J. Ortega

发表

Structure of the Blm10-20 S proteasome complex by cryo-electron microscopy. Insights into the mechanism of activation of mature yeast proteasomes.

Jack Iwanczyk, K. Sadre-Bazzaz, K. Ferrell, 2006, Journal of molecular biology.

The impact of recent improvements in cryo-electron microscopy technology on the understanding of bacterial ribosome assembly

J. Ortega, A. Razi, R. Britton, 2016, Nucleic acids research.

The Sm-like Hfq protein increases OxyS RNA interaction with target mRNAs.

G. Storz, K. Wassarman, A. Zhang, 2002, Molecular cell.

Lysine 188 substitutions convert the pattern of proteasome activation by REGγ to that of REGs α and β

M. Bogyo, T. Nazif, A. Steven, 2001 .

New HEAT-like repeat motifs in proteins regulating proteasome structure and function.

A. Steven, J. Ortega, C. Gorbea, 2004, Journal of structural biology.

Factors Defining the Functional Oligomeric State of Escherichia coli DegP Protease

Jack Iwanczyk, J. Ortega, Vivian Leong, 2011, PloS one.

Escherichia coli DegP: a Structure-Driven Functional Model

Jack Iwanczyk, J. Ortega, A. Jomaa, 2009, Journal of bacteriology.

The Escherichia coli DegP : A Structure Driven Functional Model 2 3

Jack Iwanczyk, J. Ortega, A. Jomaa, 2009 .

Role of Era in assembly and homeostasis of the ribosomal small subunit

Joseph H. Davis, J. Ortega, J. Gómez-Blanco, 2019, bioRxiv.

YphC and YsxC GTPases assist the maturation of the central protuberance, GTPase associated region and functional core of the 50S ribosomal subunit

Joseph H. Davis, J. Rubinstein, J. Ortega, 2016, Nucleic acids research.

Structural basis of sequestration of the anti-Shine-Dalgarno sequence in the Bacteroidetes ribosome

R. Bundschuh, J. Ortega, K. Fredrick, 2020, Nucleic acids research.

Porphyrin-phospholipid liposomes with tunable leakiness.

J. Ortega, A. Razi, J. Lovell, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Alternating translocation of protein substrates from both ends of ClpXP protease

A. Steven, J. Ortega, M. Maurizi, 2002, The EMBO journal.

Cryo-electron microscopy structure of the 30S subunit in complex with the YjeQ biogenesis factor.

E. Brown, G. Stewart, J. Ortega, 2011, RNA.

ClpA and ClpX ATPases bind simultaneously to opposite ends of ClpP peptidase to form active hybrid complexes.

Alasdair C Steven, A. Steven, J. Ortega, 2004, Journal of structural biology.

ClpP: a structurally dynamic protease regulated by AAA+ proteins.

J. Ortega, A. Guarné, J. Alexopoulos, 2012, Journal of structural biology.

Visualization of substrate binding and translocation by the ATP-dependent protease, ClpXP.

A. Steven, J. Ortega, T. Ishikawa, 2000, Molecular cell.

Doxorubicin encapsulated in stealth liposomes conferred with light-triggered drug release.

Shuai Shao, Ulas Sunar, Dandan Luo, 2016, Biomaterials.

Anti-cancer liposomal chemophototherapy using bilayer-localized photosensitizer and cabazitaxel

J. Ortega, J. Lovell, Yumiao Zhang, 2022, Nano Research.

Light-Triggered Release of Large Biomacromolecules from Porphyrin-Phospholipid Liposomes.

J. Ortega, G. E. Atilla‐Gokcumen, J. Lovell, 2021, Langmuir : the ACS journal of surfaces and colloids.

Surfactant‐Stripped Cabazitaxel Micelles Stabilized by Clotrimazole or Mifepristone

S. Neelamegham, J. Ortega, A. Razi, 2019, Advanced Therapeutics.

Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function.

B. Kemp, J. Ortega, C. Schéele, 2016, Cell metabolism.

Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: A model for the ClpX/ClpA-bound state of ClpP.

R. Ghirlando, J. Ortega, A. Guarné, 2010, Chemistry & biology.

A new function of human HtrA2 as an amyloid-beta oligomerization inhibitor.

J. Ortega, G. Melacini, J. Milojevic, 2009, Journal of Alzheimer's disease : JAD.

Characterization of the Autocleavage Process of the Escherichia coli HtrA Protein: Implications for its Physiological Role

Jack Iwanczyk, J. Ortega, A. Jomaa, 2008, Journal of bacteriology.

The axial channel of the 20S proteasome opens upon binding of the PA200 activator.

A. Steven, J. Ortega, J. Heymann, 2005, Journal of molecular biology.

SARS‐CoV‐2 RBD Neutralizing Antibody Induction is Enhanced by Particulate Vaccination

J. Ortega, J. Lovell, S. Sambhara, 2020, Advanced materials.

A liposome-displayed hemagglutinin vaccine platform protects mice and ferrets from heterologous influenza virus challenge

Matthew S. Miller, J. Ortega, A. Zhang, 2021, Proceedings of the National Academy of Sciences.

Alternative oligomeric states of the yeast Rvb1/Rvb2 complex induced by histidine tags.

W. Houry, J. Ortega, Y. Kakihara, 2010, Journal of molecular biology.

Yeast rvb1 and rvb2 proteins oligomerize as a conformationally variable dodecamer with low frequency.

W. Houry, J. Ortega, Vivian Leong, 2015, Journal of molecular biology.

The Replication Activity of Influenza Virus Polymerase Is Linked to the Capacity of the PA Subunit To Induce Proteolysis

J. Ortega, J. Ortín, A. Nieto, 2000, Journal of Virology.

Pch2 is a hexameric ring ATPase that remodels the chromosome axis protein Hop1

J. Ortega, E. Alani, A. Jomaa, 2013, Proceedings of the National Academy of Sciences.

Experimental and Computational Observations of Immunogenic Cobalt Porphyrin Lipid Bilayers: Nanodomain-Enhanced Antigen Association

J. Ortega, M. Karttunen, A. Razi, 2021, Pharmaceutics.

Final touches and quality control on the assembly of the eukaryotic ribosome

J. Ortega, A. Razi, 2017, The EMBO journal.

Functional domains of the 50S subunit mature late in the assembly process

Joseph H. Davis, J. Ortega, J. Williamson, 2013, Nucleic acids research.

Escherichia coli rimM and yjeQ null strains accumulate immature 30S subunits of similar structure and protein complement.

J. Ortega, Vivian Leong, A. Jomaa, 2013, RNA.

Understanding ribosome assembly: the structure of in vivo assembled immature 30S subunits revealed by cryo-electron microscopy.

E. Brown, G. Stewart, J. Maddock, 2011, RNA.

A Malaria Vaccine Adjuvant Based on Recombinant Antigen Binding to Liposomes

J. Ortega, A. Razi, C. King, 2018, Nature Nanotechnology.

Functional Proteolytic Complexes of the Human Mitochondrial ATP-dependent Protease, hClpXP*

A. Steven, J. Ortega, M. Maurizi, 2002, The Journal of Biological Chemistry.

Three‐dimensional reconstruction of a recombinant influenza virus ribonucleoprotein particle

J. Ortega, J. Carrascosa, J. Valpuesta, 2001, EMBO reports.

RbgA ensures the correct timing in the maturation of the 50S subunits functional sites

J. Ortega, M. Oeffinger, R. Britton, 2022, Nucleic acids research.

Rvb1-Rvb2: essential ATP-dependent helicases for critical complexes.

W. Houry, J. Ortega, Y. Kakihara, 2010, Biochemistry and cell biology = Biochimie et biologie cellulaire.

The PA influenza virus polymerase subunit is a phosphorylated protein.

J. Ortega, G. Smith, J. Ortín, 1998, The Journal of general virology.

Yeast Rvb1 and Rvb2 are ATP-dependent DNA helicases that form a heterohexameric complex.

W. Houry, J. Ortega, Anna Gribun, 2008, Journal of molecular biology.

Immunization with short peptide particles reveals a functional CD8+ T-cell neoepitope in a murine renal carcinoma model

Fumito Ito, J. Ortega, M. Tsuji, 2021, Journal for ImmunoTherapy of Cancer.

Position‐Scanning Peptide Libraries as Particle Immunogens for Improving CD8+ T‐Cell Responses

Fumito Ito, J. Ortega, M. Long, 2021, Advanced science.

Development, Antibiotic Production, and Ribosome Assembly in Streptomyces venezuelae Are Impacted by RNase J and RNase III Deletion

J. Ortega, M. Elliot, Vivian Leong, 2014, Journal of bacteriology.

A new system for naming ribosomal proteins.

V. G. Panse, T. Steitz, H. Noller, 2014, Current opinion in structural biology.

The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans

J. Ortega, J. Surtees, E. Alani, 2017, PLoS biology.

Comparison of the multiple oligomeric structures observed for the Rvb1 and Rvb2 proteins.

W. Houry, J. Ortega, Kevin L. Y. Cheung, 2010, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Human Mitochondrial ClpP Is a Stable Heptamer That Assembles into a Tetradecamer in the Presence of ClpX*

J. Ortega, M. Maurizi, A. Ginsburg, 2005, Journal of Biological Chemistry.

The Clp chaperones and proteases of the human malaria parasite Plasmodium falciparum.

G. McFadden, W. Houry, J. Ortega, 2010, Journal of molecular biology.

Ribosomal Proteins: Their Role in the Assembly, Structure and Function of the Ribosome

J. Ortega, A. Razi, 2017 .

Atomic-resolution map of the interactions between an amyloid inhibitor protein and amyloid β (Aβ) peptides in the monomer and protofibril states

J. Ortega, G. Melacini, Rashik Ahmed, 2017, The Journal of Biological Chemistry.

Structural basis for DNA targeting by the Tn7 transposon

J. E. Peters, J. Ortega, J. Gómez-Blanco, 2021, Nature Structural & Molecular Biology.

The cryo-EM structure of YjeQ bound to the 30S subunit suggests a fidelity checkpoint function for this protein in ribosome assembly

J. Ortega, A. Guarné, A. Razi, 2017, Proceedings of the National Academy of Sciences.

Structural determinants stabilizing the axial channel of ClpP for substrate translocation

J. Ortega, Yi-Qiang Cheng, Nabiha Husain, 2013, Molecular microbiology.

Alternative conformations and motions adopted by 30S ribosomal subunits visualized by cryo-electron microscopy

J. Ortega, J. Gómez-Blanco, V. Jha, 2020, bioRxiv.

Streptomyces IHF uses multiple interfaces to bind DNA.

J. Ortega, A. Guarné, A. Razi, 2019, Biochimica et biophysica acta. General subjects.

The Inner Cavity of Escherichia coli DegP Protein Is Not Essentialfor Molecular Chaperone and Proteolytic Activity

R. Ghirlando, Jack Iwanczyk, J. Ortega, 2006, Journal of bacteriology.

Role of the PDZ Domains in Escherichia coli DegP Protein

R. Ghirlando, Jack Iwanczyk, J. Ortega, 2007, Journal of bacteriology.

Binding properties of YjeQ (RsgA), RbfA, RimM and Era to assembly intermediates of the 30S subunit

Joseph H. Davis, J. Ortega, J. Williamson, 2016, Nucleic acids research.

Ultrastructural and Functional Analyses of Recombinant Influenza Virus Ribonucleoproteins Suggest Dimerization of Nucleoprotein during Virus Amplification

J. Ortega, J. Carrascosa, J. Valpuesta, 2000, Journal of Virology.

Antibody Induction in Mice by Liposome-Displayed Recombinant Enterotoxigenic Escherichia coli (ETEC) Colonization Antigens.

J. Ortega, E. Hall, J. Lovell, 2023, Biomedical journal.

A Potent Cancer Vaccine Adjuvant System for Particleization of Short, Synthetic CD8+ T Cell Epitopes.

J. Ortega, S. Abrams, J. Lovell, 2021, ACS nano.

Lyophilized, antigen-bound liposomes with reduced MPLA and enhanced thermostability.

J. Ortega, J. Lovell, C. Long, 2020, International journal of pharmaceutics.

Particle-based, Pfs230 and Pfs25 immunization is effective, but not improved by duplexing at fixed total antigen dose

J. Ortega, J. Lovell, C. Long, 2020, Malaria journal.

Porphyrin–phospholipid liposomes permeabilized by near-infrared light

Shuai Shao, Jonathan F. Lovell, Ravindra K. Pandey, 2014, Nature Communications.

Dual amyloid domains promote differential functioning of the chaplin proteins during Streptomyces aerial morphogenesis

J. Ortega, M. Elliot, A. Jomaa, 2011, Proceedings of the National Academy of Sciences.

Molecular Mechanism for the (-)-Epigallocatechin Gallate-Induced Toxic to Nontoxic Remodeling of Aβ Oligomers.

J. Ortega, B. VanSchouwen, G. Melacini, 2017, Journal of the American Chemical Society.

Structural consequences of the interaction of RbgA with a 50S ribosomal subunit assembly intermediate

J. Ortega, A. Guarné, A. Razi, 2019, Nucleic acids research.

Sphingomyelin Liposomes Containing Porphyrin-phospholipid for Irinotecan Chemophototherapy

J. Ortega, A. Razi, J. Lovell, 2016, Theranostics.

Activation of ClpP protease by ADEP antibiotics: insights from hydrogen exchange mass spectrometry.

J. Ortega, L. Konermann, Yi-Qiang Cheng, 2013, Journal of molecular biology.

Ribosomes in RNA Granules Are Stalled on mRNA Sequences That Are Consensus Sites for FMRP Association

Christos G. Gkogkas, W. Sossin, J. Ortega, 2021, The Journal of Neuroscience.

Binding of an amphiphilic phthalocyanine to pre-formed liposomes confers light-triggered cargo release.

J. Ortega, J. Lovell, K. Carter, 2018, Journal of materials chemistry. B.

Antibody response of a particle-inducing, liposome vaccine adjuvant admixed with a Pfs230 fragment

J. Ortega, J. Lovell, C. Long, 2020, npj Vaccines.

HPV-Associated Tumor Eradication by Vaccination with Synthetic Short Peptides and Particle-Forming Liposomes.

J. Ortega, S. Abrams, J. Lovell, 2021, Small.

Design of Hydrated Porphyrin-phospholipid Bilayers with Enhanced Magnetic Resonance Contrast Bilayers and the Penetration Dedicated to Professor Gang Zheng on the Occasion of His 50th Birthday

Trang N. Do, J. Ortega, M. Karttunen, 2022 .

Cross-linked Histone as a Nanocarrier for Gut Delivery of Hydrophobic Cargos.

J. Xia, J. Ortega, J. Lovell, 2021, ACS Applied Materials and Interfaces.

Antibody response of a particle-inducing, liposome vaccine adjuvant admixed with a Pfs230 fragment

J. Ortega, J. Lovell, C. Long, 2020, npj Vaccines.

Highly-Soluble Cyanine J-aggregates Entrapped by Liposomes for In Vivo Optical Imaging around 930 nm

J. Xia, J. Ortega, Homan Kang, 2019, Theranostics.

Lysine 188 substitutions convert the pattern of proteasome activation by REGgamma to that of REGs alpha and beta.

M. Bogyo, T. Nazif, A. Steven, 2001, EMBO Journal.

The impact of recent improvements in cryo-electron microscopy technology on the understanding of bacterial ribosome assembly.

J. Ortega, A. Razi, R. Britton, 2016, Nucleic Acids Research.

Role of Era in assembly and homeostasis of the ribosomal small subunit

Joseph H. Davis, J. Ortega, J. Gómez-Blanco, 2019, bioRxiv.

Development, Antibiotic Production, and Ribosome Assembly in Streptomyces venezuelae Are Impacted by RNase J and RNase III Deletion

J. Ortega, M. Elliot, Vivian Leong, 2014, Journal of bacteriology.

The C-terminal helix in the YjeQ zinc-finger domain catalyzes the release of RbfA during 30S ribosome subunit assembly

J. Ortega, A. Razi, Ajitha Jeganathan, 2015, RNA.

Design of Hydrated Porphyrin-Phospholipid Bilayers with Enhanced Magnetic Resonance Contrast.

Trang N. Do, J. Ortega, M. Karttunen, 2017, Small.