H. Wakimoto

发表

Single-Cell Resolution of Temporal Gene Expression during Heart Development.

J. Seidman, B. Bruneau, W. Pu, 2016, Developmental cell.

De novo mutations in histone modifying genes in congenital heart disease

Murim Choi, Hongyu Zhao, Alexander E. Lopez, 2013, Nature.

Cells of the adult human heart

Catherine L. Worth, Hao Zhang, S. Teichmann, 2020, Nature.

Dissecting spatio-temporal protein networks driving human heart development and related disorders

Francisco S. Roque, S. Brunak, J. Seidman, 2010, Molecular systems biology.

Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development

Ayellet V. Segrè, M. Daly, J. Rosenfeld, 2012, Proceedings of the National Academy of Sciences.

Nkx2.5 homeoprotein regulates expression of gap junction protein connexin 43 and sarcomere organization in postnatal cardiomyocytes.

W. Manning, P. Kang, C. Berul, 2003, Journal of molecular and cellular cardiology.

A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5.

J. Seidman, C. Seidman, C. Berul, 2002, Cold Spring Harbor symposia on quantitative biology.

Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoprotein.

W. Manning, C. Berul, H. Wakimoto, 2001, The Journal of clinical investigation.

Maturational Atrioventricular Nodal Physiology in the Mouse

C. Berul, H. Wakimoto, C. Maguire, 2000, Journal of cardiovascular electrophysiology.

Prevention of Ventricular Arrhythmia and Calcium Dysregulation in a Catecholaminergic Polymorphic Ventricular Tachycardia Mouse Model Carrying Calsequestrin‐2 Mutation

J. Seidman, C. Seidman, C. Berul, 2011, Journal of cardiovascular electrophysiology.

Slow progressive conduction and contraction defects in loss of Nkx2–5 mice after cardiomyocyte terminal differentiation

H. Wakimoto, K. Chien, K. Robertson, 2009, Laboratory Investigation.

Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy

J. Seidman, E. Olson, C. Seidman, 2010, Proceedings of the National Academy of Sciences.

Isolation of Single‐Stranded DNA

H. Wakimoto, Jianming Jiang, Yuji Wakimoto, 2014, Current protocols in molecular biology.

Control of an Epidemic Oral Candidiasis in the Neonatal Room

H. Wakimoto, S. Kimura, K. Okuzumi, 2002 .

Cardiomyocyte Proliferative Capacity Is Restricted in Mice With Lmna Mutation

J. Seidman, C. Seidman, H. Wakimoto, 2021, Frontiers in Cardiovascular Medicine.

Pheochromocytoma-Induced Cardiomyopathy is Modulated by the Synergistic Effects of Cell-Secreted Factors

J. Seidman, E. Edelman, A. Baker, 2009, Circulation. Heart failure.

Hand Hygiene Compliance in a Pediatric Long-term Care Facility

H. Wakimoto, H. Yano, K. Terashima, 2015 .

BET Bromodomain Proteins Regulate Transcriptional Reprogramming in Genetic Dilated Cardiomyopathy

Saptarsi M. Haldar, Michael A. Burke, J. Seidman, 2020, bioRxiv.

Issues to Be Addressed by Nurses to Establish Regional Infection Prevention System against Drug-Resistant Bacteria: Interview Survey of Nurses in Charge of Infection Control in Hospitals with Less than 300 Beds or Clinics and Public Health Nurses

H. Wakimoto, H. Maeda, Kimiyo Nanke, 2013 .

In Vivo Electrophysiologic Studies in Endothelial Nitric Oxide Synthase (eNOS)‐Deficient Mice

C. Berul, H. Wakimoto, T. Michel, 2001, Journal of cardiovascular electrophysiology.

LAMP2 Cardiomyopathy: Consequences of Impaired Autophagy in the Heart

J. Seidman, W. Roberts, B. Maron, 2021, Journal of the American Heart Association.

Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy

J. F. Staples, E. Ashley, S. Colan, 2020, Circulation.

Precordial leads QRST time integrals for evaluation of right ventricular overload in children with congenital heart diseases.

H. Wakimoto, T. Sawanobori, M. Hiraoka, 1997, Journal of electrocardiology.

A Targeted Disruption in Connexin40 Leads to Distinct Atrioventricular Conduction Defects

C. Berul, H. Wakimoto, D. Paul, 2000, Journal of Interventional Cardiac Electrophysiology.

Yin Yang 1 Suppresses Dilated Cardiomyopathy and Cardiac Fibrosis Through Regulation of Bmp7 and Ctgf.

J. Seidman, C. Seidman, H. Wakimoto, 2019, Circulation research.

Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies

Catherine L. Worth, S. Teichmann, J. Seidman, 2022, Science.

MYBPC3 Mutations cause Hypertrophic Cardiomyopathy by Dysregulating Myosin: Implications for Therapy

J. Seidman, H. Watkins, C. Seidman, 2018, bioRxiv.

Title : Hypertrophic Cardiomyopathy Mutations in MYBPC 3 Dysregulate Myosin : Implications for Therapy

J. Seidman, H. Watkins, H. Wakimoto, 2018 .

Implications of ventricular arrhythmia vulnerability during murine electrophysiology studies.

K. Gauvreau, P. Hammer, C. Berul, 2003, Physiological genomics.

Histone deacetylase inhibitors enhance oncolytic herpes simplex virus therapy for malignant meningioma

H. Wakimoto, R. Martuza, S. Rabkin, 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Changes in body surface potential distributions induced by isoproterenol and Na channel blockers in patients with the Brugada syndrome.

H. Wakimoto, T. Sawanobori, M. Hiraoka, 2004, International journal of cardiology.

Nkx 2-5 mutation causes anatomic hypoplasia of the cardiac conduction system

D. Roden, C. Berul, H. Wakimoto, 2022 .

[Antimicrobial susceptibility and serotype distribution in perinatal group B Streptococcus isolates--a 1999-2009 multicenter study].

H. Wakimoto, T. Hasegawa, Hiroko Sato, 2011, Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases.

Cardiac electrophysiological phenotypes in postnatal expression of Nkx2.5 transgenic mice

C. Berul, H. Wakimoto, S. Izumo, 2003, Genesis.

Developmentally Modulated Cardiac Conduction Failure in Transgenic Mice with Fetal or Postnatal Overexpression of DNA Nonbinding Mutant Nkx2.5

C. Berul, H. Wakimoto, S. Izumo, 2002, Journal of cardiovascular electrophysiology.

Mouse Model of Human Congenital Heart Disease: Progressive Atrioventricular Block Induced by a Heterozygous Nkx2-5 Homeodomain Missense Mutation

Robert H. Anderson, H. Wakimoto, M. Silberbach, 2015, Circulation. Arrhythmia and electrophysiology.

Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model

J. Seidman, L. Leinwand, N. Hübner, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Absence of Msx2 Does Not Affect Cardiac Conduction or Rescue Conduction Defects Associated with Nkx2‐5 Mutation

C. Berul, H. Wakimoto, S. Izumo, 2005, Journal of cardiovascular electrophysiology.

Pathogenesis of Cardiomyopathy Caused by Variants in ALPK3, an Essential Pseudokinase in the Cardiomyocyte Nucleus and Sarcomere

S. Gygi, J. Seidman, J. Paulo, 2022, Circulation.

Macrophages Facilitate Electrical Conduction in the Heart

Andrej J. Savol, P. Libby, J. Seidman, 2017, Cell.

IL-11 is a crucial determinant of cardiovascular fibrosis

S. V. Heesch, J. Seidman, E. Petretto, 2017, Nature.

Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma

Monica Stanciu, H. Wakimoto, R. Martuza, 2019, Nature Communications.

Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis.

J. Seidman, Da-Zhi Wang, W. Pu, 2015, The Journal of clinical investigation.

Cardiac myosin binding protein C regulates postnatal myocyte cytokinesis

Gregory M. Fomovsky, Richard T. Lee, J. Seidman, 2015, Proceedings of the National Academy of Sciences.

Allele-Specific Silencing of Mutant Myh6 Transcripts in Mice Suppresses Hypertrophic Cardiomyopathy

Christine E. Seidman, J. Seidman, C. Seidman, 2013, Science.

De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies

Stephan J Sanders, M. Daly, W. Chung, 2015, Science.

Cells and gene expression programs in the adult human heart

Matthias Heinig, Daniel Reichart, Sarah A. Teichmann, 2020, bioRxiv.

Isolation of Nuclei from Mammalian Cells and Tissues for Single‐Nucleus Molecular Profiling

J. Seidman, N. Hübner, C. Seidman, 2021, Current protocols.

5'RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy.

J. Seidman, M. Bulyk, P. D. De Jager, 2014, The Journal of clinical investigation.

Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation.

J. Seidman, R. Kucherlapati, B. Neel, 2010, The Journal of clinical investigation.

Loss of epigenetic information as a cause of mammalian aging

Andreas R. Pfenning, Brendan L. O’Connell, Margarita V. Meer, 2023, Cell.

Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice

Gregory A. Newby, J. Seidman, H. Wakimoto, 2023, Nature Medicine.

Genetic Variants Associated With Cancer Therapy–Induced Cardiomyopathy

Parth N. Patel, J. Seidman, D. O’Regan, 2019, Circulation.

Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin

Christine E Seidman, Sakthivel Sadayappan, J. Seidman, 2019, Science Translational Medicine.

Abstract 571: MYBPC3 Mutations Cause Hypertrophic Cardiomyopathy by Dysregulating Myosin: Implications for Therapy

J. Seidman, H. Watkins, C. Seidman, 2018, Circulation Research.

A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice

Christine E. Seidman, James A. Spudich, Robert S. McDowell, 2016, Science.

Dissection of Chromosome 18 Blood Pressure and Salt-Sensitivity Quantitative Trait Loci in the Spontaneously Hypertensive Rat

Nathan R. Qi, J. Seidman, T. Kurtz, 2009, Hypertension.

Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β.

Roger R Markwald, Christine E Seidman, J. Schmitt, 2010, The Journal of clinical investigation.

AAV9 Delivery of shRNA to the Mouse Heart

J. Seidman, H. Wakimoto, Jianming Jiang, 2016, Current protocols in molecular biology.

Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins.

C. Berul, H. Wakimoto, M. Donoghue, 2003, Journal of molecular and cellular cardiology.

Augmentation of QRS Wave Amplitudes in the Precordial Leads During Narrow QRS Tachycardia

K. Hirao, H. Wakimoto, M. Hiraoka, 2000, Journal of cardiovascular electrophysiology.

Perinatal Loss of Nkx2-5 Results in Rapid Conduction and Contraction Defects

H. Wakimoto, Y. Ikeda, K. Chien, 2008, Circulation research.

Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease.

Ferhaan Ahmad, J. Seidman, G. Fishman, 2008, Journal of molecular and cellular cardiology.

Analysis of T wave changes by activation recovery interval in patients with atrial septal defect.

T Sawanobori, H. Wakimoto, T. Sawanobori, 2000, International journal of cardiology.

Induction of atrial tachycardia and fibrillation in the mouse heart.

J. Triedman, P. Hammer, C. Berul, 2001, Cardiovascular research.

Loss of RNA expression and allele-specific expression associated with congenital heart disease

Yufeng Shen, Andrew J Sharp, Nihir Patel, 2016, Nature Communications.

Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage.

J. Seidman, J. Balschi, C. Seidman, 2007, The Journal of clinical investigation.

Electrophysiological characterization of murine myocardial ischemia and infarction

Richard T. Lee, A. Ducharme, C. Berul, 2001, Basic Research in Cardiology.

Molecular profiling of dilated cardiomyopathy that progresses to heart failure.

Michael A. Burke, J. Seidman, C. Seidman, 2016, JCI insight.

A Broad Phenotypic Screen Identifies Novel Phenotypes Driven by a Single Mutant Allele in Huntington’s Disease CAG Knock-In Mice

Edith T. Lopez, H. Fuchs, T. Gillis, 2013, PloS one.

Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter

V. Mootha, J. Seidman, C. Seidman, 2017, Proceedings of the National Academy of Sciences.

Comparison of Two Murine Models of Familial Hypertrophic Cardiomyopathy

F J Schoen, James O. Mudd, D. Kass, 2001, Circulation research.

Characterization of Cardiac Conduction System Abnormalities in Mice with Targeted Disruption of Six5 Gene

C. Berul, H. Wakimoto, S. Reddy, 2002, Journal of Interventional Cardiac Electrophysiology.

Phenotypic screening for heart rate variability in the mouse.

J K Triedman, J. Triedman, P. Hammer, 2000, American journal of physiology. Heart and circulatory physiology.

Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system.

D. Roden, C. Berul, H. Wakimoto, 2004, The Journal of clinical investigation.

Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis.

Michael A. Burke, J. Seidman, R. Gerszten, 2017, Cell reports.

Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis.

Michael A. Burke, J. Seidman, R. Gerszten, 2016, Cell reports.

DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging

J. Seidman, S. Bonasera, K. Tsubota, 2019, bioRxiv.

[Prevention of vertical transmission of Group B Streptococcus].

H. Wakimoto, M. Mizokami, K. Okuzumi, 2005, Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases.

Efficacy and safety of full‐dose dabrafenib and trametinib combination therapy in a patient on hemodialysis with metastatic melanoma

H. Wakimoto, R. Irisawa, K. Harada, 2020, International journal of dermatology.

Tbx5 maintains atrial identity by regulating an atrial enhancer network

J. Seidman, W. Pu, C. Seidman, 2023, bioRxiv.

Elements Affecting the Formation of Maternal Sense : Recollections of Maternity Acquired during Puberty in Parturient Women

H. Wakimoto, Ritsuko Nakajima, M. Kitagawa, 2013 .

Cardiac expression of human type 2 iodothyronine deiodinase increases glucose metabolism and protects against doxorubicin-induced cardiac dysfunction in male mice.

Jong Hun Kim, P. Larsen, R. Friedline, 2013, Endocrinology.

Relationships of Circulating Nitrite/Nitrate Levels to Severity and Multiple Organ Dysfunction Syndrome in Systemic Inflammatory Response Syndrome

H. Wakimoto, C. Mitaka, Y. Hirata, 2003, Shock.

Ventricular Arrhythmia Vulnerability in Cardiomyopathic Mice With Homozygous Mutant Myosin-Binding Protein C Gene

J. Seidman, C. Seidman, C. Berul, 2001, Circulation.

as a genetic modifier in cardiomyopathy

M. Bulyk, A. Aboukhalil, C. Seidman, 2014 .

Pulsed field gel electrophoresis analysis conditions for molecular epidemiological identification of vertical Group B Streptococcus infection.

H. Wakimoto, M. Mizokami, K. Okuzumi, 2005, Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases.

Photodynamic augmentation of oncolytic virus therapy for central nervous system malignancies.

T. Hasan, H. Wakimoto, R. Martuza, 2023, Cancer letters.

Prevalence and Clinical Consequences of Multiple Pathogenic Variants in Dilated Cardiomyopathy

S. Heymans, H. Brunner, H. Wakimoto, 2023, Circulation. Genomic and precision medicine.

Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system.

D. Roden, C. Berul, H. Wakimoto, 2004, The Journal of clinical investigation.

Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development

M. Daly, J. Rosenfeld, L. Shaffer, 2012, Proceedings of the National Academy of Sciences.

De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies

Stephan J Sanders, M. Daly, W. Chung, 2015, Science.

Loss of epigenetic information as a cause of mammalian aging

Andreas R. Pfenning, Brendan L. O’Connell, Margarita V. Meer, 2023, Cell.

Tbx5 maintains atrial identity in postnatal cardiomyocytes by regulating an atrial-specific enhancer network

Vassilios J. Bezzerides, H. Wakimoto, Carlos Perez-Cervantes, 2023, Nature Cardiovascular Research.

Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy

J. Seidman, E. Olson, C. Seidman, 2010, Proceedings of the National Academy of Sciences.

Prevention of Ventricular Arrhythmia and Calcium Dysregulation in a Catecholaminergic Polymorphic Ventricular Tachycardia Mouse Model Carrying Calsequestrin‐2 Mutation

J. Seidman, C. Seidman, C. Berul, 2011, Journal of cardiovascular electrophysiology.

Paradoxical adverse events in the oral cavity caused by anti‐tumor necrosis factor‐α therapy for pustulotic arthro‐osteitis

H. Wakimoto, Y. Kato, N. Yokogawa, 2020, The Journal of dermatology.

Quantification of gene transcripts with deep sequencing analysis of gene expression (DSAGE) using 1 to 2 µg total RNA.

H. Wakimoto, S. DePalma, Danos C. Christodoulou, 2011, Current protocols in molecular biology.

Inhibition of miR-199a-3p in a murine hypertrophic cardiomyopathy (HCM) model attenuates fibrotic remodeling

A. Zampetaki, H. Wakimoto, T. Barwari, 2023, Journal of Molecular and Cellular Cardiology plus.