J. Backer

发表

Assembly and Molecular Architecture of the Phosphoinositide 3-Kinase p85α Homodimer*

Seung Joong Kim, B. Chait, A. Sali, 2015, The Journal of Biological Chemistry.

The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration

J. Condeelis, J. Backer, S. Yip, 2007, Journal of Cell Science.

EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells

J. Condeelis, J. Backer, S. Yip, 2007, The Journal of cell biology.

Assembly of the p 85 α homodimer 1 Assembly and Molecular Architecture of the Phosphoinositide 3-Kinase p 85 α homodimer

Seung Joong Kim, B. Chait, A. Sali, 2015 .

Specific activation of p85-p110 phosphatidylinositol 3'-kinase stimulates DNA synthesis by ras- and p70 S6 kinase-dependent pathways

J. Backer, D. Chen, J. McIlroy, 1997, Molecular and cellular biology.

The Late Endosome is Essential for mTORC1 Signaling

J. Backer, P. Parker, S. Goswami, 2010, Molecular biology of the cell.

Insulin receptor substrate 1 rescues insulin action in CHO cells expressing mutant insulin receptors that lack a juxtamembrane NPXY motif

M. White, J. Backer, D. Chen, 1995, Molecular and cellular biology.

Rab5 regulates motility of early endosomes on microtubules

Anthony A. Hyman, Marino Zerial, A. Hyman, 1999, Nature Cell Biology.

Mechanism of cholesterol exchange between phospholipid vesicles.

J. Backer, E. Dawidowicz, 1981, Biochemistry.

Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition)

Sangeeta Khare, Xin Qi, Ying Wang, 2016 .

N-terminal Domains of the Class IA Phosphoinositide 3-Kinase Regulatory Subunit Play a Role in Cytoskeletal but Not Mitogenic Signaling*

J. Segall, J. Backer, S. Yip, 2001, The Journal of Biological Chemistry.

Mechanism of Two Classes of Cancer Mutations in the Phosphoinositide 3-Kinase Catalytic Subunit

Yuval Inbar, Haim J. Wolfson, Dina Schneidman-Duhovny, 2007, Science.

Mechanism of Constitutive Phosphoinositide 3-Kinase Activation by Oncogenic Mutants of the p85 Regulatory Subunit*

M. Girvin, S. Cahill, Haiyan Wu, 2005, Journal of Biological Chemistry.

Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity

P. Hawkins, L. Stephens, J. Backer, 2015, Cell reports.

Transforming growth factor beta activates Smad2 in the absence of receptor endocytosis.

J. Backer, Huaxi Xu, Ye Guang Chen, 2002, The Journal of biological chemistry.

hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells

Haiyan Wu, J. Backer, Rory J. Flinn, 2008, The Biochemical journal.

The insulin receptor and its substrate: molecular determinants of early events in insulin action.

C. Kahn, K. Siddle, P. Csermely, 1993, Recent progress in hormone research.

Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase

C. Kahn, M. Birnbaum, M. White, 1993, Molecular and cellular biology.

Insulin stimulates tyrosine phosphorylation of multiple high molecular weight substrates in Fao hepatoma cells.

M. White, J. Backer, M. G. Myers, 1992, Biochemistry.

Novel approaches to inhibitor design for the p110β phosphoinositide 3-kinase.

J. Backer, H. Dbouk, 2013, Trends in pharmacological sciences.

Myosin‐IIA heavy chain phosphorylation on S1943 regulates tumor metastasis

A. Bresnick, J. Condeelis, J. Backer, 2018, Experimental cell research.

hVps 15 , but not Ca 2 + / CaM , is required for the activity and regulation of hVps 34 in mammalian cells

J. Backer, Rory J. Flinn, Ying Yan, 2009 .

The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth.

C. Kahn, M. White, J. Backer, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Association of IRS-1 with the insulin receptor and the phosphatidylinositol 3'-kinase. Formation of binary and ternary signaling complexes in intact cells.

M. White, S. Shoelson, J. Backer, 1993, The Journal of biological chemistry.

IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase.

M. White, J. Backer, B. Cheatham, 1993, Endocrinology.

Regulation of Phosphatidylinositol 3′-Kinase by Tyrosyl Phosphoproteins

M. White, J. Backer, D. J. Van Horn, 1995, The Journal of Biological Chemistry.

Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells

J. Downward, P. Hawkins, L. Stephens, 2016, Science Signaling.

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein–coupled receptors (GPCRs)

Roger L. Williams, A. Bresnick, J. Backer, 2013, Proceedings of the National Academy of Sciences.

A biochemical mechanism for the oncogenic potential of the p110β catalytic subunit of phosphoinositide 3-kinase

A. Fiser, J. Backer, Huan Pang, 2010, Proceedings of the National Academy of Sciences.

Inhibition of Autophagy in Mitotic Animal Cells

A. Prescott, J. Backer, S. Brachmann, 2002, Traffic.

Analysis of hVps34/hVps15 interactions with Rab5 in vivo and in vitro.

J. Backer, J. Murray, 2005, Methods in enzymology.

Distinct Phosphoinositide 3-Kinases Mediate Mast Cell Degranulation in Response to G-protein-coupled VersusFcεRI Receptors*

J. Backer, D. Windmiller, 2003, The Journal of Biological Chemistry.

The class II phosphatidylinositol 3 kinase C2beta is required for the activation of the K+ channel KCa3.1 and CD4 T-cells.

Michael Loran Dustin, J. Backer, H. Wulff, 2009, Molecular biology of the cell.

Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus.

C. Kahn, J. Backer, F. Folli, 1993, The Journal of clinical investigation.

NRBF2 regulates macroautophagy as a component of Vps34 Complex I.

Fajun Yang, J. Backer, J. Pessin, 2014, The Biochemical journal.

PIP3 abundance overcomes PI3K signaling selectivity in invadopodia

A. Bresnick, J. Backer, Gerald R. V. Hammond, 2022, FEBS letters.

PI3Kβ links integrin activation and PI(3,4)P2 production during invadopodial maturation

Zahra Erami, A. Bresnick, J. Backer, 2019, Molecular biology of the cell.

Detection of the kinetics of biochemical reactions with oxygen using exchange broadening in the ESR spectra of nitroxide radicals.

S. I. Eremenko, J. Backer, V. Budker, 1977, Biochimica et biophysica acta.

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

Julia M. Hill, C. Peddie, L. Collinson, 2017, Nature Communications.

JCB Article

L. Collinson, J. Backer, C. Futter, 2001 .

Chemotaxis of Cancer Cells during Invasion and Metastasis

J. Segall, J. Condeelis, J. Backer, 2004 .

Discordant Effects of Glucosamine on Insulin-stimulated Glucose Metabolism and Phosphatidylinositol 3-Kinase Activity*

J. Backer, N. Barzilai, L. Rossetti, 1999, The Journal of Biological Chemistry.

Phosphatidylinositol-3,4,5-trisphosphate: tool of choice for class I PI 3-kinases.

J. Backer, R. S. Salamon, 2013, BioEssays : news and reviews in molecular, cellular and developmental biology.

Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase.

C. Kahn, William Arbuthnot Sir Lane, M. White, 1991, The Journal of biological chemistry.

Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat.

C. Kahn, J. Backer, F. Folli, 1992, The Journal of biological chemistry.

Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking.

E. Bedrick, J. Backer, A. Wandinger-Ness, 2008, Molecular biology of the cell.

Myotubularin Lipid Phosphatase Binds the hVPS15/hVPS34 Lipid Kinase Complex on Endosomes

J. Backer, A. Wandinger-Ness, J. Laporte, 2007, Traffic.

Identification of Atypical Peri-Nuclear Multivesicular Bodies in Oxidative and Glycolytic Skeletal Muscle of Aged and Pompe's Disease Mouse Models

J. Backer, J. Pessin, Brian A. Neel, 2015, Front. Physiol..

Cytoplasmic juxtamembrane region of the insulin receptor: a critical role in ATP binding, endogenous substrate phosphorylation, and insulin-stimulated bioeffects in CHO cells.

A. Ullrich, K. Siddle, M. White, 1991, Biochemistry.

The role of insulin receptor kinase domain autophosphorylation in receptor-mediated activities. Analysis with insulin and anti-receptor antibodies.

C. Kahn, K. Siddle, M. White, 1992, The Journal of biological chemistry.

Direct activation of the phosphatidylinositol 3'-kinase by the insulin receptor.

J. Backer, M. G. Myers, D. J. Van Horn, 1994, The Journal of biological chemistry.

Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation.

C. Kahn, M. White, J. Backer, 1992, The Journal of biological chemistry.

The SH2/SH3 domain‐containing protein GRB2 interacts with tyrosine‐phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.

A. Ullrich, M. White, J. Backer, 1993, The EMBO journal.

Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β

Haiyan Wu, J. Backer, Yi Sun, 2011, Proceedings of the National Academy of Sciences.

Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin.

L. Cantley, M. White, B. Schaffhausen, 1991, Molecular endocrinology.

Vps34p differentially regulates endocytosis from the apical and basolateral domains in polarized hepatic cells

J. Backer, A. Hubbard, P. Tuma, 2001, The Journal of cell biology.

Substrate specificity: PI(3)Kγ has it both ways

J. Backer, 2005, Nature Cell Biology.

YXXM Motifs in the PDGF-β Receptor Serve Dual Roles as Phosphoinositide 3-Kinase Binding Motifs and Tyrosine-based Endocytic Sorting Signals*

Haiyan Wu, J. Backer, Ling-Chi Wang, 2003, Journal of Biological Chemistry.

Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis

D. Schwudke, J. Backer, H. Hilbi, 2015, Proceedings of the National Academy of Sciences.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Insulin differentially regulates protein phosphotyrosine phosphatase activity in rat hepatoma cells.

C. Kahn, P. Csermely, S. Shoelson, 1992, Biochemistry.

Novel approaches to inhibitor design for the p110β PI 3-kinase

J. Backer, H. Dbouk, 2013 .

A Rapid Method for Assessing the Distribution of Gold Labeling on Thin Sections

J. Backer, T. Mayhew, G. Griffiths, 2004, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Inhibition of Phosphatidic Acid Synthesis Alters the Structure of the Golgi Apparatus and Inhibits Secretion in Endocrine Cells*

J. Backer, D. Shields, A. Siddhanta, 2000, The Journal of Biological Chemistry.

Regulation of receptor-mediated endocytosis by phorbol esters.

G. King, J. Backer, 1991, Biochemical pharmacology.

Binding kinetics of mutated insulin receptors in transfected cells grown in suspension culture: application to the Tyr----Phe 960 insulin receptor mutant.

M. White, J. Backer, P. De Meyts, 1989, Biochemical and biophysical research communications.

The insulin receptor functions normally in Chinese hamster ovary cells after truncation of the C terminus.

K. Siddle, M. White, J. Backer, 1991, The Journal of biological chemistry.

Phospholipase C gamma negatively regulates Rac/Cdc42 activation in antigen-stimulated mast cells.

J. Backer, M. El-Sibai, 2007, European journal of immunology.

Suppression of mTORC1 activation in acid-α-glucosidase-deficient cells and mice is ameliorated by leucine supplementation.

J. Backer, J. Pessin, Gong-She Yang, 2014, American journal of physiology. Regulatory, integrative and comparative physiology.

Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit.

A. Ullrich, C. Kahn, M. White, 1990, The Journal of biological chemistry.

The atypical Rho family GTPase Wrch-1 regulates focal adhesion formation and cell migration

J. Backer, S. Coniglio, M. Symons, 2007, Journal of Cell Science.

Influence of Mn2+ ion coordination on tRNAVal1 macrostructure and determination of some coordination sites of Mn2+ ions in tRNAVal1

J. Backer, I. Slepneva, S. V. Vocel, 1975 .

Optimizing transmembrane domain helicity accelerates insulin receptor internalization and lateral mobility.

C. Kahn, D. Golan, S. Shoelson, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Phosphorylation of Proteins in the Outer Mitochondrial Membrane by Protein Kinase C

J. Backer, J. Backer, J. Arcoleo, 1987 .

Rac1-stimulated macropinocytosis enhances Gβγ activation of PI3Kβ.

Zahra Erami, A. Bresnick, J. LoPiccolo, 2017, The Biochemical journal.

Regulation of the p85/p110 Phosphatidylinositol 3′-Kinase: Stabilization and Inhibition of the p110α Catalytic Subunit by the p85 Regulatory Subunit

J. Backer, J. McIlroy, Jinghua Yu, 1998, Molecular and Cellular Biology.

The iSH2 domain of PI 3-kinase is a rigid tether for p110 and not a conformational switch.

Haiyan Wu, J. Backer, Z. Fu, 2004, Archives of biochemistry and biophysics.

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

F. Natt, S. Kim, J. Backer, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest

Jean Gruenberg, Vojo Deretic, J. Backer, 2001, The Journal of cell biology.

Fyn Phosphorylates Human MAP-2c on Tyrosine 67*

A. Bresnick, J. Backer, B. Shafit-Zagardo, 2005, Journal of Biological Chemistry.

Reconstitution of a phospholipid flippase from rat liver microsomes

J. Backer, E. Dawidowicz, 1987, Nature.

Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract

V. Arshavsky, A. Bresnick, J. Backer, 2021, Scientific Reports.

Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells.

J. Backer, Ying Yan, E. Skolnik, 2006, Molecular cell.

Hepatic phosphotyrosine phosphatase activity and its alterations in diabetic rats.

C. Kahn, J. Backer, J. Meyerovitch, 1989, The Journal of clinical investigation.

Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation.

B. Peters, Z. Kan, S. Seshagiri, 2009, Cancer cell.

The rapid transmembrane movement of cholesterol in small unilamellar vesicles.

J. Backer, E. Dawidowicz, 1979, Biochimica et biophysica acta.

Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation

S. Grinstein, L. Cantley, J. Backer, 2001, The Journal of cell biology.

Coordination of Mn++ ions at contact sites between tRNA and aminoacyl-tRNA synthetase.

J. Backer, O. Lavrik, L. Weiner, 1975, Biochemical and biophysical research communications.

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

Qing Jun Wang, B. Chait, N. Heintz, 2009, Nature Cell Biology.

Phosphoinositide 3-Kinase p110β Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development

P. Musiani, C. Rommel, Haiyan Wu, 2008, Science Signaling.

Regulation of class III (Vps34) PI3Ks.

J. Backer, Y. Yan, 2007, Biochemical Society transactions.

Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase.

Jeffrey Wyckoff, Evanthia T Roussos, Sumanta Goswami, 2009, Cancer research.

Cell , Tumor , and Stem Cell Biology Differential Enhancement of Breast Cancer Cell Motility and Metastasis by Helical and Kinase Domain Mutations of Class IA Phosphoinositide 3-Kinase

J. Segall, A. Bresnick, J. Condeelis, 2009 .

Quantification of PtdIns(3,4,5)P(3) dynamics in EGF-stimulated carcinoma cells: a comparison of PH-domain-mediated methods with immunological methods.

J. Condeelis, Haiyan Wu, J. Backer, 2008, The Biochemical journal.

RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells.

K. Hahn, J. Condeelis, J. Backer, 2008, Experimental cell research.

WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells

J. Condeelis, J. Backer, M. El-Sibai, 2008, The Journal of cell biology.

Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells

K. Hahn, J. Condeelis, J. Backer, 2007, Journal of Cell Science.

Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation

J. Condeelis, J. Backer, S. Yip, 2004, The Journal of cell biology.

Cofilin determines the migration behavior and turning frequency of metastatic cancer cells

D. Soll, D. Wessels, J. Condeelis, 2007, The Journal of cell biology.

Phospholipase Cγ negatively regulates Rac/Cdc42 activation in antigen‐stimulated mast cells

J. Backer, M. El-Sibai, 2007 .

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

C. Kahn, M. White, J. Backer, 1991, Nature.

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

A. Ullrich, C. Kahn, M. White, 1988, Cell.

Lamellipodia in invasion.

J. Segall, J. Condeelis, J. Backer, 2001, Seminars in cancer biology.

In vitro binding and phosphorylation of insulin receptor substrate 1 by the insulin receptor. Role of interactions mediated by the phosphotyrosine-binding domain and the pleckstrin-homology domain.

J. Backer, C. Wjasow, Y. Zhang, 1997, European journal of biochemistry.

Two steps of insulin receptor internalization depend on different domains of the beta-subunit [published erratum appears in J Cell Biol 1993 Nov;123(4):1047]

L Orci, L. Orci, C. Kahn, 1993, The Journal of cell biology.

Phosphatidylinositol 3-kinase p85 SH2 domain specificity defined by direct phosphopeptide/SH2 domain binding.

J. Schlessinger, S. Shoelson, M. Chaudhuri, 1993, Biochemistry.

Insulin-Stimulat ed OocyteMaturation Requires Insulin Receptor Substrate 1andInteraction withtheSH2Domains ofPhosphatidylinositol 3-Kinase

M. White, J. Backer, C. R. Kahin, 1993 .

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.

M. White, J. Schlessinger, S. Shoelson, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Local signaling by the EGF receptor

J. Segall, J. Backer, S. Yip, 2003, The Journal of cell biology.

Distinct Roles for the p110α and hVPS34 Phosphatidylinositol 3′-Kinases in Vesicular Trafficking, Regulation of the Actin Cytoskeleton, and Mitogenesis

J. Backer, J. McIlroy, Yitao Zhang, 1998, The Journal of cell biology.

Protein Kinase A-Dependent and -Independent Signaling Pathways Contribute to Cyclic AMP-Stimulated Proliferation

M. Birnbaum, J. Backer, G. V. Prendergast, 1999, Molecular and Cellular Biology.

PI3Kβ-A Versatile Transducer for GPCR, RTK, and Small GTPase Signaling.

A. Bresnick, J. Backer, 2019, Endocrinology.

Role of Rab5 in the Recruitment of hVps34/p150 to the Early Endosome

Harald Stenmark, J. Backer, J. Murray, 2002, Traffic.

Wortmannin-sensitive Trafficking Pathways in Chinese Hamster Ovary Cells

J. Backer, C. Wjasow, T. McGraw, 1996, The Journal of Biological Chemistry.

The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals

M. White, S. Shoelson, J. Backer, 1992, The Journal of cell biology.

Insulin receptors internalize by a rapid, saturable pathway requiring receptor autophosphorylation and an intact juxtamembrane region

M. White, S. Shoelson, J. Backer, 1991, The Journal of cell biology.

Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells.

J. Flier, J. Backer, Y. Yamaguchi, 1991, Endocrinology.

Preparation and use of anti-phosphotyrosine antibodies to study structure and function of insulin receptor.

M. White, J. Backer, 1991, Methods in enzymology.

GPCR Signaling Mediates Tumor Metastasis via PI3Kβ.

A. Bresnick, J. Condeelis, J. Backer, 2016, Cancer research.

Characterization of a Tumor-Associated Activating Mutation of the p110β PI 3-Kinase

Haiyan Wu, J. Backer, B. Nürnberg, 2013, PloS one.

The regulation of class IA PI 3-kinases by inter-subunit interactions.

J. Backer, 2010, Current topics in microbiology and immunology.

Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110α and are disrupted in oncogenic p85 mutants

M. Girvin, S. Seshagiri, B. Jaiswal, 2009, Proceedings of the National Academy of Sciences.

Regulation of class IA PI3Ks.

J. Backer, Y. Yan, H. Wu, 2007, Biochemical Society transactions.

Class IA PI3K p110β subunit promotes autophagy through Rab5 small GTPase in response to growth factor limitation.

W. Zong, J. Backer, Yongjun Fan, 2013, Molecular cell.

Class III PI-3-kinase activates phospholipase D in an amino acid–sensing mTORC1 pathway

J. Backer, Mee-Sup Yoon, Jie Chen, 2011, The Journal of cell biology.

The regulation and function of Class III PI3Ks: novel roles for Vps34.

J. Backer, 2008, The Biochemical journal.

The regulation and function of Class III PI 3 Ks : novel roles for Vps 34

J. Backer, 2008 .

PI3Kβ is selectively required for growth factor-stimulated macropinocytosis

Zahra Erami, A. Bresnick, J. Backer, 2019, Journal of Cell Science.

Over-expression of the p110β but not p110α isoform of PI 3-kinase inhibits motility in breast cancer cells

J. Condeelis, Haiyan Wu, J. Backer, 2004 .

hVps34 Is a Nutrient-regulated Lipid Kinase Required for Activation of p70 S6 Kinase*

James T. Murray, J. Backer, J. Murray, 2005, Journal of Biological Chemistry.

The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34.

J. Backer, 2016, The Biochemical journal.

Common and Distinct Elements in Insulin and PDGF Signaling a

C. Kahn, M. White, J. Backer, 1995, Annals of the New York Academy of Sciences.

A beta version of life: p110β takes center stage

J. Backer, H. Dbouk, 2010, Oncotarget.

The structure of p85ni in class IA phosphoinositide 3-kinase exhibits interdomain disorder.

Haiyan Wu, J. Backer, G. Gerfen, 2010, Biochemistry.

G Protein–Coupled Receptor–Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness

Roger L. Williams, R. Taussig, A. Bresnick, 2012, Science Signaling.

Protein – Coupled Receptor – Mediated Activation of p 110 b by G bg Is Required for Cellular Transformation and Invasiveness

Roger L. Williams, R. Taussig, A. Bresnick, 2012 .

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

Julia M. Hill, C. Peddie, L. Collinson, 2017, Nature Communications.

Class I and class III phosphoinositide 3-kinases are required for actin polymerization that propels phagosomes

S. Grinstein, J. Backer, M. Bohdanowicz, 2010, The Journal of cell biology.

Phosphatidylinositol-3-OH kinases are Rab5 effectors

M. Zerial, M. Waterfield, M. Wilm, 1999, Nature Cell Biology.

A single discrete Rab5-binding site in phosphoinositide 3-kinase β is required for tumor cell invasion

David J. Hamelin, Zahra Erami, A. Bresnick, 2019, The Journal of Biological Chemistry.

PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling

J. Backer, E. Hirsch, E. Ciraolo, 2015, Nature Communications.

Expression and function of IRS-1 in insulin signal transmission.

C. Kahn, M. White, J. Backer, 1992, The Journal of biological chemistry.

Phosphoinositide 3-kinases and the regulation of vesicular trafficking.

J. Backer, 2000, Molecular cell biology research communications : MCBRC.

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila

T. P. Neufeld, G. Juhász, T. Neufeld, 2008, The Journal of cell biology.

mTORC1 signals from late endosomes: Taking a TOR of the endocytic system

J. Backer, Rory J. Flinn, 2010, Cell cycle.

S100A4 regulates macrophage invasion by distinct myosin-dependent and myosin-independent mechanisms

A. Bresnick, J. Backer, N. Dulyaninova, 2017, Molecular biology of the cell.

In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation

J. Backer, B. Varnum, Ying Yan, 2008, Journal of neurochemistry.

Role of Rab 5 in the Recruitment of hVps 34 / p 150 to the Early Endosome

J. Backer, J. Murray, H. Stenmark, 2002 .

Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis

J. Segall, T. Smirnova, A. Bresnick, 2011, Oncogene.

Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor.

C. Kahn, M. White, G. King, 1993, The Journal of biological chemistry.

Regulation of the p85/p110alpha phosphatidylinositol 3'-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains.

J. Backer, C. Wjasow, J. Yu, 1998, The Journal of biological chemistry.

The structure of the inter-SH2 domain of class IA phosphoinositide 3-kinase determined by site-directed spin labeling EPR and homology modeling

Eliah Aronoff-Spencer, J. Backer, Z. Fu, 2003, Proceedings of the National Academy of Sciences of the United States of America.

New methods for capturing the mystery lipid, PtdIns5P.

J. Backer, 2010, The Biochemical journal.

Effectively doubling the magnetic field in spin-1/2-spin-1, HSQC, HDQC, coupled HSQC, and coupled HDQC in solution NMR.

M. Girvin, J. Backer, S. Shekar, 2008, The Journal of chemical physics.

Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats.

J. Backer, T. Asano, Hiraku Ono, 2008, The Journal of clinical investigation.

Tyrosine phosphorylation of the insulin receptor is not required for receptor internalization: studies in 2,4-dinitrophenol-treated cells.

C. Kahn, M. White, J. Backer, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Modulation of the insulin growth factor II/mannose 6-phosphate receptor in microvascular endothelial cells by phorbol ester via protein kinase C.

G. Sahagian, G. King, J. Backer, 1990, The Journal of biological chemistry.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

BpaB25 insulins. Photoactivatable analogues that quantitatively cross-link, radiolabel, and activate the insulin receptor.

S. Shoelson, J. Backer, P. Pilch, 1993, The Journal of biological chemistry.

Macropinocytosis: mechanisms and regulation.

A. Bresnick, J. Backer, Gilbert Salloum, 2023, The Biochemical journal.

Tyrosine phosphorylation of the insulin receptor during insulin-stimulated internalization in rat hepatoma cells.

C. Kahn, M. White, J. Backer, 1989, The Journal of biological chemistry.

Specific Requirement for the p85-p110α Phosphatidylinositol 3-Kinase during Epidermal Growth Factor-stimulated Actin Nucleation in Breast Cancer Cells*

J. Segall, J. Condeelis, J. Backer, 2000, The Journal of Biological Chemistry.

Spatiotemporal hippocampal SERT expression during early postnatal life responsible for stress response differences in adulthood

M. Aschner, R. Perez-soler, M. Brenowitz, 2017 .

ALBERT EINSTEIN COLLEGE OF MEDICINE

M. Aschner, M. Brenowitz, J. Backer, 2015 .

Erratum: YXXM motifs in the PDGF-β receptor serve dual roles as phosphoinositide 3-kinase binding motifs and tyrosine-based endocytic sorting signals (The Journal of Biological Chemistry (2003) 278 (40425-40428))

Haiyan Wu, J. Backer, Ling-Chi Wang, 2003 .

PI3Kβ downstream of GPCRs – crucial partners in oncogenesis

Roger L. Williams, J. Backer, O. Vadas, 2012, Oncotarget.

The dissociation and degradation of internalized insulin occur in the endosomes of rat hepatoma cells.

C. Kahn, M. White, J. Backer, 1990, The Journal of biological chemistry.

Purification and Partial Sequence Analysis of pp 185 , the Major Cellular Substrate of the Insulin Receptor Tyrosine Kinase *

William, M. White, J. Backer, 2001 .

Phosphatidylinositol 3′‐kinase is activated by association with IRS‐1 during insulin stimulation.

B. Margolis, M. White, J. Schlessinger, 1992, The EMBO journal.

Over-expression of the p110beta but not p110alpha isoform of PI 3-kinase inhibits motility in breast cancer cells.

J. Condeelis, Haiyan Wu, J. Backer, 2004, Cell motility and the cytoskeleton.

Human VPS34 is required for internal vesicle formation within multivesicular endosomes

L. Collinson, J. Backer, C. Futter, 2001, The Journal of cell biology.

Regulation of the p85/p110α Phosphatidylinositol 3′-Kinase

J. Backer, C. Wjasow, Jinghua Yu, 1998, The Journal of Biological Chemistry.