A. Leslie

发表

Immune Selection for Altered Antigen Processing Leads to Cytotoxic T Lymphocyte Escape in Chronic HIV-1 Infection

M. Altfeld, B. Walker, E. Holmes, 2004, The Journal of experimental medicine.

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

Fabian J Theis, D. Pe’er, A. Regev, 2020, Cell.

Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection

J. C. Love, B. Walker, T. Ndung’u, 2020, Nature Medicine.

Fitness Cost of Escape Mutations in p24 Gag in Association with Control of Human Immunodeficiency Virus Type 1

B. Walker, J. Mullins, D. Stuart, 2006, Journal of Virology.

CD8+ T-cell responses to different HIV proteins have discordant associations with viral load

David Heckerman, John Frater, Christian Brander, 2007, Nature Medicine.

Single-cell profiling of tuberculosis lung granulomas reveals functional lymphocyte signatures of bacterial control

H. J. Borish, J. C. Love, Bryan D. Bryson, 2020, bioRxiv.

Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype

B. Walker, J. Mullins, C. Brander, 2006, The Journal of Immunology.

Differential Pathogen-Specific Immune Reconstitution in Antiretroviral Therapy-Treated Human Immunodeficiency Virus-Infected Children

T. Ndung’u, A. Leslie, O. Keppler, 2019, The Journal of infectious diseases.

HIV Control through a Single Nucleotide on the HLA-B Locus

B. Walker, M. Carrington, B. Walker, 2012, Journal of Virology.

Major TCR Repertoire Perturbation by Immunodominant HLA-B*44:03-Restricted CMV-Specific T Cells

T. Ndung’u, S. Buus, P. Goulder, 2018, Front. Immunol..

Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α

A. Leslie, R. Wilkinson, S. Jogai, 2020, eLife.

Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control

H. J. Borish, J. C. Love, Bryan D. Bryson, 2022, Immunity.

The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release.

D. Jewell, A. Leslie, O. Harrison, 2013, Immunity.

HLA-B*58:01for HLA-B*57 That Is Distinct from Processing Shapes an Immunodominance

B. Walker, M. Harndahl, P. Goulder, 2014 .

HLA-A*68: 02-restricted Gag-specific cytotoxic T lymphocyte responses can drive selection pressure on HIV but are subdominant and ineffective

B. Walker, T. Ndung’u, S. Buus, 2013, AIDS.

Additive Contribution of HLA Class I Alleles in the Immune Control of HIV-1 Infection

D. Heckerman, B. Walker, J. Listgarten, 2010, Journal of Virology.

Pattern recognition receptor mediated downregulation of microRNA‐650 fine‐tunes MxA expression in dendritic cells infected with influenza A virus

J. Ragoussis, A. Leslie, A. Simmons, 2015, European journal of immunology.

Effect of Dysglycemia on Urinary Lipid Mediator Profiles in Persons With Pulmonary Tuberculosis

T. Sterling, A. Leslie, G. Milne, 2022, Frontiers in Immunology.

Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis

A. Leslie, A. Steyn, V. Saini, 2018, Cell reports.

Biological differences between the sexes and susceptibility to tuberculosis.

A. Leslie, Shepherd Nhamoyebonde, 2014, The Journal of infectious diseases.

TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis.

T. Ndung’u, M. Nielsen, W. Bishai, 2019 .

HIV infection alters SARS-CoV-2 responsive immune parameters but not clinical outcomes in COVID-19 disease

T. Ndung’u, A. Sigal, A. Leslie, 2020 .

HIV control through a single nucleotide on the HLA-I locus

B. Walker, T. Ndung’u, S. Buus, 2012, Retrovirology.

Disequilibrium with HLA-B*5703 Viremia Is Independent of Its Linkage Mediated Control of HIV - HLA-A*7401

Ndung, D. Heckerman, M. Carrington, 2011 .

Impact of HLA in Mother and Child on Disease Progression of Pediatric Human Immunodeficiency Virus Type 1 Infection

B. Walker, T. Ndung’u, J. Prado, 2009, Journal of Virology.

Impact of HLA in Mother and Child on Disease Progression of Pediatric Human Immunodeﬁciency Virus Type 1 Infection (cid:1)

B. Walker, T. Ndung’u, J. Prado, 2009 .

Compensatory Mutation Partially Restores Fitness and Delays Reversion of Escape Mutation within the Immunodominant HLA-B*5703-Restricted Gag Epitope in Chronic Human Immunodeficiency Virus Type 1 Infection

B. Walker, J. Mullins, J. Prado, 2008, Journal of Virology.

HLA Footprints on Human Immunodeficiency Virus Type 1 Are Associated with Interclade Polymorphisms and Intraclade Phylogenetic Clustering

David Heckerman, Anthony D. Kelleher, Philip J. R. Goulder, 2009, Journal of Virology.

Oral abstracts of the 21st International AIDS Conference 18–22 July 2016, Durban, South Africa

Michael I. Jordan, Donald A. Jackson, J. G. Ndirangu, 2016, Journal of the International AIDS Society.

Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data

Hugo A. Wefer, Melis N. Anahtar, R. J. Hayes, 2020, BMC Medicine.

Tissue‐resident innate immunity in the lung

A. Leslie, M. Marakalala, Amanda Ardain, 2019, Immunology.

RNA and Imidazoquinolines Are Sensed by Distinct TLR7/8 Ectodomain Sites Resulting in Functionally Disparate Signaling Events

B. Beutler, A. Leslie, A. Rautanen, 2014, The Journal of Immunology.

In Functionally Disparate Signaling Events Distinct Tlr7/8 Ectodomain Sites Resulting Rna and Imidazoquinolines Are Sensed By

B. Beutler, A. Leslie, A. Rautanen, 2022 .

HIV skews the SARS-CoV-2 B cell response towards an extrafollicular maturation pathway

T. Ndung’u, A. Sigal, A. Leslie, 2022, bioRxiv.

Young and Early Career Investigators: Report from a Global HIV Vaccine Enterprise Working Group

J. Fuchs, T. Ndung’u, J. Fellay, 2010 .

HIV specific CD8+ TRM-like cells in tonsils express exhaustive signatures in the absence of natural HIV control

T. Ndung’u, S. Kazer, A. Shalek, 2022, Frontiers in Immunology.

Snapin promotes HIV‐1 transmission from dendritic cells by dampening TLR8 signaling

S. Rowland-Jones, A. Leslie, V. Cerundolo, 2017, The EMBO journal.

T. Ndung’u, A. Sigal, A. Leslie, 2021, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

The paradox of immune checkpoint inhibition re-activating tuberculosis

A. Leslie, P. Elkington, L. Tezera, 2022, European Respiratory Journal.

Immunogenicity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and Ad26.CoV2.S Vaccination in People Living With Human Immunodeficiency Virus (HIV)

T. Ndung’u, A. Sigal, P. Goulder, 2021, Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America.

SARS-CoV-2 Receptor ACE2 is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Enriched in Specific Cell Subsets Across Tissues

Fabian J Theis, Alison Yu, Alex K. Shalek, 2020, SSRN Electronic Journal.

Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties

J. Flint, P. Klenerman, D. Adams, 2010, Proceedings of the National Academy of Sciences.

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

Philip J. R. Goulder, Gordon J. Freeman, Quentin Eichbaum, 2006, Nature.

Plasma concentration of injectable contraceptive correlates with reduced cervicovaginal growth factor expression in South African women

L. McKinnon, A. Leslie, N. Garrett, 2020, Mucosal Immunology.

Human Innate Lymphoid Cell Subsets Possess Tissue‐Type Based Heterogeneity in Phenotype and Frequency

N. McGovern, F. Ginhoux, P. Klenerman, 2017, Immunity.

Unbiased Profiling Reveals Compartmentalization of Unconventional T-Cells Within the Intestinal Mucosa Irrespective of HIV Infection

T. Ndung’u, M. Fehlings, A. Leslie, 2020, Frontiers in Immunology.

Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency.

Yannick Simoni, Florent Ginhoux, N. McGovern, 2018, Immunity.

Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis

T. Ndung’u, S. Kazer, A. Shalek, 2019, Nature.

Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression.

B. Walker, T. Ndung’u, S. Kazer, 2016, Immunity.

Multimodal profiling of lung granulomas reveals cellular correlates of tuberculosis control

Winchell, H. J. Borish, J. C. Love, 2021 .

Association between injectable progestin-only contraceptives and HIV acquisition and HIV target cell frequency in the female genital tract in South African women: a prospective cohort study.

Melis N. Anahtar, B. Walker, T. Ndung’u, 2016, The Lancet. Infectious diseases.

T. Ndung’u, A. Sigal, P. Goulder, 2021, Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America.

Adaptation of HIV-1 to human leukocyte antigen class I

David Heckerman, John Frater, Rodney Phillips, 2009, Nature.

Irreversible depletion of intestinal CD4+ T cells is associated with T cell activation during chronic HIV infection

T. Ndung’u, A. Leslie, J. Z. Porterfield, 2021, JCI insight.

Role of HLA Adaptation in HIV Evolution

P. Goulder, A. Leslie, H. Kløverpris, 2016, Front. Immunol..

CD8+ TCR Bias and Immunodominance in HIV-1 Infection

B. Walker, T. Ndung’u, S. Buus, 2015, The Journal of Immunology.

HLA-A*7401–Mediated Control of HIV Viremia Is Independent of Its Linkage Disequilibrium with HLA-B*5703

D. Heckerman, M. Carrington, J. Listgarten, 2011, The Journal of Immunology.

The Hypervariable HIV-1 Capsid Protein Residues Comprise HLA-Driven CD8+ T-Cell Escape Mutations and Covarying HLA-Independent Polymorphisms

David Heckerman, Philip J. R. Goulder, Jonathan M. Carlson, 2010, Journal of Virology.

HLA-Cw*03-Restricted CD8+ T-Cell Responses Targeting the HIV-1 Gag Major Homology Region Drive Virus Immune Escape and Fitness Constraints Compensated for by Intracodon Variation

B. Walker, T. Ndung’u, J. Prado, 2010, Journal of Virology.

Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703–positive individuals and their transmission recipients

B. Walker, T. Ndung’u, J. Prado, 2009, The Journal of experimental medicine.

HLA FOOTPRINTS ON HIV-1 ARE ASSOCIATED WITH 1

Todd M. Allen, D. Heckerman, B. Walker, 2009 .

Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point

D. Heckerman, B. Walker, C. Kadie, 2008, Journal of Virology.

Philip J. R. Goulder, Christian Brander, Eric Hunter, 2007, Journal of Virology.

Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression

B. Walker, H. Günthard, C. Brander, 2007, Journal of Virology.

Control of Human Immunodeficiency Virus Type 1 Is Associated with HLA-B*13 and Targeting of Multiple Gag-Specific CD8+ T-Cell Epitopes

F. Pereyra, B. Walker, J. Mullins, 2007, Journal of Virology.

Differential Selection Pressure Exerted on HIV by CTL Targeting Identical Epitopes but Restricted by Distinct HLA Alleles from the Same HLA Supertype1

B. Walker, J. Mullins, C. Brander, 2006, The Journal of Immunology.

the Same HLA Supertype but Restricted by Distinct HLA Alleles from HIV by CTL Targeting Identical Epitopes Differential Selection Pressure Exerted on

Gareth, B. Walker, J. Mullins, 2006 .

Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA

Andrew K. Sewell, Karina Yusim, Bette Korber, 2005, The Journal of experimental medicine.

Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA

Bette Korber, Michael Bunce, Philip J. R. Goulder, 2004, Nature.

HIV evolution: CTL escape mutation and reversion after transmission

Todd M. Allen, T A Roach, M. Altfeld, 2004, Nature Medicine.

HIV escape and attenuation by cytotoxic T lymphocytes

P. Goulder, A. Leslie, 2006, Current opinion in HIV and AIDS.

Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma

T. Ndung’u, A. Sigal, B. Sewell, 2021, Nature.

Immune Escape Precedes Breakthrough Human Immunodeficiency Virus Type 1 Viremia and Broadening of the Cytotoxic T-Lymphocyte Response in an HLA-B27-Positive Long-Term-Nonprogressing Child

B. Walker, M. Feeney, P. Goulder, 2004, Journal of Virology.

Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point.

K. Shekhar, B. Walker, A. Chakraborty, 2015, Immunity.

Differential skewing of donor-unrestricted and γδ T cell repertoires in tuberculosis-infected human lungs

A. Leslie, A. Steyn, S. Behar, 2019, The Journal of clinical investigation.

Differential skewing of donor-unrestricted and gammadelta T cell repertoires in tuberculosis-infected human lungs

A. Leslie, A. Steyn, S. Behar, 2019 .

Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

T. Ndung’u, A. Sigal, M. Davenport, 2021, Nature.

Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection

B. Walker, T. Ndung’u, P. Goulder, 2016, Science Translational Medicine.

Malnutrition in HIV-Infected Children Is an Indicator of Severe Disease with an Impaired Response to Antiretroviral Therapy

T. Ndung’u, P. Goulder, A. Leslie, 2017, AIDS research and human retroviruses.

Increased Regulatory T-Cell Activity and Enhanced T-Cell Homeostatic Signaling in Slow Progressing HIV-infected Children

T. Ndung’u, P. Goulder, A. Leslie, 2019, Front. Immunol..

Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life

T. Ndung’u, P. Goulder, A. Sewell, 2020, Frontiers in Immunology.

Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy

T. Ndung’u, S. Kazer, A. Shalek, 2020, Cell reports.

Proliferative Capacity of Epitope-Specific CD8 T-Cell Responses Is Inversely Related to Viral Load in Chronic Human Immunodeficiency Virus Type 1 Infection

B. Walker, P. Klenerman, P. Goulder, 2006, Journal of Virology.

T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection

G. Schoolnik, F. Miedema, D. Tabb, 2023, Nature Medicine.

Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung

A. Sette, M. Fehlings, A. Leslie, 2021, The Journal of clinical investigation.

Lung Tissue Resident Memory T-Cells in the Immune Response to Mycobacterium tuberculosis

A. Leslie, J. Z. Porterfield, P. Ogongo, 2019, Front. Immunol..

Increased Neutrophil Count and Decreased Neutrophil CD15 Expression Correlate With TB Disease Severity and Treatment Response Irrespective of HIV Co-infection

T. Sterling, A. Leslie, A. Pym, 2020, Frontiers in Immunology.

Structure and Interactions of the Human Programmed Cell Death 1 Receptor*

John E. Ladbury, Mark D. Carr, Vaclav Veverka, 2013, The Journal of Biological Chemistry.

Human and Murine Clonal CD8+ T Cell Expansions Arise during Tuberculosis Because of TCR Selection

A. Leslie, A. Rothchild, S. Behar, 2015, PLoS pathogens.

HLA-Specific Intracellular Epitope Processing Shapes an Immunodominance Pattern for HLA-B*57 That Is Distinct from HLA-B*58:01

Greg J. Towers, Søren Buus, Mikkel Harndahl, 2013, Journal of Virology.

Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load

P. Klenerman, S. Buus, P. Goulder, 2014, AIDS.

Plasma IL-5 but Not CXCL13 Correlates With Neutralization Breadth in HIV-Infected Children

T. Ndung’u, P. Goulder, L. Morris, 2019, Front. Immunol..

Genital and systemic immune effects of the injectable, contraceptive norethisterone enanthate (NET‐EN), in South African women

L. McKinnon, S. Karim, A. Leslie, 2021, American journal of reproductive immunology.

Distinct Immunoglobulin Fc Glycosylation Patterns Are Associated with Disease Nonprogression and Broadly Neutralizing Antibody Responses in Children with HIV Infection

T. Ndung’u, P. Goulder, G. Alter, 2020, mSphere.

HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cells

A. Shalek, T. Pers, A. Leslie, 2021, JCI insight.

HIV status alters disease severity and immune cell responses in Beta variant SARS-CoV-2 infection wave

T. Ndung’u, A. Sigal, A. Leslie, 2021, eLife.

Omicron infection enhances Delta antibody immunity in vaccinated persons

R. Milo, T. Ndung’u, A. Sigal, 2022, Nature.

Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets.

Mark G. Jones, J. D’Armiento, N. Kaminski, 2021, The Journal of clinical investigation.

Type 3 ILCs in Lung Disease

A. Leslie, J. Z. Porterfield, H. Kløverpris, 2019, Front. Immunol..

Understanding the tuberculosis granuloma: the matrix revolutions

A. Leslie, P. Elkington, M. Polak, 2021, Trends in Molecular Medicine.

Vaginal microbiome-hormonal contraceptive interactions associate with the mucosal proteome and HIV acquisition

R. Heffron, L. McKinnon, A. Leslie, 2020, PLoS pathogens.

Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection

J. C. Love, B. Walker, T. Ndung’u, 2020, Nature Network Boston.

Mycobacterium tuberculosis senses host Interferon-γ via the membrane protein MmpL10

J. Essex, A. Leslie, A. Steyn, 2021, bioRxiv.

Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis

T. Sterling, A. Leslie, A. Pym, 2021, medRxiv.

TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis

T. Ndung’u, M. Nielsen, W. Bishai, 2019, Communications Biology.

2019-0605 TRAV 1-2 ( + ) CD 8 ( + ) T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis

M. Nielsen, W. Bishai, U. Lalloo, 2019 .

High-Frequency, Functional HIV-Specific T-Follicular Helper and Regulatory Cells Are Present Within Germinal Centers in Children but Not Adults

T. Ndung’u, S. Kazer, A. Shalek, 2018, Front. Immunol..

Failure to decrease HbA1c levels following TB treatment is associated with elevated Th1/Th17 CD4+ responses

T. Sterling, A. Leslie, P. Rebeiro, 2023, Frontiers in Immunology.

Infection pre-Ad26.COV2.S-vaccination primes greater class switching and reduced CXCR5 expression by SARS-CoV-2-specific memory B cells

A. Sigal, A. Leslie, S. Richardson, 2023, NPJ vaccines.

TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis

T. Ndung’u, M. Nielsen, W. Bishai, 2019, Communications Biology.

TRAV1-2(+) CD8(+) T-cells including oligoconal expansions of TRAV1-2(+) CD8(+) T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis MAIT cells are enriched in the airways in human tuberculosis

W. Bishai, U. Lalloo, A. Leslie, 2021 .

Human and Murine Clonal CD8+ T Cell Expansions Arise during Tuberculosis Because of TCR Selection

A. Leslie, A. Rothchild, S. Behar, 2015, PLoS pathogens.

Innate Lymphoid Cells Are Depleted in HIV Infection

B. Walker, T. Ndung’u, P. Goulder, 2014 .

HIV control through a single nucleotide on the HLA-I locus

T. Ndung’u, S. Buus, M. Harndahl, 2012, Journal of Virology.

Association Between Human Immunodeficiency Virus Viremia and Compromised Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Beta Variant

T. Ndung’u, A. Sigal, P. Goulder, 2022, The Journal of Infectious Diseases.

HIV-specific CD8+ T-cells in tonsils express exhaustive TRM-like signatures

T. Ndung’u, S. Kazer, A. Shalek, 2021, bioRxiv.

HIV status alters disease severity and immune cell responses in β variant SARS-CoV-2 infection wave

T. Ndung’u, A. Sigal, A. Leslie, 2021 .