D. Taatjes

发表

Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH.

Charles H. Greenberg, A. Sali, J. Ranish, 2015, Molecular cell.

The human ΔNp53 isoform triggers metabolic and gene expression changes that activate mTOR and alter mitochondrial function

D. Taatjes, Shih-Chieh Lin, Edward D. Karoly, 2013, Aging cell.

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

N. Hannett, R. Young, Tong Ihn Lee, 2018, Cell.

The Mediator complex: a central integrator of transcription

Dylan J. Taatjes, D. Taatjes, B. L. Allen, 2015, Nature Reviews Molecular Cell Biology.

Mass spectrometric measurement of formaldehyde generated in breast cancer cells upon treatment with anthracycline antitumor drugs.

D. Taatjes, V. Bierbaum, S. Kato, 2000, Chemical research in toxicology.

Activating RNAs associate with Mediator to enhance chromatin architecture and transcription

R. Shiekhattar, D. Taatjes, G. Blobel, 2013, Nature.

Mediator and Cohesin Connect Gene Expression and Chromatin Architecture

David A. Orlando, R. Young, J. Dekker, 2010, Nature.

Human TFIIH Kinase CDK7 Regulates Transcription-Associated Chromatin Modifications.

Jeremy R. Jacobsen, A. Shilatifard, Christopher C. Ebmeier, 2017, Cell reports.

The human Mediator complex: a versatile, genome-wide regulator of transcription.

D. Taatjes, Dylan J Taatjes, 2010, Trends in biochemical sciences.

Regulatory functions of the Mediator kinases CDK8 and CDK19

D. Taatjes, C. Fant, Charli B. Fant, 2018, Transcription.

ΔNp53 and aging

D. Taatjes, Shih-Chieh Lin, 2013, Aging.

All in the family: a portrait of a nuclear receptor co-activator complex.

D. Taatjes, C. Fant, Charli B. Fant, 2015, Molecular cell.

Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes.

N. Hannett, R. Young, Tong Ihn Lee, 2019, Molecular cell.

Evaluation of the Epidoxorubicin–Formaldehyde Conjugate, Epidoxoform, in a Mouse Mammary Carcinoma Model

D. Taatjes, B. Powers, T. Koch, 2002, Cancer investigation.

The Mediator kinase module: an interface between cell signaling and transcription.

D. Taatjes, Olivia Luyties, 2022, Trends in biochemical sciences.

Nuclear targeting and retention of anthracycline antitumor drugs in sensitive and resistant tumor cells.

D. Taatjes, T. Koch, 2001, Current medicinal chemistry.

Chemical Synthesis of the Multiply Phosphorylated and Biotinylated N-Terminal Transactivation Domain of Human p53 (p53TAD)

D. Taatjes, Patrick K. Chaffey, Zhongping Tan, 2017, Synlett.

Transcription regulation enters a new phase

D. Taatjes, J. Goodrich, 2018, Nature.

Backtracked and paused transcription initiation intermediate of Escherichia coli RNA polymerase

S. Weiss, X. Michalet, D. Taatjes, 2016, Proceedings of the National Academy of Sciences.

FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2.

T. Cech, E. Podell, Christopher C. Ebmeier, 2012, Genes & development.

Molecular biology: Mediating transcription and RNA export

D. Taatjes, Jonathan D. Rubin, 2015, Nature.

The Mediator complex as a master regulator of transcription by RNA polymerase II

William F. Richter, D. Taatjes, J. Iwasa, 2022, Nature Reviews Molecular Cell Biology.

Partitioning of cancer therapeutics in nuclear condensates

Patrick M. McCall, Jesse M. Platt, N. Hannett, 2020, Science.

Chemical inhibitors of transcription-associated kinases.

D. Taatjes, Kevin C. Clopper, 2022, Current opinion in chemical biology.

A global atlas of substrate specificities for the human serine/threonine kinome

Jared L. Johnson, O. Elemento, J. Blenis, 2022, bioRxiv.

Systematic mutagenesis of TFIIH subunit p52/Tfb2 identifies residues required for XPB/Ssl2 subunit function and genetic interactions with TFB6

Craig D. Kaplan, J. Ranish, Christopher C. Ebmeier, 2022, The Journal of biological chemistry.

TFIID Enables RNA Polymerase II Promoter-Proximal Pausing.

Zachary L. Maas, D. Taatjes, R. Dowell, 2020, Molecular cell.

Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions.

G. Superti-Furga, D. Taatjes, R. Dowell, 2019, Molecular cell.

Production of formaldehyde and DNA-adriamycin or DNA-daunomycin adducts, initiated through redox chemistry of dithiothreitol/iron, xanthine oxidase/NADH/iron, or glutathione/iron.

D. Taatjes, T. Koch, G. Gaudiano, 1997, Chemical research in toxicology.

A Novel Initiation Pathway in Escherichia Coli Transcription

S. Weiss, X. Michalet, D. Taatjes, 2016, bioRxiv.

Mediator Kinase Inhibition Impedes Transcriptional Plasticity and Prevents Resistance to ERK/MAPK-Targeted Therapy in KRAS-Mutant Cancers

Timothy E. Reddy, E. Petricoin, C. Der, 2022, bioRxiv.

The Continuing SAGA of TFIID and RNA Polymerase II Transcription.

D. Taatjes, 2017, Molecular cell.

Everything at once: cryo-EM yields remarkable insights into human RNA polymerase II transcription

D. Taatjes, Allison C Schier, Allison C. Schier, 2021, Nature Structural & Molecular Biology.

Molecular Architecture of the Human Mediator–RNA Polymerase II–TFIIF Assembly

Patricia Grob, E. Nogales, Christopher C. Ebmeier, 2011, PLoS biology.

Transcription factor enrichment analysis (TFEA): Quantifying the activity of hundreds of transcription factors from a single experiment

Robin D. Dowell, Jacob T. Stanley, Jessica T. Westfall, 2020, bioRxiv.

Structure and mechanism of the RNA polymerase II transcription machinery

D. Taatjes, Allison C Schier, Allison C. Schier, 2020, Genes & development.

Structural visualization of key steps in human transcription initiation

Yuan He, Dylan J. Taatjes, Jie Fang, 2013, Nature.

Studying transcription initiation by RNA polymerase with diffusion‐based single‐molecule fluorescence

S. Weiss, D. Taatjes, E. Lerner, 2017, Protein science : a publication of the Protein Society.

TRIM28 regulates RNA polymerase II promoter proximal pausing and pause release

S. Levine, Christopher C. Ebmeier, D. Taatjes, 2014, Nature Structural &Molecular Biology.

Molecular basis of transcription initiation in Archaea

A. Hoenger, D. Taatjes, S. De Carlo, 2010, Transcription.

The Mediator complex and transcription regulation

Dylan J. Taatjes, Christopher C. Ebmeier, D. Taatjes, 2013, Critical reviews in biochemistry and molecular biology.

p53 activates transcription by directing structural shifts within Mediator

D. Taatjes, Shih-Chieh Lin, Carrie Bernecky, 2010, Nature Structural &Molecular Biology.

Alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin.

K. Resing, D. Taatjes, T. Koch, 1996, Journal of medicinal chemistry.

Mediator Kinase Inhibition Further Activates Super-Enhancer Associated Genes in AML

S. Armstrong, R. Bronson, Christopher C. Ebmeier, 2015, Nature.

CDK8 Kinase Phosphorylates Transcription Factor STAT1 to Selectively Regulate the Interferon Response

D. Taatjes, L. Dölken, Mathias Müller, 2013, Immunity.

Regulatory diversity among metazoan co-activator complexes

R. Tjian, D. Taatjes, M. Marr, 2004, Nature Reviews Molecular Cell Biology.

Identification of Mediator Kinase Substrates in Human Cells using Cortistatin A and Quantitative Phosphoproteomics.

Christopher C. Ebmeier, D. Taatjes, R. Dowell, 2016, Cell reports.

Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3

D. Taatjes, A. J. Donner, J. Espinosa, 2008, The EMBO journal.

Transcription factor enrichment analysis (TFEA) quantifies the activity of multiple transcription factors from a single experiment

Jacob T. Stanley, Rutendo F. Sigauke, Zachary L. Maas, 2021, Communications Biology.

Transcription factor enrichment analysis (TFEA) quantifies the activity of multiple transcription factors from a single experiment

Jacob T. Stanley, Rutendo F. Sigauke, Zachary L. Maas, 2021, Communications Biology.

Mediator and cohesin connect gene expression and chromatin architecture

David A. Orlando, R. Young, J. Dekker, 2011, Nature.

Pol II phosphorylation regulates a switch between transcriptional and splicing condensates

N. Hannett, R. Young, P. Sharp, 2019, Nature.

The essential and multifunctional TFIIH complex

D. Taatjes, Jenna K. Rimel, 2018, Protein science : a publication of the Protein Society.

Transcriptional regulation: it takes a village.

B. Panning, D. Taatjes, 2008, Molecular cell.

Pol II phosphorylation regulates a switch between transcriptional and splicing condensates

N. Hannett, R. Young, P. Sharp, 2019, Nature.

The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function.

D. Taatjes, Carrie Bernecky, Matthew T Knuesel, 2009, Genes & development.

The complex structure and function of Mediator

D. Taatjes, T. M. Harper, 2017, The Journal of Biological Chemistry.

A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 Response

D. Taatjes, R. Dowell, J. Espinosa, 2017, Molecular and Cellular Biology.

CDK8 is a positive regulator of transcriptional elongation within the serum response network

Christopher C. Ebmeier, D. Taatjes, A. J. Donner, 2010, Nature Structural &Molecular Biology.

Structure, Function, and Activator-Induced Conformations of the CRSP Coactivator

Robert Tjian, Eva Nogales, Anders M Näär, 2002, Science.

The Human CDK8 Subcomplex Is a Histone Kinase That Requires Med12 for Activity and Can Function Independently of Mediator

D. Taatjes, A. J. Donner, J. Espinosa, 2008, Molecular and Cellular Biology.

The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair

Christopher C. Ebmeier, D. Taatjes, S. Guard, 2018, bioRxiv.

Multiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNA.

T. Cech, E. Podell, D. Taatjes, 2011, Journal of molecular biology.

The Δ40p53 isoform inhibits p53-dependent eRNA transcription and enables regulation by signal-specific transcription factors during p53 activation

D. Taatjes, R. Dowell, S. Ramamoorthy, 2021, PLoS biology.

RNA polymerase II transcription.

D. Taatjes, 2021, Journal of molecular biology.

Small molecule probes to target the human Mediator complex.

D. Taatjes, A. Phillips, 2013, Israel journal of chemistry.

An atlas of substrate specificities for the human serine/threonine kinome

Jared L. Johnson, O. Elemento, J. Blenis, 2023, Nature.

The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.

B. Clurman, D. Taatjes, J. Swanger, 2013, Genes & development.

Activator-Mediator binding regulates Mediator-cofactor interactions

Christopher C. Ebmeier, D. Taatjes, 2010, Proceedings of the National Academy of Sciences.

Cooperative activity of cdk 8 and GCN 5 L within Mediator directs tandem phosphoacetylation of histone

D. Taatjes, A. J. Donner, J. Espinosa, 2008 .

Structure and function of CRSP/Med2; a promoter-selective transcriptional coactivator complex.

R. Tjian, D. Taatjes, 2004, Molecular cell.

Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation.

R. Tjian, E. Nogales, A. Näär, 2002, Genes & development.

Mediator and post-recruitment regulation of RNA polymerase II

D. Taatjes, Matthew T Knuesel, 2011, Transcription.

Activator-mediator binding stabilizes RNA polymerase II orientation within the human mediator-RNA polymerase II-TFIIF assembly.

D. Taatjes, Carrie Bernecky, 2012, Journal of molecular biology.

Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription

Zachary L. Maas, Jared L. Johnson, J. Marineau, 2020, Genes & development.

Distinct conformational states of nuclear receptor–bound CRSP–Med complexes

Robert Tjian, Tilman Schneider-Poetsch, R. Tjian, 2004, Nature Structural &Molecular Biology.

Redox pathway leading to the alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin.

K. Resing, D. Taatjes, T. Koch, 1997, Journal of medicinal chemistry.

Crystal structure of epidoxorubicin-formaldehyde virtual crosslink of DNA and evidence for its formation in human breast-cancer cells.

D. J. Harrington, E. Podell, D. Taatjes, 1999, Acta crystallographica. Section D, Biological crystallography.

Doxoform and Daunoform: anthracycline-formaldehyde conjugates toxic to resistant tumor cells.

D. Taatjes, D. Fenick, T. Koch, 1997, Journal of medicinal chemistry.

Merging established mechanisms with new insights: Condensates, hubs, and the regulation of RNA polymerase II transcription.

D. Taatjes, Megan Palacio, 2021, Journal of molecular biology.

The role of XPB/Ssl2 dsDNA translocation processivity in transcription-start-site scanning.

D. Taatjes, S. Hahn, S. Tsutakawa, 2021, Journal of molecular biology.

The role of XPB/Ssl2 dsDNA translocation processivity in transcription-start-site scanning

D. Taatjes, S. Hahn, S. Tsutakawa, 2020, bioRxiv.

Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome

D. Taatjes, R. Dowell, D. Bentley, 2023, bioRxiv.

The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair

Christopher C. Ebmeier, D. Taatjes, S. Guard, 2018, Scientific Reports.

Epidoxoform: a hydrolytically more stable anthracycline-formaldehyde conjugate toxic to resistant tumor cells.

D. Taatjes, D. Fenick, T. Koch, 1998, Journal of medicinal chemistry.

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

N. Hannett, Tong Ihn Lee, D. Taatjes, 2018, Cell.

TFIID Enables RNA Polymerase II Promoter-Proximal Pausing.

Zachary L. Maas, D. Taatjes, R. Dowell, 2020, Molecular cell.

Structural visualization of key steps in human transcription initiation

E. Nogales, D. Taatjes, Jie Fang, 2013, Nature.

Suppression of p53 response by targeting p53-Mediator binding with a stapled peptide

A. Schepartz, Christopher C. Ebmeier, D. Taatjes, 2019, bioRxiv.

Multiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNA.

T. Cech, E. Podell, D. Taatjes, 2011, Journal of molecular biology.

Mediator and Can Function Independently of Kinase That Requires Med12 for Activity the Human Cdk8 Subcomplex Is a Histone

D. Taatjes, A. J. Donner, Matthew T Knuesel, 2008 .

Nuclear targeting and nuclear retention of anthracycline-formaldehyde conjugates implicates DNA covalent bonding in the cytotoxic mechanism of anthracyclines.

D. Taatjes, D. Fenick, T. Koch, 1999, Chemical research in toxicology.

Mediator kinase inhibition impedes transcriptional plasticity and prevents resistance to ERK/MAPK-targeted therapy in KRAS-mutant cancers

C. Der, D. Taatjes, Merve Cakir, 2024, NPJ precision oncology.

A redox pathway leading to the alkylation of nucleic acids by doxorubicin and related anthracyclines: application to the design of antitumor drugs for resistant cancer.

D. Taatjes, D. Fenick, T. Koch, 1970, Current pharmaceutical design.