J. Zigman

发表

A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin.

J. Holst, J. Olsen, T. Schwartz, 2012, Endocrinology.

Mice lacking ghrelin receptors resist the development of diet-induced obesity.

B. Lowell, R. Seeley, N. Balthasar, 2005, The Journal of clinical investigation.

Central Serotonin and Melanocortin Pathways Regulating Energy Homeostasis

M. Low, M. Rubinstein, L. Tecott, 2003, Annals of the New York Academy of Sciences.

Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner

M. Lutter, I. Sakata, J. Zigman, 2010, Biological Psychiatry.

Serotonin Reciprocally Regulates Melanocortin Neurons to Modulate Food Intake

Olivier Boss, Jeffrey M. Friedman, Joel K. Elmquist, 2006, Neuron.

5-HT2CRs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasis

Kevin W. Williams, Joel K. Elmquist, B. Lowell, 2008, Neuron.

Chronic social defeat stress disrupts regulation of lipid synthesis[S]

Michael Lutter, M. Lutter, A. Bookout, 2010, Journal of Lipid Research.

Central Nervous System Regulation of Energy Metabolism

M. Tschöp, J. Zigman, R. Nogueiras, 2008, Annals of the New York Academy of Sciences.

Disrupted hippocampal growth hormone secretagogue receptor 1α interaction with dopamine receptor D1 plays a role in Alzheimer′s disease

R. Swerdlow, J. Zigman, Heng Du, 2019, Science Translational Medicine.

Acyl-ghrelin Is Permissive for the Normal Counterregulatory Response to Insulin-Induced Hypoglycemia

J. Zigman, Kripa Shankar, S. Osborne-Lawrence, 2019, Diabetes.

Melanocortin regulation of histaminergic neurons via perifornical lateral hypothalamic melanocortin 4 receptors

J. Elmquist, J. Zigman, Charlotte E. Lee, 2020, Molecular metabolism.

Mechanisms of homeostatically regulated behaviors

C. Saper, J. Elmquist, J. Zigman, 2013 .

Disruption of cue-potentiated feeding in mice with blocked ghrelin signaling

J. Zigman, A. Walker, Imikomobong E. Ibia, 2012, Physiology & Behavior.

β1-adrenergic receptors mediate plasma acyl-ghrelin elevation and depressive-like behavior induced by chronic psychosocial stress

J. Zigman, Kripa Shankar, S. Osborne-Lawrence, 2019, Neuropsychopharmacology.

Expression of Serum Retinol Binding Protein and Transthyretin within Mouse Gastric Ghrelin Cells

I. Sakata, J. Zigman, A. Walker, 2013, PloS one.

In search of an effective obesity treatment: A shot in the dark or a shot in the arm?

J. Elmquist, J. Zigman, 2006, Proceedings of the National Academy of Sciences.

A solitary hyperfunctioning thyroid nodule harboring thyroid carcinoma: review of the literature

D. Mathews, J. Zigman, Stacey L Woodruff, 2013, Thyroid Research.

Colocalization of ghrelin O-acyltransferase and ghrelin in gastric mucosal cells.

J. Elmquist, I. Sakata, J. Zigman, 2009, American journal of physiology. Endocrinology and metabolism.

A Role for ΔFosB in Calorie Restriction-Induced Metabolic Changes

A. Rush, M. Lutter, E. Nestler, 2011, Biological Psychiatry.

“A LEAP 2 conclusions? Targeting the ghrelin system to treat obesity and diabetes”

J. Zigman, S. Varshney, Kripa Shankar, 2020, Molecular metabolism.

Ghrelin Receptor Agonist Rescues Excess Neonatal Mortality in a Prader-Willi Syndrome Mouse Model.

J. Zigman, Kripa Shankar, S. Osborne-Lawrence, 2018, Endocrinology.

Altered ghrelin secretion in mice in response to diet-induced obesity and Roux-en-Y gastric bypass

J. Zigman, Bharath K. Mani, J. F. Zechner, 2014, Molecular metabolism.

Monitoring FoxO1 Localization in Chemically Identified Neurons

B. Lowell, D. Olson, J. Elmquist, 2008, The Journal of Neuroscience.

Genetic deletion of the ghrelin receptor (GHSR) impairs growth and blunts endocrine response to fasting in Ghsr-IRES-Cre mice

R. Adan, J. Zigman, S. Dickson, 2021, Molecular metabolism.

Ghrelin's Relationship to Blood Glucose.

J. Zigman, Kripa Shankar, Bharath K. Mani, 2019, Endocrinology.

Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions

A. Bookout, J. Elmquist, J. Zigman, 2021, Molecular metabolism.

LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue

J. Zigman, S. Varshney, Kripa Shankar, 2021, Molecular metabolism.

Combined Loss of Ghrelin Receptor and Cannabinoid CB1 Receptor in Mice Decreases Survival but does not Additively Reduce Body Weight or Eating

J. Elmquist, J. Zigman, Charlotte E. Lee, 2020, Neuroscience.

Ghrelin Protects Against Insulin-Induced Hypoglycemia in a Mouse Model of Type 1 Diabetes Mellitus

J. Zigman, Kripa Shankar, S. Osborne-Lawrence, 2020, Frontiers in Endocrinology.

LEAP 2 changes with body mass and food intake in humans and mice

Jimmy D Bell, J. Zigman, M. Thorner, 2019 .

LEAP2 changes with body mass and food intake in humans and mice.

Jimmy D Bell, Elizabeth Louise Thomas, J. Zigman, 2019, The Journal of clinical investigation.

Ghrelin as a Survival Hormone

J. Zigman, Bharath K. Mani, 2017, Trends in Endocrinology & Metabolism.

β1-Adrenergic receptor deficiency in ghrelin-expressing cells causes hypoglycemia in susceptible individuals.

J. Zigman, S. Osborne-Lawrence, Bharath K. Mani, 2016, The Journal of clinical investigation.

Hindbrain Ghrelin Receptor Signaling Is Sufficient to Maintain Fasting Glucose

J. Elmquist, I. Sakata, J. Zigman, 2012, PloS one.

Ghrelin induces abdominal obesity via GHS-R-dependent lipid retention.

J. Zigman, I. Guschina, A. Mode, 2009, Molecular endocrinology.

Shift in Kiss1 Cell Activity Requires Estrogen Receptor α

J. Elmquist, J. Zigman, C. Elias, 2013, The Journal of Neuroscience.

GOAT induced ghrelin acylation regulates hedonic feeding

P. Pfluger, J. Zigman, H. Kirchner, 2012, Hormones and Behavior.

Ghrelin's Roles in Stress, Mood, and Anxiety Regulation

J. Zigman, J. Chuang, 2010, International journal of peptides.

Novel Regulator of Acylated Ghrelin, CF801, Reduces Weight Gain, Rebound Feeding after a Fast, and Adiposity in Mice

James L. Hougland, J. Zigman, A. Abizaid, 2015, Front. Endocrinol..

Ghrelin Indirectly Activates Hypophysiotropic CRF Neurons in Rodents

J. Zigman, M. Perelló, A. Cabral, 2012, PloS one.

Glucose-mediated control of ghrelin release from primary cultures of gastric mucosal cells.

I. Sakata, J. Zigman, S. Osborne-Lawrence, 2012, American journal of physiology. Endocrinology and metabolism.

The effect of glutamate on ghrelin release in mice

I. Sakata, J. Zigman, T. Sakai, 2017, Cell biology international.

Expression of cone transducin, Gz alpha, and other G-protein alpha-subunit messenger ribonucleic acids in pancreatic islets.

D. Steiner, J. Zigman, G. Westermark, 1994, Endocrinology.

Hypothalamic loss of Snord116 and Prader-Willi syndrome hyperphagia: the buck stops here?

J. Zigman, Juan A. Rodriguez, 2018, The Journal of clinical investigation.

PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis.

B. Lowell, J. Elmquist, Jean J. Zhao, 2010, Cell metabolism.

Estradiol modulates Kiss1 neuronal response to ghrelin.

J. Zigman, C. Elias, Charlotte E. Lee, 2014, American journal of physiology. Endocrinology and metabolism.

Pursuing the Mechanisms Underlying Alcohol-Induced Changes in the Ghrelin System: New Insights from Preclinical and Clinical Investigations

James L. Hougland, G. Koob, J. Zigman, 2020, bioRxiv.

Characterization of Gastric and Neuronal Histaminergic Populations Using a Transgenic Mouse Model

I. Sakata, J. Zigman, M. Perelló, 2013, PloS one.

Neuroanatomical and functional characterization of CRF neurons of the amygdala using a novel transgenic mouse model

I. Sakata, J. Zigman, M. Perelló, 2015, Neuroscience.

Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons.

J. Friedman, R. Coppari, J. Elmquist, 2011, The Journal of clinical investigation.

Characterization of Kiss1 neurons using transgenic mouse models

A. Bookout, J. Zigman, C. Elias, 2011, Neuroscience.

J. Elmquist, J. Zigman, Joel K Elmquist, 2022 .

An eGFP-expressing subpopulation of growth hormone secretagogue receptor cells are distinct from kisspeptin, tyrosine hydroxylase, and RFamide-related peptide neurons in mice

J. Zigman, Z. Andrews, Jeremy T. Smith, 2013, Peptides.

Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia.

B. Lowell, Zongfang Yang, G. Shulman, 2007, Cell metabolism.

Human G(olf) alpha: complementary deoxyribonucleic acid structure and expression in pancreatic islets and other tissues outside the olfactory neuroepithelium and central nervous system.

D. Steiner, J. Zigman, E. Boel, 1993, Endocrinology.

Leptin Directly Activates SF1 Neurons in the VMH, and This Action by Leptin Is Required for Normal Body-Weight Homeostasis

Robert A. McGovern, Joel K. Elmquist, B. Lowell, 2006, Neuron.

Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility.

B. Lowell, R. Coppari, J. Elmquist, 2010, Cell metabolism.

Estradiol-Dependent Decrease in the Orexigenic Potency of Ghrelin in Female Rats

S. Woods, J. Zigman, D. Clegg, 2007, Diabetes.

High co-expression of the ghrelin and LEAP2 receptor GHSR with pancreatic polypeptide in mouse and human islets.

J. Zigman, G. Yeo, Kripa Shankar, 2021, Endocrinology.

Expression of ghrelin receptor mRNA in the rat and the mouse brain

C. Saper, J. Elmquist, J. Zigman, 2006, The Journal of comparative neurology.

Ghrelin mediates exercise endurance and the feeding response post-exercise

J. Elmquist, J. Zigman, S. Osborne-Lawrence, 2018, Molecular metabolism.

Ghrelin mediates stress-induced food-reward behavior in mice.

M. Lutter, I. Sakata, J. Zigman, 2011, The Journal of clinical investigation.

High-fat Feeding Promotes Obesity via Insulin Receptor/PI3k-Dependent Inhibition of SF-1 VMH Neurons

B. Lowell, T. Horvath, A. Husch, 2011, Nature Neuroscience.

The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress

M. Lutter, E. Nestler, J. Elmquist, 2008, Nature Neuroscience.

Impact of thyroxine-binding globulin on thyroid hormone economy during pregnancy.

J. Garber, J. Zigman, S. Cohen, 2003, Thyroid : official journal of the American Thyroid Association.

Ghrelin Promotes and Protects Nigrostriatal Dopamine Function via a UCP2-Dependent Mitochondrial Mechanism

R. Roth, T. Horvath, J. Zigman, 2009, The Journal of Neuroscience.

Role of calcium and EPAC in norepinephrine-induced ghrelin secretion.

J. Repa, I. Sakata, J. Zigman, 2014, Endocrinology.

Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin★

J. Elmquist, J. Zigman, S. Osborne-Lawrence, 2013, Molecular metabolism.

Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.

T. Schwartz, M. S. Engelstoft, M. K. Nøhr, 2013, Molecular metabolism.

Electrophysiological Properties of Genetically Identified Histaminergic Neurons

J. Elmquist, J. Zigman, K. Williams, 2020, Neuroscience.

Characterization of a novel ghrelin cell reporter mouse

B. Lowell, Guanghua Xiao, R. Coppari, 2009, Regulatory Peptides.

Growth hormone secretagogue receptor signaling in the supramammillary nucleus targets nitric oxide-producing neurons and controls recognition memory in mice

J. Zigman, J. Fehrentz, M. Perelló, 2022, Psychoneuroendocrinology.

Ghrelin

M. Andermann, H. Grill, A. Dagher, 2015, Molecular metabolism.

Circulating Ghrelin Acts on GABA Neurons of the Area Postrema and Mediates Gastric Emptying in Male Mice

J. Zigman, E. Portiansky, M. Perelló, 2017, Endocrinology.

Ghrelin activates hypophysiotropic corticotropin-releasing factor neurons independently of the arcuate nucleus

J. Zigman, E. Portiansky, M. Perelló, 2016, Psychoneuroendocrinology.

Neuroanatomical characterization of a growth hormone secretagogue receptor‐green fluorescent protein reporter mouse

J. Zigman, Charlotte E. Lee, Z. Andrews, 2014, The Journal of comparative neurology.

The central nervous system sites mediating the orexigenic actions of ghrelin.

J. Zigman, B. Mason, Qian Wang, 2014, Annual review of physiology.

The Role of Ghrelin in Reward-Based Eating

J. Zigman, M. Perelló, 2012, Biological Psychiatry.

Brain imaging demonstrates a reduced neural impact of eating in obesity

Binu P. Thomas, M. Lutter, Hanzhang Lu, 2016, Obesity.

Ghrelin cell–expressed insulin receptors mediate meal- and obesity-induced declines in plasma ghrelin

J. Zigman, S. Varshney, Kripa Shankar, 2021, JCI insight.

Obesity Impairs the Action of the Neuroendocrine Ghrelin System

S. Bouret, J. Zigman, Z. Andrews, 2016, Trends in Endocrinology & Metabolism.

Proton- and ammonium-sensing by histaminergic neurons controlling wakefulness

H. Haas, I. Sakata, J. Zigman, 2012, Front. Syst. Neurosci..

Genetic tracing of Nav1.8‐expressing vagal afferents in the mouse

J. Elmquist, I. Sakata, J. Zigman, 2011, The Journal of comparative neurology.

Toward a consensus nomenclature for ghrelin, its non‐acylated form, liver expressed antimicrobial peptide 2 and growth hormone secretagogue receptor

J. Zigman, L. Leggio, M. Perelló, 2022, Journal of neuroendocrinology.

Lowering oxidative stress in ghrelin cells stimulates ghrelin secretion.

J. Zigman, S. Osborne-Lawrence, Bharath K. Mani, 2020, American journal of physiology. Endocrinology and metabolism.

Ghrelin and eating behavior: evidence and insights from genetically-modified mouse models

J. Zigman, M. Perelló, A. Uchida, 2013, Front. Neurosci..

Ghrelin secretion stimulated by β1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice

I. Sakata, J. Zigman, J. Richardson, 2010, Proceedings of the National Academy of Sciences.

Metabolic insights from a GHSR-A203E mutant mouse model

B. Holst, J. Zigman, M. Perelló, 2020, Molecular metabolism.

Ghrelin directly stimulates glucagon secretion from pancreatic alpha-cells.

J. Repa, I. Sakata, J. Zigman, 2011, Molecular endocrinology.

A β3-Adrenergic-Leptin-Melanocortin Circuit Regulates Behavioral and Metabolic Changes Induced by Chronic Stress

M. Lutter, E. Nestler, J. Elmquist, 2010, Biological Psychiatry.

Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism

J. Zigman, Z. Andrews, R. Stark, 2023, bioRxiv.

G protein-coupled receptor 120 signaling regulates ghrelin secretion in vivo and in vitro.

I. Sakata, J. Zigman, T. Sakai, 2014, American journal of physiology. Endocrinology and metabolism.

Ghrelin receptor signaling targets segregated clusters of neurons within the nucleus of the solitary tract

J. Zigman, E. Portiansky, M. Perelló, 2018, Brain Structure and Function.

A closer look at alcohol‐induced changes in the ghrelin system: novel insights from preclinical and clinical data

James L. Hougland, G. Koob, J. Zigman, 2021, Addiction biology.

Effects of thermoneutrality on food intake, body weight, and body composition in a Prader‐Willi syndrome mouse model

J. Zigman, S. Varshney, Kripa Shankar, 2023, Obesity.

Research Resource: A Chromogranin A Reporter for Serotonin and Histamine Secreting Enteroendocrine Cells.

T. Schwartz, M. S. Engelstoft, K. V. Grunddal, 2015, Molecular endocrinology.

Distribution and neurochemical characterization of protein kinase C-theta and -delta in the rodent hypothalamus

A. Zinn, T. Sacktor, B. Lowell, 2010, Neuroscience.

Functional implications of limited leptin receptor and ghrelin receptor coexpression in the brain

J. Elmquist, I. Sakata, J. Zigman, 2012, The Journal of comparative neurology.

The role of ghrelin-responsive mediobasal hypothalamic neurons in mediating feeding responses to fasting

J. Zigman, Z. Andrews, S. Osborne-Lawrence, 2017, Molecular metabolism.

Erratum: Expression of ghrelin receptor mRNA in the rat and the mouse brain (Journal of Comparative Neurology 494 (528-548))

C. Saper, J. Elmquist, J. Zigman, 2006 .

5-HT2CRs Expressed by Pro-opiomelanocortin Neurons Regulate Insulin Sensitivity in Liver

Philipp E. Scherer, Kevin W. Williams, Joel K. Elmquist, 2010, Nature Neuroscience.

Ghrelin signalling in AgRP neurons links metabolic state to the sensory regulation of AgRP neural activity

J. Zigman, Z. Andrews, S. Lockie, 2023, bioRxiv.

Liver-expressed antimicrobial peptide 2 elevation contributes to age-associated cognitive decline

J. Zigman, Heng Du, Jing Tian, 2023, JCI insight.

Hypoglycemic Effect of Combined Ghrelin and Glucagon Receptor Blockade

J. Zigman, M. J. Charron, R. Unger, 2017, Diabetes.

Ghrelin does not impact the blunted counterregulatory response to recurrent hypoglycemia in mice

J. Zigman, S. Varshney, Kripa Shankar, 2023, Frontiers in Endocrinology.

Differential effects of chronic social stress and fluoxetine on meal patterns in mice

Andrea G. Gillman, M. Lutter, C. McClung, 2013, Appetite.

Molecular determinants of energy homeostasis.

M. Lutter, J. Elmquist, J. Zigman, 2006, The American journal of psychiatry.

Ghrelin receptor signaling targets segregated clusters of neurons within the nucleus of the solitary tract

J. Zigman, E. Portiansky, M. Perelló, 2018, Brain Structure and Function.

A Strong Stomach for Somatostatin.

J. Zigman, Bharath K. Mani, 2015, Endocrinology.

Ghrelin’s orexigenic action in the lateral hypothalamic area involves indirect recruitment of orexin neurons and arcuate nucleus activation

S. Cantel, H. Schiöth, J. Zigman, 2023, Psychoneuroendocrinology.

Associations of postprandial ghrelin, liver-expressed antimicrobial peptide 2 and leptin levels with body composition, disease progression and survival in patients with amyotrophic lateral sclerosis.

J. Zigman, P. Mccombe, S. Ngo, 2023, European journal of neurology.

Differential effects of chronic social stress and fluoxetine on meal patterns in mice

Andrea G. Gillman, M. Lutter, C. McClung, 2013, Appetite.

Characterization of a novel ghrelin cell reporter mouse

B. Lowell, Guanghua Xiao, R. Coppari, 2009, Regulatory Peptides.

β1-Adrenergic receptor deficiency in ghrelin-expressing cells causes hypoglycemia in susceptible individuals.

J. Zigman, S. Osborne-Lawrence, Bharath K. Mani, 2016, The Journal of clinical investigation.

Functional implications of limited leptin receptor and ghrelin receptor coexpression in the brain

J. Elmquist, I. Sakata, J. Zigman, 2012, The Journal of comparative neurology.

Ghrelin mediates stress-induced food-reward behavior in mice.

M. Lutter, I. Sakata, J. Zigman, 2011, The Journal of clinical investigation.

Mice lacking ghrelin receptors resist the development of diet-induced obesity.

B. Lowell, R. Seeley, N. Balthasar, 2005, The Journal of clinical investigation.

Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin★

J. Elmquist, J. Zigman, S. Osborne-Lawrence, 2013, Molecular metabolism.

A β3-Adrenergic-Leptin-Melanocortin Circuit Regulates Behavioral and Metabolic Changes Induced by Chronic Stress

M. Lutter, E. Nestler, J. Elmquist, 2010, Biological Psychiatry.

The intersection between ghrelin, metabolism and circadian rhythms

J. Zigman, Soumya S Kulkarni, Omprakash Singh, 2023, Nature reviews. Endocrinology.

Ghrelin enhances tubular magnesium absorption in the kidney

J. Zigman, C. Hiremath, Jing Zhang, 2024, Frontiers in physiology.

A long-acting LEAP2 analog reduces hepatic steatosis and inflammation and causes marked weight loss in mice

J. Zigman, S. Varshney, Kripa Shankar, 2024, Molecular metabolism.

The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis

J. Zigman, S. Estill, S. Osborne-Lawrence, 2014, Molecular Psychiatry.