G. Parkinson

发表

New parameters for the refinement of nucleic acid-containing structures.

H. Berman, L. Clowney, A. Brünger, 1996, Acta crystallographica. Section D, Biological crystallography.

Towards the Inhibition of Protein–Protein Interactions (PPIs) in STAT3: Insights into a New Class of Benzothiadiazole Derivatives

G. Parkinson, A. Pedretti, M. Mori, 2020, Molecules.

G‐quadruplexes: Emerging roles in neurodegenerative diseases and the non‐coding transcriptome

G. Parkinson, S. Neidle, A. Isaacs, 2015, FEBS letters.

Quadruplex DNA: sequence, topology and structure

Sarah W. Burge, G. Parkinson, S. Neidle, 2006, Nucleic acids research.

Crystal structure of parallel quadruplexes from human telomeric DNA

Stephen Neidle, G. Parkinson, S. Neidle, 2002, Nature.

Structure of a G-quadruplex-ligand complex.

Stephen Neidle, Gary N Parkinson, G. Parkinson, 2003, Journal of molecular biology.

Structural basis of DNA quadruplex recognition by an acridine drug.

Stephen Neidle, Gary N Parkinson, G. Parkinson, 2008, Journal of the American Chemical Society.

Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes.

G. Parkinson, N. Campbell, S. Neidle, 2012, Journal of medicinal chemistry.

Crystal structure of a promoter sequence in the B-raf gene reveals an intertwined dimer quadruplex.

G. Parkinson, M. Zloh, S. Neidle, 2013, Journal of the American Chemical Society.

Near-infrared dual bioluminescence imaging in mouse models of cancer using infraluciferin

M. Lythgoe, G. Parkinson, T. Kalber, 2019, eLife.

Aromatic hydrogen bond in sequence-specific protein DNA recognition

Gary Parkinson, Helen Berman, Thomas A. Kunkel, 1996, Nature Structural Biology.

Indirect readout of DNA sequence at the primary-kink site in the CAP-DNA complex: DNA binding specificity based on energetics of DNA kinking.

H M Berman, S. Chen, R. Ebright, 2001, Journal of molecular biology.

C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes

G. Parkinson, M. Zloh, A. Isaacs, 2012, Scientific Reports.

A thymine tetrad in d(TGGGGT) quadruplexes stabilized with Tl+/Na+ ions.

G. Parkinson, J. A. Subirana, C. Gouyette, 2004, Nucleic acids research.

Structural basis for binding of porphyrin to human telomeres.

G. Parkinson, S. Neidle, R. Ghosh, 2007, Biochemistry.

Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter

G. Parkinson, S. Neidle, A. K. Todd, 2007, Nucleic acids research.

Crystal structure of the potassium form of an Oxytricha nova G-quadruplex.

Stephen Neidle, Shozeb Haider, Gary N Parkinson, 2002, Journal of molecular biology.

A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex.

L. Mazzarella, E. Novellino, G. Parkinson, 2014, Acta crystallographica. Section D, Biological crystallography.

Selectivity in ligand recognition of G-quadruplex loops.

Stephen Neidle, Gary N Parkinson, G. Parkinson, 2009, Biochemistry.

Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation

G. Parkinson, S. Neidle, A. Reszka, 2012, Nucleic acids research.

Targeting the DNA minor groove with fused ring dicationic compounds: comparison of in silico screening and a high-resolution crystal structure.

G. Parkinson, N. Campbell, S. Neidle, 2006, Bioorganic & medicinal chemistry letters.

A New Class of Symmetric Bisbenzimidazole‐Based DNA Minor Groove‐Binding Agents Showing Antitumor Activity.

G. Parkinson, S. Neidle, L. Kèlland, 2001 .

A new class of symmetric bisbenzimidazole-based DNA minor groove-binding agents showing antitumor activity.

G. Parkinson, S. Neidle, L. Kèlland, 2001, Journal of medicinal chemistry.

Holliday Junctions formed from Telomeric DNA

A. Ramanathan, G. Parkinson, S. Haider, 2018 .

Structural characterization and antimicrobial evaluation of atractyloside, atractyligenin, and 15-didehydroatractyligenin methyl ester.

G. Parkinson, S. Gibbons, P. Stapleton, 2012, Journal of natural products.

Characterisation of Ilomastat for Prolonged Ocular Drug Release

Rose M. Sheridan, P. Khaw, G. Parkinson, 2012, AAPS PharmSciTech.

G‐quadruplex‐binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo

L. Partridge, A. Chiò, H. Zetterberg, 2017, EMBO molecular medicine.

1 NEAR-INFRARED DUAL BIOLUMINESCENCE IMAGING IN 1 MOUSE MODELS OF CANCER USING INFRALUCIFERIN 2

M. Lythgoe, G. Parkinson, T. Kalber, 2022 .

The absence of inorganic salt is required for the crystallization of the complete oligomerization domain of Salmonella typhimurium histone-like nucleoid-structuring protein.

G. Parkinson, J. Ladbury, S. Perkins, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

Selectivity of major isoquinoline alkaloids from Chelidonium majus towards telomeric G-quadruplex: A study using a transition-FRET (t-FRET) assay.

M. Hoffmann, J. Šponer, G. Parkinson, 2017, Biochimica et biophysica acta. General subjects.

Isolation and characterization of a new anticancer diterpenoid from Jatropha gossypifolia

G. Parkinson, S. Gibbons, A. Falodun, 2012, Pharmaceutical Chemistry Journal.

Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form.

W. Denny, G. Parkinson, S. Neidle, 2003, Journal of medicinal chemistry.

The application of DNA and RNA G-quadruplexes to therapeutic medicines.

Gary N Parkinson, Gavin W Collie, G. Parkinson, 2011, Chemical Society reviews.

Observation of the coexistence of sodium and calcium ions in a DNA G-quadruplex ion channel.

G. Parkinson, S. Neidle, P. Hazel, 2007, Journal of the American Chemical Society.

Telomere maintenance as a target for anticancer drug discovery

Gary Parkinson, Stephen Neidle, G. Parkinson, 2002, Nature Reviews Drug Discovery.

Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes.

G. Parkinson, S. Neidle, Francisco Cuenca, 2008, Journal of molecular biology.

Crystallographic studies of quadruplex nucleic acids.

G. Parkinson, N. Campbell, 2007, Methods.

Topology variation and loop structural homology in crystal and simulated structures of a bimolecular DNA quadruplex.

G. Parkinson, S. Neidle, P. Hazel, 2006, Journal of the American Chemical Society.

Structure of the CAP-DNA complex at 2.5 angstroms resolution: a complete picture of the protein-DNA interface.

Helen M. Berman, Angelo Gunasekera, A. Gunasekera, 1997, Journal of molecular biology.

The structure of telomeric DNA.

G. Parkinson, S. Neidle, 2003, Current opinion in structural biology.

Putative DNA quadruplex formation within the human c-kit oncogene.

Stephen Neidle, Mire Zloh, Alan K Todd, 2005, Journal of the American Chemical Society.

Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives.

S. Moro, G. Parkinson, S. Neidle, 2008, Bioorganic & medicinal chemistry.

A structural analysis of G-quadruplex/ligand interactions.

G. Parkinson, S. Neidle, S. Haider, 2011, Biochimie.

A new crystal form for the dodecamer C-G-C-G-A-A-T-T-C-G-C-G: symmetry effects on sequence-dependent DNA structure.

G. Parkinson, S. Neidle, E. Johansson, 2000, Journal of molecular biology.

Predictive modelling of topology and loop variations in dimeric DNA quadruplex structures

G. Parkinson, S. Neidle, P. Hazel, 2006, Nucleic acids research.

Nanofiber-based delivery of therapeutic peptides to the brain.

Michael A. Briggs, A. Schätzlein, G. Parkinson, 2013, ACS nano.

A naphthalene diimide G-quadruplex ligand inhibits cell growth and down-regulates BCL-2 expression in an imatinib-resistant gastrointestinal cancer cell line.

G. Parkinson, S. Neidle, M. Gunaratnam, 2018, Bioorganic & medicinal chemistry.

Structural basis for telomeric G-quadruplex targeting by naphthalene diimide ligands.

Stephen Neidle, Gary N Parkinson, Gavin W Collie, 2012, Journal of the American Chemical Society.

A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex

G. Parkinson, S. Neidle, S. Haider, 2010, Nucleic acids research.

Structural Insights into the Quadruplex-Duplex 3' Interface Formed from a Telomeric Repeat: A Potential Molecular Target.

G. Parkinson, S. Neidle, S. Haider, 2016, Journal of the American Chemical Society.

Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs.

Stephen Neidle, Mekala Gunaratnam, Gary N Parkinson, 2008, Journal of medicinal chemistry.

Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes.

G. Parkinson, S. Neidle, A. Reszka, 2009, Chemical communications.

Quadruplex DNA crystal structures and drug design.

Stephen Neidle, Gary N Parkinson, G. Parkinson, 2008, Biochimie.

Structural basis of telomeric RNA quadruplex--acridine ligand recognition.

G. Parkinson, S. Neidle, G. Collie, 2011, Journal of the American Chemical Society.

Electrospray mass spectrometry of telomeric RNA (TERRA) reveals the formation of stable multimeric G-quadruplex structures.

E. De Pauw, G. Parkinson, S. Neidle, 2010, Journal of the American Chemical Society.

BMPQ-1 binds selectively to (3+1) hybrid topologies in human telomeric G-quadruplex multimers

G. Parkinson, S. Haider, Zhu Liu, 2020, Nucleic acids research.

Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X‐ray crystallography

G. Parkinson, T. Bui, A. Drake, 2013, FEBS letters.

Structural Basis of Transcription Activation: The CAP-αCTD-DNA Complex

Gary Parkinson, Helen M. Berman, Huanwang Yang, 2002, Science.

A high-throughput fluorescence polarization assay for discovering inhibitors targeting the DNA-binding domain of signal transducer and activator of transcription 3 (STAT3)

G. Parkinson, G. Wells, A. Wilderspin, 2018, Oncotarget.

Characterization of Carbamazepine-Nicatinamide Cocrystal Polymorphs with Rapid Heating DSC and XRPD

G. Parkinson, S. Gaisford, A. Buanz, 2011 .

H-NS forms a superhelical protein scaffold for DNA condensation

John E. Ladbury, Stefan T. Arold, G. Parkinson, 2010, Proceedings of the National Academy of Sciences.

Holliday Junctions Formed from Human Telomeric DNA.

A. Ramanathan, G. Parkinson, S. Haider, 2018, Journal of the American Chemical Society.

HELIX: a new modular nucleic acid crystallization screen

G. Parkinson, Júlia Viladoms, 2014 .

The Application of DNA and RNA G‐Quadruplexes to Therapeutic Medicines

Gavin W. Collie, G. Parkinson, Gary N. Parkinson, 2012 .

Crystal and molecular structure of a new Z-DNA crystal form: d[CGT(2-NH2-A)CG] and its platinated derivative.

H. Berman, B. Gaffney, G. Parkinson, 1996, Biochemistry.

Structural basis of transcription activation: the CAP-alpha CTD-DNA complex.

R. Ebright, H. Berman, Huanwang Yang, 2002, Science.

Refinement strategies for protein–nucleic acid complexes

R. Ebright, H. Berman, B. Schneider, 1996 .

Molecular dynamics and principal components analysis of human telomeric quadruplex multimers.

Stephen Neidle, Shozeb Haider, Gary N Parkinson, 2008, Biophysical journal.

Crystal structure of FMN-dependent nitroreductase from Escherichia coli B: a prodrug-activating enzyme.

G. Parkinson, S. Neidle, J. V. Skelly, 2000, Journal of medicinal chemistry.

Structural Insights into Regulation of Insulin Expression Involving i-Motif DNA Structures in the Insulin-Linked Polymorphic Region

Zoë A. E. Waller, G. Parkinson, S. Haider, 2023, bioRxiv.

Out-of-shape DNA minor groove binders: induced fit interactions of heterocyclic dications with the DNA minor groove.

G. Parkinson, S. Neidle, W. Wilson, 2005, Biochemistry.

Crystal structure and nmr conformation of a cyclic pseudotetrapeptide containing urethane backbone linkages

H. Berman, G. Parkinson, J. Baum, 1994, Biopolymers.

X-Ray Crystallographic Studies of G-Quadruplex Structures.

Gary N Parkinson, Gavin W Collie, G. Parkinson, 2019, Methods in molecular biology.

Crystal structures of PI 3 KC 2 α PX domain indicate conformational change associated with ligand binding

G. Parkinson, P. Driscoll, S. Djordjević, 2008 .

Bmc Structural Biology Crystal Structures of Pi3k-c2α Px Domain Indicate Conformational Change Associated with Ligand Binding

G. Parkinson, P. Driscoll, S. Djordjević, 2008 .

Native de novo structural determinations of non-canonical nucleic acid motifs by X-ray crystallography at long wavelengths

G. Parkinson, S. Haider, A. Wagner, 2020, Nucleic acids research.