K. Shinozuka

发表

Involvement of the glutamate receptor δ2 subunit in the long-term depression of glutamate responsiveness in cultured rat Purkinje cells

T. Hirano, K. Araki, M. Mishina, 1994, Neuroscience Letters.

Comparative inhibition of chloramphenicol acetyltransferase gene expression by antisense oligonucleotide analogues having alkyl phosphotriester, methylphosphonate and phosphorothioate linkages.

G. Zon, K. Shinozuka, G. Quinnan,, 1987, Nucleic acids research.

Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus.

M. Reitz, H. Mitsuya, G. Zon, 1987, Proceedings of the National Academy of Sciences of the United States of America.

SYNTHESIS AND CHARACTERIZATION OF POLYAMINE-BASED BIOMIMETIC CATALYSTS AS ARTIFICIAL RIBONUCLEASE

H. Sawai, K. Shinozuka, K. Shimizu, 2001, Nucleosides, nucleotides & nucleic acids.

Synthesis and RNA cleaving activities of polyamine derived novel artificial ribonuclease

H. Sawai, K. Shinozuka, K. Shimizu, 1994 .

Selective binding of trisamine-modified phosphorothioate antisense DNA to target mRNA improves antisense activity and reduces toxicity.

H. Sawai, K. Shinozuka, T. Miike, 2002, Biochemical and biophysical research communications.

Phosphorothioate and normal oligodeoxyribonucleotides with 5'-linked acridine: characterization and preliminary kinetics of cellular uptake.

L. Neckers, K. Shinozuka, K. Mori, 1988, Gene.

Synthesis of a New Ruthenium Complex of a Macrocyclic Ligand Containing 1,10-Phenanthroline, and Its Photo-Mediated Covalent Binding to DNA

H. Sawai, K. Shinozuka, S. Ogawa, 1996 .

Synthesis of a New Copper Complex of a Macrocyclic Compound Consisting of 1,10-Phenanthroline, and Its DNA Binding and Cleaving Activity

H. Sawai, K. Shinozuka, S. Ogawa, 1994 .

Synthesis and DNA Cleaving Activity of Copper-complex of Macrocyclic Compound Containing 1,10-Phenanthroline

H. Sawai, K. Shinozuka, S. Ogawa, 1992 .

Comparative inhibition of ras p21 protein synthesis with phosphorus-modified antisense oligonucleotides.

G. Zon, K. Shinozuka, W. Wilson, 1989, Anti-cancer drug design.

Regulation of viral expression of human immunodeficiency virus in vitro by an antisense phosphorothioate oligodeoxynucleotide against rev (art/trs) in chronically infected cells.

H. Mitsuya, G. Zon, S. Broder, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Labeling of phosphorothioate antisense oligonucleotides with yttrium-90.

S. Tanada, H. Ozaki, H. Sawai, 1999, Nuclear medicine and biology.

Duplex Stabilizing Effect and Nuclease Resistant Property of Novel Oligonucleotides Containing C-2 Branched Polyamine-Bearing Deoxyinosine Derivative

H. Sawai, K. Shinozuka, H. Ikeda, 2002 .

A new synthetic approach to 8-chloroflavins and their conversion into 8-(substituted-amino)flavins.

K. Shinozuka, F. Yoneda, Ryoko Matsushita, 1980 .

An Approach to Prebiotic Synthesis of α-Oligoribonucleotides and Description of Their Properties: Selective Advantage of β-RNA over α-RNA

H. Sawai, K. Shinozuka, T. Itoh, 1997, Journal of Molecular Evolution.

Oligodeoxyribonucleoside methylphosphonates. NMR and UV spectroscopic studies of Rp-Rp and Sp-Sp methylphosphonate (Me) modified duplexes of (d[GGAATTCC])2.

M. Bower, M. Summers, C. Powell, 1987, Nucleic acids research.

Divalent metal ion-catalyzed pyrophosphate bond formation in aqueous solution. Synthesis of nucleotides containing polyphosphate

H. Sawai, K. Shinozuka, H. Wakabayashi, 1992 .

Nucleoside complexing. A13C NMR spectroscopic investigation of the metal binding sites in 7-methylguanosine, 7-methylinosine and some related new synthetic betains

K. Shinozuka, L. Marzilli, B. L. Heyl, 1985 .

Spermine moiety attached to the C-5 position of deoxyuridine enhances the duplex stability of the phosphorothioate DNA/complementary DNA and shows the susceptibility of the substrate to RNase H.

K. Shinozuka, H. Sakai, T. Moriguchi, 2008, Chemical & pharmaceutical bulletin.

Synthesis and Properties of Novel Oligodeoxynucleotides Containing 6,3'-Methanodeoxyuridine

K. Shinozuka, T. Moriguchi, Fumisada Yamato, 2008 .

A new synthesis of 10‐arylisoalloxazines (10‐arylflavins)

K. Shinozuka, F. Yoneda, A. Koshiro, 1979 .

Effect of Imino Group of a Linker Arm at the C5 Position of a Pyrimidine Nucleoside on the Thermal Stabilities of DNA/DNA and DNA/RNA Duplexes

H. Ozaki, H. Sawai, K. Shinozuka, 2004, Nucleosides, nucleotides & nucleic acids.

NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS

H. Ozaki, H. Sawai, K. Shinozuka, 2004 .

Bis-s-triazolo[1,5-a:1',5'-c]pyrimidine and some simple derivatives

K. Shinozuka, D. J. Brown, 1980 .

Distal Effect of Amide and Amino Groups on the Oxygen Activation Ability and Rate of the Redox Reaction of Simplified Analogs of Bleomycin

H. Sawai, K. Shinozuka, T. Arai, 1998 .

Chemistry of mono(guanine) complexes of cisplatin and its relevance to the N7,O6 chelate hypothesis

K. Shinozuka, L. Marzilli, B. Lippert, 1985 .

Facile Synthesis of α-Anomeric Pyrimidine Nucleosides

H. Sawai, K. Shinozuka, A. Nakamura, 1994 .

Synthesis of 10-Arylpyrimido [4, 5-b] quinoline-2, 4 (3H, 10H) diones (10-Aryl-5-deazaflavins) and Their Use in Oxidations of Alcohols and Amines

K. Shinozuka, F. Hirayama, K. Uekama, 1980 .

A novel bleomycin model compound bearing hydrophilic steric factor exhibited high oxygen activating capacity

H. Sawai, K. Shinozuka, J. Kohda, 1995 .

Facile synthesis of nucleotides containing polyphosphates by Mn(II) and Cd(II) ion-catalyzed pyrophosphate bond formation in aqueous solution

H. Sawai, K. Shinozuka, M. Shimazu, 1990 .

Second-sphere ‘communication’ between two cis-bound guanine nucleotides. Factors influencing conformations of dynamic adducts of cis-type platinum anticancer drugs with guanine nucleotides as deduced by circular dichroism spectroscopy

K. Shinozuka, L. Marzilli, G. Natile, 2000 .

Antifungal Activity of Fatty Acids against Pyricularia oryzae Related to Antifungal Constituents of Miscanthus sinensis

K. Shinozuka, A. Mori, C. Nishino, 1987 .

Avidin–Biotin Technology in Gold Nanoparticle-Decorated Graphene Field Effect Transistors for Detection of Biotinylated Macromolecules with Ultrahigh Sensitivity and Specificity

A. Kuwana, K. Shinozuka, M. Hossain, 2020, ACS omega.

Graphene field-effect transistor biosensor for detection of biotin with ultrahigh sensitivity and specificity

A. Kuwana, K. Shinozuka, R. Ichige, 2020, Biosensors and Bioelectronics.

Synthesis and Duplex-Forming Property of Oligonucleotides Bearing a Novel Polyamine-Modified Intercalator at the Terminal or the Internal Position

K. Shinozuka, M. Tachibana, T. Moriguchi, 2006, Nucleosides, nucleotides & nucleic acids.

Synthesis of a novel 2′-deoxyuridine derivative bearing a cyanomethoxycarbonylmethyl group at C-5 position and its use for versatile post-synthetic functionalization of oligodeoxyribonucleotides

H. Ozaki, H. Sawai, K. Shinozuka, 1998 .

Novel method of the synthesis and hybridization properties of an oligonucleotide containing non-ionic diisopropylsilyl internucleotide linkage.

K. Shinozuka, T. Moriguchi, M. Sekine, 2013, Bioorganic & medicinal chemistry.

Synthesis and ribonuclease H related biochemical properties of α-anomeric 2′-deoxypyrimidine homooligomer and its phosphorothioate analog

H. Ozaki, H. Sawai, K. Shinozuka, 1996 .

Sequence dependent effects in methylphosphonate deoxyribonucleotide double and triple helical complexes.

G. Zon, K. Shinozuka, W. Wilson, 1990, Nucleic acids research.

Novel DNA Analog for Potential Gene Regulating Agent. A Convenient Synthesis of α-Oligodeoxyribonucleotide Phosphorothioate Bearing 3′-Monophosphate

H. Sawai, K. Shinozuka, Y. Hirota, 1991 .

Alternate stranded triplex formation of chimeric DNA composed of tandem α- and β-anomeric strands

H. Sawai, K. Shinozuka, T. Moriguchi, 2002 .

Synthesis and properties of 2′–5′ and 3′–5′ linked α-oligoriboadenylates

H. Sawai, K. Shinozuka, H. Taira, 1996 .

Physicochemical properties of phosphorothioate oligodeoxynucleotides.

K. Shinozuka, J. S. Cohen, C. Stein, 1988, Nucleic acids research.

Synthesis of phosphorothioate analogues of oligodeoxyribonucleotides and their antiviral activity against human immunodeficiency virus (HIV).

H. Mitsuya, G. Zon, S. Broder, 1988, Gene.

UO2+2-Catalyzed Oligothioadenylate Synthesis with High Regio- and Stereoselectivity

H. Sawai, K. Shinozuka, M. Shimazu, 1993 .

Stabilizing effect of propionic acid derivative of anthraquinone--polyamine conjugate incorporated into α-β chimeric oligonucleotides on the alternate-stranded triple helix.

K. Shinozuka, T. Moriguchi, A. Azam, 2011, Bioconjugate chemistry.

Modified alpha-beta chimeric oligoDNA bearing a multi-conjugate of 2,2-bis(hydroxymethyl)propionic acid-anthraquinone-polyamine exhibited improved and stereo-nonspecific triplex-forming ability.

K. Shinozuka, T. Moriguchi, A. Azam, 2006, Chemical communications.

Alpha-beta chimeric oligo-DNA bearing intercalator-conjugated nucleobase inside the linker sequence remarkably improves thermal stability of an alternate-stranded triple helix.

K. Shinozuka, T. Moriguchi, M. Hasegawa, 2004, Bioorganic & medicinal chemistry letters.

Novel anthraquinone conjugate of 2,2-bis(hydroxymethyl)propionic acid incorporated to a TFO with phosphodiester linkage facilitates triplex formation with dsDNA bearing a pyrimidine-gapped polypurine sequence.

K. Shinozuka, T. Moriguchi, Megumi Sato, 2004, Bioorganic & medicinal chemistry letters.

Multi-functionalization of oligodeoxynucleotide: a facile post-synthetic modification technique for the preparation of oligodeoxynucleotides with two different functional molecules

H. Ozaki, H. Sawai, K. Shinozuka, 2000 .

Pseudo-Dumbbell-Type Molecular Beacon Probes Bearing Modified Deoxyuridine Derivatives and a Silylated Pyrene as a Fluorophore

K. Shinozuka, J. A. Chowdhury, T. Moriguchi, 2015 .

Termini-free Molecular Beacon Utilizing Silylated Perylene and Anthraquinone Attached to the C-5 Position of Pyrimidine Nucleobase

K. Shinozuka, T. Moriguchi, Yuzuru Sato, 2012 .

Synthesis and Properties of Molecular Beacon DNA Probe Bearing Novel Silylated Pyrene Derivative

M. G. Uddin, K. Shinozuka, T. Moriguchi, 2011 .

Temperature Dependent Duplex Formation of 3′-Phosphate Bearing α-2′-Deoxyoctathymidylate Phosphorothioate and Polyriboadenylic Acid Complex

H. Sawai, K. Shinozuka, T. Morita, 1992 .

Regio- and stereocontrolled synthesis of 2′-5′ linked phosphorothioate oligoadenylates by uranyl ion catalyst in aqueous solution

H. Sawai, K. Shinozuka, M. Shimazu, 2002 .

Novel dinucleoside phosphotriester unit conjugated with an intercalative moiety in a stereospecific manner enhances thermal stability of an alternate-stranded triple helix

K. Shinozuka, T. Moriguchi, N. Matsumoto, 2003 .

Novel Anthraquinone Conjugate (I) of 2,2‐Bis(hydroxymethyl)propionic Acid Incorporated to a TFO with Phosphodiester Linkage Facilitates Triplex Formation with dsDNA Bearing a Pyrimidine‐Gapped Polypurine Sequence.

K. Shinozuka, T. Moriguchi, Megumi Sato, 2004 .

Synthesis and Spectroscopic Properties of a Novel Bifunctional Pyrene Derivative and its Incorporation into OligoDNA

K. Shinozuka, F. Yoneda, T. Moriguchi, 2014 .

3-Alkylthio-s-triazolo[3,4-i]purines and 9-Alkylbis-s-triazolo[3,4-b:3',4'-i]purines

K. Shinozuka, D. J. Brown, D. J. Brown, 1982 .

Synthesis and anti-HIV-1 activity of novel 10-thiaisoalloxazines, a structural analog of C-5 and/or C-6 substituted pyrimidine acyclonucleoside.

K. Shinozuka, M. Baba, S. Shigeta, 2003, Chemical & pharmaceutical bulletin.

Systematic Evaluation of Hybridization Property and Photo-Crosslinking Ability of Modified Oligonucleotides Containing Benzophenone-Bearing Glycol Nucleoside Analogs

K. Shinozuka, T. Moriguchi, Dai Motegi, 2020 .

Major oxidative products of cytosine are substrates for the nucleotide incision repair pathway.

K. Shinozuka, L. Gros, A. Ishchenko, 2007, DNA repair.

Development of the excimer probe responsible for DNA target bearing the silylated pyrenes at base moiety.

K. Shinozuka, T. Moriguchi, Kenya Suzuki, 2014, Bioorganic & medicinal chemistry letters.

Triazolopteridines. I. Simple s-Triazolo[4,3-c]pteridines and their derived [1,5-c] isomers

K. Shinozuka, D. J. Brown, 1981 .

HMQC and proton and phosphorus-31 NMR studies of platinum amMine adducts of tetradeoxyribonucleotides. Relationship between phosphorus-31 shift and potential hydrogen-bonding interactions in pGpG moieties cross-linked by platinum

M. Summers, G. Zon, K. Shinozuka, 1988 .

One-step synthesis of 8-chloroflavins by the cyclization of 5-nitro-6-(N-substituted-anilino)uracils with the Vilsmeier reagent. Vilsmeier reagent as a reducing agent

K. Shinozuka, F. Yoneda, Y. Sakuma, 1978 .

Facile Synthesis of a Phosphotriester Intermediates for Solution-Phase Preparation of Oligonucleotide Phosphorothioates.

K. Shinozuka, K. Mori, T. Miyashita, 1999 .

Inhibitory effect of flavonoids on DNA-dependent DNA and RNA polymerases

K. Shinozuka, S. Tawata, Y. Kikuchi, 1988, Experientia.

Synthesis and nuclease susceptibility of alpha-oligodeoxyribonucleotide phosphorothioate.

H. Sawai, K. Shinozuka, T. Morita, 1991, Nucleic acids symposium series.

Cholesterol biosynthesis pathway intermediates and inhibitors regulate glucose-stimulated insulin secretion and secretory granule formation in pancreatic beta-cells.

K. Shinozuka, H. Yokota-Hashimoto, T. Takeuchi, 2010, Endocrinology.

SYNTHESIS AND ANTI-HIV PROPERTY OF NOVEL OLIGO-DNA PHOSPHOROTHIOATE ANALOGS BEARING AN INTERCALATIVE MOIETY AND/OR POLYAMINE RESIDUES

H. Sawai, K. Shinozuka, M. Matsukura, 1998 .

Synthesis and Properties of Novel Fluorescently Labeled Oligonucleotides Possessing Silylated Pyrene at the 5′-Terminus

K. Shinozuka, T. Moriguchi, Takahiko Kato, 2015 .

Modification of second-sphere communication, leading to an unusually high abundance of the head-to-head conformer of cisplatin cross-link retro models.

K. Shinozuka, L. Marzilli, G. Natile, 2002, Inorganic chemistry.

Investigation of a Facile Synthetic Method for Phosphorothioate Dimer Synthons In Oligonucleotide Phosphorothioates Synthesis

K. Shinozuka, K. Kondo, Kohei Yamada, 2000, Nucleosides, nucleotides & nucleic acids.

Modified OligoDNA Having Two Consecutive Silylated-pyrene Moieties in Minor Groove Exhibiting an Excimer Fluorescent Signal upon Binding to Fully Complementary DNA Strand

K. Shinozuka, M. Uddin, T. Moriguchi, 2010 .

Facile and stereoselective synthesis of 2'-5'-oligothioadenylate by UO2(2+) ion catalyst.

H. Sawai, K. Shinozuka, M. Shimazu, 1992, Nucleic acids symposium series.