G. Dolton

发表

A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides*

D. Price, A. Sewell, John J Miles, 2011, The Journal of Biological Chemistry.

VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium

Andrew K. Sewell, Dmitry Chudakov, Mikhail Shugay, 2019, Nucleic Acids Res..

GPU-Accelerated Discovery of Pathogen-Derived Molecular Mimics of a T-Cell Insulin Epitope

A. Sewell, L. Wooldridge, H. A. van den Berg, 2020, Frontiers in Immunology.

Optimized Peptide–MHC Multimer Protocols for Detection and Isolation of Autoimmune T-Cells

Andrew K. Sewell, Dmitriy M. Chudakov, Ernest Choy, 2018, Front. Immunol..

A novel tumor antigen derived from enhanced degradation of bax protein in human cancers.

C. Fegan, M. Mason, G. Dolton, 2011, Cancer research.

Anti-CD8 Antibodies Can Trigger CD8+ T Cell Effector Function in the Absence of TCR Engagement and Improve Peptide–MHCI Tetramer Staining

A. Sewell, John J Miles, S. Burrows, 2011, The Journal of Immunology.

Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination

Katharina Gaus, Yuanqing Ma, Oreste Acuto, 2016, Proceedings of the National Academy of Sciences.

ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells

Hideaki, Nagase, K. Ladell, 2019, Scientific Reports.

ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells

K. Ladell, G. Dolton, M. Kashiwagi, 2019, Scientific Reports.

PD-1+ Polyfunctional T Cells Dominate the Periphery after Tumor-Infiltrating Lymphocyte Therapy for Cancer

M. Donia, I. Svane, S. Ott, 2017, Clinical Cancer Research.

CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features

A. Sewell, G. Dolton, P. Rizkallah, 2020, Cell reports.

Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope

T. Elliott, A. Sewell, G. Dolton, 2019, The Journal of Biological Chemistry.

Autoreactive T effector memory differentiation mirrors &bgr; cell function in type 1 diabetes

C. Beam, S. Heck, A. Sewell, 2018, The Journal of clinical investigation.

T-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen Targeting*

Katherine K. Matthews, A. Sewell, B. Baker, 2012, The Journal of Biological Chemistry.

Metabolic Adaptation of Human CD4+ and CD8+ T-Cells to T-Cell Receptor-Mediated Stimulation

A. Sewell, G. Dolton, D. Cole, 2017, Front. Immunol..

Simultaneous Aerosol and Intramuscular Immunization with Influenza Vaccine Induces Powerful Protective Local T Cell and Systemic Antibody Immune Responses in Pigs

A. Sewell, G. Dolton, E. Tchilian, 2020, The Journal of Immunology.

Loss of Src Homology Region 2 Domain-Containing Protein Tyrosine Phosphatase-1 Increases CD8+ T Cell-APC Conjugate Formation and Is Associated with Enhanced In Vivo CTL Function1

G. Dolton, J. Sathish, R. J. Matthews, 2007, The Journal of Immunology.

Enhanced In Vivo CTL Function Conjugate Formation and Is Associated with T Cell-APC + Phosphatase-1 Increases CD8 Domain-Containing Protein Tyrosine Loss of Src Homology Region 2

G. Dolton, J. Sathish, F. Leroy, 2006 .

Neutrophils Recruited by IL-22 in Peripheral Tissues Function as TRAIL-Dependent Antiviral Effectors against MCMV

P. Klenerman, S. Clare, G. Dougan, 2014, Cell host & microbe.

Sewell, A. K. (2018). Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham

A. Sewell, John J Miles, G. Dolton, 2018 .

VDJdb in the pandemic era: a compendium of T cell receptors specific for SARS-CoV-2

F. Luciani, A. Sewell, E. B. Clemens, 2022, Nature Methods.

A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen*

A. Sewell, G. Dolton, P. Rizkallah, 2016, The Journal of Biological Chemistry.

Genome-wide CRISPR-Cas9 Screening Reveals Ubiquitous T cell Cancer Targeting via the monomorphic MHC class I related protein MR1

M. Donia, I. Svane, A. Sewell, 2019, Nature Immunology.

Nonstimulatory peptide–MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling

Shvetha Sankaran, P. MacAry, A. Sewell, 2018, Nature Communications.

T cell receptor alpha variable 12‐2 bias in the immunodominant response to Yellow fever virus

D. Speiser, A. Sewell, G. Dolton, 2017, European journal of immunology.

Enhanced Detection of Antigen-Specific CD4+ T Cells Using Altered Peptide Flanking Residue Peptide–MHC Class II Multimers

A. Sewell, K. Ladell, G. Dolton, 2015, The Journal of Immunology.

MHC Class II Multimers - Residue Peptide T Cells Using Altered Peptide Flanking +Detection of Antigen-Specific CD4

A. Sewell, G. Dolton, A. Godkin, 2015 .

Antibody Stabilization of Peptide–MHC Multimers Reveals Functional T Cells Bearing Extremely Low-Affinity TCRs

M. Donia, I. Svane, A. Sewell, 2014, The Journal of Immunology.

Comparison of peptide–major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells

A. Sewell, John J Miles, K. Ladell, 2014, Clinical and experimental immunology.

A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells

Gao Huang, A. Sewell, A. Skowera, 2015, Clinical and experimental immunology.

Structural basis of human β-cell killing by CD8+ T cells in Type 1 diabetes

J. Drijfhout, A. Sewell, B. Jakobsen, 2011, Nature Immunology.

Structural basis for the killing of human beta cells by CD 8 + T cells in type 1 diabetes

J. Drijfhout, A. Sewell, B. Jakobsen, 2012 .

Role of SHP-1 in in vivo CD8+ T cell responses to antigenic stimulation

G. Dolton, 2008 .

Protein tyrosine phosphatases as negative regulators of the immune response.

G. Dolton, J. Sathish, R. Matthews, 2006, Biochemical Society transactions.

VDJdb: a curated database of T-cell receptor sequences with known antigen specificity

Andrew K. Sewell, Paul G. Thomas, Dmitry Chudakov, 2017, Nucleic Acids Res..

Human leucocyte antigen class I‐redirected anti‐tumour CD4+ T cells require a higher T cell receptor binding affinity for optimal activity than CD8+ T cells

J. E. Brewer, A. Sewell, B. Jakobsen, 2016, Clinical and experimental immunology.

More tricks with tetramers: a practical guide to staining T cells with peptide–MHC multimers

Mark Peakman, M. Donia, I. Svane, 2015, Immunology.

Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope

P. Goulder, A. Sewell, G. Dolton, 2021, Cell.

PigsSystemic Antibody Immune Responses in Induces Powerful Protective Local T Cell and Immunization with Influenza Vaccine Simultaneous Aerosol and Intramuscular

G. Dolton, Veronica Martini, M. Edmans, 2021 .

Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig

A. Sewell, John J Miles, G. Dolton, 2018, PLoS pathogens.

Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope

Andrew K. Sewell, John J. Miles, David K. Cole, 2017, Front. Immunol..

Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry

Thomas S. Watkins, Katherine K. Matthews, A. Sewell, 2018, The Journal of clinical investigation.

Peptide length determines the outcome of TCR/peptide-MHCI engagement.

A. Sewell, J. Rossjohn, S. Burrows, 2013, Blood.

CRISPR-mediated TCR replacement generates superior anticancer transgenic T cells.

A. Sewell, G. Dolton, M. Legut, 2018, Blood.

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

A. Sewell, J. Rossjohn, John J Miles, 2016, The Journal of clinical investigation.

Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors

A. Sewell, M. Roederer, John J Miles, 2016, Immunology and cell biology.

Identification of human viral protein-derived ligands recognized by individual major histocompatibility complex class I (MHCI)-restricted T-cell receptors

A. Sewell, M. Roederer, John J Miles, 2016 .

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

A. Sewell, J. Rossjohn, John J Miles, 2016, The Journal of clinical investigation.

Genetic and Structural Basis for Selection of a Ubiquitous T Cell Receptor Deployed in Epstein-Barr Virus Infection

Andrew K. Sewell, John J. Miles, David A. Price, 2010, PLoS pathogens.

Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life

T. Ndung’u, P. Goulder, A. Sewell, 2020, Frontiers in Immunology.

Peptide–MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations

Andrew K. Sewell, Mark Peakman, Barbara Szomolay, 2018, The Journal of Immunology.

Circulating β cell‐specific CD8+ T cells restricted by high‐risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes

J. Ilonen, M. Knip, J. Toppari, 2019, Clinical and experimental immunology.

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

Charles J. Vaske, Rohan N. Borkar, Brian D. Kelly, 2016, Journal of Immunotherapy for Cancer.

Purity of transferred CD8+ T cells is crucial for safety and efficacy of combinatorial tumor immunotherapy in the absence of SHP-1

K. Ladell, G. Dolton, J. Hindley, 2016, Immunology and cell biology.

Title : CRISPR-mediated TCR replacement generates superior anticancer transgenic T-cells Running title : TCR replacement for cancer immunotherapy

A. Sewell, G. Dolton, M. Legut, 2017 .

Identi fi cation of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors

A. Sewell, M. Roederer, John J Miles, 2016 .

T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones

A. Sewell, John J Miles, G. Dolton, 2016, Journal of immunological methods.

Peptide length determines the outcome of T cell receptor / peptide-MHCI

A. Sewell, J. Rossjohn, John J Miles, 2012 .

Peptide Super-Agonist Enhances T-Cell Responses to Melanoma

M. Donia, I. Svane, A. Sewell, 2019, Front. Immunol..

Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells

A. Sewell, John J Miles, S. Burrows, 2016, The Journal of Immunology.

Human MR 1-Restricted ProcessingTools To Study Microbial Antigen System : MR 1 with a CRISPR / Cas 9 Lentiviral Engineering of Isogenic Cells Deficient for Lewinsohn and

A. Sewell, John J Miles, S. Burrows, 2016 .

Running title : GAD 65 epitopes on β-cells

A. Sewell, A. Skowera, G. Dolton, 2014 .

Genome-wide CRISPR-Cas9 Screening Reveals Ubiquitous T cell Cancer Targeting via the monomorphic MHC class I related protein MR1

M. Donia, I. Svane, A. Sewell, 2019, Nature Immunology.

ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells

K. Ladell, G. Dolton, M. Kashiwagi, 2019, Scientific Reports.

Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics

Thomas S. Watkins, Katherine K. Matthews, A. Sewell, 2015, Immunology and cell biology.

β-Cell–Specific CD8 T Cell Phenotype in Type 1 Diabetes Reflects Chronic Autoantigen Exposure

Katherine K. Matthews, P. Bingley, S. Heck, 2014, Diabetes.

Partially differentiated polyfunctional T cells dominate the periphery after tumor-infiltrating lymphocytes therapy for cancer

M. Donia, I. Svane, S. Ott, 2016 .

Antigen Specificity Determines the Pro- or Antitumoral Nature of CD8+ T Cells

Simone Cuff, G. Dolton, Garry Dolton, 2009, The Journal of Immunology.

A Polypropylene sulfide nanoparticle p24 vaccine promotes dendritic cell-mediated specific immune responses against HIV-1

M. Swartz, F. Nestle, A. Sewell, 2016 .

Antitumoral Nature of CD 8 Antigen Specificity Determines the Pro-or

G. Dolton, R. Matthews, Gallimore Simone Cuff, 2009 .

Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope

T. Elliott, A. Sewell, G. Dolton, 2019, The Journal of Biological Chemistry.

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.

A. Sewell, John J Miles, L. Wooldridge, 2016, The Journal of clinical investigation.

Peptide length determines the outcome of TCR/peptide-MHCI engagement.

A. Sewell, J. Rossjohn, S. Burrows, 2013, Blood.

Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig

A. Sewell, John J Miles, G. Dolton, 2018, PLoS pathogens.

Polypropylene Sulfide Nanoparticle p24 Vaccine Promotes Dendritic Cell-Mediated Specific Immune Responses against HIV-1.

K. Ladell, G. Dolton, J. Birchall, 2016, The Journal of investigative dermatology.

Structural basis of human β-cell killing by CD8+ T cells in Type 1 diabetes

J. Drijfhout, A. Sewell, B. Jakobsen, 2011, Nature Immunology.

Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination

K. Gaus, J. Rossjohn, G. Dolton, 2016, Proceedings of the National Academy of Sciences.

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

Charles J. Vaske, Rohan N. Borkar, David M. Schauder, 2016, Journal for ImmunoTherapy of Cancer.

Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy

C. Fegan, M. Donia, I. Svane, 2023, Cell.

Autoreactive T effector memory differentiation mirrors &bgr; cell function in type 1 diabetes

C. Beam, S. Heck, A. Sewell, 2018, The Journal of clinical investigation.

Peptide Super-Agonist Enhances T-Cell Responses to Melanoma

M. Donia, I. Svane, A. Sewell, 2019, Front. Immunol..