N. Usman

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The Structural Basis of Hammerhead Ribozyme Self-Cleavage

W. Scott, J. Murray, D. Terwey, 1998, Cell.

Template-directed ligation of peptides to oligonucleotides.

G. F. Joyce, S. Kent, N. Usman, 1996, Chemistry & biology.

The rapid chemical synthesis of arabinonucleotides

N. Usman, M. Damha, K. K. Ogilvie, 1987 .

Total chemical synthesis of a 77-nucleotide-long RNA sequence having methionine-acceptance activity.

R. Cedergren, N. Usman, K. Nicoghosian, 1988, Proceedings of the National Academy of Sciences of the United States of America.

The molecular structure of the complex of Hoechst 33258 and the DNA dodecamer d(CGCGAATTCGCG).

A. Wang, N. Usman, M. Teng, 1988, Nucleic acids research.

Synthesis of 2'-modified nucleotides and their incorporation into hammerhead ribozymes.

A. Karpeisky, N. Usman, L. Beigelman, 1995, Nucleic acids research.

An oligodeoxyribonucleotide that supports catalytic activity in the hammerhead ribozyme domain.

S. Harvey, R. Cedergren, N. Usman, 1995, Nucleic acids research.

Synthesis of RNA containing inosine: analysis of the sequence requirements for the 5' splice site of the Tetrahymena group I intron.

S. Benner, A. Rich, R. Green, 1991, Nucleic acids research.

Use of binding energy by an RNA enzyme for catalysis by positioning and substrate destabilization.

D. Herschlag, N. Usman, G. Narlikar, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Automated Chemical Synthesis of Long Oligoribonucleotides Using 2′-O-Silylated Ribonucleoside 3′-O-Phosphoramidites on a Controlled-Pore Glass Support: Synthesis of a 43-Nucleotide Sequence Similar to the 3′-Half Molecule of an Escher

R. Cedergren, N. Usman, K. K. Ogilvie, 1988 .

Synthesis and biological activities of a phosphorodithioate analog of 2',5'-oligoadenylate.

N. Usman, L. Beigelman, B. Dong, 1995, Nucleic acids research.

Chemical Modification of Hammerhead Ribozymes

A. Karpeisky, N. Usman, L. Beigelman, 1995, The Journal of Biological Chemistry.

2′-O-Methyl Thiomethyl Modifications in Hammerhead Ribozymes

A. Karpeisky, N. Usman, L. Beigelman, 1997 .

2′-SUBSTITUTED PHOSPHOROTHIOATE CONTAINING OLIGORIBONUCLEOTIDES: AN APPLICATION TO THE SYNTHESIS AND PURIFICATION OF HAMMERHEAD RIBOZYMES

L. Maloney, N. Usman, S. Grimm, 1996 .

Characterization of HIV-1 REV protein: binding stoichiometry and minimal RNA substrate.

J. Hauber, K. Cook, N. Usman, 1991, Nucleic acids research.

Minimum ribonucleotide requirement for catalysis by the RNA hammerhead domain.

R. Cedergren, N. Usman, P. Chartrand, 1992, Biochemistry.

Structural variation induced by different nucleotides at the cleavage site of the hammerhead ribozyme.

O. Uhlenbeck, A. Pardi, J. Simorre, 1998, Biochemistry.

Base and sugar requirements for RNA cleavage of essential nucleoside residues in internal loop B of the hairpin ribozyme: implications for secondary structure.

U. Sørensen, A. Karpeisky, N. Usman, 1996, Nucleic acids research.

Prevention of guanine modification and chain cleavage during the solid phase synthesis of oligonucleotides using phosphoramidite derivatives.

N. Usman, M. Damha, R. Pon, 1986, Nucleic acids research.

Crystal structure of an RNA duplex containing phenyl-ribonucleotides, hydrophobic isosteres of the natural pyrimidines.

N. Usman, L. Beigelman, M. Egli, 2000, RNA.

Synthesis of nucleoside 5′-deoxy-5′-difluoromethylphosphonates

N. Usman, J. Matulić-Adamić, 1994 .

SYNTHESIS AND INCORPORATION OF 5'-AMINO- AND 5'-MERCAPTO-5'-DEOXY-2'-O-METHYL NUCLEOSIDES INTO HAMMERHEAD RIBOZYMES

L. Maloney, N. Usman, L. Beigelman, 1997 .

Conversion of ribonucleosides to protected 3′-deoxynucleosides

N. Usman, G. Hakimelahi, K. K. Ogilvie, 1983 .

Conversion of ribonucleosides to protected 3′-deoxynucleosides

N. Usman, G. Hakimelahi, K. K. Ogilvie, 1983 .

TRANSPORT OF ADENINE MONO- AND DINUCLEOSIDE MONOPHOSPHATES ACROSS LIQUID MEMBRANES AND EXTRACTION OF OLIGONUCLEOTIDES WITH SYNTHETIC CARRIERS

N. Usman, J. Rebek, J. D. Mendoza, 1994 .

Synthesis of pyridinone ribonucleoside 3′-O-phosphoramidites and their incorporation into oligoribonucleotides

N. Usman, L. Beigelman, J. Matulić-Adamić, 1996 .

Chemical synthesis of oligoribonucleotides containing 2-aminopurine: substrates for the investigation of ribozyme function.

A. Rich, J. Doudna, J. Szostak, 1990, The Journal of organic chemistry.

Chemical synthesis of biologically active oligoribonucleotides using beta-cyanoethyl protected ribonucleoside phosphoramidites.

S. Scaringe, C. Francklyn, N. Usman, 1990, Nucleic acids research.

RNA hydration: a detailed look.

N. Usman, M. Egli, M Egli, 1996, Biochemistry.

Synthesis, deprotection, analysis and purification of RNA and ribozymes.

S. Scaringe, N. Usman, S. Grimm, 1995, Nucleic acids research.

The automated chemical synthesis of long oligoribuncleotides using 2'-O-silylated ribonucleoside 3'-O-phosphoramidites on a controlled-pore glass support: synthesis of a 43-nucleotide sequence similar to the 3'-half molecule of an Escherichia coli formylmethionine tRNA

R. Cedergren, N. Usman, K. K. Ogilvie, 1987 .

The 2,6-diaminopurine riboside.5-methylisocytidine wobble base pair: an isoenergetic substitution for the study of G.U pairs in RNA.

S. Strobel, T. Cech, N. Usman, 1994, Biochemistry.

Preparation of ribonucleoside 3′-O-phosphoramidites and their application to the automated solid phase synthesis of oligonucleotides

N. Usman, R. Pon, K. K. Ogilvie, 1985 .

2′-(trimethylsilyl)ethoxymethyl protection of the 2′-hydroxyl group in oligoribonucleotide synthesis

N. Usman, F. Wincott, 1994 .

Morpholino-Linked Ribozymes: A Convergent Synthetic Approach

N. Usman, L. Bellon, J. Scherrer, 1996 .

Chemically modified hammerhead ribozymes with improved catalytic rates.

A. Karpeisky, N. Usman, L. Beigelman, 1996, Biochemistry.

Rescue of abasic hammerhead ribozymes by exogenous addition of specific bases.

D. Herschlag, N. Usman, L. Beigelman, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Hammerhead ribozyme engineering.

N. Usman, L. Beigelman, J. Mcswiggen, 1996, Current opinion in structural biology.

Synthesis and Structure of 1-Deoxy-1-phenyl-beta-D-ribofuranose and Its Incorporation into Oligonucleotides.

N. Usman, L. Beigelman, M. Egli, 1996, The Journal of organic chemistry.

Synthesis of 6-Aza- & 6-Methyl-pyrimidine Ribonucleoside Phosphoramidites and Their Incorporation in Hammerhead Ribozymes

A. Karpeisky, N. Usman, L. Beigelman, 1995 .

New Structural Motifs for Hammerhead Ribozymes. Catalytic Activity of Abasic Nucleotide Substituted Ribozymes

A. Karpeisky, N. Usman, L. Beigelman, 1995 .

Synthesis of 1-deoxy-d-ribofuranose phosphoramidite & the incorporation of abasic nucleotides in stem-loop II of a hammerhead ribozyme

A. Karpeisky, N. Usman, L. Beigelman, 1994 .

Preparation of glyceronucleoside phosphoramidite synthons and their use in the solid phase synthesis of acyclic oligonucleotides

N. Usman, K. K. Ogilvie, C. Juby, 1988 .

Developments in the chemical synthesis of naturally occurring DNA and RNA sequences with normal and unusual linkages

N. Usman, M. Damha, R. Pon, 1987 .

Developments in the Chemical Synthesis of Naturally Occurring DNA and RNA Sequences with Normal and Unusual Linkages.

N. Usman, M. Damha, R. Pon, 1987 .

SYNTHESIS OF 5'-DEOXY-5'-DIFLUOROMETHYL PHOSPHONATE NUCLEOTIDE ANALOGS

N. Usman, J. Matulić-Adamić, P. Haeberli, 1995 .

Solution and solid phase chemical synthesis of arabinonucleotides

N. Usman, M. Damha, K. K. Ogilvie, 1989 .

Evidence for the rate-limiting departure of the 5'-oxygen in nonenzymatic and hammerhead ribozyme-catalyzed reactions

M. Komiyama, N. Usman, K. Taira, 1996 .

The synthesis and functional evaluation of RNA and DNA polymers having the sequence of Escherichia coli tRNA(fMet).

R. Cedergren, N. Usman, J. Perreault, 1989, European journal of biochemistry.

A practical method for the production of RNA and ribozymes.

N. Usman, F. Wincott, 1997, Methods in molecular biology.

Synthesis and Incorporation of 5′-Amino- (I) and 5′-Mercapto-5′-deoxy-2′-O-methyl Nucleosides (II) into Hammerhead Ribozymes.

L. Maloney, N. Usman, L. Beigelman, 1998 .

Preparation of Ribonucleoside 3′-O-Phosphoramidites and Their Application to the Automated Solid Phase Synthesis of Oligonucleotides.

N. Usman, K. K. Ogilvie, R. T. P. and, 1986 .

Modified nucleosides for ribozyme structure–activity studies

A. Karpeisky, N. Usman, L. Beigelman, 1996 .

Solution and Solid Phase Chemical Synthesis of Arabinonucleotides.

N. Usman, M. Damha, K. K. Ogilvie, 1989 .

Design, Synthesis, and Function of Therapeutic Hammerhead Ribozymes

N. Usman, D. Stinchcomb, 1996 .

Nuclease-resistant synthetic ribozymes: developing a new class of therapeutics.

N. Usman, L. Blatt, Nassim Usman, 2000, The Journal of clinical investigation.

Exploiting the chemical synthesis of RNA.

R. Cedergren, N. Usman, Robert Cedergren, 1992, Trends in biochemical sciences.

Crystal structures of an A-form duplex with single-adenosine bulges and a conformational basis for site-specific RNA self-cleavage.

N. Usman, M. Egli, S. Grimm, 1996, Chemistry & biology.

Optimizing the Cell Efficacy of Synthetic Ribozymes

T. Jarvis, A. Karpeisky, N. Usman, 1996, The Journal of Biological Chemistry.

Relationship between 2'-hydroxyls and magnesium binding in the hammerhead RNA domain: a model for ribozyme catalysis.

D. Labuda, R. Cedergren, N. Usman, 1991, Biochemistry.

Template-directed primer extension catalyzed by the Tetrahymena ribozyme.

D. Bartel, J. Doudna, J. Szostak, 1991, Molecular and cellular biology.

Ordered differential display: a simple method for systematic comparison of gene expression profiles.

S. Lukyanov, N. Usman, M. Matz, 1997, Nucleic acids research.

Conformational influence of the ribose 2'-hydroxyl group: crystal structures of DNA-RNA chimeric duplexes

A. Rich, N. Usman, M. Egli, 1993 .

X-ray crystallographic observation of "in-line" and "adjacent" conformations in a bulged self-cleaving RNA/DNA hybrid.

N. Usman, M. Egli, V. Tereshko, 2001, RNA.

Conformational influence of the ribose 2'-hydroxyl group: crystal structures of DNA-RNA chimeric duplexes.

A. Rich, N. Usman, M. Egli, 1993, Biochemistry.

Exploiting the Chemical Synthesis of RNA

R. Cedergren, N. Usman, 1993 .

Chapter 30. Catalytic RNA (Ribozymes) as Drugs

N. Usman, J. Mcswiggen, 1995 .

Crystal structure of an Okazaki fragment at 2-A resolution.

A. Rich, N. Usman, M. Egli, 1992, Proceedings of the National Academy of Sciences of the United States of America.

The crystal structure of r(CCCCGGGG) in two distinct lattices.

N. Usman, M. Egli, S. Portmann, 1995, Biochemistry.

Large scale chemical synthesis, purification and crystallization of RNA-DNA chimeras.

A. Rich, N. Usman, M. Egli, 1992, Nucleic Acids Research.

The Crystal Structure of r(CCCCGGGG) in Two Distinct Lattices

N. Usman, M. Egli, S. Portmann, 1996 .

Mixed DNA/RNA polymers are cleaved by the hammerhead ribozyme.

D. Labuda, R. Cedergren, N. Usman, 1990, Biochemistry.

Specificity for aminoacylation of an RNA helix: an unpaired, exocyclic amino group in the minor groove.

R. Green, J. Doudna, S. Scaringe, 1991, Science.

Synthesis of 5′-C-Methyl-D-allo- & L-Talo-ribonucleoside 3′-O-Phosphoramidites & Their Incorporation into Hammerhead Ribozymes

A. Karpeisky, N. Usman, L. Beigelman, 1995 .

Total chemical synthesis of a ribozyme derived from a group I intron.

J. Szostak, N. Usman, S. Whoriskey, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of vascular smooth muscle cell proliferation by ribozymes that cleave c-myb mRNA.

A. Beaudry, T. Jarvis, N. Usman, 1996, RNA.

Synthesis and incorporation of 2′-amino acid conjugated nucleotides into ribozymes

N. Usman, L. Beigelman, J. Matulić-Adamić, 1995 .

Enzymatic aminoacylation of single-stranded RNA with an RNA cofactor.

S. Scaringe, P. Schimmel, K. Musier-Forsyth, 1991, Proceedings of the National Academy of Sciences of the United States of America.