J. Boucher

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Formation of nitrogen oxides and citrulline upon oxidation of N omega-hydroxy-L-arginine by hemeproteins.

J. Boucher, A. Genet, S. Vadon, 1992, Biochemical and biophysical research communications.

Aminoboronic acids and esters: from synthetic challenges to the discovery of unique classes of enzyme inhibitors.

J. Boucher, F. Carreaux, S. Touchet, 2011, Chemical Society reviews.

Distinction between 2′- and 3′-Phosphate Isomers of a Fluorescent NADPH Analogue Led to Strong Inhibition of Cancer Cells Migration

A. Escargueil, P. Abbe, J. Boucher, 2021, Antioxidants.

Dual Oxidase-2 Has an Intrinsic Ca2+-dependent H2O2-generating Activity*

J. Boucher, J. Francon, Rabii Ameziane-El-Hassani, 2005, Journal of Biological Chemistry.

Homocysteine induces oxidative stress by uncoupling of NO synthase activity through reduction of tetrahydrobiopterin.

J. Boucher, M. Devynck, M. David-Dufilho, 2004, Free radical biology & medicine.

Metabolic stability of superoxide adducts derived from newly developed cyclic nitrone spin traps.

J. Boucher, D. Mansuy, N. Beziere, 2014, Free Radical Biology & Medicine.

Oxidative decarboxylation of tris-(p-carboxyltetrathiaaryl)methyl radical EPR probes by peroxidases and related hemeproteins: intermediate formation and characterization of the corresponding cations.

J. Boucher, D. Mansuy, C. Decroos, 2010, Archives of biochemistry and biophysics.

Nitric oxide biosynthesis, nitric oxide synthase inhibitors and arginase competition for L-arginine utilization

J. Boucher, J. Tenu, C. Moali, 1999, Cellular and Molecular Life Sciences CMLS.

Memory TH2 cells induce alternatively activated macrophages to mediate protection against nematode parasites

J. Boucher, C. Rozo, W. Gause, 2006, Nature Medicine.

Reactions of Recombinant Neuronal Nitric Oxide Synthase with Redox Cycling Xenobiotics: A Mechanistic Study

J. Boucher, N. Čėnas, Mindaugas Lesanavičius, 2022, International journal of molecular sciences.

Single-electron reduction of quinone and nitroaromatic xenobiotics by recombinant rat neuronal nitric oxide synthase.

J. Boucher, M. Sari, H. Nivinskas, 2013, Acta biochimica Polonica.

Synthesis and evaluation of ω-borono-α-amino acids as active-site probes of arginase and nitric oxide synthases

J. Boucher, F. Carreaux, R. Danion-Bougot, 2000 .

Synthesis of boronic acid analogs of L-arginine as alternate substrates or inhibitors of nitric oxide synthase.

J. Boucher, F. Carreaux, B. Carboni, 1998, Bioorganic & medicinal chemistry letters.

Cytochromes P450 and flavin monooxygenases--targets and sources of nitric oxide.

J. Boucher, D. Mansuy, J. S. Kang, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Expression in yeast, new substrates, and construction of a first 3D model of human orphan cytochrome P450 2U1: Interpretation of substrate hydroxylation regioselectivity from docking studies.

M. Loriot, P. Beaune, J. Boucher, 2015, Biochimica et biophysica acta.

Arginase activity in alternatively activated macrophages protects PI3Kp110δ deficient mice from dextran sodium sulfate induced intestinal inflammation

J. Boucher, N. Van Rooijen, P. Murray, 2014, European journal of immunology.

Protective Role of Arginase in a Mouse Model of Colitis1

A. Gobert, J. Boucher, C. Drachenberg, 2004, The Journal of Immunology.

Spectral and 3D model studies of the interaction of orphan human cytochrome P450 2U1 with substrates and ligands.

J. Boucher, D. Mansuy, N. Pietrancosta, 2017, Biochimica et biophysica acta. General subjects.

Spectroscopic, catalytic and binding properties of Bacillus subtilis NO synthase-like protein: comparison with other bacterial and mammalian NO synthases.

J. Boucher, D. Mansuy, D. Stuehr, 2012, Journal of inorganic biochemistry.

Analogies and surprising differences between recombinant nitric oxide synthase-like proteins from Staphylococcus aureus and Bacillus anthracis in their interactions with l-arginine analogs and iron ligands.

J. Boucher, D. Mansuy, I. Mikula, 2006, Journal of inorganic biochemistry.

Helicobacter pylori arginase mutant colonizes arginase II knockout mice.

J. Boucher, T. Testerman, Songhee H. Kim, 2011, World journal of gastroenterology.

Unstability of cinnabarinic acid, an endogenous metabolite of tryptophan, under situations mimicking physiological conditions.

J. Boucher, D. Mansuy, Rogelio J Gómez-Piñeiro, 2022, Biochimie.

This information is current as Apoptosis by Activation of Arginase II Induces Macrophage Helicobacter pylori

A. Gobert, J. Boucher, S. Cederbaum, 2002 .

Helicobacter pylori Induces Macrophage Apoptosis by Activation of Arginase II1

A. Gobert, J. Boucher, S. Cederbaum, 2002, The Journal of Immunology.

Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile.

J. Boucher, D. Mansuy, F. Acher, 2008, Bioorganic & medicinal chemistry.

Structure-based discovery of a small non-peptidic Neuropilins antagonist exerting in vitro and in vivo anti-tumor activity on breast cancer model.

M. Montès, J. Boucher, O. Hermine, 2014, Cancer letters.

SHIP-deficient mice develop spontaneous intestinal inflammation and arginase-dependent fibrosis.

J. Boucher, K. Jacobson, L. Sly, 2011, The American journal of pathology.

Effect of uncoupling endothelial nitric oxide synthase on calcium homeostasis in aged porcine endothelial cells.

J. Boucher, Y. Frapart, J. Vilaine, 2009, Cardiovascular research.

Metabolism of Anethole Dithiolethione by Rat and Human Liver Microsomes: Formation of Various Products Deriving from Its O-Demethylation and S-Oxidation. Involvement of Cytochromes P450 and Flavin Monooxygenases in These Pathways

J. Boucher, D. Mansuy, P. Dansette, 2018, Drug Metabolism and Disposition.

Toward stable electron paramagnetic resonance oximetry probes: synthesis, characterization, and metabolic evaluation of new ester derivatives of a tris-(para-carboxyltetrathiaaryl)methyl (TAM) radical.

J. Boucher, D. Mansuy, G. Bertho, 2013, Chemical research in toxicology.

Microsomal formation of nitric oxide and cyanamides from non-physiological N-hydroxyguanidines: N-hydroxydebrisoquine as a model substrate.

J. Boucher, D. Mansuy, B. Clement, 1999, Biochemical pharmacology.

High-performance liquid chromatographic separation of 11-hydroxylauric acid enantiomers : Application to the determination of the stereochemistry of microsomal lauric acid (ω-1) hydroxylation

J. Boucher, M. Delaforge, R. Azerad, 1990 .

Oxygen activation in NO synthases: evidence for a direct role of the substrate

J. Boucher, M. Couture, J. Santolini, 2016, FEBS open bio.

Superoxide anion efficiently performs the oxidative cleavage of CNOH bonds of amidoximes and N-hydroxyguanidines with formation of nitrogen oxides

J. Boucher, D. Mansuy, P. Battioni, 1995 .

Oxidative metabolism of linoleic acid by human leukocytes.

J. Boucher, M. Delaforge, D. Mansuy, 1989, Biochemical and biophysical research communications.

Inhibition of arginase in rat and rabbit alveolar macrophages by Nω‐hydroxy‐D,L‐indospicine, effects on L‐arginine utilization by nitric oxide synthase

J. Boucher, S. Vadon-Le Goff, K. Racké, 1997, British journal of pharmacology.

Metabolism of lipoxins A4 and B4 and of their all-trans isomers by human leukocytes and rat liver microsomes.

J. Boucher, M. Delaforge, D. Mansuy, 1991, Biochemical and biophysical research communications.

Solid‐Phase Synthesis of Substrate‐Based Dipeptides and Heterocyclic Pseudo‐dipeptides as Potential NO Synthase Inhibitors

J. Boucher, Jean‐François Hernandez, Jean Martinez, 2020, ChemMedChem.

Importance of valine 567 in substrate recognition and oxidation by neuronal nitric oxide synthase.

J. Boucher, D. Mansuy, M. Sari, 2004, Journal of inorganic biochemistry.

MacrophagesNitric Oxide Synthase Translation in by Attenuating Inducible Helicobacter pylori Arginase II Restricts Host Defense to

J. Boucher, M. Asim, K. Wilson, 2010 .

l-Arginine Availability Modulates Local Nitric Oxide Production and Parasite Killing in Experimental Trypanosomiasis

B. Veyret, A. Gobert, J. Boucher, 2000, Infection and Immunity.

Oxidative and reductive metabolism of tris(p-carboxyltetrathiaaryl)methyl radicals by liver microsomes.

J. Boucher, D. Mansuy, G. Bertho, 2009, Chemical research in toxicology.

Formation of nitrogen oxides including NO from oxidative cleavage of CN(OH) bonds: A general cytochrome P450-dependent reaction.

J. Boucher, M. Delaforge, D. Mansuy, 1995 .

Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation.

J. Boucher, M. Duin, M. van Duin, 2008, American journal of respiratory and critical care medicine.

Dehydration of alkyl- and arylaldoximes as a new cytochrome P450-catalyzed reaction: mechanism and stereochemical characteristics.

J. Boucher, M. Delaforge, D. Mansuy, 1994, Biochemistry.

Microperoxidase 8 catalyzed nitration of phenol by nitrogen dioxide radicals.

J. Boucher, D. Mansuy, J. Mahy, 2001, European journal of biochemistry.

Mitochondrial Arginase II Modulates Nitric-Oxide Synthesis through Nonfreely Exchangeable l-Arginine Pools in Human Endothelial Cells

J. Boucher, L. Walch, M. David-Dufilho, 2006, Journal of Pharmacology and Experimental Therapeutics.

Relationship between the structure of guanidines and N‐hydroxyguanidines, their binding to inducible nitric oxide synthase (iNOS) and their iNOS‐catalysed oxidation to NO

J. Boucher, D. Mansuy, D. Stuehr, 2005, The FEBS journal.

Reactions between iron porphyrins and tetrahydropterins

J. Boucher, D. Mansuy, P. Battioni, 2004 .

Particular ability of liver P450s3A to catalyze the oxidation of N omega-hydroxyarginine to citrulline and nitrogen oxides and occurrence in no synthases of a sequence very similar to the heme-binding sequence in P450s.

J. Boucher, S. Vadon, M. Delaforge, 1993, Biochemical and biophysical research communications.

N omega-hydroxyl-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase.

J. Boucher, S. Vadon, M. Delaforge, 1994, Biochemical and biophysical research communications.

Substrate specificity of NO synthases: detailed comparison of L-arginine, homo-L-arginine, their N omega-hydroxy derivatives, and N omega-hydroxynor-L-arginine.

J. Boucher, D. Mansuy, M. Sari, 1998, Biochemistry.

Substrate Specificity of NO Synthases: Detailed Comparison of l-Arginine, Homo-l-arginine, Their Nω-Hydroxy Derivatives, and Nω-Hydroxynor-l-arginine†

J. Boucher, D. Mansuy, M. Sari, 1998 .

Mouse Strain Susceptibility to Trypanosome Infection: An Arginase-Dependent Effect1

B. Veyret, A. Gobert, J. Boucher, 2004, The Journal of Immunology.

Infection: An Arginase-Dependent Effect Mouse Strain Susceptibility to Trypanosome

B. Veyret, A. Gobert, J. Boucher, 2022 .

Unprecedented ipso aromatic nucleophilic substitution upon oxidative decarboxylation of tris(p-carboxyltetrathiaaryl)methyl (TAM) radicals: a new access to diversely substituted TAM radicals.

T. Prangé, J. Boucher, D. Mansuy, 2011, Chemical communications.

Oxidation of tris-(p-carboxyltetrathiaaryl)methyl radical EPR probes: evidence for their oxidative decarboxylation and molecular origin of their specific ability to react with O2*-.

J. Boucher, D. Mansuy, G. Bertho, 2009, Chemical communications.

L-arginine uptake by cationic amino acid transporter 2 is essential for colonic epithelial cell restitution.

Lori A. Coburn, J. Boucher, K. Wilson, 2012, American journal of physiology. Gastrointestinal and liver physiology.

In vivo effects of arginase inhibition and of L-arginine on allergen-induced airway hyperresponsiveness in a guinea pig model of allergic asthma

J. Boucher, M. Duin, H. Meurs, 2018 .

Synthesis and evaluation of new ω-borono-α-amino acids as rat liver arginase inhibitors

J. Boucher, D. Mansuy, F. Carreaux, 2005 .

Nω-Hydroxyamino-α-amino acids as a new class of very strong inhibitors of arginases

J. Boucher, S. Vadon, M. Delaforge, 1996, JBIC Journal of Biological Inorganic Chemistry.

Interaction of anions with rat liver arginase: specific inhibitory effects of fluoride.

J. Boucher, D. Mansuy, S. Pèthe, 2002, Journal of inorganic biochemistry.

On the mechanism of nitric oxide formation upon oxidative cleavage of C = N(OH) bonds by NO-synthases and cytochromes P450.

J. Boucher, D. Mansuy, B. Clement, 1995, Biochimie.

Hydroxylation of leukotriene B4 in leukocytes from various species: identification of a metabolite to authentic 5S,12R,19-trihydroxy-6Z,8E,10E,14Z-eicosatetra enoic acid and relative importance of 19- and 20-hydroxylations.

J. Boucher, M. Delaforge, D. Mansuy, 1989, Biochemical and biophysical research communications.

TLR4/IFNγ pathways induce tumor regression via NOS II-dependent NO and ROS production in murine breast cancer models

J. Boucher, L. Rochette, C. Vergely, 2016, Oncoimmunology.

Reactivity of the heme–dioxygen complex of the inducible nitric oxide synthase in the presence of alternative substrates

J. Boucher, D. Mansuy, D. Stuehr, 2006, The FEBS journal.

Comparison of wild type neuronal nitric oxide synthase and its Tyr588Phe mutant towards various L-arginine analogues.

J. Boucher, D. Mansuy, Toru Shimizu, 2010, Journal of inorganic biochemistry.

Oxidations of N(omega)-hydroxyarginine analogues and various N-hydroxyguanidines by NO synthase II: key role of tetrahydrobiopterin in the reaction mechanism and substrate selectivity.

J. Boucher, D. Mansuy, D. Stuehr, 2001, Chemical research in toxicology.

The New α-Amino Acid Nω-Hydroxy-nor-L-arginine: A High- Affinity Inhibitor of Arginase Well Adapted to Bind to Its Manganese Cluster.

J. Boucher, M. Delaforge, D. Mansuy, 1997 .

Endothelium- and nitric oxide-dependent vasorelaxing activities of gamma-butyrobetaine esters: possible link to the antiischemic activities of mildronate.

J. Boucher, T. Münzel, A. Kleschyov, 2004, European journal of pharmacology.

Effects of gamma-butyrobetaine and mildronate on nitric oxide production in lipopolysaccharide-treated rats.

J. Boucher, L. Baumane, M. Dzintare, 2004, Basic & clinical pharmacology & toxicology.

Light-induced formation of NO in endothelial cells by photoactivatable NADPH analogues targeting nitric-oxide synthase.

J. Boucher, F. Simon, P. Tauc, 2019, Biochimica et biophysica acta. General subjects.

New 1,4‐Dihydropyridines Down‐regulate Nitric Oxide in Animals with Streptozotocin‐induced Diabetes Mellitus and Protect Deoxyribonucleic Acid against Peroxynitrite Action

J. Boucher, L. Baumane, N. Sjakste, 2016, Basic & clinical pharmacology & toxicology.

Alternative nitric oxide-producing substrates for NO synthases.

J. Boucher, D. Mansuy, 2004, Free radical biology & medicine.

OXIDATION OF N-HYDROXYGUANIDINES BY CYTOCHROMES P450 AND NO-SYNTHASES AND FORMATION OF NITRIC OXIDE

J. Boucher, D. Mansuy, 2002, Drug metabolism reviews.

Diastereoselective functionalizations of enecarbamates derived from pipecolic acid towards 5-guanidinopipecolates as arginine mimetics.

J. Boucher, Jean‐Claude Kizirian, V. Bonnet, 2008, Organic & biomolecular chemistry.

New Catalytic Properties of Iron Porphyrins: Model Systems for Cytochrome P450-Catalyzed Dehydration of Aldoximes

J. Boucher, D. Mansuy, P. Battioni, 1998 .

Comparison of Various Aryl-Dithiolethiones and Aryl-Dithiolones As Hydrogen Sulfide Donors in the Presence of Rat Liver Microsomes

J. Boucher, D. Mansuy, P. Dansette, 2020, Drug Metabolism and Disposition.

New 2-bromomethyl-8-substituted-benzo[c]chromen-6-ones. Synthesis and biological properties.

F. Bihel, J. Kraus, J. Boucher, 2005, Bioorganic & medicinal chemistry letters.

Mechanistic and metabolic inferences from the binding of substrate analogues and products to arginase.

J. Boucher, D. Mansuy, D. Christianson, 2001, Biochemistry.

Inhibitory effects and spectral interactions of isomeric methoxyindazoles on recombinant nitric oxide synthases.

J. Boucher, S. Rault, P. Schumann-Bard, 2003, Nitric oxide : biology and chemistry.

Microperoxidase 8 catalysed nitrogen oxides formation from oxidation of N-hydroxyguanidines by hydrogen peroxide.

J. Boucher, D. Mansuy, J. Mahy, 2002, European journal of biochemistry.

New 2-bromomethyl-8-substituted-benzo[c]chromen-6-ones. Synthesis and biological properties.

F. Bihel, J. Kraus, J. Boucher, 2005, Bioorganic & medicinal chemistry letters.

N-Hydroxyguanidines oxidation by a N3S copper-complex mimicking the reactivity of Dopamine beta-Hydroxylase.

J. Boucher, P. Slama, M. Réglier, 2009, Journal of inorganic biochemistry.

Oxidation of arylamidoximes by various chemical and biomimetic systems: comparison with their oxidations by hemeproteins

J. Boucher, D. Mansuy, Sandrine Vadon-Le Goff, 2000 .

Capto-dative substituent effects. 121 - New ketene equivalents for diels-alder cycloadditions

J. Boucher, L. Stella, 1982 .

Microsomal cytochrome P450 dependent oxidation of N-hydroxyguanidines, amidoximes, and ketoximes: mechanism of the oxidative cleavage of their C=N(OH) bond with formation of nitrogen oxides.

J. Boucher, D. Mansuy, B. Clement, 1998, Biochemistry.

The influence of captodative effect on the dienophilicity of olefins. The easy diels-alder reaction of α-methylthioacrylonitrile with cyclohexadiene

J. Boucher, L. Stella, 1985 .

Oxidation of arylamidoximes by hydrogen peroxide and horseradish peroxidase in water: Easy preparation and X-ray structure of O-(arylimidoyl)arylamidoximes

J. Boucher, S. Vadon, D. Mansuy, 1996 .

Aromatic N-hydroxyguanidines as new reduction cosubstrates for dopamine beta-hydroxylase.

J. Boucher, P. Slama, M. Réglier, 2004, Biochemical and biophysical research communications.

Nomega-hydroxy-L-arginine homologues and hydroxylamine as nitric oxide-dependent vasorelaxant agents.

J. Boucher, D. Mansuy, T. Munzel, 2005, European journal of pharmacology.

Inhibitor coordination interactions in the binuclear manganese cluster of arginase.

J. Boucher, D. Mansuy, D. Christianson, 2004, Biochemistry.

Coordination chemistry of the heme in cystathionine beta-synthase: formation of iron(II)-isonitrile complexes.

J. Boucher, M. Delaforge, D. Mansuy, 2001, Biochemical and biophysical research communications.

Human Orphan Cytochrome P450 2U1 Catalyzes the ω-Hydroxylation of Leukotriene B4

J. Boucher, D. Mansuy, N. Pietrancosta, 2022, International journal of molecular sciences.

Spectroscopic investigation of isonitrile complexes of ferric and ferrous microperoxidase 8.

J. Boucher, J. Mahy, S. Lecomte, 2005, Journal of inorganic biochemistry.

Microperoxidase 8 (mp8) as a convenient model for hemoproteins: formation and characterisation of new iron(II)-nitrosoalkane complexes of biological relevance.

J. Boucher, D. Mansuy, J. Mahy, 2001, Advances in experimental medicine and biology.

Formation of iron(II)-nitrosoalkane complexes: a new activity of microperoxidase 8.

J. Boucher, D. Mansuy, J. Mahy, 2000, Biochemical and biophysical research communications.

Effects of the new arginase inhibitor N(omega)-hydroxy-nor-L-arginine on NO synthase activity in murine macrophages.

J. Boucher, D. Mansuy, J. Tenu, 1999, Nitric oxide : biology and chemistry.

Metabolic activation of the antitumor drug 5-(Aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by NO synthases.

J. Boucher, D. Mansuy, D. Stuehr, 2008, Chemical research in toxicology.

Rational design of a fluorescent NADPH derivative imaging constitutive nitric-oxide synthases upon two-photon excitation

C. Dessy, J. Boucher, P. Tauc, 2012, Proceedings of the National Academy of Sciences.

Metabolism of nilutamide in rat lung.

M. Lag, J. Holme, J. Boucher, 2006, Biochemical pharmacology.

Dienophilie des olefines captodatives

J. Boucher, L. Stella, 1986 .

Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation

F. Bushman, E. Wherry, K. Bittinger, 2014, Science.

Mechanism of melanoma cells selective apoptosis induced by a photoactive NADPH analogue

J. Boucher, S. Rocchi, A. Slama-Schwok, 2016, Oncotarget.

EPR characterization of molecular targets for NO in mammalian cells and organelles

J. Boucher, J. Drapier, Y. Henry, 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).

J. Boucher, B. Kessler, C. Schofield, 2011, Journal of molecular biology.

Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion

Charles C. Kim, J. Boucher, W. Gause, 2014, Nature Immunology.

Putative role of nitric oxide synthase isoforms in the changes of nitric oxide concentration in rat brain cortex and cerebellum following sevoflurane and isoflurane anaesthesia.

J. Boucher, L. Baumane, M. Dzintare, 2005, European journal of pharmacology.

Cytochrome P450 2U1, a very peculiar member of the human P450s family

J. Boucher, D. Mansuy, L. Ducassou, 2017, Cellular and Molecular Life Sciences.

First non-alpha-amino acid guanidines acting as efficient NO precursors upon oxidation by NO-synthase II or activated mouse macrophages.

J. Boucher, D. Mansuy, D. Stuehr, 2002, Biochemistry.

Importance of Val567 on heme environment and substrate recognition of neuronal nitric oxide synthase

J. Boucher, G. Zoppellaro, H. Hersleth, 2018, FEBS open bio.

Role of Arginine Guanidinium Moiety in Nitric-oxide Synthase Mechanism of Oxygen Activation

J. Boucher, T. Mattioli, D. Stuehr, 2009, The Journal of Biological Chemistry.

Critical role of Val567 in substrate recognition by neuronal nitric oxide synthase for NO formation activity

J. Boucher, D. Mansuy, M. Sari, 2003 .

TLR Agonists That Induce IFN-β Abrogate Resident Macrophage Suppression of T Cells

J. Boucher, G. Krystal, K. Bennewith, 2010, The Journal of Immunology.

TLR Agonists That Induce IFN-

J. Boucher, G. Krystal, K. Bennewith, 2010 .

Arginase II Restricts Host Defense to Helicobacter pylori by Attenuating Inducible Nitric Oxide Synthase Translation in Macrophages

A. Gobert, J. Boucher, M. Asim, 2010, The Journal of Immunology.

Regulation of NADPH-dependent Nitric Oxide and reactive oxygen species signalling in endothelial and melanoma cells by a photoactive NADPH analogue

J. Boucher, P. Tauc, E. Deprez, 2014, Oncotarget.

l-Arginine Binding to Human Inducible Nitric Oxide Synthase: An Antisymmetric Funnel Route toward Isoform-Specific Inhibitors?

Nicolas Floquet, Jean-François Hernandez, Jean-Luc Boucher, 2011, J. Chem. Inf. Model..

Synthesis, Characterization and NO Synthase Inhibition Testing of 2‐Aryl‐5‐aroyl‐3,4,5,6‐tetrahydropyrimidinium Chlorides

J. Boucher, B. Clement, U. Girreser, 2015 .

Synthesis and evaluation of pyrido[1,2-a]pyrimidines as inhibitors of nitric oxide synthases.

J. Boucher, B. Clement, U. Girreser, 2009, European journal of medicinal chemistry.

Membrane-bound human orphan cytochrome P450 2U1: Sequence singularities, construction of a full 3D model, and substrate docking.

François André, J. Boucher, D. Mansuy, 2017, Biochimie.

Mechanism of H2S Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes

J. Boucher, D. Mansuy, P. Dansette, 2019, Drug Metabolism and Disposition.

Implication of folate deficiency in CYP2U1 loss of function

A. Durr, F. Lamari, S. Picaud, 2021, The Journal of experimental medicine.

N-hydroxyguanidines as new heme ligands: UV-visible, EPR, and resonance Raman studies of the interaction of various compounds bearing a C=NOH function with microperoxidase-8.

J. Boucher, D. Mansuy, J. Mahy, 2001, Biochemistry.

Reduction of nilutamide by NO synthases: implications for the adverse effects of this nitroaromatic antiandrogen drug.

J. Boucher, D. Mansuy, M. Sari, 2003, Chemical research in toxicology.

CYP2U1 activity is altered by missense mutations in hereditary spastic paraplegia 56

A. Durr, F. Rivier, G. Stevanin, 2018, Human mutation.

Efficient formation of nitric oxide from selective oxidation of N-aryl N'-hydroxyguanidines by inducible nitric oxide synthase.

J. Boucher, D. Mansuy, D. Stuehr, 1999, Biochemistry.

Synthesis and evaluation of new omega-borono-alpha-amino acids as rat liver arginase inhibitors.

J. Boucher, D. Mansuy, F. Carreaux, 2005, Bioorganic & Medicinal Chemistry.

Modulation of cholinergic airway reactivity and nitric oxide production by endogenous arginase activity

J. Boucher, S. Vadon-Le Goff, H. Meurs, 2000, British journal of pharmacology.

Pseudoxanthoma elasticum overlaps hereditary spastic paraplegia type 56

A. Durr, C. Orssaud, G. Stevanin, 2020, Journal of internal medicine.

Reactions of amino acids, peptides, and proteins with oxidized metabolites of tris(p-carboxyltetrathiaaryl)methyl radical EPR probes.

J. Boucher, D. Mansuy, C. Decroos, 2014, Chemical research in toxicology.

A Novel Entry to the Bicyclo[4.2.2]decatriene and Tetraene Systems: The Unexpected 1,4‐Cycloaddition of 2‐(Methylthio)acrylonitrile to Cyclooctatetraene.

J. Boucher, L. Stella, I. D. Riggi, 1998 .

A Novel Entry to the Bicyclo[4.2.2]decatriene and Tetraene Systems: The Unexpected 1,4-Cycloaddition of 2-(Methylthio)acrylonitrile to Cyclooctatetraene

J. Boucher, L. Stella, I. D. Riggi, 1997 .

Metabolic stability of superoxide and hydroxyl radical adducts of a cyclic nitrone toward rat liver microsomes and cytosol: A stopped-flow ESR spectroscopy study.

J. Boucher, D. Mansuy, N. Beziere, 2010, Free radical biology & medicine.

Involvement of NO in the Endothelium-Independent Relaxing Effects of N ω-Hydroxy-l-arginine and Other Compounds Bearing a C=NOH Function in the Rat Aorta

J. Boucher, D. Mansuy, N. Callizot, 2002, Journal of Pharmacology and Experimental Therapeutics.

The endogenous neurotransmitter, serotonin, modifies neuronal nitric oxide synthase activities

J. Boucher, M. Sari, C. Grillon, 2007, Free radical research.

Detection of a nitric oxide synthase possibly involved in the regulation of the Rhodococcus sp R312 nitrile hydratase.

J. Boucher, D. Mansuy, M. Sari, 1998, Biochemical and biophysical research communications.

Formation of nitric oxide synthase-iron(II) nitrosoalkane complexes: severe restriction of access to the iron(II) site in the presence of tetrahydrobiopterin.

J. Boucher, D. Mansuy, M. Sari, 1998, Biochemistry.

Synthesis and effects on arginase and nitric oxide synthase of two novel analogues of Nω-hydroxyarginine, Nω-hydroxyindospicine and p-hydroxyamidinophenylalanine

J. Boucher, S. Vadon, D. Mansuy, 1996 .

Very general formation of tetrahydropterin cation radicals during reaction of iron porphyrins with tetrahydropterins: model for the corresponding NO-synthase reaction.

J. Boucher, D. Mansuy, Y. Frapart, 2004, Chemical communications.

Cytochrome P450 catalyzes the oxidation of N omega-hydroxy-L-arginine by NADPH and O2 to nitric oxide and citrulline.

J. Boucher, A. Genet, S. Vadon, 1992, Biochemical and Biophysical Research Communications - BBRC.

Formation of nitric oxide by cytochrome P450-catalyzed oxidation of aromatic amidoximes.

J. Boucher, M. Delaforge, D. Mansuy, 1992, Biochemical and biophysical research communications.

S-Ethyl-Isothiocitrullin-Based Dipeptides and 1,2,4-Oxadiazole Pseudo-Dipeptides: Solid Phase Synthesis and Evaluation as NO Synthase Inhibitors

J. Boucher, Jean‐François Hernandez, A. Ejjoummany, 2023, Molecules.