J. Hochman

发表

Localization of antibody-combining sites within the variable portions of heavy and light chains.

D. Inbar, J. Hochman, D. Givol, 1972, Proceedings of the National Academy of Sciences of the United States of America.

Quantitation of physiological and biochemical barriers to siRNA liver delivery via lipid nanoparticle platform.

Marian E. Gindy, J. Hochman, M. Ou, 2014, Molecular pharmaceutics.

Role of Mechanistic Transport Studies in Lead Optimization

M. Bock, Jiunn H. Lin, J. Hochman, 2006 .

Antigen-induced conformational changes in antibodies and their Fab fragments studied by circular polarization of fluorescence.

I. Z. Steinberg, J. Schlessinger, J. Hochman, 1975, Proceedings of the National Academy of Sciences of the United States of America.

P-glycoprotein-mediated efflux of indinavir metabolites in Caco-2 cells expressing cytochrome P450 3A4.

J. Hochman, C. Tang, J. Lin, 2001, The Journal of pharmacology and experimental therapeutics.

Establishment of P‐Glycoprotein Structure–Transport Relationships to Optimize CNS Exposure in Drug Discovery

R. Sheridan, J. Hochman, Sookhee N. Ha, 2015 .

In vitro and in vivo analysis of the mechanism of absorption enhancement by palmitoylcarnitine.

J. Hochman, E. LeCluyse, J. Fix, 1994, The Journal of pharmacology and experimental therapeutics.

Effects of fibrates on human organic anion-transporting polypeptide 1B1-, multidrug resistance protein 2- and P-glycoprotein-mediated transport

R. Stocco, J. Hochman, M. Abramovitz, 2005, Xenobiotica; the fate of foreign compounds in biological systems.

Endocytosis and dissociation of class I MHC molecules labeled with fluorescent beta-2 microglobulin.

L. Mátyus, J. Hochman, M. Edidin, 1991, Journal of immunology.

Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors.

A. Simon, G. McGaughey, Hemaka A. Rajapakse, 2007, Bioorganic & medicinal chemistry letters.

Comparative studies of drug-metabolizing enzymes in dog, monkey, and human small intestines, and in Caco-2 cells.

J. Hochman, T. Prueksaritanont, K. Vyas, 1996, Drug metabolism and disposition: the biological fate of chemicals.

Development and characterization of LLC-PK1 cells containing Sprague-Dawley rat Abcb1a (Mdr1a): comparison of rat P-glycoprotein transport to human and mouse.

R. Kim, J. Hochman, T. Rushmore, 2006, Journal of pharmacological and toxicological methods.

Is Electron Transfer Mediated by Random Diffusion Alone

J. Hochman, K. Rajarathnam, M. Schindler, 1988 .

Differences in the absorption, metabolism and biliary excretion of a diastereomeric pair of α v β 3 - antagonists in rat: limited role of P-glycoprotein

B. Ma, J. Hochman, C. Tang, 2002, Xenobiotica; the fate of foreign compounds in biological systems.

siRNA-Mediated Knockdown of P450 Oxidoreductase in Rats: A Tool to Reduce Metabolism by CYPs and Increase Exposure of High Clearance Compounds

Marian E. Gindy, B. Carr, J. Hochman, 2014, Pharmaceutical Research.

Specific associations of fluorescent beta-2-microglobulin with cell surfaces. The affinity of different H-2 and HLA antigens for beta-2-microglobulin.

J. Hochman, R. Demars, M. Edidin, 1988, Journal of immunology.

Synthesis, location, and lateral mobility of fluorescently labeled ubiquinone 10 in mitochondrial and artificial membranes.

J. Hochman, K. Rajarathnam, M. Schindler, 1989, Biochemistry.

Associations Between Class I MHC Antigens and Viral Glycoproteins Detected by Fluorescence Resonance Energy Transfer

J. Hochman, M. Edidin, 1987 .

Selective anchoring in the specific plasma membrane domain: a role in epithelial cell polarity

J. Hochman, M. Edidin, E. Rodriguez-Boulan, 1988, The Journal of cell biology.

Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties

Mohan R. Pradhan, D. Lane, J. Hochman, 2019, Molecules.

Specific associations of fluorescent β-2-microglobulin with cell surfaces. The affinity of different H-2 and HLA antigens for β-2-microglobulin

J. Hochman, R. Demars, M. Edidin, 1988 .

Lateral mobility of cytochrome c on intact mitochondrial membranes as determined by fluorescence redistribution after photobleaching.

J. Hochman, M. Schindler, S. Ferguson-Miller, 1982, Proceedings of the National Academy of Sciences of the United States of America.

siRNA-Mediated Knockdown of P450 Oxidoreductase in Rats: A Tool to Reduce Metabolism by CYPs and Increase Exposure of High Clearance Compounds

Marian E. Gindy, B. Carr, J. Hochman, 2014, Pharmaceutical Research.

Aggregation and diffusion in the mitochondrial electron-transfer chain: role in electron flow and energy transfer.

J. Hochman, M. Schindler, S. Ferguson-Miller, 1986, Biochemical Society transactions.

Adapting ADME and pharmacokinetic analysis to the next generation of therapeutic modalities.

J. Hochman, 2020, Journal of pharmaceutical sciences.

Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors.

D. Hazuda, A. Simon, G. McGaughey, 2007, Bioorganic & medicinal chemistry letters.

Identification of novel, orally bioavailable spirohydantoin CGRP receptor antagonists.

Cory R. Theberge, J. Vacca, J. Hochman, 2006, Bioorganic & medicinal chemistry letters.

Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges.

A. Peier, D. Lane, J. Hochman, 2018, Bioorganic & medicinal chemistry.

Influence of P-glycoprotein on the transport and metabolism of indinavir in Caco-2 cells expressing cytochrome P-450 3A4.

J. Hochman, J. Lin, M. Yamazaki, 2000, The Journal of pharmacology and experimental therapeutics.

Drug-drug interactions related to altered absorption and plasma protein binding: theoretical and regulatory considerations, and an industry perspective.

J. Hochman, T. Prueksaritanont, Cuyue Tang, 2015, Journal of pharmaceutical sciences.

In vitro substrate identification studies for p-glycoprotein-mediated transport: species difference and predictability of in vivo results.

J. Hochman, J. Lin, T. Ohe, 2001, The Journal of pharmacology and experimental therapeutics.

Mechanisms of absorption enhancement and tight junction regulation

P. Artursson, J. Hochman, 1994 .

Simultaneous in Vitro Measurement of Intestinal Tissue Permeability and Transepithelial Electrical Resistance (TEER) Using Sweetana–Grass Diffusion Cells

J. Hochman, E. LeCluyse, R. Cargill, 1992, Pharmaceutical Research.

Acyl glucuronidation and glucosidation of a new and selective endothelin ET(A) receptor antagonist in human liver microsomes.

B. Ma, J. Hochman, R. Subramanian, 2003, Drug metabolism and disposition: the biological fate of chemicals.

RNA-Induced Silencing Complex-Bound Small Interfering RNA Is a Determinant of RNA Interference-Mediated Gene Silencing in Mice

J. Burchard, A. Sachs, J. Hochman, 2011, Molecular Pharmacology.

Overcoming Cellular and Systemic Barriers to Design the Next Wave of Peptide Therapeutics

J. Hochman, T. Sawyer, Ruchia Duggal, 2021 .

Drug–Drug Interaction Studies: Regulatory Guidance and An Industry Perspective

Donghui Cui, Thomayant Prueksaritanont, X. Chu, 2013, The AAPS Journal.

Metabolite identification of small interfering RNA duplex by high-resolution accurate mass spectrometry.

J. Hochman, I. Chen, M. Beverly, 2008, Rapid communications in mass spectrometry : RCM.

First Demonstration of Cerebrospinal Fluid and Plasma Aβ Lowering with Oral Administration of a β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates

Alison R. Gregro, Amy S. Espeseth, Min Xu, 2009, Journal of Pharmacology and Experimental Therapeutics.

First Demonstration of Cerebrospinal Fluid and Plasma A (cid:1) Lowering with Oral Administration of a (cid:1) -Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates □ S

Alison R. Gregro, Amy S. Espeseth, Min Xu, 2008 .

Formation of extensive canalicular networks by rat hepatocytes cultured in collagen-sandwich configuration.

K. Audus, J. Hochman, E. LeCluyse, 1994, The American journal of physiology.

Using real-time quantitative TaqMan RT-PCR to evaluate the role of dexamethasone in gene regulation of rat P-glycoproteins mdr1a/1b and cytochrome P450 3A1/2.

J. Hochman, Scott E. Fauty, T. Prueksaritanont, 2004, Journal of pharmaceutical sciences.

Cultured rat hepatocytes.

J. Hochman, A. Parkinson, P. Bullock, 1996, Pharmaceutical biotechnology.

Evaluation of drug interactions with P-glycoprotein in drug discovery: in vitro assessment of the potential for drug-drug interactions with P-glycoprotein.

J. Hochman, T. Ohe, M. Yamazaki, 2002, Current drug metabolism.

An active antibody fragment (Fv) composed of the variable portions of heavy and light chains.

D. Inbar, J. Hochman, D. Givol, 1973, Biochemistry.

Regeneration and maintenance of bile canalicular networks in collagen-sandwiched hepatocytes.

K. Audus, J. Hochman, E. LeCluyse, 2000, Toxicology in vitro : an international journal published in association with BIBRA.

Monoclonal Antibodies with Identical Fc Sequences Can Bind to FcRn Differentially with Pharmacokinetic Consequences

B. Carr, J. Hochman, P. Lu, 2011, Drug Metabolism and Disposition.

Generation of monospecific peptide antibodies to the DNA binding domain of p53.

G. Tuchscherer, J. Hochman, D. Henderson, 2000, BioTechniques.

Interactions of Human P-glycoprotein with Simvastatin, Simvastatin Acid, and Atorvastatin

Julia Qiu, Cuyue Tang, Thomayant Prueksaritanont, 2004, Pharmaceutical Research.

with oral administration of a BACE1 inhibitor in nonhuman primates

Amy S. Espeseth, Adam T. Gates, D. Hazuda, 2008 .

An effective electron donor to cytochrome oxidase. Purification, identification, and kinetic characterization of a contaminant of ruthenium red, hexaamineruthenium II/III.

J. Hochman, S. Ferguson-Miller, B. Partridge, 1981, The Journal of biological chemistry.

Comparison of imidazole- and 2-methyl imidazole-containing farnesyl-protein transferase inhibitors: interaction with and metabolism by rat hepatic cytochrome P450s.

J. Hochman, C. Tang, J. Lin, 2000, Drug metabolism and disposition: the biological fate of chemicals.

Effect of P-glycoprotein-mediated efflux on cerebrospinal fluid concentrations in rhesus monkeys.

J. Hochman, T. Prueksaritanont, S. Graham, 2009, Biochemical pharmacology.

Mobility in the mitochondrial electron transport chain.

J. Hochman, M. Schindler, S. Ferguson-Miller, 1985, Biochemistry.

Folding and interaction of subunits at the antibody combining site.

M. Gavish, D. Inbar, J. Hochman, 1976, Biochemistry.

Pharmacokinetics of IgG1 monoclonal antibodies produced in humanized Pichia pastoris with specific glycoforms: a comparative study with CHO produced materials.

J. Hochman, Liming Liu, T. Prueksaritanont, 2011, Biologicals : journal of the International Association of Biological Standardization.

Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides

R. Evers, Joe R. Cannon, D. Lane, 2021, Pharmaceutical Research.

Drug–Drug Interaction Studies: Regulatory Guidance and An Industry Perspective

X. Chu, J. Hochman, T. Prueksaritanont, 2013, The AAPS Journal.

Mini review on molecular modeling of P-glycoprotein (Pgp).

R. Sheridan, J. Hochman, Sookhee N. Ha, 2007, Current topics in medicinal chemistry.

Folding, association, and interactions of domains in the antibody molecule.

M. Gavish, I. Z. Steinberg, J. Schlessinger, 1977, Cold Spring Harbor Symposia on Quantitative Biology.

Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application to Mdm2/X dual antagonists

J. Hochman, C. Verma, S. Kannan, 2023, bioRxiv.

Circular dichroism study of the antibody combining site.