 Ligand Blockade1

Loise M. Francisco, G. Freeman, R. Bronson, 2009, The Journal of Immunology.

OX40 Ligand Self-Reactivity but Promotion of Diabetes by Paradoxical Dampening of Anti-Islet

C. Benoist, L. Poirot, D. Mathis, 2003 .

Analysis of lymphocyte costimulation in vivo using transgenic and 'knockout' mice.

A. Sharpe, 1995, Current opinion in immunology.

Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3

A. Sharpe, L. Berg, C. Gurniak, 1995, Science.

Retroviral transduction of the human c-Ha-ras-1 oncogene into midgestation mouse embryos promotes rapid epithelial hyperplasia

R. Jaenisch, P. Baldacci, A. Sharpe, 1989, Molecular and cellular biology.

Heparin is essential for the storage of specific granule proteases in mast cells

A. Sharpe, D. Friend, G. W. Wong, 1999, Nature.

DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8⁺ T cells independently of PD-1 and PD-L1.

G. Freeman, A. Sharpe, P. Santamaria, 2013, International immunology.

Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice

S. Gygi, J. Rabinowitz, J. Paulo, 2018, Proceedings of the National Academy of Sciences.

Costimulation and autoimmunity.

A. Sharpe, A. Schweitzer, E. Tivol, 1996, Current opinion in immunology.

Brief report: increased expression of a short splice variant of CTLA-4 exacerbates lupus in MRL/lpr mice.

V. Kuchroo, A. Sharpe, G. Tsokos, 2013, Arthritis and rheumatism.

Autoimmunity Lacking Exons 2 and 3 Causes Overexpression of the CTLA-4 Isoform

V. Kuchroo, F. Quintana, A. Sharpe, 2011 .

Overexpression of the CTLA-4 Isoform

V. Kuchroo, A. Sharpe, M. Oukka, 2011 .

Paradoxical Effect of Reduced Costimulation in T Cell-Mediated Colitis12

A. Sharpe, Gisen Kim, M. Kronenberg, 2007, The Journal of Immunology.

Blockade of CTLA-4 on CD4+CD25+ Regulatory T Cells Abrogates Their Function In Vivo1

Loise M. Francisco, A. Sharpe, F. Powrie, 2006, The Journal of Immunology.

Synergistic Costimulation by Both B7 Molecules Regulates Colitis Pathogenesis

A. Sharpe, Gisen Kim, M. Kronenberg, 2006, Annals of the New York Academy of Sciences.

Cells Abrogates Their Function In Vivo Regulatory + CD 25 + Blockade of CTLA-4 on CD 4

Loise M. Francisco, A. Sharpe, F. Powrie, 2006 .

An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells.

G. Freeman, D. Hafler, V. Kuchroo, 2004, Immunity.

Memory/Effector T Cells Invadosome-like Protrusions Formed by Antigen Recognition Is Facilitated by

C. Carman, T. Springer, A. Sharpe, 2012 .

Programmed death ligand 2 – A link between inflammation and bone loss in rheumatoid arthritis

G. Freeman, S. Moestrup, A. Sharpe, 2019, Journal of translational autoimmunity.

Auto-antibody production and glomerulonephritis in congenic Slamf1 2/2 and Slamf2 2/2 (B6.129) but not in Slamf1 2/2 and Slamf2 2/2 (BALB/c.129) mice

A. Sharpe, D. Brown, V. Vanguri, 2011 .

Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease.

J. Qi, J. Bradner, A. Melnick, 2019, Blood.

Modulates the Level of IgG 1-Adrenergic Receptor 2 β ( B 7-2 ) , and the Stimulation of the B Cell Receptor , CD 86

A. Sharpe, D. Kasprowicz, V. Sanders, 2000 .

Impairment of the PD-1 pathway increases atherosclerotic lesion development and inflammation

G. Freeman, A. Sharpe, G. Stavrakis, 2011 .

Impairment of the Programmed Cell Death-1 Pathway Increases Atherosclerotic Lesion Development and Inflammation

G. Freeman, A. Sharpe, A. Lichtman, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Monitoring PD-1 Phosphorylation to Evaluate PD-1 Signaling during Antitumor Immune Responses

G. Freeman, J. Ritz, A. Sharpe, 2021, Cancer Immunology Research.

Intercellular Adhesion Molecule 1 Is Critical for Activation of CD28-Deficient T Cells1

J. Gaglia, G. Freeman, V. Kuchroo, 2000, The Journal of Immunology.

Intercellular Adhesion Molecule 1 Is Critical for Activation of CD28-Deficient T Cells

J. Gaglia, G. Freeman, V. Kuchroo, 2000 .

for Activation of CD28-Deficient T Cells Intercellular Adhesion Molecule 1 Is Critical

J. Gaglia, G. Freeman, V. Kuchroo, 2000 .

CTLA-4 Controls Regulatory T Cell Peripheral Homeostasis and Is Required for Suppression of Pancreatic Islet Autoimmunity1

A. Sharpe, A. Abbas, M. Goodall, 2009, The Journal of Immunology.

Induction of B 7-1 in podocytes is associated with nephrotic syndrome

R. Kalluri, M. Rastaldi, M. Kretzler, 2018 .

SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.

S. Gygi, Noah Dephoure, A. Sharpe, 2012, Molecular cell.

B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: implications for induction of antitumor immunity to T cell tumors.

G. Freeman, D. Hafler, F. Benazzo, 1997, Journal of immunology.

The Function of Donor versus Recipient Programmed Death-Ligand 1 in Corneal Allograft Survival1

G. Freeman, M. Dana, A. Sharpe, 2007, The Journal of Immunology.

Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection

Sang-Jun Ha, Gordon J. Freeman, Surojit Sarkar, 2011, Proceedings of the National Academy of Sciences.

Enhancing therapeutic vaccination by blocking PD-1–mediated inhibitory signals during chronic infection

Scott N. Mueller, G. Freeman, E. Wherry, 2008, The Journal of experimental medicine.

Emerging concepts in PD-1 checkpoint biology.

G. Freeman, A. Sharpe, Kristen E. Pauken, 2021, Seminars in immunology.

Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent

Koichi Araki, Bruce R. Blazar, Laurence A. Turka, 2016, Science.

T follicular regulatory cells

A. Sharpe, P. Sage, 2016, Immunological reviews.

The role of donor and recipient B7-1 (CD80) in allograft rejection.

P. Linsley, A. Sharpe, T. Strom, 1997, Journal of immunology.

Cognate Stimulatory B-Cell–T-Cell Interactions Are Critical for T-Cell Help Recruited by Glycoconjugate Vaccines

D. Kasper, A. Sharpe, A. Chandraker, 1999, Infection and Immunity.

B7 Expression on T Cells Down-Regulates Immune Responses through CTLA-4 Ligation via R-T Interactions1

J. Allison, A. Sharpe, B. Blazar, 2004, The Journal of Immunology.

Ligation via R-T Interactions Immune Responses through CTLA-4 B7 Expression on T Cells Down-Regulates

J. Allison, A. Sharpe, B. Blazar, 2003 .

4-1BB and OX40 Act Independently to Facilitate Robust CD8 and CD4 Recall Responses1

A. Sharpe, E. Bertram, T. Watts, 2004, The Journal of Immunology.

4-1 BB and OX 40 Act Independently to Facilitate Robust CD 8 and CD 4 Recall Responses 1

A. Sharpe, E. Bertram, T. Watts, 2004 .

Alloimmune Responses In Vivo CD28-Independent CD8+ T Cell-Mediated CD70 Signaling Is Critical for

A. Sharpe, H. Auchincloss, A. Salama, 2013 .

Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM).

A. Rudensky, G. Freeman, T. Mak, 2005, Blood.

Myocarditis and Pneumonitis in MRL Mice Critical Checkpoint for Autoimmune Programmed Death Ligand 1 Regulates a

A. Sharpe, V. Kelley, J. Menke, 2013 .

Programmed Death Ligand 1 Regulates a Critical Checkpoint for Autoimmune Myocarditis and Pneumonitis in MRL Mice1

A. Sharpe, F. Schoen, V. Kelley, 2008, The Journal of Immunology.

Mice lprFas for Autoimmune Disease in MRL-Costimulation by B 7-1 and B 7-2 Is Required

A. Sharpe, A. Schwarting, V. Kelley, 2000 .

Costimulation by B7-1 and B7-2 Is Required for Autoimmune Disease in MRL-Faslpr Mice1

A. Sharpe, A. Schwarting, V. Kelley, 2000, The Journal of Immunology.

2 Blocking Antibodies Absence of B 7 . 1 / B 7 . 2 or in the Presence of Lupus : Autoimmunity Arises Either in the B 7 Costimulation in the Development of

A. Sharpe, M. Mamula, M. Kashgarian, 1999 .

CD160 Stimulates CD8+ T Cell Responses and Is Required for Optimal Protective Immunity to Listeria monocytogenes

Jefte M. Drijvers, M. Peluso, G. Freeman, 2018, ImmunoHorizons.

The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells.

A. Sharpe, P. Sage, Scott B. Lovitch, 2014, Immunity.

Impaired Regulatory T-Cell Response and Enhanced Atherosclerosis in the Absence of Inducible Costimulatory Molecule

A. Sharpe, G. Sukhova, A. Lichtman, 2006, Circulation.

The ICOS Molecule Plays a Crucial Role in the Development of Mucosal Tolerance1

H. Weiner, V. Kuchroo, R. Sobel, 2005, The Journal of Immunology.

Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4(+) T Cell Immunity.

Thomas S. Watkins, J. McCarthy, C. Poh, 2016, Immunity.

B7 Expression on T Cells Down-Regulates Immune Responses through CTLA-4 Ligation via R-T Interactions.

J. Allison, A. Sharpe, B. Blazar, 2004, The Journal of Immunology.

CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice.

P. Nickerson, A. Sharpe, T. Strom, 1997, Journal of immunology.

Requirement of CDC45 for Postimplantation Mouse Development

Anindya Dutta, A. Sharpe, F. Kuo, 2001, Molecular and Cellular Biology.

PD-1 Protects against Inflammation and Myocyte Damage in T Cell-Mediated Myocarditis

A. Sharpe, A. Lichtman, N. Grabie, 2012, The Journal of Immunology.

The Programmed Death-1 Pathway Counter-Regulates Inflammation-Induced Osteoclast Activity in Clinical and Experimental Settings

G. Freeman, S. Moestrup, A. Sharpe, 2022, Frontiers in Immunology.

Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging.

G. Freeman, A. Sharpe, M. Haigis, 2015, Cell reports.

Proatherogenic immune responses are regulated by the PD-1/PD-L pathway in mice.

A. Sharpe, G. Sukhova, A. Lichtman, 2007, The Journal of clinical investigation.

Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production.

A. Sharpe, A. Schweitzer, Schweitzer An, 1998, Journal of immunology.

PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions

G. Freeman, A. Sharpe, D. Umetsu, 2010, Mucosal Immunology.

PD-1 Regulates Self-Reactive CD8+ T Cell Responses to Antigen in Lymph Nodes and Tissues1

G. Freeman, A. Sharpe, M. Keir, 2007, The Journal of Immunology.

A novel function for programmed death ligand-1 regulation of angiogenesis.

R. Dana, A. Sharpe, Yiping Jin, 2011, The American journal of pathology.

Homeostatic Survival Invariant NKT Cell Function and + CD4ICOS/ICOSL Interaction Is Required for

G. Freeman, A. Sharpe, D. Umetsu, 2008 .

ICOS/ICOSL Interaction Is Required for CD4+ Invariant NKT Cell Function and Homeostatic Survival1

G. Freeman, A. Sharpe, D. Umetsu, 2008, The Journal of Immunology.

CTLA-4 Deficient Mice ICOS Contributes to T Cell Expansion in Broeren

A. Sharpe, A. Hofhuis, A. Coyle, 2005 .

ICOS Contributes to T Cell Expansion in CTLA-4 Deficient Mice1

A. Sharpe, F. Hofhuis, A. Coyle, 2005, The Journal of Immunology.

the Development of Mucosal Tolerance The ICOS Molecule Plays a Crucial Role in

H. Weiner, V. Kuchroo, R. Sobel, 2005 .

Cutting Edge: Inducible Costimulator Protein Regulates Both Th1 and Th2 Responses to Cutaneous Leishmaniasis1

A. Sharpe, A. Satoskar, A. McAdam, 2002, The Journal of Immunology.

Cutaneous Leishmaniasis Regulates Both Th1 and Th2 Responses to Cutting Edge: Inducible Costimulator Protein

A. Sharpe, A. Satoskar, A. McAdam, 2002 .

Immune checkpoint inhibitor-associated myocarditis: manifestations and mechanisms.

L. Galluzzi, A. Sharpe, R. Kitsis, 2021, The Journal of clinical investigation.

The PTEN pathway in Tregs functions as a critical driver of the immunosuppressive tumor microenvironment and tolerance to apoptotic cells

Loise M. Francisco, J. Wolchok, D. Munn, 2015, Journal of Immunotherapy for Cancer.

Regulation of T-cell chemotaxis by programmed death-ligand 1 (PD-L1) in dry eye-associated corneal inflammation.

R. Dana, G. Freeman, A. Sharpe, 2010, Investigative ophthalmology & visual science.

The role of CTLA-4 in regulating Th2 differentiation.

A. Sharpe, S. Boyd, A. Abbas, 1999, Journal of immunology.

Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses.

J. Bluestone, A. Sharpe, J. Auger, 1999, Journal of immunology.

ICOS is critical for CD40-mediated antibody class switching

G. Freeman, A. Sharpe, T. Chernova, 2001, Nature.

Transmitting T Help from APC to CTL Cutting Edge: A Crucial Role for B7-CD28 in

J. Allison, A. Sharpe, T. Wolfe, 2013 .

Cutting Edge: A Crucial Role for B7-CD28 in Transmitting T Help from APC to CTL1

J. Allison, A. Sharpe, T. Wolfe, 2002, The Journal of Immunology.

from Receptor/Ligand-Deficient Mice T Cells + c-Jun N-Terminal Kinase) in CD4 (Extracellular Signal-Regulated Kinase and Regulates Mitogen-Activated Protein Kinases Cutting Edge: CTLA-4 (CD152) Differentially

R. Lechler, A. Sharpe, H. Schneider, 2002 .

PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability

A. Sharpe, O. Akbari, Jacob D. Painter, 2022, Nature Communications.

Functional Equivalency of B7-1 and B7-2 for Costimulating Plasmid DNA Vaccine-Elicited CTL Responses1

M. Kuroda, S. Santra, M. Lifton, 2000, The Journal of Immunology.

Costimulating Plasmid DNA Vaccine-Elicited Functional Equivalency of B 7-1 and B 7-2 for Sharpe and

M. Kuroda, S. Santra, M. Lifton, 2000 .

Inducible co-stimulator null MRL-Faslpr mice: uncoupling of autoantibodies and T cell responses in lupus.

A. Sharpe, A. Schwarting, V. Kelley, 2005, Journal of the American Society of Nephrology : JASN.

B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells

Kelsey K. Finn, A. Sharpe, L. Turka, 2017, The Journal of Immunology.

The multifaceted functions of follicular regulatory T cells.

A. Sharpe, P. Sage, 2020, Current opinion in immunology.

Mechanism of action of donor-specific transfusion in inducing tolerance: role of donor MHC molecules, donor co-stimulatory molecules, and indirect antigen presentation.

A. Sharpe, H. Auchincloss, M. Sayegh, 2004, Journal of the American Society of Nephrology : JASN.

PD-1 Blockade on Tumor Microenvironment-Resident ILC2s Promotes TNF-α Production and Restricts Progression of Metastatic Melanoma

A. Sharpe, O. Akbari, Jacob D. Painter, 2021, Frontiers in Immunology.

A negative regulatory function of B7 revealed in B7-1 transgenic mice.

G. Freeman, A. Sharpe, A. Abbas, 1994, Immunity.

Studies in B7-Deficient Mice Reveal a Critical Role for B7 Costimulation in Both Induction and Effector Phases of Experimental Autoimmune Encephalomyelitis

V. Kuchroo, R. Sobel, A. Sharpe, 1999, The Journal of experimental medicine.

Programmed Death 1 Ligand (PD-L) 1 and PD-L2 Limit Autoimmune Kidney Disease: Distinct Roles

Keir, T. Mayadas, A. Sharpe, 2007 .

Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8+ T cell activation and cytolysis

G. Freeman, A. Sharpe, Hong-Bo Pang, 2003, European journal of immunology.

The Cell Surface Receptor SLAM Controls T Cell and Macrophage Functions

S. Feske, A. Sharpe, A. Satoskar, 2004, The Journal of experimental medicine.

TFR-derived Fibrinogen-like Protein 2 regulates production of autoantibodies and induction of systemic autoimmunity

Monika S. Kowalczyk, A. Regev, N. Yosef, 2020 .

The Novel Costimulatory Programmed Death Ligand 1/B7.1 Pathway Is Functional in Inhibiting Alloimmune Responses In Vivo

G. Freeman, A. Sharpe, S. Rodig, 2011, The Journal of Immunology.

T helper differentiation in resistant and susceptible B7‐deficient mice infected with Leishmania major

A. Sharpe, A. Satoskar, Julia A. Brown, 2002, European journal of immunology.

Genomic organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86)

A. Sharpe, G. Gray, Sophia S. Wang, 2004, Immunogenetics.

Disparate T Cells Alloresponses in Murine Recipients of MHC Pathways in Regulating In Vivo Opposing Roles of CD28:B7 and CTLA-4:B7

A. Sharpe, B. Blazar, P. Taylor, 1999 .

Role of B7 Costimulatory Molecules in the Adjuvant Activity of the Heat-Labile Enterotoxin of Escherichia coli1

A. Sharpe, S. Michalek, J. Clements, 2002, The Journal of Immunology.

Reciprocal expression of co‐stimulatory molecules, B7‐1 and B7‐2, on murine T cells following activation

H. Weiner, V. Kuchroo, S. Zamvil, 1995, European journal of immunology.

The complexity of the B7-CD28/CTLA-4 costimulatory pathway.

A. Sharpe, A. Schweitzer, 1998, Agents and actions. Supplements.

Suppression of Pancreatic Islet Peripheral Homeostasis and Is Required for CTLA-4 Controls Regulatory T Cell

A. Sharpe, M. Goodall, D. Sansom, 2008 .

Enterotoxin of Adjuvant Activity of the Heat-Labile Role of B 7 Costimulatory Molecules in the

A. Sharpe, S. Michalek, J. Clements, 2002 .

Mutual regulation between B7-1 (CD80) expressed on T cells and IL-4.

A. Sharpe, A. Schweitzer, 1999, Journal of immunology.

This information is current as Expressed on T Cells and IL-4 Mutual Regulation Between B 7-1 ( CD 80 )

A. Sharpe, A. Schweitzer, 1999 .

Association of B7-1 co-stimulation with the development of graft arterial disease. Studies using mice lacking B7-1, B7-2, or B7-1/B7-2.

P. Libby, R. Mitchell, A. Sharpe, 2000, The American journal of pathology.

PD-L1 Prevents the Development of Autoimmune Heart Disease in Graft-versus-Host Disease

A. Sharpe, M. Shlomchik, J. McNiff, 2018, The Journal of Immunology.

T-cell stimulation: an abundance of B7s

A. Sharpe, A. Abbas, 1999, Nature Medicine.

Coinfection with Streptococcus pneumoniae Modulates the B Cell Response to Influenza Virus

J. Whittle, A. Sharpe, S. Hensley, 2014, Journal of Virology.

Cutting Edge: An NK Cell-Independent Role for Slamf4 in Controlling Humoral Autoimmunity

A. Sharpe, D. Brown, C. Terhorst, 2011, The Journal of Immunology.

Late virus replication events in microglia are required for neurovirulent retrovirus-induced spongiform neurodegeneration: evidence from neural progenitor-derived chimeric mouse brains

E. Snyder, A. Sharpe, J. Portis, 1996, Journal of virology.

PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program

C. Klein, G. Freeman, W. Leonard, 2022, Nature.

Adherence to and penetration of the intestinal epithelium by reovirus type 1 in neonatal mice.

A. Sharpe, J. Wolf, J. S. Trier, 1987, Gastroenterology.

B7-Deficient Mice Reveal an Alternative Functional CTLA-4 Counterreceptor

G. Freeman, A. Sharpe, F. Borriello, 1996 .

B7-1 (CD80) and B7-2 (CD86) have complementary roles in mediating allergic pulmonary inflammation and airway hyperresponsiveness.

A. Sharpe, L. Kobzik, P. Finn, 2000, American journal of respiratory cell and molecular biology.

Overexpression of PD-1 on T cells promotes tolerance in cardiac transplantation via ICOS-dependent mechanisms

A. Sharpe, J. Azzi, X. Li, 2021, JCI insight.

Balance and imbalance in the immune system: life on the edge.

A. Sharpe, S. Topalian, 2014, Immunity.

Type 2 innate lymphoid cell suppression by regulatory T cells attenuates airway hyperreactivity and requires inducible T‐cell costimulator–inducible T‐cell costimulator ligand interaction

G. Freeman, A. Sharpe, O. Akbari, 2017, The Journal of allergy and clinical immunology.

Memory Th2 Effector Cells Can Develop in the Absence of B7-1/B7-2, CD28 Interactions, and Effector Th Cells After Priming with an Intestinal Nematode Parasite1

A. Sharpe, W. Gause, J. Urban, 2002, The Journal of Immunology.

The SLAM family member CD48 (Slamf2) protects lupus-prone mice from autoimmune nephritis.

R. Colvin, M. Selig, A. Sharpe, 2011, Journal of autoimmunity.

Programmed Death-1 (PD-1):PD-Ligand 1 Interactions Inhibit TCR-Mediated Positive Selection of Thymocytes1

G. Freeman, A. Sharpe, M. Keir, 2005, The Journal of Immunology.

Selection of Thymocytes Interactions Inhibit TCR-Mediated Positive Programmed Death-1 (PD-1):PD-Ligand 1

G. Freeman, A. Sharpe, M. Keir, 2005 .

Either B7 Costimulation or IL-2 Can Elicit Generation of Primary Alloreactive CTL1

A. Sharpe, A. McAdam, E. Farkash, 2000, The Journal of Immunology.

B7 Costimulation Is Critical for Antibody Class Switching and CD8+ Cytotoxic T-Lymphocyte Generation in the Host Response to Vesicular Stomatitis Virus

A. Sharpe, A. McAdam, E. Farkash, 2000, Journal of Virology.

Either B 7 Costimulation or IL-2 Can Elicit Generation of Primary Alloreactive CTL 1

A. Sharpe, A. McAdam, E. Farkash, 2000 .

T Cells that Control Autoimmune Diabetes

J. Bluestone, A. Sharpe, D. Lenschow, 2000 .

CD28-Regulated Activation of Th2 Responses Knockout Mice Is Characterized by Lymphoproliferative Disorder in CTLA-4

J. Bluestone, A. Sharpe, J. Auger, 1999 .

A Role for the B7-1/B7-2:CD28/CTLA-4 Pathway During Negative Selection1

Sheryl K Elkin, A. Sharpe, J. Buhlmann, 2003, The Journal of Immunology.

The Role of B7 Costimulation in CD4/CD8 T Cell Homeostasis

J. Allison, A. Sharpe, R. Hodes, 2000, The Journal of Immunology.

Genetic background determines the requirement for B7 costimulation in induction of autoimmunity

V. Kuchroo, R. Sobel, A. Sharpe, 2002, European journal of immunology.

The Role of Costimulation in T Cell Differentiation

A. Sharpe, J. Buhlmann, 2002 .

Gata6+ resident peritoneal macrophages promote the growth of liver metastasis

P. Kubes, A. Sharpe, Mokarram Hossain, 2022, Nature Communications.

The B7-CD28/CTLA-4 costimulatory pathways in autoimmune disease of the central nervous system.

D. E. Anderson, D. Hafler, A. Sharpe, 1999, Current opinion in immunology.

Physiologic Control of IDO Competence in Splenic Dendritic Cells

Loise M. Francisco, B. Baban, D. Munn, 2011, The Journal of Immunology.

Reovirus Cytopathology: Effects on Cellular Macromolecular Synthesis and the Cytoskeleton

A. Sharpe, B. Fields, 1984 .

Intestinal Nematode Parasite and Effector Th Cells After Priming with an the Absence of B 7-1 / B 7-2 , CD 28 Interactions , Memory Th 2 Effector Cells Can Develop in Urban and

A. Sharpe, W. Gause, J. Urban, 2002 .

B 7-dependent T-cell costimulation in mice lacking CD 28 and CTLA 4

R. Mitchell, G. Freeman, A. Sharpe, 2001 .

Cell Homeostasis The Role of B 7 Costimulation in CD 4 / CD 8 T

J. Allison, A. Sharpe, R. Hodes, 2000 .

Experimental murine schistosomiasis in the absence of B7 costimulatory molecules: reversal of elicited T cell cytokine profile and partial inhibition of egg granuloma formation.

A. Sharpe, M. Stadecker, H. J. Hernandez, 1999, Journal of immunology.

current as Formation and Partial Inhibition of Egg Granuloma Reversal of Elicited T Cell Cytokine Profile Absence of B 7 Costimulatory Molecules : Experimental Murine Schistosomiasis in the Stadecker

A. Sharpe, M. Stadecker, H. J. Hernandez, 1999 .

Program death-1 (PD-1) signaling and regulatory T cells (Tregs) collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes (CTLs) in advanced acute myeloid leukemia (AML) Running title: PD-1 blockade and adoptive CTL therapy for AML

D. Munn, J. Tolar, C. June, 2010 .

ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity.

G. Freeman, A. Sharpe, O. Akbari, 2015, Immunity.

Differentiation of IL-10-Producing Tr 1 Cells Coordinately Act Together to Promote and the Costimulatory Receptor ICOS that Transcription Factor c-Maf , Cytokine IL-21 , Cutting Edge : IL-27 Induces the

Hulin Jin, A. Awasthi, A. Sharpe, 2009 .

CTLA-4 Ablation and Interleukin-12–Driven Differentiation Synergistically Augment Cardiac Pathogenicity of Cytotoxic T Lymphocytes

A. Sharpe, A. Lichtman, G. Stavrakis, 2007, Circulation research.

IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection

G. Freeman, A. Sharpe, S. Ha, 2008, Proceedings of the National Academy of Sciences.

Mouse Inducible Costimulatory Molecule (ICOS) Expression Is Enhanced by CD28 Costimulation and Regulates Differentiation of CD4+ T Cells1

G. Freeman, V. Kuchroo, A. Sharpe, 2000, The Journal of Immunology.

in T Cell-Mediated Colitis Paradoxical Effect of Reduced Costimulation

A. Sharpe, Gisen Kim, M. Kronenberg, 2007 .

CD48 controls T-cell and antigen-presenting cell functions in experimental colitis.

A. Sharpe, H. Yagita, Y. Latchman, 2006, Gastroenterology.

Targeting PI3Kδ function for amelioration of murine chronic graft‐versus‐host disease

J. Byrd, K. Okkenhaug, J. Ritz, 2019, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Autoantibody Responses and Pathology Regulated by B7-1 and B7-2 Costimulation in MRL/lpr Lupus1

A. Sharpe, M. Mamula, M. Kashgarian, 2000, The Journal of Immunology.

Lupus lpr MRL/Regulated by B7-1 and B7-2 Costimulation in Autoantibody Responses and Pathology

A. Sharpe, M. Mamula, M. Kashgarian, 2000 .

Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease

A. Sharpe, D. Wraith, G. Anderson, 2009, Proceedings of the National Academy of Sciences.

Ox40L-Ox40 pathway plays distinct roles in regulating Th2 responses but does not determine outcome of cutaneous leishmaniasis caused by Leishmania mexicana and Leishmania major.

A. Sharpe, A. Satoskar, S. Oghumu, 2015, Experimental parasitology.

Inclusion of CD80 in HSV Targets the Recombinant Virus to PD-L1 on DCs and Allows Productive Infection and Robust Immune Responses

G. Freeman, S. Wechsler, A. Sharpe, 2014, PloS one.

B7-2 is required for the progression but not the initiation of the type 2 immune response to a gastrointestinal nematode parasite.

F. Finkelman, A. Sharpe, J. Urban, 1999, Journal of immunology.

This information is current as to a Gastrointestinal Nematode Parasite the Initiation of the Type 2 Immune Response B 7-2 Is Required for the Progression But Not

F. Finkelman, A. Sharpe, J. Urban, 1999 .

Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function

Jefte M. Drijvers, P. Sorger, Jia-Ren Lin, 2022, Science.

Anti-CD3 mAb treatment cures PDL1-/-.NOD mice of diabetes but precipitates fatal myocarditis.

A. Sharpe, M. Sayegh, M. Keir, 2011, Clinical immunology.

Distinct Roles PD-L2 Limit Autoimmune Kidney Disease: Programmed Death 1 Ligand (PD-L) 1 and

T. Mayadas, A. Sharpe, V. Kelley, 2007 .

PD‐L1 and PD‐L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis

G. Freeman, A. Sharpe, A. Satoskar, 2006, European journal of immunology.

in Alloimmune Responses CD28-independent Costimulation of T Cells

A. Sharpe, H. Auchincloss, L. Turka, 2001 .

CD 28-independent Costimulation of T Cells in Alloimmune Responses 1

A. Sharpe, L. Turka, M. Sayegh, 2001 .

T Cells + of CD4 Costimulation and Regulates Differentiation (ICOS) Expression Is Enhanced by CD28 Mouse Inducible Costimulatory Molecule

G. Freeman, V. Kuchroo, A. Sharpe, 2000 .

Monoclonal Antibody Blockade MiceUsing Costimulatory Molecule-Deficient Encephalomyelitis : A Comparative Study Experimental Autoimmune A Critical Role for B 7 / CD 28 Costimulation in

Stephen, J. Bluestone, A. Sharpe, 1999 .

Transgenic Expression of CXCR3 on T Cells Enhances Susceptibility to Cutaneous Leishmania major Infection by Inhibiting Monocyte Maturation and Promoting a Th2 Response

A. Sharpe, A. Satoskar, S. Varikuti, 2014, Infection and Immunity.

Leishmania major infection by inhibiting monocyte maturation and promoting a

A. Sharpe, C. Rappleye, S. Oghumu, 2014 .

Transgenic expression of CXCR 3 on T cells enhances susceptibility to cutaneous 1 Leishmania major infection by inhibiting monocyte maturation and promoting a 2 Th 2 response

A. Sharpe, S. Varikuti, C. Rappleye, 2014 .

Role of abortive retroviral infection of neurons in spongiform CNS degeneration

R. Jaenisch, A. Sharpe, J. Hunter, 1990, Nature.

Cutting Edge: Transplantation Tolerance through Enhanced CTLA-4 Expression 1

C. Ariyan, A. Sharpe, P. Salvalaggio, 2003, The Journal of Immunology.

through Enhanced CTLA-4 Expression Cutting Edge: Transplantation Tolerance

C. Ariyan, A. Sharpe, P. Salvalaggio, 2003 .

Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions.

Megan E. McNerney, M. McNerney, A. Sharpe, 2006, Blood.

PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity

A. Sharpe, O. Akbari, Jacob D. Painter, 2020, Nature Communications.

Distinct roles for B7 costimulation in contact hypersensitivity and humoral immune responses to epicutaneous antigen

A. Sharpe, T. Kupper, I. Williams, 1998, European journal of immunology.

Distinct clinical patterns and immune infiltrates are observed at time of progression on targeted therapy versus immune checkpoint blockade for melanoma

L. Chin, R. Sullivan, K. Flaherty, 2016, Oncoimmunology.

ABCB5 Identifies Immunoregulatory Dermal Cells.

A. Sharpe, T. Kupper, Q. Zhan, 2015, Cell reports.

Inhibitory Functions Cutting Edge: TIGIT Has T Cell-Intrinsic

V. Kuchroo, A. Sharpe, S. Levin, 2010 .

Host B7-1 and B7-2 costimulatory molecules contribute to the eradication of B7-1-transfected P815 tumor cells via a CD8+ T cell-dependent mechanism.

J. Bluestone, A. Sharpe, M. Mokyr, 1999, Journal of Immunology.

T Cell-Dependent Mechanism + CD 8 B 7-1-Transfected P 815 Tumor Cells Via a Contribute to the Eradication of Host B 7-1 and B 7-2 Costimulatory Molecules and

J. Bluestone, A. Sharpe, M. Mokyr, 1999 .

Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells.

G. Freeman, A. Sharpe, M. Haigis, 2022, Cell metabolism.

The interaction of mammalian reoviruses with the cytoskeleton of monkey kidney CV-1 cells.

A. Sharpe, B. Fields, L. B. Chen, 1982, Virology.

Specific disruption of vimentin filament organization in monkey kidney CV-1 cells by diphtheria toxin, exotoxin A, and cycloheximide.

A. Sharpe, B. Fields, J. Murphy, 1980, Proceedings of the National Academy of Sciences of the United States of America.

B7h (ICOS-L) maintains tolerance at the fetomaternal interface.

A. Sharpe, P. Fiorina, A. Mellor, 2013, The American journal of pathology.

Recovery from EAE is associated with decreased survival of encephalitogenic T cells in the CNS of B7‐1/B7‐2‐deficient mice

R. Ransohoff, V. Kuchroo, R. Sobel, 2003, European journal of immunology.

B7 (CD80 and CD86)

J. Gribben, G. Freeman, A. Sharpe, 1998 .

Intestinal M cells: a pathway for entry of reovirus into the host.

D. Rubin, A. Sharpe, R. Finberg, 1981, Science.

The Role of LAT in Increased CD8 (cid:1) T Cell Exhaustion in Trigeminal Ganglia of Mice Latently Infected with Herpes Simplex Virus 1 (cid:1)

G. Freeman, S. Wechsler, L. BenMohamed, 2011 .

B7‐1/2, but not PD‐L1/2 molecules, are required on IL‐10‐treated tolerogenic DC and DC‐derived exosomes for in vivo function

Loise M. Francisco, A. Sharpe, Seonhee Kim, 2009, European journal of immunology.

SnapShot: B7/CD28 Costimulation

A. Sharpe, V. Vanguri, A. Paterson, 2009, Cell.

Neural Stem Cells as Engraftable Packaging Lines Can Mediate Gene Delivery to Microglia: Evidence from Studying Retroviral env-Related Neurodegeneration

E. Snyder, A. Sharpe, W. Lynch, 1999, Journal of Virology.

Prevention of CAR-T-cell dysfunction

A. Sharpe, M. LaFleur, Brian C. Miller, 2020, Nature Biomedical Engineering.

CD48-deficient mice have a pronounced defect in CD4(+) T cell activation.

G. Freeman, A. Sharpe, H. Reiser, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Human-mouse interspecies collagen I heterotrimer is functional during embryonic development of Mov13 mutant mouse embryos

A. Schnieke, A. Sharpe, A. Berns, 1990, Molecular and cellular biology.

ABCB 5 Identifies Immunoregulatory Dermal Cells Graphical Abstract Highlights

A. Sharpe, T. Kupper, R. Abdi, 2018 .

Age-associated remodeling of T cell immunity and metabolism.

A. Sharpe, M. Haigis, SeongJun Han, 2022, Cell metabolism.

Developmental Mutations Generated by Retroviral Insertional Mutagenesis

R. Jaenisch, T. Noda, A. Sharpe, 1992 .

Inactivation of Ebola Virus and SARS-CoV-2 in Cell Culture Supernatants and Cell Pellets by Gamma Irradiation

R. Davey, A. Sharpe, J. Connor, 2022, Viruses.

The CD154/CD40 Interaction Required for Retrovirus-Induced Murine Immunodeficiency Syndrome Is Not Mediated by Upregulation of the CD80/CD86 Costimulatory Molecules

A. Sharpe, W. Cook, W. Green, 2002, Journal of Virology.

The CD 154 / CD 40 Interaction Required for Retrovirus-Induced Murine Immunodeficiency Syndrome Is Not Mediated by Upregulation of the CD 80 / CD 86 Costimulatory Molecules

A. Sharpe, W. Cook, W. Green, 2002 .

Essential and Partially Overlapping Role of CD3γ and CD3δ for Development of αβ and γδ T Lymphocytes

D. Allen, A. Sharpe, M. Salio, 1998, The Journal of experimental medicine.

Essential and Partially Overlapping Role of CD3 (cid:103) and CD3 (cid:100) for Development of (cid:97)(cid:98) and (cid:103)(cid:100) T Lymphocytes

D. Allen, A. Sharpe, M. Salio, 1998 .

Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin

Walter Witke, J. Hartwig, T. Stossel, 1995, Cell.

Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1.

Loise M. Francisco, C. Hunter, A. Sharpe, 2012, Immunity.

Induction of B7-1 in podocytes is associated with nephrotic syndrome.

R. Kalluri, M. Rastaldi, M. Kretzler, 2004, The Journal of clinical investigation.

Programmed Death 1 Ligand (PD-L) 1 and PD-L2 Limit Autoimmune Kidney Disease: Distinct Roles1

T. Mayadas, A. Sharpe, V. Kelley, 2007, The Journal of Immunology.

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4.

J. Bluestone, A. Sharpe, A. Schweitzer, 1995, Immunity.

Spatially organized multicellular immune hubs in human colorectal cancer

Linda T. Nieman, N. Hacohen, A. Regev, 2021, Cell.

Progressive immune dysfunction with advancing disease stage in renal cell carcinoma.

Steven L. Chang, Shuqiang Li, K. Livak, 2021, Cancer cell.

Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice

Young-Bum Kim, Olivier Boss, Arlene H. Sharpe, 2000, Molecular and Cellular Biology.

Neuronal Programmed Cell Death-1 Ligand Expression Regulates Retinal Ganglion Cell Number in Neonatal and Adult Mice

Loise M. Francisco, J. Caprioli, A. Sharpe, 2012, Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society.

Role of the immune modulator programmed cell death-1 during development and apoptosis of mouse retinal ganglion cells.

Loise M. Francisco, G. Freeman, A. Sharpe, 2009, Investigative ophthalmology & visual science.

Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancer

Linda T. Nieman, N. Hacohen, A. Regev, 2021, bioRxiv.

Programmed Death-Ligand 1 in Corneal The Function of Donor versus Recipient

G. Freeman, M. Dana, A. Sharpe, 2007 .

The Role of LAT in Increased CD8+ T Cell Exhaustion in Trigeminal Ganglia of Mice Latently Infected with Herpes Simplex Virus 1

G. Freeman, S. Wechsler, L. BenMohamed, 2011, Journal of Virology.

Pathogenesis of Reovirus Infection

A. Sharpe, B. Fields, 1983 .

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway

John G Doench, J. Doench, A. Sharpe, 2021, Cell.

Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth

George F. Murphy, Reinhard Dummer, Christian Posch, 2015, Cell.

Tissue expression of PD-L1 mediates peripheral T cell tolerance

G. Freeman, A. Sharpe, M. Sayegh, 2006, The Journal of experimental medicine.

Reovirus inhibition of cellular DNA synthesis: role of the S1 gene

A. Sharpe, B. Fields, 1981, Journal of virology.

Genetics of reovirus: Identification of the ds RNA segments encoding the polypeptides of the μ and σ size classes

A. Sharpe, B. Fields, R. F. Ramig, 1978 .

The Programmed Death-1 Ligand 1:B7-1 Pathway Restrains Diabetogenic Effector T Cells In Vivo

G. Freeman, A. Sharpe, M. Sayegh, 2011, The Journal of Immunology.

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

Lieping Chen, A. Sharpe, M. Tomayko, 2010, Nature Immunology.

Role of the host cell in persistent viral infection: Coevolution of L cells and reovirus during persistent infection

R. Ahmed, A. Sharpe, B. Fields, 1981, Cell.

Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses

N. Hacohen, L. Garraway, G. Freeman, 2021, Science Translational Medicine.

TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti-PD-1/anti-CTLA-4 immunotherapy.

G. Freeman, Kwok-Kin Wong, P. Lizotte, 2018, JCI insight.

Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses.

G. Freeman, A. Sharpe, M. Butte, 2007, Immunity.

PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells.

G. Freeman, V. Kuchroo, R. Sobel, 2004, Proceedings of the National Academy of Sciences of the United States of America.

The diverse functions of the PD1 inhibitory pathway

A. Sharpe, Kristen E. Pauken, 2017, Nature Reviews Immunology.

Transgenic mouse model of kidney disease: Insertional inactivation of ubiquitously expressed gene leads to nephrotic syndrome

R. Jaenisch, T. Noda, A. Sharpe, 1990, Cell.

Coinhibitory Pathways in Immunotherapy for Cancer.

G. Freeman, G. Dranoff, A. Sharpe, 2016, Annual review of immunology.

The double-edged sword: Harnessing PD-1 blockade in tumor and autoimmunity

D. Hafler, A. Sharpe, Liliana E. Lucca, 2021, Science Immunology.

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

Loise M. Francisco, G. Freeman, V. Kuchroo, 2009, The Journal of experimental medicine.

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

G. Freeman, T. Okazaki, T. Honjo, 2001, Nature Immunology.

The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

G. Freeman, E. Wherry, R. Ahmed, 2007, Nature Immunology.

Expression of T-Cell Exhaustion Molecules and Human Endogenous Retroviruses as Predictive Biomarkers for Response to Nivolumab in Metastatic Clear Cell Renal Cell Carcinoma

P. Catalano, G. Freeman, Catherine J. Wu, 2020, Clinical Cancer Research.

Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation.

A. Sharpe, Li Wu, K. Georgopoulos, 1996, Immunity.

Reovirus inhibition of cellular RNA and protein synthesis: role of the S4 gene.

A. Sharpe, B. Fields, 1982, Virology.

The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo.

F. Alt, A. Sharpe, A. Wynshaw-Boris, 1996, Cell.

The CBFβ Subunit Is Essential for CBFα2 (AML1) Function In Vivo

F. Alt, A. Sharpe, A. Wynshaw-Boris, 1996, Cell.

The B7 family revisited.

G. Freeman, A. Sharpe, R. Greenwald, 2005, Annual review of immunology.

Transplacental Antiretroviral Therapy with 9-(2‐Phosphonylmethoxyethyl)adenine Is Embryotoxic in Transgenic Mice

R. Jaenisch, A. Sharpe, J. Balzarini, 1991, Journal of Acquired Immune Deficiency Syndromes.

Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family.

G. Freeman, A. Sharpe, F. Schildberg, 2016, Immunity.

An Important Role of CD80/CD86-CTLA-4 Signaling during Photocarcinogenesis in Mice1

J. Bluestone, A. Sharpe, S. Beissert, 2005, The Journal of Immunology.

THE MOLECULAR BASIS OF REOVIRUS VIRULENCE

H. Weiner, D. Rubin, R. Ahmed, 1980 .

A genetic map of reovirus. II. Assignment of the double-stranded RNA-negative mutant groups C, D, and E to genome segments.

A. Sharpe, B. Fields, R. F. Ramig, 1978, Virology.

Genetics of reovirus: identification of the ds RNA segments encoding the polypeptides of the mu and sigma size classes.

A. Sharpe, B. Fields, R. F. Ramig, 1978, Virology.

The aging lung: Physiology, disease, and immunity

A. Sharpe, M. Haigis, C. Garcia-de-Alba, 2021, Cell.

Cutting Edge: TIGIT Has T Cell-Intrinsic Inhibitory Functions

Vijay K. Kuchroo, Silvia Spoerl, Arlene H. Sharpe, 2011, The Journal of Immunology.

LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

G. Freeman, Yang Shi, A. Sharpe, 2018, Cell.

The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin

F. McKeon, A. Sharpe, S. Ryeom, 2003, Nature Immunology.

Paradoxical Dampening of Anti-Islet Self-Reactivity but Promotion of Diabetes by OX40 Ligand1

C. Benoist, L. Poirot, D. Mathis, 2003, The Journal of Immunology.

PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance

Loise M. Francisco, G. Freeman, C. Lian, 2020, The Journal of experimental medicine.

Summary and Recommendations from the National Cancer Institute’s Clinical Trials Planning Meeting on Novel Therapeutics for Non-Muscle Invasive Bladder Cancer

S. Groshen, C. Tangen, C. Drake, 2016, Bladder cancer.

TCR-sequencing in cancer and autoimmunity: barcodes and beyond.

S. Raychaudhuri, D. Hafler, A. Sharpe, 2022, Trends in immunology.

Microenvironmental correlates of immune checkpoint inhibitor response in human melanoma brain metastases revealed by T cell receptor and single-cell RNA sequencing

McKenzie L. Shaw, Brian L. Shaw, S. Carter, 2021, bioRxiv.

The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection

T. Golub, Jun Lu, A. Rao, 2017, Nature Immunology.

Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade

R. Weinberg, C. Paweletz, G. Freeman, 2019, Proceedings of the National Academy of Sciences.

Inhibitory signaling sustains a distinct early memory CD8+ T cell precursor that is resistant to DNA damage

Jesse M. Platt, E. Wherry, A. Sharpe, 2021, Science Immunology.

Role of PD-1 during effector CD8 T cell differentiation

G. Freeman, R. Ahmed, A. Sharpe, 2018, Proceedings of the National Academy of Sciences.

Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma

Ashton C. Berger, D. Neuberg, P. Catalano, 2020, Nature Medicine.

Enhancing the Efficacy of Checkpoint Blockade Through Combination Therapies

A. Sharpe, M. LaFleur, Vikram R. Juneja, 2016 .

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity

A. Rudensky, G. Freeman, Youjin Lee, 2015, The Journal of experimental medicine.

The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment

Loise M. Francisco, J. Wolchok, D. Munn, 2015, Science Advances.

Anti-CD48 Monoclonal Antibody Attenuates Experimental Autoimmune Encephalomyelitis by Limiting the Number of Pathogenic CD4+ T Cells

R. Sobel, A. Sharpe, D. Brown, 2016, The Journal of Immunology.

Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system

R. Jaenisch, E. Li, A. Sharpe, 1992, Cell.

Circulatory antigen processing by mucosal dendritic cells controls CD8(+) T cell activation.

A. Sharpe, B. Guleng, C. Karp, 2013, Immunity.

B7 Expression on T Cells Down-Regulates Immune Responses through CTLA-4 Ligation via R-T Interactions.

J. Allison, A. Sharpe, P. Taylor, 2004, The Journal of Immunology.

B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions [corrections].

J. Allison, A. Sharpe, B. Blazar, 2004, Journal of immunology.

The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells

R. Xavier, M. Schirmer, S. Schreiber, 2015, eLife.

The kinase DYRK 1 A reciprocally regulates the differentiation of Th 17 and regulatory T cells

R. Xavier, M. Schirmer, S. Schreiber, 2015 .

Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial

Jeffrey W. Clark, N. Hacohen, J. Meyerhardt, 2023, Nature Medicine.

E. Snyder, A. Sharpe, W. Lynch, 1999 .

Development of autoimmunity in mice lacking DNA topoisomerase 3β

A. Shaw, A. Sharpe, S. Mohanty, 2007, Proceedings of the National Academy of Sciences.

Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses.

C. Benoist, D. Hafler, V. Kuchroo, 2014, Immunity.

PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity

Freeman, G. Freeman, W. Haining, 2017, The Journal of experimental medicine.

TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.

G. Freeman, G. Dranoff, A. Sharpe, 2007, Immunity.

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

A. Yang, F. McKeon, R. Bronson, 2000, Nature.

irRECIST for the Evaluation of Candidate Biomarkers of Response to Nivolumab in Metastatic Clear Cell Renal Cell Carcinoma: Analysis of a Phase II Prospective Clinical Trial

P. Catalano, C. Horak, G. Freeman, 2019, Clinical Cancer Research.

PD-L1 Antibodies to Its Cytoplasmic Domain Most Clearly Delineate Cell Membranes in Immunohistochemical Staining of Tumor Cells

G. Freeman, S. Signoretti, F. Hodi, 2015, Cancer Immunology Research.

Introduction to checkpoint inhibitors and cancer immunotherapy

A. Sharpe, 2017, Immunological reviews.

Retroviruses and mouse embryos: a rapid model for neurovirulence and transplacental antiviral therapy.

R. Jaenisch, A. Sharpe, R. Ruprecht, 1987, Science.

Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade

G. Freeman, E. Wherry, R. Ahmed, 2006, The Journal of experimental medicine.

Immune checkpoint receptors in autoimmunity.

A. Sharpe, D. Liang, Dillon G. Patterson, 2023, Current opinion in immunology.

Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity

A. Sharpe, Kristen E. Pauken, Debattama R. Sen, 2021, Nature Immunology.

A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade

R. Jain, A. Sharpe, Meromit Singer, 2020, Proceedings of the National Academy of Sciences.

Adverse Events Following Cancer Immunotherapy: Obstacles and Opportunities.

A. Sharpe, A. Lichtman, Kristen E. Pauken, 2019, Trends in immunology.

CD39 Expression Identifies Terminally Exhausted CD8+ T Cells

P. Klenerman, E. Wherry, G. Lauer, 2015, PLoS pathogens.

Infusion of anti-B7.1 (CD80) and anti-B7.2 (CD86) monoclonal antibodies inhibits murine graft-versus-host disease lethality in part via direct effects on CD4+ and CD8+ T cells.

A. Sharpe, G. Gray, R. Korngold, 1996, Journal of immunology.

Opposing roles of CD28:B7 and CTLA-4:B7 pathways in regulating in vivo alloresponses in murine recipients of MHC disparate T cells.

A. Sharpe, B. Blazar, P. Taylor, 1999, Journal of immunology.

Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells

E. Wherry, A. Sharpe, Kristen E. Pauken, 2015, The Journal of experimental medicine.

The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood

Loise M. Francisco, C. Carman, A. Sharpe, 2012, Nature Immunology.

The effects of age and systemic metabolism on anti-tumor T cell responses

Jefte M. Drijvers, A. Sharpe, M. Haigis, 2020, eLife.

Response to BRAF Inhibition in Melanoma Is Enhanced When Combined with Immune Checkpoint Blockade

G. Freeman, K. Flaherty, Dennie T. Frederick, 2014, Cancer Immunology Research.

The ras and myc oncogenes cooperate in tumor induction in many tissues when introduced into midgestation mouse embryos by retroviral vectors.

R. Jaenisch, P. Baldacci, T. Thompson, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Deletion of a conserved Il4 silencer impairs T helper type 1–mediated immunity

F. Alt, Suneet Agarwal, C. Bassing, 2004, Nature Immunology.

A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation.

S Askari, T. Mayadas, A. Sharpe, 1996, Immunity.

Syngeneic monoclonal antiidiotype can induce cellular immunity to reovirus

A. Sharpe, M. Greene, B. Fields, 1984, The Journal of experimental medicine.

Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia.

D. Munn, J. Tolar, B. Levine, 2010, Blood.

Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients.

A. Sharpe, N. Killeen, B. Blazar, 2003, Blood.

Functional consequences of dysregulated B7-1 (CD80) and B7-2 (CD86) expression in B or T lymphocytes of transgenic mice.

A. Sharpe, A. Abbas, L. van Parijs, 1997, Journal of immunology.

Induction of autoimmune disease in CTLA-4−/− mice depends on a specific CD28 motif that is required for in vivo costimulation

A. Sharpe, A. Singer, X. Tai, 2007, Proceedings of the National Academy of Sciences.

FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program

A. Rudensky, Alos Diallo, A. Sharpe, 2019, The Journal of experimental medicine.

Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection

A. Rudensky, G. Freeman, A. Kamphorst, 2014, The Journal of experimental medicine.

Circulating T follicular regulatory and helper cells have memory-like properties.

J. Godec, A. Sharpe, U. V. von Andrian, 2014, The Journal of clinical investigation.

Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity

G. Berry, G. Freeman, A. Sharpe, 2002, Nature Medicine.

Role of the PD‐1 Pathway in the Immune Response

A. Sharpe, L. Riella, A. Chandraker, 2012, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

PD-L1 – PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection

C. Hunter, A. Sharpe, I. Brodsky, 2022, Nature Immunology.

Repertoire analyses reveal T cell receptor sequence features that influence T cell fate

Joyce B. Kang, S. Raychaudhuri, A. Sharpe, 2022, Nature Immunology.

Allelic variation in class I HLA determines CD8+ T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2

Michael D Healy, Kelsey K. Finn, Benjamin P. Roscoe, 2021, Science Immunology.

Treg-specific LAG3 deletion reveals a key role for LAG3 in regulatory T cells to inhibit CNS autoimmunity

A. Sharpe, D. Vignali, C. Workman, 2018, The Journal of Immunology.

Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses

Alos Diallo, V. Kuchroo, A. Sharpe, 2019, Nature Immunology.

Suppression by TFR cells leads to durable and selective inhibition of B cell effector function

Nicolas Chevrier, W. Haining, V. Kuchroo, 2016, Nature Immunology.

TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection.

S. Akira, J. Serody, A. Sharpe, 2008, Blood.

The B7/CD28 costimulatory family in autoimmunity

A. Sharpe, M. Keir, 2005, Immunological reviews.

CD28 Costimulation Regulates Genome-Wide Effects on Alternative Splicing

W. Haining, A. Sharpe, M. Butte, 2012, PloS one.

Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes

F. Gilliland, A. Sharpe, H. Allayee, 2019, Nature Communications.

The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3

C. Disteche, G. Freeman, S. Edelhoff, 1997, Mammalian Genome.

Development of preclinical and clinical models for immune-related adverse events following checkpoint immunotherapy: a perspective from SITC and AACR

Theresa L. Walunas, A. Villani, E. Jaffee, 2021, Journal for ImmunoTherapy of Cancer.

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

V. Kuchroo, Hulin Jin, A. Sharpe, 2009, Nature Immunology.

A Cre-driven allele-conditioning line to interrogate CD4+ conventional T cells.

E. Wherry, A. Sharpe, I. Taniuchi, 2021, Immunity.

Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V.

A. Rao, A. Sharpe, K. Ansel, 2012, Immunity.

T-Cell Costimulation and Coinhibition in Atherosclerosis

A. Sharpe, A. Lichtman, I. Gotsman, 2008, Circulation research.

p 73-deficientmicehaveneurological , pheromonal and inflammatory defectsbutlackspontaneoustumours

F. McKeon, R. Bronson, A. Sharpe, 2022 .

B7-1/B7-2 Costimulation Regulates Plaque Antigen–Specific T-Cell Responses and Atherogenesis in Low-Density Lipoprotein Receptor–Deficient Mice

P. Libby, A. Sharpe, A. Lichtman, 2004, Circulation.

CD80 Expression on B Cells Regulates Murine T Follicular Helper Development, Germinal Center B Cell Survival, and Plasma Cell Generation

A. Sharpe, Shannon M. Anderson, M. Shlomchik, 2012, The Journal of Immunology.

CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease

A. Sharpe, D. Barber, V. V. Ganusov, 2016, PLoS pathogens.

B7/CD28-Dependent CD4+CD25+ Regulatory T Cells Are Essential Components of the Memory-Protective Immunity to Candida albicans1

A. Sharpe, P. Mosci, C. Montagnoli, 2002, The Journal of Immunology.

Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality.

G. Freeman, D. Munn, R. Ahmed, 2013, Blood.

Complete sequence determination of the mouse and human CTLA4 gene loci: cross-species DNA sequence similarity beyond exon borders.

A. Sharpe, G. Gray, Paul W. Wu, 1999, Genomics.

A phase II study of combined therapy with a BRAF inhibitor (vemurafenib) and interleukin-2 (aldesleukin) in patients with metastatic melanoma

R. Sullivan, K. Flaherty, Dennie T. Frederick, 2018, Oncoimmunology.

Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling

W. Haining, S. Turley, N. Danial, 2019, Nature Immunology.

Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality.

G. Freeman, S. Furlan, D. Munn, 2016, The Journal of clinical investigation.

Nippostrongylus brasiliensis Can Induce B7-Independent Antigen-Specific Development of IL-4-Producing T Cells from Naive CD4 T Cells In Vivo1

A. Sharpe, W. Gause, J. Urban, 2002, The Journal of Immunology.

Naive CD 4 T Cells In Vivo Development of IL-4-Producing T Cells from B 7-Independent Antigen-Specific Can Induce

A. Sharpe, W. Gause, J. Urban, 2002 .

A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system

John G Doench, J. Doench, W. Haining, 2019, Nature Communications.

Costimulation and regulation of autoimmunity and tolerance.

A. Sharpe, 2005, Journal of Pediatric Gastroenterology and Nutrition - JPGN.

The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens

J. Lohr, A. Sharpe, A. Abbas, 2003, Nature Immunology.

T Cell Activation Depends on Extracellular Alanine.

J. Rabinowitz, A. Sharpe, M. Haigis, 2019, Cell reports.

Maternal transmission of retroviral disease and strategies for preventing infection of the neonate

R. Jaenisch, A. Sharpe, J. Hunter, 1989, Journal of virology.

The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection.

Loise M. Francisco, G. Freeman, E. Wherry, 2020, Cell reports.

Mitochondrial Metabolism in T Cell Activation and Senescence: A Mini-Review

A. Sharpe, M. Haigis, N. Ron-Harel, 2014, Gerontology.

Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models

R. Jain, G. Freeman, A. Sharpe, 2022, bioRxiv.

Transgenic mice for the preparation of hygromycin-resistant primary embryonic fibroblast feeder layers for embryonic stem cell selections.

E. Simpson, P. Laird, A. Sharpe, 1995, Nucleic acids research.

Interaction of human PD-L1 and B7-1.

G. Freeman, A. Sharpe, M. Butte, 2008, Molecular immunology.

OR.100. PD-L1 Regulates the Development, Maintenance and Function of Induced-regulatory T Cells

Loise M. Francisco, G. Freeman, V. Kuchroo, 2009 .

PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II

V. Shah, A. Sharpe, Z. Lou, 2022, Cell reports.

Response toBRAF Inhibition inMelanoma Is EnhancedWhen Combined with Immune Checkpoint Blockade

G. Freeman, K. Flaherty, Dennie T. Frederick, 2014 .

A new therapeutic strategy for malaria: targeting T cell exhaustion

G. Freeman, A. Sharpe, G. Freeman, 2012, Nature Immunology.

Programmed Death-1 Ligand 1 Interacts Specifically with the B 7-1 Costimulatory Molecule to Inhibit T Cell Responses

G. Freeman, A. Sharpe, M. Butte, 2022 .

Overexpression of the CTLA-4 Isoform Lacking Exons 2 and 3 Causes Autoimmunity

V. Kuchroo, F. Quintana, A. Sharpe, 2012, The Journal of Immunology.

Roles of CD48 in regulating immunity and tolerance.

A. Sharpe, C. Terhorst, Shannon L. McArdel, 2016, Clinical immunology.

When killers become thieves: Trogocytosed PD-1 inhibits NK cells in cancer

A. Sharpe, A. Santoni, G. Sciumè, 2020, bioRxiv.

Abstract A83: Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

F. Hodi, F. Hodi, W. Haining, 2020, Poster Presentations - Proffered Abstracts.

Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling

J. Godec, A. Sharpe, K. Wucherpfennig, 2016, Science Signaling.

Maternal transmission of retroviral disease: transgenic mice as a rapid test system for evaluating perinatal and transplacental antiretroviral therapy.

R. Jaenisch, A. Sharpe, J. Hunter, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of the murine B7-1 genomic locus reveals an additional exon encoding an alternative cytoplasmic domain and a chromosomal location of chromosome 16, band B5.

C. Disteche, G. Freeman, S. Edelhoff, 1994, Journal of immunology.

Rap1-GTP Is a Negative Regulator of Th Cell Function and Promotes the Generation of CD4+CD103+ Regulatory T Cells In Vivo1

G. Freeman, A. Sharpe, V. Boussiotis, 2005, The Journal of Immunology.

Regulatory T Cells In Vivo + CD 103 + CD 4 Function and Promotes the Generation of Rap 1-GTP Is a Negative Regulator of Th Cell

G. Freeman, A. Sharpe, V. Boussiotis, 2005 .

Antigen Recognition Is Facilitated by Invadosome-like Protrusions Formed by Memory/Effector T Cells

C. Carman, T. Springer, A. Sharpe, 2012, The Journal of Immunology.

Liver Stromal Cells Restrict Macrophage Maturation and Stromal IL-6 Limits the Differentiation of Cirrhosis-linked Macrophages.

P. Kharchenko, C. Lian, A. Sharpe, 2022, Journal of hepatology.

CRISPR Screens to Identify Regulators of Tumor Immunity.

A. Sharpe, M. LaFleur, 2021, Annual review of cancer biology.

Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling

W. Haining, S. Turley, N. Danial, 2019, Nature Immunology.

Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses

Alos Diallo, V. Kuchroo, A. Sharpe, 2019, Nature Immunology.

The phosphatase PTEN-mediated control of PI-3 kinase in T regs cells maintains homeostasis and lineage stability

J. Bluestone, A. Sharpe, J. Rathmell, 2015 .

The Pathogenic Th17 Cell Response to Major Schistosome Egg Antigen Is Sequentially Dependent on IL-23 and IL-1β

A. Sharpe, C. Dinarello, Patrick M. Smith, 2011, The Journal of Immunology.

Targeting PD-L2–RGMb overcomes microbiome-related immunotherapy resistance

G. Freeman, J. Wargo, A. Sharpe, 2023, Nature.

PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity

G. Freeman, W. Haining, K. Yates, 2019, Nature Immunology.

Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function

G. Freeman, V. Kuchroo, R. Sobel, 2018, The Journal of Immunology.

Genetic Evidence That the Differential Expression of the Ligand-Independent Isoform of CTLA-4 Is the Molecular Basis of the Idd5.1 Type 1 Diabetes Region in Nonobese Diabetic Mice1

V. Kuchroo, R. Sobel, A. Sharpe, 2009, The Journal of Immunology.

Nonobese Diabetic Mice Type 1 Diabetes Region in Idd5.1 the Isoform of CTLA-4 Is the Molecular Basis of Expression of the Ligand-Independent Genetic Evidence That the Differential

R. Sobel, A. Sharpe, L. Wicker, 2009 .

Podoplanin+ tumor lymphatics are rate limiting for breast cancer metastasis

R. Kalluri, A. Sharpe, Valerie S. LeBleu, 2018, PLoS biology.

B7 co‐stimulatory requirements differ for induction of immune responses by DNA, protein and recombinant pox virus vaccination

S. Santra, N. Letvin, A. Sharpe, 2000, European journal of immunology.

Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes

F. Gilliland, A. Sharpe, H. Allayee, 2019, Nature Communications.

Evaluation of predictive biomarkers for nivolumab in patients (pts) with metastatic clear cell renal cell carcinoma (mccRCC) from the CheckMate-025 (CM-025) trial.

P. Catalano, G. Freeman, Catherine J. Wu, 2020 .

Immunogenomic characterization of advanced clear cell renal cell carcinoma treated with PD-1 blockade.

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Dependent on IL-23 and IL-1 Schistosome Egg Antigen Is Sequentially The Pathogenic Th 17 Cell Response to Major Stadecker

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Microenvironmental landscape of human melanoma brain metastases in response to immune checkpoint inhibition.

McKenzie L. Shaw, Brian L. Shaw, S. Carter, 2022, Cancer immunology research.

BET-bromodomain and EZH2 inhibitor treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes.

J. Qi, J. Bradner, J. Ritz, 2022, Blood.

MRC OX-2 defines a novel T cell costimulatory pathway.

A. Sharpe, F. Borriello, S. Scott, 1997, Journal of immunology.

Role of Selenof as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins

S. Gygi, R. Everley, V. Gladyshev, 2018, Cell reports.

Dendritic cells giveth and taketh away

A. Sharpe, A. Abbas, 2005, Nature Immunology.

Single-cell profiling reveals unique features of diabetogenic T cells in anti-PD-1-induced type 1 diabetes mice

A. Sharpe, Kristen E. Pauken, Dillon G. Patterson, 2023, The Journal of experimental medicine.

Differential expression of alternate mB7-2 transcripts.

G. Freeman, A. Sharpe, L. Nadler, 1995, Journal of immunology.

Importance of B7-1-expressing host antigen-presenting cells for the eradication of B7-2 transfected P815 tumor cells.

J. Bluestone, A. Sharpe, M. Mokyr, 1998, Journal of immunology.

B 7-2 Transfected P 815 Tumor Cells Antigen-Presenting Cells for the Eradication Importance of B 7-1-Expressing Host and Margalit

J. Bluestone, A. Sharpe, B. Mokyr, 1998 .

CD 48-deficient mice have a pronounced defect in CD 4 1 T cell activation

G. Freeman, A. Sharpe, H. Reiser, 1999 .

Prevention and treatment of factor VIII inhibitors in murine hemophilia A.

A. Sharpe, M. Collins, L. Hoyer, 2000 .

B-cell-specific checkpoint molecules that regulate anti-tumour immunity

A. Regev, O. Rozenblatt-Rosen, V. Kuchroo, 2023, Nature.

Abstract 1019:In vivoCRISPR screening identifies Ptpn2 as a target for cancer immunotherapy

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PD-L1 and immune infiltrates are differentially expressed in distinct subgroups of gastric cancer

J. Barrett, S. Park, D. Hodgson, 2018, Oncoimmunology.

B7-1 or B7-2 Is Required to Produce the Lymphoproliferative Phenotype in Mice Lacking Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4)

A. Sharpe, D. Mandelbrot, A. McAdam, 1999, The Journal of experimental medicine.

Analysis of 3'-azido-3'-deoxythymidine levels in tissues and milk by isocratic high-performance liquid chromatography.

R. Jaenisch, A. Sharpe, D. Trites, 1990, Journal of chromatography.

In vitro assay to sensitively measure T(FR) suppressive capacity and T(FH) stimulation of B cell responses.

A. Sharpe, P. Sage, 2015, Methods in molecular biology.

Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8+ T-cell effector differentiation

D. Root, W. Haining, G. Cowley, 2014, Proceedings of the National Academy of Sciences.

graft rejection in allogeneic bone marrow transplant recipients Ligation of OX 40 ( CD 134 ) regulates graft-versus-host disease ( GVHD )

A. Sharpe, N. Killeen, B. Blazar, 2003 .

Uncoupled glycerol-3-phosphate shuttle in kidney cancer reveals that cytosolic GPD is essential to support lipid synthesis.

A. Sharpe, M. Haigis, J. Crowley, 2023, Molecular cell.

PD-L1 interacts specifically with B7-1 to regulate T cell function (88.24)

A. Sharpe, M. Butte, M. Keir, 2007, The Journal of Immunology.

Targeted reconstruction of T cell receptor sequence from single cell RNA-sequencing links CDR3 length to T cell differentiation state

P. Klenerman, N. Yosef, W. Haining, 2016, bioRxiv.

Human PD-1 agonist treatment alleviates neutrophilic asthma by reprogramming T cells.

A. Sharpe, O. Akbari, Jacob D. Painter, 2022, The Journal of allergy and clinical immunology.

The phosphatase PTEN-mediated control of PI-3 kinase in Tregs cells maintains homeostasis and lineage stability

J. Bluestone, A. Sharpe, J. Rathmell, 2014, Nature Immunology.

Suppression by TFR cells leads to durable and selective inhibition of B cell effector function

Nicolas Chevrier, W. Haining, V. Kuchroo, 2016, Nature Immunology.

Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells.

A. Sharpe, M. Haigis, Ilaria Elia, 2022, Cell Metabolism.

Impairment of the Programmed Cell Death-1 Pathway Increases Atherosclerotic Lesion Development and Inflammation

A. Sharpe, A. Lichtman, G. Stavrakis, 2011, Arteriosclerosis, Thrombosis and Vascular Biology.

TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection.

S. Akira, J. Serody, A. Sharpe, 2008, Blood.

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

F. Hodi, W. Haining, K. Yates, 2019, Nature Immunology.

The phosphatase PTEN-mediated control of PI-3 kinase in T regs cells maintains homeostasis and lineage stability

J. Bluestone, A. Sharpe, J. Rathmell, 2015 .

Circulating T follicular regulatory and helper cells have memory-like properties.

A. Sharpe, U. V. von Andrian, P. Sage, 2014, The Journal of clinical investigation.

T-Cell Costimulation and Coinhibition in Atherosclerosis

A. Sharpe, A. Lichtman, I. Gotsman, 2008, Circulation research.

Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent

G. Sica, A. Kamphorst, T. Owonikoko, 2017, Science.

Inhibitors of the PD-1 Pathway in Tumor Therapy

C. Drake, A. Sharpe, M. LaFleur, 2018, The Journal of Immunology.

TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti-PD-1/anti-CTLA-4 immunotherapy.

E. Henske, A. Sharpe, H. Lam, 2018, JCI insight.

Antigen Recognition Is Facilitated by Invadosome-like Protrusions Formed by Memory/Effector T Cells

C. Carman, T. Springer, A. Sharpe, 2012, The Journal of Immunology.

This information is current as Intestinal Nematode Parasite and Effector Th Cells After Priming with an the Absence of B 7-1 / B 7-2 , CD 28 Interactions , Memory Th 2 Effector Cells Can Develop in Urban and

A. Sharpe, W. Gause, J. Urban, 2002 .

The phosphatase PTEN-mediated control of PI-3 kinase in Tregs cells maintains homeostasis and lineage stability

J. Bluestone, A. Sharpe, J. Rathmell, 2014, Nature Immunology.

Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality.

D. Munn, R. Ahmed, A. Sharpe, 2013, Blood.

Tissue expression of PD-L1 mediates peripheral T cell tolerance

A. Sharpe, M. Sayegh, M. Keir, 2006, The Journal of experimental medicine.

Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent

G. Sica, A. Kamphorst, T. Owonikoko, 2017, Science.

Enhancing therapeutic vaccination by blocking PD-1–mediated inhibitory signals during chronic infection

Scott N. Mueller, E. Wherry, R. Ahmed, 2008, The Journal of experimental medicine.

THE ROLE OF THE REOVIRUS HEMAGGLUTININ IN VIRAL VIRULENCE *

H. Weiner, A. Sharpe, D. Drayna, 1980, Annals of the New York Academy of Sciences.

Essential and Partially Overlapping Role of CD3 (cid:103) and CD3 (cid:100) for Development of (cid:97)(cid:98) and (cid:103)(cid:100) T Lymphocytes

D. Allen, A. Sharpe, M. Salio, 1998 .

This information is current as Responses Facilitate Robust CD 8 and CD 4 Recall 4-1 BB and OX 40 Act Independently to and

A. Sharpe, E. Bertram, T. Watts, 2004 .

in cells maintains lineage stability.

J. Bluestone, A. Sharpe, P. Sage, 2016 .

ABCB5 Identifies Immunoregulatory Dermal Cells.

A. Sharpe, T. Kupper, Q. Zhan, 2015, Cell reports.