B. Schaffhausen

B. Schaffhausen, G. Fimia, R. Maione, 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Attenuation of SARS coronavirus by a short hairpin RNA expression plasmid targeting RNA-dependent RNA polymerase☆

B. Schaffhausen, Li Shen, Hongxia Wang, 2004, Virology.

Genetic analysis of polyomavirus large T nuclear localization: nuclear localization is required for productive association with pRb family members

B. Schaffhausen, B. Bockus, S. Howes, 1996, Journal of virology.

Tumor antigen(s) in cell productively infected by wild-type polyoma virus and mutant NG-18.

B. Schaffhausen, T. Benjamin, J. Silver, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Comparisons between Murine Polyomavirus and Simian Virus 40 Show Signiﬁcant Differences in Small T Antigen Function (cid:1)

T. Roberts, B. Schaffhausen, Shaida Andrabi, 2011 .

A completely transformation-defective point mutant of polyomavirus middle T antigen which retains full associated phosphatidylinositol kinase activity

T. Roberts, B. Schaffhausen, B. Druker, 1990, Journal of virology.

A Transformation-Defective Polyomavirus Middle T Antigen with a Novel Defect in PI3 Kinase Signaling

B. Schaffhausen, C. Rouleau, D. Denis, 2016, Journal of Virology.

Protein domains connect cell cycle stimulation directly to initiation of DNA replication.

B. Schaffhausen, P. Rose, B. Bockus, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Phosphorylation of polyomavirus large T antigen: effects of viral mutations and cell growth state

B. Schaffhausen, B. Bockus, 1987, Journal of virology.

Localization of the phosphorylations of polyomavirus large T antigen

B. Schaffhausen, B. Bockus, 1987, Journal of virology.

Construction and functional characterization of polyomavirus genomes that separately encode the three early proteins

B. Schaffhausen, R. Kamen, A. Cowie, 1984, Journal of virology.

Signaling from Polyomavirus Middle T and Small T Defines Different Roles for Protein Phosphatase 2A

X. Cullere, B. Schaffhausen, K. P. Mullane, 1998, Molecular and Cellular Biology.

J Domain-Independent Regulation of the Rb Family by Polyomavirus Large T Antigen

B. Schaffhausen, Tara Love, Tara M Love, 2000, Journal of Virology.

Characterization of pp85, a target of oncogenes and growth factor receptors

T. Roberts, B. Schaffhausen, B. Druker, 1990, Molecular and cellular biology.

Mechanisms of transformation by polyoma virus middle T antigen.

T. Roberts, B. Schaffhausen, D. Pallas, 1989, Biochimica et biophysica acta.

The hunt for Ras targets

B. Schaffhausen, L. Feig, 1994, Nature.

Serine 257 Phosphorylation Regulates Association of Polyomavirus Middle T Antigen with 14-3-3 Proteins

X. Cullere, T. Roberts, B. Schaffhausen, 1998, Journal of Virology.

Polyoma virus middle T antigen: relationship to cell membranes and apparent lack of ATP-binding activity

B. Schaffhausen, T. Benjamin, G. Arakere, 1982, Molecular and cellular biology.

Regulation of protein kinase C ζ by PI 3-kinase and PDK-1

A. Newton, A. Toker, Ching-shih Chen, 1998, Current Biology.

Transformation by polyoma virus is drastically reduced by substitution of phenylalanine for tyrosine at residue 315 of middle-sized tumor antigen.

G. Carmichael, B. Schaffhausen, T. Benjamin, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Antibody to the nonapeptide Glu-Glu-Glu-Glu-Tyr-Met-Pro-Met-Glu is specific for polyoma middle T antigen and inhibits in vitro kinase activity.

J. Casnellie, B. Schaffhausen, T. Benjamin, 1982, The Journal of biological chemistry.

Carboxy terminus of polyoma middle-sized tumor antigen is required for attachment to membranes, associated protein kinase activities, and cell transformation.

G. Carmichael, B. Schaffhausen, D. Dorsky, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Transformation-defective polyoma middle T antigen mutants defective in PLCgamma, PI-3, or src kinase activation enhance ERK2 activation and promote retinoic acid-induced, cell differentiation like wild-type middle T.

K. Marks, A. Yen, B. Schaffhausen, 1999, Experimental cell research.

Immunization against the polyoma tumor‐specific transplantation antigen (TSTA) with polyoma T‐antigens

T. Roberts, B. Schaffhausen, T. Roberts, 1988, International journal of cancer.

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

L. Cantley, T. Roberts, B. Schaffhausen, 1985, Nature.

Cellular proteins that associate with the middle and small T antigens of polyomavirus

T. Roberts, B. Schaffhausen, D. Pallas, 1988, Journal of virology.

Oncogenes and Phosphatidylinositol Turnover a

L. Cantley, T. Roberts, B. Schaffhausen, 1986 .

Characterization of middle T antigen expressed by using an adenovirus expression system

T. Roberts, B. Schaffhausen, K. Berkner, 1987, Journal of virology.

Polyomavirus large T can support DNA replication in human cells.

E. Androphy, B. Schaffhausen, F. Sverdrup, 1998, Virology.

Zinc-binding and protein-protein interactions mediated by the polyomavirus large T antigen zinc finger

B. Schaffhausen, P. Rose, 1995, Journal of virology.

Signal transduction. The hunt for Ras targets.

B. Schaffhausen, L. Feig, 1994, Nature.

Free energies of acetyl transfer from ring-substituted acetanilides

W. Jencks, B. Schaffhausen, K. Tornheim, 1971 .

Conformational changes associated with f-1 histone-deoxyribonucleic acid complexes. Circular dichroism studies.

G. Fasman, B. Schaffhausen, A. Adler, 1970, Biochemistry.

Polyoma T (tumor) antigen species in abortively and stably transformed cells.

B. Schaffhausen, T. Benjamin, J. Silver, 1979, Journal of supramolecular structure.

POLYOMA VIRUS HR-T GENE PRODUCTS

G. Carmichael, B. Schaffhausen, T. Benjamin, 1980 .

Phosphorylation of polyoma T antigens

B. Schaffhausen, T. Benjamin, 1979, Cell.

Purification and characterization of phosphoinositide 3-kinase from rat liver.

L. Cantley, B. Schaffhausen, B. D. Cohen, 1990, The Journal of biological chemistry.

Abundant expression of polyomavirus middle T antigen and dihydrofolate reductase in an adenovirus recombinant

T. Roberts, B. Schaffhausen, K. Berkner, 1987, Journal of virology.

Lessons in Signaling and Tumorigenesis from Polyomavirus Middle T Antigen

B. Schaffhausen, M. Fluck, 2009, Microbiology and Molecular Biology Reviews.

Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer.

T. Roberts, B. Schaffhausen, 2009, Virology.

The p110α Isoform of Phosphatidylinositol 3-Kinase Is Essential for Polyomavirus Middle T Antigen-Mediated Transformation

T. Roberts, Jean J. Zhao, B. Schaffhausen, 2007, Journal of Virology.

Large-scale production of polyoma middle T antigen by using genetically engineered tumors

M. Israel, T. Roberts, B. Schaffhausen, 1985, Molecular and cellular biology.

Expression of polyoma early gene products in E. coli.

T. Roberts, B. Schaffhausen, D. Kaplan, 1985, Nucleic acids research.

Genetic Analysis of the Polyomavirus DnaJ Domain

B. Schaffhausen, K. Whalen, R. de Jesus, 2005, Journal of Virology.

Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen.

T. Roberts, B. Schaffhausen, B. Druker, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Activation of CREB/ATF Sites by Polyomavirus Large T Antigen

B. Schaffhausen, A. Leger, Tara Love, 2005, Journal of Virology.

Mutations in polyomavirus middle T antigen affecting tumorigenesis.

C. Gélinas, B. Schaffhausen, M. Bastin, 1989, Virology.

Polyomavirus small t antigen: overproduction in bacteria, purification, and utilization for monoclonal and polyclonal antibody production

C. Schley, T. Roberts, B. Schaffhausen, 1986, Journal of virology.

Transformation by polyoma ts-a mutants. I. Characterization of the transformed phenotype.

B. Schaffhausen, C. Stewart, M. Fluck, 1985, Virology.

The major site of tyrosine phosphorylation in polyomavirus middle T antigen is not required for transformation

A. Mes-Masson, B. Schaffhausen, J. Hassell, 1984, Journal of virology.

TheMajorSiteofTyrosine Phosphorylation inPolyomavirus Middle T Antigen isNotRequired forTransformation

A. Mes-Masson, B. Schaffhausen, 1984 .

The T/t common region of simian virus 40 large T antigen contains a distinct transformation-governing sequence

E. Marsilio, D. Livingston, B. Schaffhausen, 1991, Journal of virology.

Altered conformational effects of phosphorylated lysine-rich histone (f-1) in f-1--deoxyribonucleic acid complexes. Circular dichroism and immunological studies.

G. Fasman, B. Schaffhausen, T. Langan, 1971, Biochemistry.

Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit.

L. Cantley, S. Shoelson, B. Schaffhausen, 1993, The Journal of biological chemistry.

A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity

L. Cantley, B. Schaffhausen, K. Auger, 1993, Molecular and cellular biology.

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.

M. White, J. Schlessinger, S. Shoelson, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Deficiency in histone acetylation in nontransforming host range mutants of polyoma virus.

B. Schaffhausen, T. Benjamin, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains

B. Miao, A. Degterev, Junying Yuan, 2010, Proceedings of the National Academy of Sciences.

SH2 domain structure and function.

B. Schaffhausen, 1995, Biochimica et biophysica acta.

and Domain Genetic Analysis of the Polyomavirus DnaJ

B. Schaffhausen, K. Whalen, R. de Jesus, 2005 .

Transgenic Expression of Polyomavirus Middle T Antigen in the Mouse Prostate Gives Rise to Carcinoma

M. Loda, S. Signoretti, T. Roberts, 2011, Journal of Virology.

Lentivirus-mediated oncogene introduction into mammary cells in vivo induces tumors.

B. Schaffhausen, M. Jechlinger, Yi Li, 2008, Neoplasia.

Surveillance mechanism linking Bub1 loss to the p53 pathway

T. Roberts, Jean J. Zhao, B. Schaffhausen, 2007, Proceedings of the National Academy of Sciences.

Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificity

L. Cantley, Songyang Zhou, B. Schaffhausen, 1994, Molecular and cellular biology.

Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase.

L. Cantley, B. Schaffhausen, O. Janssen, 1994, The Journal of biological chemistry.

A new class of mutations reveals a novel function for the original phosphatidylinositol 3-kinase binding site

T. Roberts, B. Schaffhausen, A. Mikami, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Polyomavirus Small t Antigen Interacts with Yes-Associated Protein To Regulate Cell Survival and Differentiation

W. Hahn, T. Roberts, B. Schaffhausen, 2014, Journal of Virology.

The Phosphatidylinositol 3-Kinase (PI3K) Isoform Dependence of Tumor Formation Is Determined by the Genetic Mode of PI3K Pathway Activation Rather than by Tissue Type

T. Roberts, B. Schaffhausen, Sang Hyun Lee, 2014, Journal of Virology.

Phosphorylation sites in polyomavirus large T antigen that regulate its function in viral, but not cellular, DNA synthesis

B. Schaffhausen, B. Bockus, A. Chatterjee, 1997, Journal of virology.

Essential role of PDK1 in regulating endothelial cell migration

B. Schaffhausen, R. Piva, F. Bussolino, 2007, The Journal of cell biology.

Essential role of PDK 1 in regulating endothelial cell migration

B. Schaffhausen, R. Piva, F. Bussolino, 2007 .

NMRKIN: Simulating line shapes from two-dimensional spectra of proteins upon ligand binding

U. Günther, B. Schaffhausen, 2002, Journal of biomolecular NMR.

DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication.

P. Silver, J. Decaprio, J. Pipas, 1997, Genes & development.

Papillomavirus E7 Oncoproteins Share Functions with Polyomavirus Small T Antigens

W. Hahn, D. Livingston, T. Roberts, 2014, Journal of Virology.

Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner

T. Roberts, B. Schaffhausen, Shaida Andrabi, 2007, Proceedings of the National Academy of Sciences.

Interactions of polyomavirus middle T with the SH2 domains of the pp85 subunit of phosphatidylinositol-3-kinase

B. Schaffhausen, Y. Liu, R. Kapeller, 1992, Journal of virology.

Characterization of an immortalizing N-terminal domain of polyomavirus large T antigen

B. Schaffhausen, O. Gjoerup, T. Davin, 1994, Journal of virology.

Phosphatidylinositol-3 kinase and growth regulation.

L. Cantley, B. Schaffhausen, S. Soltoff, 1992, Cold Spring Harbor symposia on quantitative biology.

Tyrosine phosphorylation is a signal for the trafficking of pp85, an 85-kDa phosphorylated polypeptide associated with phosphatidylinositol kinase activity.

T. Roberts, H. Piwnica-Worms, B. Schaffhausen, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Viral Interference with DNA Repair by Targeting of the Single-Stranded DNA Binding Protein RPA

B. Schaffhausen, O. Gjoerup, Rowena deJesus, 2013, PLoS pathogens.

The DnaJ domain of polyomavirus large T antigen is required to regulate Rb family tumor suppressor function

J. Decaprio, T. Roberts, B. Schaffhausen, 1997, Journal of virology.

Nuclear magnetic resonance structure of the P395S mutant of the N-SH2 domain of the p85 subunit of PI3 kinase: an SH2 domain with altered specificity.

U. Günther, B. Schaffhausen, B. Weyrauch, 2003, Biochemistry.

Protein Phosphatase 2A Isoforms Utilizing Aβ Scaffolds Regulate Differentiation through Control of Akt Protein*

B. Schaffhausen, Justin H Hwang, T. Jiang, 2013, The Journal of Biological Chemistry.

Oncogenes and phosphatidylinositol turnover.

L. Cantley, T. Roberts, B. Schaffhausen, 1986, Annals of the New York Academy of Sciences.

The hr-t gene of polyoma virus.

G. Carmichael, B. Schaffhausen, T. Benjamin, 1980, Cold Spring Harbor symposia on quantitative biology.

Probing Src homology 2 domain ligand interactions by differential line broadening.

U. Günther, B. Schaffhausen, T. Mittag, 2002, Biochemistry.

Tyrosine phosphorylation in signal transduction.

T. Roberts, H. Piwnica-Worms, B. Schaffhausen, 1988, Cold Spring Harbor symposia on quantitative biology.

Backbone assignment of the N-terminal polyomavirus large T antigen

U. Günther, C. Ludwig, B. Schaffhausen, 2009, Biomolecular NMR assignments.

Phosphatidylinositol kinases and cell transformation.

L. Cantley, T. Roberts, B. Schaffhausen, 1986, Symposium on Fundamental Cancer Research.

IMMUNIZATION AGAJNST THE POLYOMA TUMOR-SPECIFIC TRANSPLANTATION

B. Schaffhausen, T. M. Roberts, Deanda, 2006 .

Retinol modulates site-specific mobility of apo-cellular retinol-binding protein to promote ligand binding.

U. Günther, B. Schaffhausen, L. Franzoni, 2006, Journal of the American Chemical Society.

Residual transforming activity of PY1178T, a mutant lacking the principal in vitro tyrosine phosphorylation site, is not affected by removal of the secondary tyrosine phosphorylation site at residue 322.

G. Carmichael, B. Schaffhausen, T. Benjamin, 1985, Virology.

Cellular Proteins ThatAssociate withtheMiddle andSmallT Antigens ofPolyomavirus

B. Schaffhausen, Dana-Farber CancerInstitute, W. Morgan, 1988 .

Comparisons between Murine Polyomavirus and Simian Virus 40 Show Significant Differences in Small T Antigen Function

T. Roberts, B. Schaffhausen, Shaida Andrabi, 2011, Journal of Virology.

Polyomavirus Large T Antigen Binds Symmetrical Repeats at the Viral Origin in an Asymmetrical Manner

B. Schaffhausen, A. Bohm, C. Harrison, 2013, Journal of Virology.

Essential role of PDK1 in regulating endothelial cell migration

B. Schaffhausen, R. Piva, F. Bussolino, 2007, The Journal of cell biology.