J. Murray

发表

The Structural Basis of Hammerhead Ribozyme Self-Cleavage

W. Scott, J. Murray, D. Terwey, 1998, Cell.

Capturing the Structure of a Catalytic RNA Intermediate: The Hammerhead Ribozyme

B. Stoddard, A. Klug, W. Scott, 1996, Science.

Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR.

J. Murray, C. Torrance, P. Dokurno, 2006, Bioorganic & medicinal chemistry letters.

Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping.

M. Drysdale, J. Murray, R. Hubbard, 2007, Bioorganic & medicinal chemistry letters.

Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.

M. Drysdale, N. Foloppe, J. Murray, 2009, Journal of medicinal chemistry.

Shielded hydrogen bonds as structural determinants of binding kinetics: application in drug design.

F. J. Luque, X. Barril, J. Murray, 2011, Journal of the American Chemical Society.

Fragment screening by weak affinity chromatography: comparison with established techniques for screening against HSP90.

B. Davis, J. Murray, R. Hubbard, 2013, Analytical chemistry.

Off-rate screening (ORS) by surface plasmon resonance. An efficient method to kinetically sample hit to lead chemical space from unpurified reaction products.

J. Murray, P. Brough, S. Roughley, 2014, Journal of medicinal chemistry.

Dynamic undocking and the quasi-bound state as tools for drug discovery

F. J. Luque, X. Barril, B. Davis, 2016, Nature Chemistry.

The three-dimensional structures of two complexes between recombinant MS2 capsids and RNA operator fragments reveal sequence-specific protein-RNA interactions.

J. Murray, L. Liljas, P. Stockley, 1997, Journal of molecular biology.

Experiences in fragment-based lead discovery.

Roderick E Hubbard, J. Murray, R. Hubbard, 2011, Methods in enzymology.

Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures

F. von Delft, J. Murray, R. Hubbard, 2020, Communications Chemistry.

Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures

F. von Delft, J. Murray, R. Hubbard, 2020, Communications Chemistry.

Design of LRRK2 inhibitors using a CHK1-derived crystallographic surrogate

J. Murray, R. Hubbard, M. Hentzer, 2019 .

The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography.

J. Murray, R. Russell, S. Mobashery, 2003, Journal of the American Chemical Society.

Synthesis and characterisation of oligodeoxynucleotides containing thio analogues of (6-4) pyrimidine-pyrimidinone photo-dimers.

J. Murray, B. Connolly, M. A. Warren, 1998, Journal of molecular biology.

Incorporation of a fluorescent nucleotide into oligoribonucleotides

J. Murray, J. Arnold, P. Stockley, 1994 .

Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2.

Alan Robertson, J. Bower, J. Murray, 2005, Bioorganic & medicinal chemistry letters.

Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.

B. Davis, M. Drysdale, N. Foloppe, 2012, Bioorganic & medicinal chemistry.

Multi-substituted isonitrile and mixed ligand derivatives of Fe3(CO)12; the crystal structure of Fe3(CO)10(CNBut)2

J. Murray, B. K. Nicholson, A. Whitton, 1990 .

Incorporation of 6-thioguanosine into oligoribonucleotides

J. Murray, J. Arnold, P. Stockley, 1995 .

Crystal structure of an RNA aptamer–protein complex at 2.8 Å resolution

A. Ellington, J. Murray, S. Phillips, 1998, Nature Structural Biology.

Crystal structure of the bacterial ribosomal decoding site complexed with amikacin containing the γ-amino-α-hydroxybutyryl (haba) group

E. Westhof, J. Kondo, J. Murray, 2006 .

Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding

Eric Westhof, Quentin Vicens, Benoît Masquida, 2005, Nucleic acids research.

RNA Bacteriophage Capsid-Mediated Drug Delivery and Epitope Presentation

Chris J. Adams, Jeremy C. Simpson, Peter G. Stockley, 2003, Intervirology.

A convenient synthesis of S-cyanoethyl-protected 4-thiouridine and its incorporation into oligoribonucleotides

J. Murray, J. Arnold, P. Stockley, 1994 .

The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations alone.

W. Scott, J. Murray, N. Walter, 1998, Chemistry & biology.

Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution.

B. Davis, Andrew Potter, J. Murray, 2011, Bioorganic & medicinal chemistry letters.

Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site.

Samy O Meroueh, J. Murray, S. Meroueh, 2006, Chemistry & biology.

Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.

Mike Wood, Terry Shaw, M. Drysdale, 2011, Journal of medicinal chemistry.

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

A. Strasser, F. Colland, J. Murray, 2016, Nature.

Dissecting the key recognition features of the MS2 bacteriophage translational repression complex.

J. Murray, P. Stockley, N. Stonehouse, 1998, Nucleic acids research.

Probing sequence-specific RNA recognition by the bacteriophage MS2 coat protein

Chris J. Adams, Peter G. Stockley, Nicola J. Stonehouse, 1995, Nucleic Acids Res..

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells

M. Drysdale, J. Murray, Rachel J Parsons, 2010, Cancer Chemotherapy and Pharmacology.

New tertiary constraints between the RNA components of active yeast spliceosomes: a photo-crosslinking study.

J. Murray, P. Stockley, C. Adams, 2004, RNA.

Structure-guided design of alpha-amino acid-derived Pin1 inhibitors.

B. Davis, Andrew Potter, J. Murray, 2009, Bioorganic & medicinal chemistry letters.

Crystal structure of an RNA bacteriophage coat proteinoperator complex

Lars Liljas, Peter G. Stockley, Nicola J. Stonehouse, 1994, Nature.

Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1).

J. Murray, R. Hubbard, M. Hentzer, 2017, Journal of medicinal chemistry.

Crystal structures of MS2 coat protein mutants in complex with wild-type RNA operator fragments.

J. Murray, L. Liljas, P. Stockley, 1998, Nucleic acids research.

Molecular interactions in the RNA bacteriophage MS2.

A. Clarke, J. Murray, L. Liljas, 1996, Biochemical Society Transactions.

Conventional and time-resolved ribozyme X-ray crystallography.

W. Scott, J. Murray, 2000, Methods in enzymology.

Crystal structure of the bacterial ribosomal decoding site complexed with amikacin containing the gamma-amino-alpha-hydroxybutyryl (haba) group.

E. Westhof, J. Kondo, J. Murray, 2006, Biochimie.

PAC-FragmentDEL – photoactivated covalent capture of DNA-encoded fragments for hit discovery

W. Finnie, J. Murray, R. Hubbard, 2022, RSC medicinal chemistry.

Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase.

Mike Wood, Ben Davis, Terry Shaw, 2017, Journal of medicinal chemistry.

Crystallographic studies of RNA hairpins in complexes with recombinant MS2 capsids: implications for binding requirements.

J. Murray, L. Liljas, P. Stockley, 1999, RNA.

A helical twist-induced conformational switch activates cleavage in the hammerhead ribozyme.

W. Scott, C. Dunham, J. Murray, 2003, Journal of molecular biology.

Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1

B. Davis, J. Murray, R. Hubbard, 2019, ACS omega.

Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors.

N. Foloppe, J. Murray, R. Hubbard, 2021, Journal of medicinal chemistry.

Does a single metal ion bridge the A-9 and scissile phosphate groups in the catalytically active hammerhead ribozyme structure?

W. Scott, J. Murray, William G. Scott, 2000, Journal of molecular biology.

Capture and visualization of a catalytic RNA enzyme-product complex using crystal lattice trapping and X-ray holographic reconstruction.

W. Scott, A. Szöke, J. Murray, 2000, Molecular cell.

A pH-dependent conformational change, rather than the chemical step, appears to be rate-limiting in the hammerhead ribozyme cleavage reaction.

W. Scott, C. Dunham, J. Murray, 2002, Journal of molecular biology.

Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.

M. Drysdale, J. Murray, Rachel J Parsons, 2011, Journal of medicinal chemistry.

Secondary Structure Mapping of an RNA Ligand That Has High Affinity for the MetJ Repressor Protein and Interference Modification Analysis of the Protein-RNA Complex*

J. Murray, P. Stockley, C. Adams, 1999, The Journal of Biological Chemistry.