M. Dottore

发表

High CD123 levels enhance proliferation in response to IL-3, but reduce chemotaxis by downregulating CXCR4 expression.

Nicole L. Wittwer, G. Brumatti, C. Marchant, 2017, Blood advances.

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling

M. Dottore, Angel F. Lopez, T. Nero, 2018, Nature Communications.

Targeting human CALR‐mutated MPN progenitors with a neoepitope‐directed monoclonal antibody

A. Reinisch, M. Dottore, Angel F. Lopez, 2022, EMBO reports.

Interferon-y Upregulates Interleukin-3 ( IL-3 ) Receptor Expression in Human Endothelial Cells and Synergizes With IL-3 in Stimulating Major Histocompatibility Complex Class I 1 Expression and Cytokine Production

William, M. Vadas, M. Dottore, 2002 .

Interferon-gamma upregulates interleukin-3 (IL-3) receptor expression in human endothelial cells and synergizes with IL-3 in stimulating major histocompatibility complex class II expression and cytokine production.

J. Gamble, M. Vadas, M. Dottore, 1995, Blood.

A human interleukin 3 analog with increased biological and binding activities.

M. F. Shannon, S. Barry, M. Vadas, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Specific human granulocyte-macrophage colony-stimulating factor antagonists.

M. F. Shannon, M. Vadas, M. Dottore, 1994, Proceedings of the National Academy of Sciences of the United States of America.

The receptor for interleukin 3 is selectively induced in human endothelial cells by tumor necrosis factor alpha and potentiates interleukin 8 secretion and neutrophil transmigration.

J. Gamble, G. Goodall, M. Vadas, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Differential binding of IL-3 and GM-CSF to human monocytes.

M. Vadas, J. Moss, M. Dottore, 1992, Growth factors.

Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis

R. Majeti, M. Dottore, Angel F. Lopez, 2018, Science Advances.

Residue 21 of human granulocyte‐macrophage colony‐stimulating factor is critical for biological activity and for high but not low affinity binding.

M. F. Shannon, M. Vadas, M. Dottore, 1992, The EMBO journal.

HEMATOPOIESIS Identiﬁcation of a 14-3-3 Binding Sequence in the Common b Chain of the Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), Interleukin-3 (IL-3), and IL-5 Receptors That Is Serine-Phosphorylated by GM-CSF

M. Dottore, C. Bagley, M. Berndt, 1999 .

Differential functional activation of chemokine receptor CXCR4 is mediated by G proteins in breast cancer cells.

S. McColl, M. Dottore, J. Holland, 2006, Cancer research.

Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody.

M. Dottore, Angel F. Lopez, T. Nero, 2014, Cell reports.

Two contiguous residues in human interleukin-3, Asp21 and Glu22, selectively interact with the alpha- and beta-chains of its receptor and participate in function.

M. F. Shannon, G. Goodall, S. Barry, 1994, The Journal of biological chemistry.

Identification of residues in the first and fourth helices of human granulocyte-macrophage colony-stimulating factor involved in biologic activity and in binding to the alpha- and beta-chains of its receptor.

M. F. Shannon, M. Vadas, M. Dottore, 1994, Blood.

Identification of a 14-3-3 Binding Sequence in the Common β Chain of the Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), Interleukin-3 (IL-3), and IL-5 Receptors That Is Serine-Phosphorylated by GM-CSF

M. Dottore, Angel F. Lopez, C. Bagley, 1999 .

The Structure of the GM-CSF Receptor Complex Reveals a Distinct Mode of Cytokine Receptor Activation

M. Dottore, Angel F. Lopez, H. Ramshaw, 2008, Cell.

Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch

C. Begley, M. Dottore, Angel F. Lopez, 2006, The EMBO journal.

M. F. Shannon, M. Vadas, M. Dottore, 1994, Blood.

Identification of a 14-3-3 binding sequence in the common beta chain of the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors that is serine-phosphorylated by GM-CSF.

M. Dottore, C. Bagley, M. Berndt, 1999, Blood.

High Yield Production of a Soluble Human Interleukin-3 Variant from E. coli with Wild-Type Bioactivity and Improved Radiolabeling Properties

M. Dottore, Angel F. Lopez, James M. Murphy, 2013, PloS one.

CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors

Michael J. Wilson, M. Dottore, Angel F. Lopez, 2015, mAbs.

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling

M. Dottore, Angel F. Lopez, T. Nero, 2018, Nature Communications.

Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.

Michael W Parker, M. Dottore, Angel F. Lopez, 2016, Structure.

Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival.

M. Dottore, M. Berndt, B. McClure, 2000, Molecular cell.

Differential functional activation of chemokine receptor CXCR4 is mediated by G proteins in breast cancer cells.

S. McColl, M. Dottore, J. Holland, 2006, Cancer research.