M. Nakane

M. Nakane, W. Noonan, G. Reinhart, 2008, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Mechanistic Analysis of VDR-Mediated Renin Suppression

Xiaoan Ruan, M. Nakane, P. Kroeger, 2007, Nephron Physiology.

Vitamin D Analogs Modulate the Expression of Plasminogen Activator Inhibitor-1, Thrombospondin-1 and Thrombomodulin in Human Aortic Smooth Muscle Cells

M. Nakane, J. Wu-Wong, Junli Ma, 2006, Journal of Vascular Research.

Effects of vitamin D analogs on the expression of plasminogen activator inhibitor-1 in human vascular cells.

M. Nakane, J. R. Wu-wong, Junli Ma, 2006, Thrombosis research.

Role of Phosphorus and Vitamin D Analogs in the Pathogenesis of Vascular Calcification

M. Nakane, J. R. Wu-wong, S. Morgan, 2006, Journal of Pharmacology and Experimental Therapeutics.

Expression of soluble guanylate cyclase activity requires both enzyme subunits.

F. Murad, M. Nakane, W. Buechler, 1991, Biochemical and biophysical research communications.

nitric oxide synthases

F. Murad, H. Schmidt, M. Nakane, 1992 .

Characterization and localization of endothelial nitric oxide synthase using specific monoclonal antibodies.

F. Murad, J. Polak, M. Nakane, 1993, The American journal of physiology.

Isoforms of nitric oxide synthase: functions in the cardiovascular system.

M. Nakane, J. Pollock, U. Förstermann, 1993, European heart journal.

A-350619: a novel activator of soluble guanylyl cyclase.

M. Nakane, J. Brioni, R. Moreland, 2003, Life sciences.

Pulmonary soluble guanylate cyclase, a nitric oxide receptor, is increased during the perinatal period.

M. Nakane, S. M. de la Monte, K. Bloch, 1997, The American journal of physiology.

trans-Activation and repression properties of the novel nonsteroid glucocorticoid receptor ligand 2,5-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5-(1-methylcyclohexen-3-y1)-1H-[1]benzopyrano[3,4-f]quinoline (A276575) and its four stereoisomers.

M. Nakane, J. Kuk, G. Carter, 2002, Molecular pharmacology.

Bioassay for EDRF/NO by accumulation of cyclic GMP in RFL-6 fetal rat lung fibroblasts

F. Murad, J. Mitchell, H. Schmidt, 1992 .

TH1 and TH2 cytokine inhibition by 3,5-bis(trifluoromethyl)pyrazoles, a novel class of immunomodulators.

Julie A. Wilkins, U. Warrior, M. Nakane, 2002, Cellular immunology.

Cardiovascular disease in chronic kidney failure: the role of VDR activators.

M. Nakane, R. Fryer, P. Kroeger, 2006, Current opinion in investigational drugs.

Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists.

M. Nakane, J. Brioni, R. Moreland, 2005, Bioorganic & medicinal chemistry.

2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist

D. Donnelly-roberts, Jill M. Wetter, M. Nakane, 2005, Neuropharmacology.

Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3-methylphenyl)acetamides: selective dopamine D4 receptor agonists.

D. Donnelly-roberts, M. Nakane, J. Brioni, 2004, Bioorganic & medicinal chemistry.

Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets

M. Nakane, J. Brioni, R. Moreland, 2005, Pharmacology Biochemistry and Behavior.

A nonsteroidal glucocorticoid receptor antagonist.

M. Nakane, J. Rosen, J. Miner, 2003, Molecular endocrinology.

Differential effects of Vitamin D analogs on calcium transport

M. Nakane, J. R. Wu-wong, M. Osinski, 2007, The Journal of Steroid Biochemistry and Molecular Biology.

Elevated phosphorus modulates vitamin D receptor-mediated gene expression in human vascular smooth muscle cells.

Xiaoan Ruan, M. Nakane, P. Kroeger, 2007, American journal of physiology. Renal physiology.

Differential Inhibition of Renin mRNA Expression by Paricalcitol and Calcitriol in C57/BL6 Mice

M. Nakane, R. Fryer, J. R. Wu-wong, 2007, Nephron Physiology.

Cloning of Guonylyl Cyclase Isoforms

F. Murad, M. Nakane, 1994 .

Cardiovascular disease in chronic kidney failure: is there a role for vitamin D analogs?

Xiaoan Ruan, M. Nakane, P. Kroeger, 2005, Current opinion in investigational drugs.

Synthesis and characterization of non-steroidal ligands for the glucocorticoid receptor: selective quinoline derivatives with prednisolone-equivalent functional activity.

M. Nakane, S. Elmore, P. Kym, 2001, Journal of medicinal chemistry.

Novel potent and selective inhibitors of inducible nitric oxide synthase.

M. Nakane, J. Pollock, J. Kuk, 1995, Molecular pharmacology.

Expression of choline acetyltransferase activity in a co-culture of spinal cord and skeletal muscle cells is inhibited by myogenic differentiation inhibitors.

M. Nakane, S. Kawashima, M. Kengaku, 1991, Brain research. Developmental brain research.

Inhibition by transforming growth factor beta of choline acetyltransferase stimulation in a co-culture of spinal cord and muscle cells from mice.

M. Nakane, T. Deguchi, A. Kawata, 1990, Brain research. Developmental brain research.

Functional expression of three isoforms of human nitric oxide synthase in baculovirus-infected insect cells.

H. Esumi, M. Nakane, J. Pollock, 1995, Biochemical and biophysical research communications.

Isoforms of nitric-oxide synthase: purification and regulation.

M. Nakane, J. Pollock, U. Förstermann, 1994, Methods in enzymology.

Species Heterogeneity of Pineal Hydroxyindole‐O‐Methyltransferase

M. Nakane, T. Deguchi, E. Yokoyama, 1983, Journal of neurochemistry.

In vivo pharmacological evaluation of two novel type II (inducible) nitric oxide synthase inhibitors.

M. Nakane, G. Carter, W. R. Tracey, 1995, Canadian journal of physiology and pharmacology.

Synthesis and activity of 2-[4-(4-[3H]-2-cyanophenyl)piperazinyl]-N-(2,4,6-[3H]3-3-methylphenyl)acetamide: a selective dopamine D4 receptor agonist and radioligand.

D. Donnelly-roberts, M. Nakane, J. Brioni, 2004, Bioorganic & medicinal chemistry letters.

Localization of nitric oxide synthase, NADPH diaphorase and soluble guanylyl cyclase in adult rabbit retina

S. Massey, S. Mills, H. Schmidt, 1998, Visual Neuroscience.

Phosphorylation by calcium calmodulin-dependent protein kinase II and protein kinase C modulates the activity of nitric oxide synthase.

F. Murad, M. Nakane, U. Förstermann, 1991, Biochemical and biophysical research communications.

Ascorbic acid insufficiency impairs spatial memory formation in juvenile AKR1A(cid:2)knockout mice

M. Nakane, T. Homma, J. Fujii, 2019 .

Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction.

D. Donnelly-roberts, Jill M. Wetter, G. Gintant, 2006, Journal of medicinal chemistry.

Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists.

Meena Patel, M. Nakane, J. Brioni, 2005, Journal of medicinal chemistry.

Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators.

David D. Anderson, M. Nakane, S. Elmore, 2004, Bioorganic & medicinal chemistry letters.

Activators of soluble guanylate cyclase for the treatment of male erectile dysfunction

M. Nakane, J. Brioni, R. Moreland, 2002, International Journal of Impotence Research.

Neurons in rat hippocampus that synthesize nitric oxide

R. Weinberg, H. Schmidt, M. Nakane, 1993, The Journal of comparative neurology.

Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction.

F. Murad, H. Schmidt, M. Nakane, 1992, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.

F. Murad, J. Mitchell, H. Schmidt, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Ca2+/calmodulin-dependent NO synthase type I: a biopteroflavoprotein with Ca2+/calmodulin-independent diaphorase and reductase activities.

F. Murad, H. Schmidt, M. Nakane, 1992, Biochemistry.

The nitric oxide-cyclic GMP signal transduction pathway in vascular smooth muscle preparations and other tissues.

F. Murad, H. Schmidt, M. Nakane, 1992, Japanese journal of pharmacology.

Acrylamide analog as a novel nitric oxide-independent soluble guanylyl cyclase activator.

M. Nakane, J. Brioni, R. Moreland, 2006, Journal of pharmacological sciences.

Activation of soluble guanylate cyclase causes relaxation of corpus cavernosum tissue: synergism of nitric oxide and YC-1

M. Nakane, R. Moreland, L. Miller, 2002, International Journal of Impotence Research.

Isoforms of nitric oxide synthase. Characterization and purification from different cell types.

F. Murad, J. Mitchell, H. Schmidt, 1991, Biochemical pharmacology.

Molecular cloning of a cDNA coding for 70 kilodalton subunit of soluble guanylate cyclase from rat lung.

F. Murad, M. Nakane, T. Kuno, 1988, Biochemical and biophysical research communications.

Molecular cloning and expression of cDNAs coding for soluble guanylate cyclase from rat lung.

F. Murad, M. Nakane, T. Kuno, 1990, The Journal of biological chemistry.

Identification of an endothelial-like type III NO synthase in LLC-PK1 kidney epithelial cells.

F. Murad, M. Nakane, J. Pollock, 1994, The American journal of physiology.

Co-purification of an atrial natriuretic factor receptor and particulate guanylate cyclase from rat lung.

F. Murad, S. Waldman, M. Nakane, 1986, The Journal of biological chemistry.

Guanylate cyclase in neuroblastoma N1E 115 cells: presence of endogenous activator.

M. Nakane, T. Deguchi, E. Amano, 1979, Journal of cyclic nucleotide research.

Production and properties of antibody to soluble guanylate cyclase purified from bovine brain.

M. Nakane, T. Deguchi, 1980, Biochimica et biophysica acta.

A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects.

M. Nakane, S. Elmore, R. Turner, 2003, Molecular endocrinology.

Expression of VDR and CYP24A1 mRNA in human tumors

Xiaoan Ruan, M. Nakane, Mark G. Anderson, 2005, Cancer Chemotherapy and Pharmacology.

Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle

F. Murad, M. Nakane, J. Pollock, 1993, FEBS letters.

Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions.

M. Nakane, J. Pollock, U. Förstermann, 1994, Hypertension.

The biochemical and neurologic basis for the treatment of male erectile dysfunction.

M. Nakane, J. Brioni, R. Moreland, 2001, The Journal of pharmacology and experimental therapeutics.

Soluble guanylate cyclase from rat lung exists as a heterodimer.

F. Murad, S. Waldman, M. Nakane, 1986, The Journal of biological chemistry.

Inducible NO synthase II and neuronal NO synthase I are constitutively expressed in different structures of guinea pig skeletal muscle: implications for contractile function

M. Nakane, U. Förstermann, E. Closs, 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase.

F. Murad, H. Schmidt, M. Nakane, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Nitric oxide synthase isozymes antibodies

M. Nakane, J. Pollock, U. Förstermann, 1995, The Histochemical Journal.

Nitric oxide synthase isozymes antibodies

M. Nakane, J. Pollock, U. Förstermann, 2004, The Histochemical Journal.

Nitric oxide synthases in the cardiovascular system.

M. Nakane, J. Pollock, U. Förstermann, 1993, Trends in cardiovascular medicine.

Vitamin D analogs down‐regulate plasminogen activator inhibitor‐1 in human coronary artery smooth muscle cells

M. Nakane, J. Ruth Wu-Wong, J. Ma, 2005, Journal of thrombosis and haemostasis : JTH.

Cloning of guanylyl cyclase isoforms.

F. Murad, M. Nakane, 1994, Advances in pharmacology.

SUBCELLULAR DISTRIBUTION AND ACTIVATION BY NON‐IONIC DETERGENTS OF GUANYLATE CYCLASE IN CEREBRAL CORTEX OF RAT

M. Nakane, T. Deguchi, E. Amano, 1976, Journal of neurochemistry.

Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats.

D. Donnelly-roberts, J. Sullivan, M. Nakane, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Mechanistic analysis for time-dependent effects of cinacalcet on serum calcium, phosphorus, and parathyroid hormone levels in 5/6 nephrectomized rats

M. Nakane, Yung-wu Chen, J. R. Wu-wong, 2013, Physiological reports.

Nitric oxide synthases in neuronal cells, macrophages and endothelium are NADPH diaphorases, but represent only a fraction of total cellular NADPH diaphorase activity.

M. Nakane, J. Pollock, U. Förstermann, 1993, Biochemical and biophysical research communications.

Ca2+/calmodulin-regulated nitric oxide synthases.

F. Murad, H. Schmidt, M. Nakane, 1992, Cell calcium.

Statins do not directly activate vitamin D receptor

M. Nakane, J. Wu-Wong, T. Ju, 2007, Journal of thrombosis and haemostasis : JTH.

A-315456: a selective α1D-adrenoceptor antagonist with minimal dopamine D2 and 5-HT1A receptor affinity

J. Sullivan, M. Nakane, J. Brioni, 2001 .

N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine.

J. Sullivan, M. Nakane, M. Williams, 2002, Journal of medicinal chemistry.

Nitric oxide synthase and guanylate cyclase levels in canine basilar artery after subarachnoid hemorrhage.

M. Nakane, J. Pollock, B. Weir, 1995, Journal of neurosurgery.

Systemic Activation of the Calcium Sensing Receptor Produces Acute Effects on Vascular Tone and Circulatory Function in Uremic and Normal Rats: Focus on Central versus Peripheral Control of Vascular Tone and Blood Pressure by Cinacalcet

M. Nakane, J. Segreti, R. Fryer, 2007, Journal of Pharmacology and Experimental Therapeutics.

Purification and properties of guanylate cyclase from the synaptosomal soluble fraction of rat brain.

M. Nakane, T. Deguchi, 1978, Biochimica et biophysica acta.

Neurons in rat cerebral cortex that synthesize nitric oxide: NADPH diaphorase histochemistry, NOS immunocytochemistry, and colocalization with GABA

R. Weinberg, H. Schmidt, M. Nakane, 1993, Neuroscience Letters.

Developmental changes of cytosolic and particulate nitric oxide synthase in rat brain.

M. Nakane, J. Pollock, U. Förstermann, 1993, Brain research. Developmental brain research.

The nitric oxide-cyclic GMP signal transduction system for intracellular and intercellular communication.

J Pollock, F. Murad, M. Nakane, 1993, Advances in second messenger and phosphoprotein research.

Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction.

D. Donnelly-roberts, J. Sullivan, M. Nakane, 2004, Journal of medicinal chemistry.

Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning.

D. Donnelly-roberts, J. Sullivan, M. Nakane, 2004, Journal of medicinal chemistry.

Isoforms of Nitric Oxide Synthase and the Nitric Oxide-Cyclic Gmp Signal Transduction System

F. Murad, H. Schmidt, Takahiro Matsumoto, 1993 .

Differential Effects of Vitamin D Receptor Agonists on Gene Expression in Neonatal Rat Cardiomyocytes

M. Wolf, M. Nakane, Yung-wu Chen, 2011, Cardiovascular Drugs and Therapy.

Role of fibronectin in the inhibitory effect of TGF-beta on choline acetyltransferase activity in co-cultures of spinal cord neurons and myotubes.

M. Nakane, S. Kawashima, M. Kengaku, 1991, Brain research. Developmental brain research.

Soluble Guanylyl Cyclase: Physiological Role as an NO Receptor and the Potential Molecular Target for Therapeutic Application

M. Nakane, 2003, Clinical chemistry and laboratory medicine.

Differential effects of Vitamin D analogs on bone formation and resorption

M. Nakane, Y. Li, J. R. Wu-wong, 2006, The Journal of Steroid Biochemistry and Molecular Biology.

Characterization and localization of nitric oxide synthase in non‐adrenergic non‐cholinergic nerves from bovine retractor penis muscles

F. Murad, H. Schmidt, M. Nakane, 1992, British journal of pharmacology.

Existence of nitric oxide synthase in rat hippocampal pyramidal cells.

R. Tsien, F. Murad, R. Scheller, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Comparison of the Pharmacological Effects of Paricalcitol and Doxercalciferol on the Factors Involved in Mineral Homeostasis

M. Nakane, J. R. Wu-wong, W. Noonan, 2010, International journal of endocrinology.

Role of Phospholipid in the Transmitter-Induced Synthesis of Cyclic GMP in Nervous Tissue

M. Nakane, T. Deguchi, S. Ohsako, 1982 .

The nitric oxide synthase inhibitor, L-NG-monomethylarginine, reduces carrageenan-induced pleurisy in the rat.

M. Nakane, J. Kuk, G. Carter, 1995, The Journal of pharmacology and experimental therapeutics.

[10] - Purification of Endothelial Nitric Oxide Synthase

M. Nakane, J. Pollock, 1996 .

A Non-Steroidal, Glucocorticoid Receptor Antagonist

M. Nakane, J. Rosen, J. Miner, 2003, Molecular endocrinology.

Particulate and Soluble Bovine Endothelial Nitric Oxide Synthases Are Structurally Similar Proteins Yet Different from Soluble Brain Nitric Oxide Synthase

F. Murad, M. Nakane, J. Pollock, 1992, Journal of cardiovascular pharmacology.

Characterization and localization of nitric oxide synthase in non-adrenergic non-cholinergic nerves from bovine retractor penis muscles l *

H. Schmidt, M. Nakane, J. Pollock, 2006 .

Monoclonal antibody to soluble guanylate cyclase of rat brain

M. Nakane, T. Deguchi, Masaki Nakane, 1982, FEBS letters.

Synthesis and structure-activity relationships of CP-122,721, a second-generation NK-1 receptor antagonist.

J. Lowe, M. Nakane, S. Mclean, 1998, Bioorganic & medicinal chemistry letters.

Different Effects of Calcidiol and Calcitriol on Regulating Vitamine D Receptor Target Gene Expression in Human Vascular Smooth Muscle Cells. JCvD 2013;1(2):15-20

M. Nakane, W. Qiang, J. R. Wu-wong, 2013 .

Expression and characterization of hydroxyindole O-methyltransferase from a cloned cDNA in Chinese hamster ovary cells.

M. Nakane, T. Deguchi, S. Ohsako, 1987, Brain research.

Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist.

J. Sullivan, M. Nakane, J. Kuk, 2004, Journal of medicinal chemistry.

Comparative pharmacology of human dopamine D(2)-like receptor stable cell lines coupled to calcium flux through Galpha(qo5).

M. Nakane, J. Brioni, R. Moreland, 2004, Biochemical pharmacology.

Vitamin D receptor (VDR) localization in human promyelocytic leukemia cells

M. Nakane, G. Gagné, D. Dixon, 2006, Leukemia & lymphoma.