J. P. Kennedy

发表

Insulin Reveals Akt Signaling as a Novel Regulator of Norepinephrine Transporter Trafficking and Norepinephrine Homeostasis

S. Robertson, Heinrich J.G. Matthies, W. A. Owens, 2010, The Journal of Neuroscience.

Application of combinatorial chemistry science on modern drug discovery.

Craig W Lindsley, J. P. Kennedy, C. Lindsley, 2008, Journal of combinatorial chemistry.

Centrally Active Allosteric Potentiators of the M4 Muscarinic Acetylcholine Receptor Reverse Amphetamine-Induced Hyperlocomotor Activity in Rats

S. Jadhav, J. P. Kennedy, C. Lindsley, 2008, Journal of Pharmacology and Experimental Therapeutics.

A novel class of H3 antagonists derived from the natural product guided synthesis of unnatural analogs of the marine bromopyrrole alkaloid dispyrin.

J. P. Kennedy, C. Lindsley, P. Conn, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and Structure–Activity Relationships of Allosteric Potentiators of the M4 Muscarinic Acetylcholine Receptor

J. P. Kennedy, C. Lindsley, P. Conn, 2009, ChemMedChem.

Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS.

S. Fesik, A. Waterson, O. Rossanese, 2018, ACS medicinal chemistry letters.

Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.

J. P. Kennedy, C. Lindsley, C. Hopkins, 2010, Bioorganic & medicinal chemistry letters.

Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.

J. P. Kennedy, C. Lindsley, C. Hopkins, 2010, Bioorganic & medicinal chemistry letters.

Total synthesis of Eudistomins Y1–Y6

J. P. Kennedy, C. Lindsley, Micah L. Breininger, 2009 .

Progress towards the synthesis of piperazimycin A: synthesis of the non-proteogenic amino acids and elaboration into dipeptides

J. P. Kennedy, C. Lindsley, 2010 .

Progress toward the synthesis of piperazimycin A : exploration of the synthesis of γ-hydroxy and γ-chloropiperazic acids

J. P. Kennedy, C. Lindsley, J. T. Brogan, 2008 .

Lead Optimization in Drug Discovery

Thomas M. Bridges, Craig W. Lindsley, David Weaver, 2008 .

Inhibition of Mammalian Target of Rapamycin Is Required for Optimal Antitumor Effect of HER2 Inhibitors against HER2-Overexpressing Cancer Cells

J. P. Kennedy, C. Lindsley, C. Arteaga, 2009, Clinical Cancer Research.

A Selective Allosteric Potentiator of the M1 Muscarinic Acetylcholine Receptor Increases Activity of Medial Prefrontal Cortical Neurons and Restores Impairments in Reversal Learning

M. Quirk, A. Levey, E. Christian, 2009, The Journal of Neuroscience.

Cancer Therapy : Preclinical Inhibition of Mammalian Target of Rapamycin Is Required for Optimal Antitumor Effect of HER 2 Inhibitors against HER 2-Overexpressing Cancer Cells

J. P. Kennedy, C. Lindsley, C. Arteaga, 2009 .

Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties.

J. P. Kennedy, C. Lindsley, P. Conn, 2008, Bioorganic & medicinal chemistry letters.

Novel Selective Allosteric Activator of the M1 Muscarinic Acetylcholine Receptor Regulates Amyloid Processing and Produces Antipsychotic-Like Activity in Rats

A. Deutch, A. Levey, R. Kessler, 2008, The Journal of Neuroscience.

Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists.

D. Sheffler, J. P. Kennedy, C. Lindsley, 2008, Bioorganic & medicinal chemistry letters.

Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer.

G. Mills, J. P. Kennedy, C. Lindsley, 2009, Cancer research.

Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.

S. Fesik, A. Waterson, O. Rossanese, 2018, Journal of medicinal chemistry.

Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange

E. Olejniczak, S. Fesik, A. Waterson, 2014, Proceedings of the National Academy of Sciences.

Structures of Clostridium botulinum Neurotoxin Serotype A Light Chain complexed with small-molecule inhibitors highlight active-site flexibility.

Kim D Janda, Saul Tzipori, Nicholas R Silvaggi, 2007, Chemistry & biology.

Akt-dependent and isoform-specific regulation of dopamine transporter cell surface expression.

J. Javitch, S. Russo, J. P. Kennedy, 2010, ACS chemical neuroscience.

Dysregulation of the Norepinephrine Transporter Sustains Cortical Hypodopaminergia and Schizophrenia-Like Behaviors in Neuronal Rictor Null Mice

D. Polley, J. Veenstra-VanderWeele, S. Robertson, 2010, PLoS biology.

Impaired Striatal Akt Signaling Disrupts Dopamine Homeostasis and Increases Feeding

Scott J. Russo, Craig W. Lindsley, R. Neve, 2011, PloS one.

Genetic Recombination During Transformation in Bacillus subtilis : Appearance of a Deoxyribonucleic Acid Methylase

J. P. Kennedy, 2022 .

Diphenylpyrazoles as replication protein a inhibitors.

S. Fesik, B. Vangamudi, A. Waterson, 2015, ACS medicinal chemistry letters.

Discovery of a potent inhibitor of replication protein a protein-protein interactions using a fragment-linking approach.

S. Fesik, B. Vangamudi, A. Waterson, 2013, Journal of medicinal chemistry.

Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A.

S. Fesik, B. Vangamudi, A. Waterson, 2013, ACS medicinal chemistry letters.

Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system.

S. Jadhav, J. Meiler, Z. Xiang, 2010, ACS chemical neuroscience.

Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system.

S. Jadhav, J. Meiler, Z. Xiang, 2010, ACS chemical neuroscience.

Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin a inhibitors.

Kim D Janda, Saul Tzipori, Grant E Boldt, 2006, Journal of combinatorial chemistry.

Identification of a potent botulinum neurotoxin a protease inhibitor using in situ lead identification chemistry.

Kim D Janda, Grant E Boldt, J. P. Kennedy, 2006, Organic letters.

Superactivation of the botulinum neurotoxin serotype A light chain metalloprotease: a new wrinkle in botulinum neurotoxin.

J. P. Kennedy, K. Janda, T. Dickerson, 2006, Journal of the American Chemical Society.

Evaluation of "credit card" libraries for inhibition of HIV-1 gp41 fusogenic core formation.

J. P. Kennedy, K. Janda, Hong Lu, 2006, Journal of combinatorial chemistry.

Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators.

J. P. Kennedy, C. Lindsley, C. Hopkins, 2010, Bioorganic & medicinal chemistry letters.

Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer.

G. Mills, J. P. Kennedy, C. Lindsley, 2009, Cancer Research.

A novel class of H3 antagonists derived from the natural product guided synthesis of unnatural analogs of the marine bromopyrrole alkaloid dispyrin.

J. P. Kennedy, C. Lindsley, P. Conn, 2009, Bioorganic & medicinal chemistry letters.

Total synthesis and biological evaluation of the marine bromopyrrole alkaloid dispyrin: elucidation of discrete molecular targets with therapeutic potential.

J. P. Kennedy, C. Lindsley, J. Brogan, 2008, Journal of natural products.

Centrally Active Allosteric Potentiators of the M4 Muscarinic Acetylcholine Receptor Reverse Amphetamine-Induced Hyperlocomotor Activity in Rats

S. Jadhav, J. P. Kennedy, C. Lindsley, 2008, Journal of Pharmacology and Experimental Therapeutics.