Xichen Lin

发表

Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms.

Mark S. Sundrud, A. Regev, R. Young, 2014, Immunity.

Discovery of Tertiary Amine and Indole Derivatives as Potent RORγt Inverse Agonists.

J. D. Elliott, Yonghui Wang, Zhijun Xiang, 2014, ACS medicinal chemistry letters.

Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists.

Wei Zhang, Xichen Lin, R. Copley, 2018, Journal of medicinal chemistry.

Discovery of CNS Penetrant CXCR2 Antagonists for the Potential Treatment of CNS Demyelinating Disorders.

J. D. Elliott, Wei Zhang, Yan Xu, 2016, ACS medicinal chemistry letters.

Indole-propionic acid derivatives as potent, S1P3-sparing and EAE efficacious sphingosine-1-phosphate 1 (S1P1) receptor agonists.

J. D. Elliott, Wei Zhang, Yan Xu, 2012, Bioorganic & medicinal chemistry letters.

Development of efficient new methodology for generation, cyclization and functional trapping of iminyl and amidyl radicals

Xichen Lin, D. Stien, S. Weinreb, 2001 .

Mild and Regioselective N-Alkylation of 2-Pyridones in Water

Ting-Hai Yang, Xichen Lin, X. Dai, 2015 .

A catalyst-free N–H insertion/Mannich-type reaction cascade of α-nitrodiazoesters

J. D. Elliott, Xichen Lin, Ting Yang, 2013 .

A mild and efficient carboxylate-directed C–H arylation of aryl carboxylic acids with iodobenzenes in water

J. D. Elliott, Xichen Lin, Ting Yang, 2015 .

Model studies on total synthesis of the chartellines, spirocyclic β-lactam alkaloids from a marine bryozoan

Xichen Lin, S. Weinreb, 2001 .

Chiral 2-aminopyrimidin-4(1H)-one derivative as the novel bifunctional organocatalyst: enantioselective Aldol reaction of isatins with ketones

Xichen Lin, Jianyu Xu, Jian Li, 2015 .

Explorations on the total synthesis of the unusual marine alkaloid chartelline A.

Xichen Lin, S. Weinreb, Cuixiang Sun, 2006, The Journal of organic chemistry.

2-Aminopyrimidin-4(1H)-one as the novel bioisostere of urea: discovery of novel and potent CXCR2 antagonists.

J. D. Elliott, Wei Zhang, Xichen Lin, 2014, Bioorganic & medicinal chemistry letters.

Efficient and C2-selective arylation of indoles, benzofurans, and benzothiophenes with iodobenzenes in water at room temperature

Xichen Lin, Ting Yang, Yulong Xu, 2015 .

A mild new procedure for production, cyclization and trapping of amidyl radicals: application to a formal total synthesis of peduncularine

Xichen Lin, D. Stien, S. Weinreb, 2000 .

A Catalyst‐Free N—H Insertion/Mannich‐Type Reaction Cascade of α‐Nitrodiazoesters.

J. D. Elliott, Xichen Lin, Ting Yang, 2013 .

Novel complex crystal structure of prolyl hydroxylase domain-containing protein 2 (PHD2): 2,8-Diazaspiro[4.5]decan-1-ones as potent, orally bioavailable PHD2 inhibitors.

J. D. Elliott, Wei Zhang, Xichen Lin, 2013, Bioorganic & medicinal chemistry.

Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors.

J. D. Elliott, Yonghui Wang, Zhijun Xiang, 2015, ACS medicinal chemistry letters.

Discovery of novel 1,2,4-thiadiazole derivatives as potent, orally active agonists of sphingosine 1-phosphate receptor subtype 1 (S1P(1)).

J. D. Elliott, Wei Zhang, Xichen Lin, 2012, Journal of medicinal chemistry.

3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent.

J. Boehm, P. Bamborough, Wei-Chang Fu, 2018, ACS medicinal chemistry letters.

Discovery of novel N-(5-(arylcarbonyl)thiazol-2-yl)amides and N-(5-(arylcarbonyl)thiophen-2-yl)amides as potent RORγt inhibitors.

J. D. Elliott, Wei Zhang, Yonghui Wang, 2014, Bioorganic & medicinal chemistry.

Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent RORγt inverse agonists.

J. D. Elliott, Wei Zhang, Yonghui Wang, 2015, Bioorganic & medicinal chemistry.

Discovery of thiadiazole amides as potent, S1P₃-sparing agonists of sphingosine-1-phosphate 1 (S1P₁) receptor.

J. D. Elliott, Wei Zhang, Yonghui Wang, 2012, Bioorganic & medicinal chemistry letters.

From RORγt Agonist to Two Types of RORγt Inverse Agonists.

Yonghui Wang, M. Lobera, Zhijun Xiang, 2018, ACS medicinal chemistry letters.

Design and development of arrayable syntheses to accelerate SAR studies of pyridopyrimidinone and pyrimidopyrimidinone

Zehong Wan, Xichen Lin, J. Callahan, 2009 .

Discovery of thiadiazole amides as potent, S1P₃-sparing agonists of sphingosine-1-phosphate 1 (S1P₁) receptor.

J. D. Elliott, Wei Zhang, Yonghui Wang, 2012, Bioorganic & medicinal chemistry letters.