J. Chiorini

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Classical conditioning in the cat as a function of the CS-US interval

D. Mcadam, J. Knott, J. Chiorini, 1965 .

Protection from experimental endotoxemia by a recombinant adeno‐associated virus encoding interleukin 10

S. Pillemer, J. Chiorini, B. Baum, 2001, The journal of gene medicine.

The parvovirus capsid odyssey: from the cell surface to the nucleus.

J. Chiorini, C. Parrish, C. Harbison, 2008, Trends in microbiology.

Structurally Mapping the Diverse Phenotype of Adeno-Associated Virus Serotype 4

J. Chiorini, N. Muzyczka, R. McKenna, 2006, Journal of Virology.

Profiling Autoantibodies against Salivary Proteins in Sicca Conditions

J. Chiorini, I. Alevizos, P. Burbelo, 2019, Journal of dental research.

Toxicity and biodistribution of a first-generation recombinant adenoviral vector, encoding aquaporin-1, after retroductal delivery to a single rat submandibular gland.

J. Chiorini, B. Baum, R. Irwin, 2006, Human gene therapy.

Functional Correction of CNS Phenotypes in a Lysosomal Storage Disease Model Using Adeno-Associated Virus Type 4 Vectors

I. Martins, B. Davidson, J. Chiorini, 2005, The Journal of Neuroscience.

Btbd7 Regulates Epithelial Cell Dynamics and Branching Morphogenesis

Kenneth M. Yamada, J. Chiorini, Kazue Matsumoto, 2010, Science.

Structure of Adeno-Associated Virus Type 4

T. Baker, J. Chiorini, N. Muzyczka, 2005, Journal of Virology.

Transfer of the AQP1 cDNA for the correction of radiation-induced salivary hypofunction.

James B. Mitchell, G. Illei, C. Van Waes, 2006, Biochimica et biophysica acta.

Immune reactivity after adenoviral-mediated aquaporin-1 cDNA transfer to human parotid glands.

G. Illei, J. Chiorini, B. Baum, 2017, Oral diseases.

Targeting primary Sjögren’s syndrome

J. Chiorini, T. Odani, 2019, Modern rheumatology.

SARS-CoV-2 infection of the oral cavity and saliva

Daniel S. Chertow, S. Teichmann, R. Scheuermann, 2021, Nature Medicine.

Adeno-associated virus serotype 2-mediated gene transfer to the parotid glands of nonhuman primates.

J. Chiorini, B. Baum, C. Dunbar, 2007, Human gene therapy.

Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics.

I. Bossis, Y. Loh, L. Nieman, 2004, Proceedings of the National Academy of Sciences of the United States of America.

AAV transcytosis through barrier epithelia and endothelium.

J. Chiorini, G. Di Pasquale, 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

Regulation of gene expression for translation initiation factor eIF-2 alpha: importance of the 3' untranslated region.

E. Urcelay, J. Chiorini, B. Safer, 1996, The Biochemical journal.

Glycosylation, hypogammaglobulinemia, and resistance to viral infections.

M. Hegde, T. Chun, J. Justement, 2014, The New England journal of medicine.

Viral Gene Transfer to Developing Mouse Salivary Glands

J. Chiorini, M. Hoffman, T. Onodera, 2012, Journal of dental research.

Gene-edited pseudogene resurrection corrects p47phox-deficient chronic granulomatous disease.

J. Chiorini, D. Kuhns, S. Afione, 2017, Blood advances.

Gangliosides Are Essential for Bovine Adeno-Associated Virus Entry

J. Chiorini, Michaela Schmidt, 2006, Journal of Virology.

Competitive blocking of salivary gland [18F]DCFPyL uptake via localized, retrograde ductal injection of non-radioactive DCFPyL: a preclinical study

P. Choyke, J. Chiorini, C. Zheng, 2021, EJNMMI Research.

Inhibition of bone morphogenetic protein 6 receptors ameliorates Sjögren’s syndrome in mice

N. Zhang, J. Chiorini, W. Swaim, 2020, Scientific Reports.

Integrated Single-Cell Atlases Reveal an Oral SARS-CoV-2 Infection and Transmission Axis

S. Teichmann, R. Scheuermann, S. Pittaluga, 2020, medRxiv.

ATAC2GRN: optimized ATAC-seq and DNase1-seq pipelines for rapid and accurate genome regulatory network inference

J. Chiorini, T.J.F. Pranzatelli, D. Michael, 2018, BMC Genomics.

Inhibition of PrKX, a Novel Protein Kinase, and the Cyclic AMP-Dependent Protein Kinase PKA by the Regulatory Proteins of Adeno-Associated Virus Type 2

Linda Yang, R. Kotin, J. Chiorini, 1998, Molecular and Cellular Biology.

BAAV Transcytosis Requires an Interaction with β-1-4 Linked- Glucosamine and gp96

J. Chiorini, M. Agbandje-McKenna, N. Kaludov, 2010, PloS one.

LocaL administration of soLuBLe cd40:fc to the saLivary gLands of non-oBese diaBetic mice does not ameLiorate autoimmune disease

G. Illei, P. Tak, J. Chiorini, 2012 .

HCV Infection Alters Salivary Gland Histology and Saliva Composition

J. Chiorini, J. Maldonado, P. Pérez, 2022, Journal of dental research.

Gene Therapy for Sjögren’s Syndrome

J. Chiorini, H. Yin, 2021, Sjögren's Syndrome and Oral Health.

High-Resolution Structural Characterization of a New Adeno-associated Virus Serotype 5 Antibody Epitope toward Engineering Antibody-Resistant Recombinant Gene Delivery Vectors

J. Chiorini, R. McKenna, M. Agbandje-McKenna, 2018, Journal of Virology.

Adeno-Associated Virus Serotype 1 (AAV1)- and AAV5-Antibody Complex Structures Reveal Evolutionary Commonalities in Parvovirus Antigenic Reactivity

T. Baker, J. Chiorini, N. Muzyczka, 2014, Journal of Virology.

BAAV Mediated GJB2 Gene Transfer Restores Gap Junction Coupling in Cochlear Organotypic Cultures from Deaf Cx26Sox10Cre Mice

M. Bortolozzi, F. Mammano, J. Chiorini, 2011, PloS one.

Lysosome-associated membrane protein 3 misexpression in salivary glands induces a Sjögren’s syndrome-like phenotype in mice

J. Chiorini, M. Noguchi, N. Hirata, 2021, Annals of the Rheumatic Diseases.

LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization

J. Chiorini, M. Noguchi, Tsutomu Tanaka, 2021, Autophagy.

Gene Expression Profiles from Disease Discordant Twins Suggest Shared Antiviral Pathways and Viral Exposures among Multiple Systemic Autoimmune Diseases

J. Chiorini, M. Weller, F. Miller, 2015, PloS one.

Bovine AAV Transcytosis Inhibition by Tannic Acid Results in Functional Expression of CFTR in Vitro and Altered Bio-Distribution in Vivo

J. Chiorini, W. Swaim, L. Ostedgaard, 2011, Gene Therapy.

Recovery of radiation-induced dry eye and corneal damage by pretreatment with adenoviral vector-mediated transfer of erythropoietin to the salivary glands in mice.

J. Chiorini, B. Baum, C. Zheng, 2013, Human gene therapy.

Long‐term transduction of miniature pig parotid glands using serotype 2 adeno‐associated viral vectors

J. Chiorini, B. Baum, C. Zheng, 2009, The journal of gene medicine.

Glucagon-Like Peptide-1 Gene Therapy

J. Chiorini, A. Rowzee, N. Cawley, 2011, Experimental diabetes research.

Use of localized gene transfer to develop novel treatment strategies for the salivary component of Sjögren's syndrome

Y. Loh, Jianghuai Wang, J. Chiorini, 2008 .

Immune responses following salivary gland administration of recombinant adeno‐associated virus serotype 2 vectors

P. Tak, I. Bossis, Jianghuai Wang, 2005, The journal of gene medicine.

High-efficiency transfer of the T cell co-stimulatory molecule B7-2 to lymphoid cells using high-titer recombinant adeno-associated virus vectors.

R. Kotin, M. Hallek, E. Urcelay, 1995, Human gene therapy.

Transduction of Salivary Gland Acinar Cells with a Novel AAV Vector 44.9

J. Chiorini, R. Weigert, W. Swaim, 2020, Molecular therapy. Methods & clinical development.

Extended transgene expression from a nonintegrating adenoviral vector containing retroviral elements.

J. Chiorini, B. Baum, C. Zheng, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

Transduction, tropism, and biodistribution of AAV vectors in the lacrimal gland.

J. Chiorini, E. Rocha, G. Di Pasquale, 2011, Investigative ophthalmology & visual science.

Sustained Exendin-4 Secretion through Gene Therapy Targeting Salivary Glands in Two Different Rodent Models of Obesity/Type 2 Diabetes

J. Chiorini, J. Egan, R. Vettor, 2012, PLoS ONE.

Deficiency of Adenosine Deaminase 2 (DADA2): Hidden Variants, Reduced Penetrance, and Unusual Inheritance

D. Kastner, J. Chiorini, N. Sobreira, 2020, Journal of Clinical Immunology.

Association of bone morphogenetic protein 6 with exocrine gland dysfunction in patients with Sjögren's syndrome and in mice.

G. Illei, J. Chiorini, M. Weller, 2013, Arthritis and rheumatism.

PrKX Is a Novel Catalytic Subunit of the cAMP-dependent Protein Kinase Regulated by the Regulatory Subunit Type I*

R. Kotin, J. Chiorini, B. Zimmermann, 1999, The Journal of Biological Chemistry.

Gene therapy using IL-27 ameliorates Sjögren's syndrome-like autoimmune exocrinopathy

J. Chiorini, Wendy C. Carcamo, A. Peck, 2012, Arthritis Research & Therapy.

Correction of Ductal CFTR Activity Rescues Acinar Cell and Pancreatic and Salivary Gland Functions in Mouse Models of Autoimmune Disease

S. Muallem, J. Chiorini, W. Swaim, 2017 .

Restoration of CFTR Activity in Ducts Rescues Acinar Cell Function and Reduces Inflammation in Pancreatic and Salivary Glands of Mice.

S. Muallem, J. Chiorini, W. Swaim, 2017, Gastroenterology.

Pharmacological Rescue of Ductal CFTR Rescue Pancreatic and Salivary glands Acinar Cells and Tissue Function in Mouse Models of Autoimmune diseases

S. Muallem, J. Chiorini, W. Swaim, 2017 .

Sclerosing Sialadenitis Is Associated With Salivary Gland Hypofunction and a Unique Gene Expression Profile in Sjögren’s Syndrome

J. Chiorini, B. Warner, Benjamin N French, 2021, Frontiers in Immunology.

Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors

D. Harlan, J. Chiorini, O. Gavrilova, 2009, Virology Journal.

Local delivery of AAV2-CTLA4IgG decreases sialadenitis and improves gland function in the C57BL/6.NOD-Aec1Aec2 mouse model of Sjögren's syndrome

J. Chiorini, T. Uede, A. Peck, 2012, Arthritis Research & Therapy.

Identification of adeno-associated virus contamination in cell and virus stocks by PCR.

J. Chiorini, S. Afione, H. Katano, 2004, BioTechniques.

Gene therapy: Sjögren’s syndrome

P. Tak, J. Chiorini, N. Roescher, 2010 .

Adeno-Associated Virus Type 2 Rep78 Inhibition of PKA and PRKX: Fine Mapping and Analysis of Mechanism

R. Kotin, J. Chiorini, S. Afione, 2002, Journal of Virology.

Examining the cross-reactivity and neutralization mechanisms of a panel of mAbs against adeno-associated virus serotypes 1 and 5.

J. Chiorini, M. Agbandje-McKenna, C. Parrish, 2012, The Journal of general virology.

Intranasal administration of adeno-associated virus type 12 (AAV12) leads to transduction of the nasal epithelia and can initiate transgene-specific immune response.

J. Chiorini, J. A. Misplon, C. Lo, 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6

J. Chiorini, J. Gutkind, M. Weller, 2010, Nature Medicine.

Recombinant adeno-associated virus serotype 2 vectors mediate stable interleukin 10 secretion from salivary glands into the bloodstream.

R. Kotin, J. Chiorini, B. Baum, 2002, Human gene therapy.

Matriptase Deletion Initiates a Sjögren’s Syndrome-Like Disease in Mice

J. Chiorini, Xibao Liu, W. Swaim, 2014, PloS one.

Adeno-Associated Virus Type 12 (AAV12): a Novel AAV Serotype with Sialic Acid- and Heparan Sulfate Proteoglycan-Independent Transduction Activity

J. Chiorini, C. Zheng, S. Afione, 2007, Journal of Virology.

Comparison of Prostate-Specific Membrane Antigen Expression Levels in Human Salivary Glands to Non-Human Primates and Rodents.

P. Choyke, J. Chiorini, J. Roy, 2020, Cancer biotherapy & radiopharmaceuticals.

Binding of Adeno-associated Virus Type 5 to 2,3-Linked Sialic Acid Is Required for Gene Transfer*

M. Welsh, J. Chiorini, S. Keshavjee, 2001, The Journal of Biological Chemistry.

FIXing hemophilia B with gene therapy

J. Chiorini, 2006 .

Enteric viruses replicate in salivary glands and infect through saliva

Y. Belkaid, J. Chiorini, N. Altan-Bonnet, 2022, Nature.

Transient detection of E1‐containing adenovirus in saliva after the delivery of a first‐generation adenoviral vector to human parotid gland

G. Illei, Shuying Liu, J. Chiorini, 2010, The journal of gene medicine.

Peptide-based ELISAs are not sensitive and specific enough to detect muscarinic receptor type 3 autoantibodies in serum from patients with Sjögren's syndrome

G. Illei, J. Chiorini, A. Kingman, 2010, Annals of the rheumatic diseases.

Advances in salivary gland gene therapy – oral and systemic implications

J. Chiorini, B. Baum, C. Zheng, 2015, Expert opinion on biological therapy.

Toxicity and Biodistribution of the Serotype 2 Recombinant Adeno-Associated Viral Vector, Encoding Aquaporin-1, after Retroductal Delivery to a Single Mouse Parotid Gland

J. Chiorini, C. Zheng, M. Vallant, 2014, PloS one.

Assessment of the safety and biodistribution of a regulated AAV2 gene transfer vector after delivery to murine submandibular glands.

T. Clackson, J. Chiorini, V. Rivera, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Clinical and laboratory evaluation of sicca complaints: distinctive aspects of primary, secondary and non-Sjogren syndrome

J. Chiorini, P. Louzada-Junior, D. Garcia, 2022, Advances in Rheumatology.

Hepatitis Delta Virus Detected in Salivary Glands of Sjögren's Syndrome Patients and Recapitulates a Sjögren's Syndrome-Like Phenotype in Vivo

Michael A. Smith, J. Chiorini, M. Weller, 2016, Pathogens & immunity.

Local expression of tumor necrosis factor-receptor 1:immunoglobulin G can induce salivary gland dysfunction in a murine model of Sjögren's syndrome

P. Tak, J. Chiorini, N. Roescher, 2009, Arthritis research & therapy.

Adeno-Associated Virus (AAV) Type 5 Rep Protein Cleaves a Unique Terminal Resolution Site Compared with Other AAV Serotypes

R. Kotin, J. Chiorini, S. Afione, 1999, Journal of Virology.

PKA/PrKX activity is a modulator of AAV/adenovirus interaction

J. Chiorini, G. Di Pasquale, 2003, The EMBO journal.

Cross-contamination of the human salivary gland HSG cell line with HeLa cells: A STR analysis study.

J. Chiorini, C. Delporte, S. Tran, 2018, Oral diseases.

Mutation in the platelet-derived growth factor receptor alpha inhibits adeno-associated virus type 5 transduction.

J. Chiorini, S. Leppla, I. Pilz, 2012, Virology.

Different osteogenic potentials of recombinant human BMP-6 adeno-associated virus and adenovirus in two rat strains.

J. Chiorini, Hongwei Li, G. Helm, 2006, Tissue engineering.

Myoepithelial Cell Function in Salivary Gland Physiology and Disease

J. Chiorini, J. Maldonado, P. Riveros, 2021, Sjögren's Syndrome and Oral Health.

The family Parvoviridae

J. Chiorini, A. Davison, D. Gatherer, 2014, Archives of Virology.

Gene Therapy of Salivary Diseases.

J. Chiorini, B. Baum, C. Zheng, 2017, Methods in molecular biology.

Effect of Soluble ICAM-1 on a Sjögren's Syndrome-like Phenotype in NOD Mice Is Disease Stage Dependent

G. Illei, P. Tak, J. Chiorini, 2011, PloS one.

Interleukin-12 induces salivary gland dysfunction in transgenic mice, providing a new model of Sjögren's syndrome.

P. Tak, J. Chiorini, W. Swaim, 2009, Arthritis and rheumatism.

Recombinant Adeno-Associated Viral Vector Types 4 and 5

B. Davidson, J. Chiorini, 2003 .

Recombinant adeno-associated viral vector types 4 and 5. Preparation and application for CNS gene transfer.

B. Davidson, J. Chiorini, 2003, Methods in molecular medicine.

Correction of LAMP3-associated salivary gland hypofunction by aquaporin gene therapy

J. Chiorini, M. Noguchi, C. Zheng, 2022, Scientific Reports.

Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material.

Terence R Flotte, Hiroaki Mizukami, Mauro Giacca, 2010, Human gene therapy.

Aquaporin gene therapy corrects Sjögren’s syndrome phenotype in mice

J. Chiorini, W. Swaim, C. Zheng, 2016, Proceedings of the National Academy of Sciences.

Viral vector tropism for supporting cells in the developing murine cochlea

J. Chiorini, Richard J. H. Smith, M. Hildebrand, 2011, Hearing Research.

Sjogren's syndrome: An update on disease pathogenesis, clinical manifestations and treatment.

J. Chiorini, K. Sivils, A. Rasmussen, 2019, Clinical immunology.

The family Parvoviridae

J. Chiorini, A. Davison, D. Gatherer, 2013, Archives of Virology.

ICTV Virus Taxonomy Profile: Parvoviridae

J. Chiorini, J. Hughes, M. Canuti, 2019, The Journal of general virology.

Cloning of an Avian Adeno-Associated Virus (AAAV) and Generation of Recombinant AAAV Particles

I. Bossis, J. Chiorini, 2003, Journal of Virology.

Scalable purification of adeno-associated virus type 2, 4, or 5 using ion-exchange chromatography.

J. Chiorini, N. Kaludov, B. Handelman, 2002, Human gene therapy.

Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction

James B. Mitchell, G. Illei, Shuying Liu, 2012, Proceedings of the National Academy of Sciences.

AAV2-mediated transfer of the human aquaporin-1 cDNA restores fluid secretion from irradiated miniature pig parotid glands

J. Chiorini, B. Baum, C. Zheng, 2010, Gene Therapy.

Development of a gene transfer-based treatment for radiation-induced salivary hypofunction.

G. Illei, Shuying Liu, J. Chiorini, 2010, Oral oncology.

Local adeno-associated virus-mediated interleukin 10 gene transfer has disease-modifying effects in a murine model of Sjögren's syndrome.

S. Pillemer, P. Tak, Jianghuai Wang, 2003, Human gene therapy.

Late responses to adenoviral-mediated transfer of the aquaporin-1 gene for radiation-induced salivary hypofunction

G. Illei, Shuying Liu, J. Chiorini, 2016, Gene Therapy.

Lysosomal exocytosis of HSP70 stimulates monocytic BMP6 expression in Sjögren’s syndrome

J. Chiorini, M. Noguchi, A. Ribeiro-Silva, 2022, The Journal of clinical investigation.

Temporal changes in salivary glands of non-obese diabetic mice as a model for Sjögren's syndrome.

G. Illei, P. Tak, J. Chiorini, 2012, Oral diseases.

Re-engineering primary epithelial cells from rhesus monkey parotid glands for use in developing an artificial salivary gland.

D. Mooney, J. Chiorini, B. Baum, 2006, Tissue engineering.

Computational modeling of epithelial fluid and ion transport in the parotid duct after transfection of human aquaporin-1.

J. Sneyd, J. Chiorini, V. Suresh, 2017, American journal of physiology. Gastrointestinal and liver physiology.

TACI-Fc gene therapy improves autoimmune sialadenitis but not salivary gland function in non-obese diabetic mice.

G. Illei, P. Tak, J. Chiorini, 2012, Oral diseases.

IL17: potential therapeutic target in Sjögren's syndrome using adenovirus-mediated gene transfer

J. Chiorini, A. Peck, C. Nguyen, 2010, Laboratory Investigation.

Into the Future: Autonomic Neuropathy, MicroRNAs, and Gene Therapy

J. Chiorini, I. Alevizos, N. Nikolov, 2011 .

LAMP3 induces apoptosis and autoantigen release in Sjögren’s syndrome patients

J. Chiorini, M. Noguchi, N. Hirata, 2020, Scientific Reports.

Sjögren syndrome: advances in the pathogenesis from animal models.

J. Chiorini, D. Čiháková, P. Caturegli, 2009, Journal of autoimmunity.

In vivo genetic manipulation of inner ear connexin expression by bovine adeno-associated viral vectors

F. Mammano, J. Chiorini, M. Praetorius, 2017, Scientific Reports.

Viral-mediated delivery of the late-infantile neuronal ceroid lipofuscinosis gene, TPP-I to the mouse central nervous system

B. Davidson, J. Chiorini, Ronald E. Haskell, 2003, Gene Therapy.

Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system.

I. Martins, R. Kotin, B. Davidson, 2000, Proceedings of the National Academy of Sciences of the United States of America.

A key transcription factor for eukaryotic initiation factor-2 alpha is strongly homologous to developmental transcription factors and may link metabolic genes to cellular growth and development.

J. Chiorini, B. Safer, B. Efiok, 1994, The Journal of biological chemistry.

Systemic gene therapy for methylmalonic acidemia using the novel adeno-associated viral vector 44.9

J. Chiorini, R. Chandler, C. Venditti, 2022, Molecular therapy. Methods & clinical development.

Identification of PDGFR as a receptor for AAV-5 transduction

Giovanni Di Pasquale, D. Scudiero, A. Monks, 2003, Nature Medicine.

Adeno-Associated Virus Type 5 (AAV5) but Not AAV2 Binds to the Apical Surfaces of Airway Epithelia and Facilitates Gene Transfer

R. Kotin, B. Davidson, J. Chiorini, 2000, Journal of Virology.

Infection efficiency of human and mouse embryonic stem cells using adenoviral and adeno-associated viral vectors.

B. Davidson, J. Mcwhir, J. Chiorini, 2003, Cloning and stem cells.

Adeno-associated virus type 5 reduces learning deficits and restores glutamate receptor subunit levels in MPS VII mice CNS.

I. Martins, B. Davidson, J. Chiorini, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

Autophagy as a modulator of cell death machinery

J. Chiorini, Tsutomu Tanaka, M. Noguchi, 2020, Cell Death & Disease.

Transduction of murine cerebellar neurons with recombinant FIV and AAV5 vectors

B. Davidson, J. Chiorini, T. Dubensky, 2000, Neuroreport.

Biologically active Rep proteins of adeno-associated virus type 2 produced as fusion proteins in Escherichia coli

M. Weitzman, R. Kotin, E. Urcelay, 1994, Journal of virology.

Deficiency of Adenosine Deaminase 2 (DADA2): Hidden Variants, Reduced Penetrance, and Unusual Inheritance

D. Kastner, J. Chiorini, N. Sobreira, 2020, Journal of Clinical Immunology.

Cloning and Characterization of Adeno-Associated Virus Type 5

Linda Yang, R. Kotin, J. Chiorini, 1999, Journal of Virology.

Sequence requirements for stable binding and function of Rep68 on the adeno-associated virus type 2 inverted terminal repeats

R. Kotin, J. Chiorini, B. Safer, 1994, Journal of virology.

Virus Taxonomy The ICTV Report on Virus Classification and Taxon Nomenclature Parvoviridae Chapter Parvoviridae

J. Chiorini, J. Hughes, M. Canuti, 2020 .

Capsid Antibodies to Different Adeno-Associated Virus Serotypes Bind Common Regions

Edward B. Miller, R. Samulski, T. Baker, 2013, Journal of Virology.

T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus

R. Davey, D. Meyerholz, J. Chiorini, 2011, Proceedings of the National Academy of Sciences.

Production and persistence of specific antibodies in COVID-19 patients with hematologic malignancies: role of rituximab

K. Dobbs, J. Chiorini, H. Su, 2021, Blood Cancer Journal.

Regulation of eukaryotic translation initiation factor expression during T-cell activation.

N. Sonenberg, J. Chiorini, R. Frederickson, 1993, Biochimica et biophysica acta.

Coordinated control of connexin 26 and connexin 30 at the regulatory and functional level in the inner ear

F. Mammano, J. Chiorini, S. Ortolano, 2008, Proceedings of the National Academy of Sciences.

Adeno-Associated Virus Serotype 4 (AAV4) and AAV5 Both Require Sialic Acid Binding for Hemagglutination and Efficient Transduction but Differ in Sialic Acid Linkage Specificity

J. Chiorini, J. Zabner, K. Brown, 2001, Journal of Virology.

Comment on Kis et al , page 2928 Host EBV communication

J. Chiorini, 2006 .

Isolation and characterization of the promoter and flanking regions of the gene encoding the human protein-synthesis-initiation factor 2α

J. Chiorini, B. Safer, J. Hershey, 1989 .

Mechanisms of translational regulation by a human eIF5-mimic protein

J. Chiorini, Donghui Zhou, T. Fujiwara, 2011, Nucleic acids research.

Virus Serotype 5 Structural Insights into Adeno-Associated

J. Chiorini, N. Muzyczka, R. McKenna, 2014 .

Structural Insights into Adeno-Associated Virus Serotype 5

J. Chiorini, N. Muzyczka, R. McKenna, 2013, Journal of Virology.

Pathogenic effect of interleukin-17A in induction of Sjögren's syndrome-like disease using adenovirus-mediated gene transfer

J. Chiorini, Wendy C. Carcamo, A. Peck, 2010, Arthritis research & therapy.

Determination of adeno-associated virus Rep68 and Rep78 binding sites by random sequence oligonucleotide selection

R. Kotin, J. Chiorini, B. Safer, 1995, Journal of virology.

Location of Immunization and Interferon-γ Are Central to Induction of Salivary Gland Dysfunction in Ro60 Peptide Immunized Model of Sjögren's Syndrome

P. Tak, J. Chiorini, N. Roescher, 2011, PloS one.

Gene transfer using bovine adeno-associated virus in the guinea pig cochlea

Y. Raphael, J. Chiorini, S. B. Shibata, 2009, Gene Therapy.

Local Administration of Soluble CD40:Fc to the Salivary Glands of Non-Obese Diabetic Mice Does Not Ameliorate Autoimmune Inflammation

P. Tak, J. Chiorini, T. Uede, 2012, PloS one.

Autoantibodies Against Proteins Previously Associated With Autoimmunity in Adult and Pediatric Patients With COVID-19 and Children With MIS-C

L. Notarangelo, K. Dobbs, J. Chiorini, 2022, Frontiers in Immunology.

Autoantibodies Detected in MIS-C Patients due to Administration of Intravenous Immunoglobulin

L. Notarangelo, K. Dobbs, J. Chiorini, 2021, medRxiv.

Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 4.

J. Chiorini, R. McKenna, L. Govindasamy, 2003, Virology.

A difference in the rate of ribosomal elongation balances the synthesis of eukaryotic translation initiation factor (eIF)-2 alpha and eIF-2 beta.

J. Chiorini, B. Safer, S. Miyamoto, 1993, The Journal of biological chemistry.

Oral vaccination with adeno-associated virus vectors expressing the Neu oncogene inhibits the growth of murine breast cancer.

J. Chiorini, V. Patel, G. Di Pasquale, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

Production, purification, crystallization and preliminary X-ray structural studies of adeno-associated virus serotype 5.

J. Chiorini, N. Muzyczka, R. McKenna, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

Parathyroid Hormone Resistance and Autoantibodies to the PTH1 Receptor.

J. Chiorini, W. Simonds, S. Rosenzweig, 2021, New England Journal of Medicine.

Tyrosine kinase receptor Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein.

J. Chiorini, M. Weller, P. Sinn, 2011, Virology.

Adeno-associated virus type 4 (AAV4) targets ependyma and astrocytes in the subventricular zone and RMS

I. Martins, B. Davidson, J. Chiorini, 2005, Gene Therapy.

Targeting the splicing of mRNA in autoimmune diseases: BAFF inhibition in Sjögren's syndrome as a proof of concept.

P. Tak, X. Mariette, J. Chiorini, 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

Adeno-associated virus type 5: transduction efficiency and cell-type specificity in the primate retina.

R. Kotin, B. Davidson, S. Russell, 2003, Human gene therapy.

Structure of Adeno-Associated Virus Serotype 5

T. Baker, J. Chiorini, N. Olson, 2004, Journal of Virology.

Novel AAV44.9-Based Vectors Display Exceptional Characteristics for Retinal Gene Therapy.

S. Boye, J. Chiorini, S. Crosson, 2020, Molecular therapy : the journal of the American Society of Gene Therapy.

Evidence of a Sjögren’s disease-like phenotype following COVID-19

J. Chiorini, D. Kleiner, J. Maldonado, 2022, medRxiv.

Secreted and Transmembrane Mucins Inhibit Gene Transfer with AAV4 More Efficiently than AAV5*

J. Chiorini, J. Pilewski, J. Zabner, 2002, The Journal of Biological Chemistry.

Identification and Mutagenesis of the Adeno-Associated Virus 5 Sialic Acid Binding Region

J. Chiorini, M. Agbandje-McKenna, S. Afione, 2014, Journal of Virology.

Rho GTPases Modulate Entry of Ebola Virus and Vesicular Stomatitis Virus Pseudotyped Vectors

R. Mandell, B. Davidson, J. Chiorini, 2009, Journal of Virology.

Salivary glands as a potential gene transfer target for gene therapeutics of some monogenetic endocrine disorders.

Ioannis Bossis, Bruce J Baum, I. Bossis, 2005, The Journal of endocrinology.

Cloning of adeno-associated virus type 4 (AAV4) and generation of recombinant AAV4 particles

R. Kotin, J. Chiorini, B. Safer, 1997, Journal of virology.

Developing a gene therapy for Sjögren's syndrome

G. Illei, P. Tak, J. Chiorini, 2006 .

TACI-Fc gene therapy improves auto-immune sialadenitis but not salivary gland function in NOD mice

G. Illei, P. Tak, J. Chiorini, 2012 .

Characterization of Human and Murine T-Cell Immunoglobulin Mucin Domain 4 (TIM-4) IgV Domain Residues Critical for Ebola Virus Entry

J. Chiorini, W. Maury, Bethany A. Rhein, 2016, Journal of Virology.

Identification of RNA aptamer which specifically interacts with PtdIns(3)P.

T. Iwanaga, J. Chiorini, Tsutomu Tanaka, 2019, Biochemical and biophysical research communications.

Salivary gland LAMP3 mRNA expression is a possible predictive marker in the response to hydroxychloroquine in Sjögren’s disease

J. Chiorini, M. Noguchi, C. Zheng, 2023, PloS one.

Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system.

I. Martins, R. Kotin, B. Davidson, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Design and Testing of Vector-Producing HEK293T Cells Bearing a Genomic Deletion of the SV40 T Antigen Coding Region

J. Chiorini, J. Reiser, S. Afione, 2020, Molecular therapy. Methods & clinical development.

In vivo genetic manipulation of inner ear connexin expression by bovine adeno-associated viral vectors

F. Mammano, J. Chiorini, M. Praetorius, 2017, Scientific Reports.

A novel bovine virus efficiently transduces inner ear neuroepithelial cells.

Mark E. Schneider, I. Bossis, J. Chiorini, 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

Use of localized gene transfer to develop novel treatment strategies for the salivary component of Sjögren ' s syndrome

Y. Loh, J. Chiorini, B. Baum, 2008 .

Lysosome‐Associated Membrane Protein 3 Induces Lysosome‐Dependent Cell Death by Impairing Autophagic Caspase 8 Degradation in the Salivary Glands of Individuals With Sjögren's Disease

J. Chiorini, M. Noguchi, C. Zheng, 2023, Arthritis & rheumatology.

Advances in salivary gland gene therapy – oral and systemic implications

J. Chiorini, B. Baum, C. Zheng, 2015, Expert opinion on biological therapy.

Cloning and Characterization of a Bovine Adeno-Associated Virus

I. Bossis, J. Chiorini, H. Katano, 2004, Journal of Virology.

Intranasal administration of adeno-associated virus type 12 (AAV12) leads to transduction of the nasal epithelia and can initiate transgene-specific immune response.

J. Chiorini, J. A. Misplon, C. Lo, 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

Neutralizing antibodies against adeno-associated viruses in Sjögren’s patients: implications for gene therapy

J. Chiorini, I. Alevizos, A. Cotrim, 2017, Gene Therapy.

Structural Insights into Adeno-Associated Virus Serotype 5

J. Chiorini, N. Muzyczka, R. McKenna, 2013, Journal of Virology.

Molecular Characterization of the Heparin-Dependent Transduction Domain on the Capsid of a Novel Adeno-Associated Virus Isolate, AAV(VR-942)

J. Chiorini, L. Govindasamy, M. Agbandje-McKenna, 2008, Journal of Virology.

Identification and Characterization of Novel Adeno-Associated Virus Isolates in ATCC Virus Stocks

J. Chiorini, Charles Buck, Michaela Schmidt, 2006, Journal of Virology.

The parvovirus capsid odyssey: from the cell surface to the nucleus.

J. Chiorini, C. Parrish, C. Harbison, 2008, Trends in microbiology.

Structural and antigenic characterization of the avian adeno-associated virus capsid

J. Chiorini, M. Mietzsch, P. Chipman, 2023, Journal of virology.

Glycosylation, hypogammaglobulinemia, and resistance to viral infections.

M. Hegde, T. Chun, J. Justement, 2014, The New England journal of medicine.

LAMP3 transfer via extracellular particles induces apoptosis in Sjögren’s disease

J. Chiorini, M. Noguchi, B. Warner, 2023, Scientific Reports.

TScan-II: A genome-scale platform for the de novo identification of CD4+ T cell epitopes

J. Chiorini, S. Muthuswamy, Yumei Leng, 2023, Cell.

Integrated Epigenetic Mapping of Human and Mouse Salivary Gene Regulation

J. Chiorini, H. Yin, B. Warner, 2018, Journal of dental research.

Local gene therapy and the identification of therapeutic targets in Sjögren’s syndrome

J. Chiorini, N. Roescher, G. Illei, 2012 .

Inhibition of JAK-STAT pathway corrects salivary gland inflammation and interferon driven immune activation in Sjögren’s disease

J. Chiorini, S. Jang, M. Tandon, 2024, Annals of the rheumatic diseases.