J. Gan

发表

Structural basis for the aldolase and epimerase activities of Staphylococcus aureus dihydroneopterin aldolase.

Yue Li, Honggao Yan, J. Błaszczyk, 2007, Journal of molecular biology.

Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis

J. Gan, Siyun Kuang, Jun Zheng, 2017, Proceedings of the National Academy of Sciences.

Structure-guided protein engineering increases enzymatic activities of the SGNH family esterases

J. Gan, Jixi Li, Zhengyang Li, 2020, Biotechnology for Biofuels.

Structure-guided protein engineering increases enzymatic activities of the SGNH family esterases

J. Gan, Xue-Wei Xu, Jixi Li, 2020, Biotechnology for Biofuels.

Structural analysis and functional study of phosphofructokinase B (PfkB) from Mycobacterium marinum.

J. Gan, C. Ji, Jixi Li, 2021, Biochemical and biophysical research communications.

Structural Insight into the Mechanism of Double-Stranded RNA Processing by Ribonuclease III

D. Court, J. Gan, X. Ji, 2006, Cell.

Identification and characterization of acetyltransferase‐type toxin‐antitoxin locus in Klebsiella pneumoniae

Z. Deng, Hong-Yu Ou, J. Gan, 2018, Molecular microbiology.

Structural insights into the specific recognition of DSR by the YTH domain containing protein Mmi1.

Jinhao Xu, Jinbiao Ma, J. Gan, 2017, Biochemical and biophysical research communications.

Selective cadmium regulation mediated by a cooperative binding mechanism in CadR

Kang Wang, J. Gan, Zhijun Liu, 2019, Proceedings of the National Academy of Sciences.

Structural mimicry of CD4 by a cross-reactive HIV-1 neutralizing antibody with CDR-H2 and H3 containing unique motifs.

D. Dimitrov, J. Gan, P. Prabakaran, 2006, Journal of molecular biology.

The complex structures of ALKBH2 mutants cross-linked to dsDNA reveal the conformational swing of β-hairpin

Cai-Guang Yang, J. Gan, Baoen Chen, 2014, Science China Chemistry.

High-resolution DNA quadruplex structure containing all the A-, G-, C-, T-tetrads

Jinzhong Lin, J. Gan, Jinbiao Ma, 2018, Nucleic acids research.

A Peptide Binder of E3 Ligase Adaptor SPOP Disrupts Oncogenic SPOP‐Protein Interactions in Kidney Cancer Cells

Hualiang Jiang, Yue Huang, Cai-Guang Yang, 2020, Chinese Journal of Chemistry.

Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation

J. Gan, H. He, Siyun Kuang, 2020, Advanced science.

Crystal structure of Pseudomonas aeruginosa RsaL bound to promoter DNA reaffirms its role as a global regulator involved in quorum-sensing

J. Gan, Haihua Liang, W. Kong, 2016, Nucleic acids research.

The transcription factor OsSUF4 interacts with SDG725 in promoting H3K36me3 establishment

Q. Luo, J. Gan, W. Shen, 2019, Nature Communications.

Structure-guided development of Pb2+-binding DNA aptamers

J. Gan, Yixi Zhang, Hehua Liu, 2022, Scientific Reports.

Structure of Severe Acute Respiratory Syndrome Coronavirus Receptor-binding Domain Complexed with Neutralizing Antibody*

Yang Feng, Ponraj Prabakaran, Xiaodong Xiao, 2006, Journal of Biological Chemistry.

TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization

J. Lieberman, J. Gan, H. He, 2021, Cell Death & Differentiation.

Molecular insights into the master regulator CysB‐mediated bacterial virulence in Pseudomonas aeruginosa

J. Gan, Haihua Liang, Yixi Zhang, 2019, Molecular microbiology.

Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma.

Yue Huang, Cai-Guang Yang, J. Gan, 2022, Cell chemical biology.

Dysregulation of ClpP by Small-Molecule Activators Used Against Xanthomonas oryzae pv. oryzae Infections.

Cai-Guang Yang, J. Gan, Baoan Song, 2021, Journal of agricultural and food chemistry.

Structural and biochemical analyses of shikimate dehydrogenase AroE from Aquifex aeolicus: implications for the catalytic mechanism.

Yue Li, Honggao Yan, J. Gan, 2007, Biochemistry.

Structural basis for guide RNA trimming by RNase D ribonuclease in Trypanosoma brucei

J. Gan, Jinbiao Ma, Yixi Zhang, 2020, Nucleic acids research.

Structure of RapA, a Swi2/Snf2 protein that recycles RNA polymerase during transcription.

A. Joachimiak, J. Gan, X. Ji, 2008, Structure.

The SiaA/B/C/D signaling network regulates biofilm formation in Pseudomonas aeruginosa

X. Deng, J. Gan, Haihua Liang, 2020, The EMBO journal.

The SiaA/B/C/D signaling network regulates biofilm formation in Pseudomonas aeruginosa

M. Li, X. Deng, J. Gan, 2020, The EMBO journal.

Crystal structure of human archease, a key cofactor of tRNA splicing ligase complex.

J. Gan, Suhua Li, Jixi Li, 2020, The international journal of biochemistry & cell biology.

Structural insights into RNA duplexes with multiple 2 (cid:2) -5 (cid:2) -linkages

J. Gan, Zhipu Luo, Hehua Liu, 2017 .

A unique DNA-binding mode of African swine fever virus AP endonuclease

J. Gan, Jinbiao Ma, Jixi Li, 2020, Cell Discovery.

Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues

J. Gan, Jinbiao Ma, Zhen Huang, 2019, Nature Communications.

Structural basis for multiple gene regulation by human DUX4.

J. Gan, Jinbiao Ma, Jixi Li, 2018, Biochemical and biophysical research communications.

Structural insights into DNA degradation by human mitochondrial nuclease MGME1

J. Gan, Jinbiao Ma, Jixi Li, 2018, Nucleic acids research.

Structural insight into the role of VAL1 B3 domain for targeting to FLC locus in Arabidopsis thaliana.

J. Gan, Jinbiao Ma, Mengmeng Zhang, 2018, Biochemical and biophysical research communications.

Unique 5′-P recognition and basis for dG:dGTP misincorporation of ASFV DNA polymerase X

J. Gan, Jinbiao Ma, Jixi Li, 2017, PLoS biology.

Structural basis for single-stranded RNA recognition and cleavage by C3PO

J. Gan, Jinbiao Ma, Baixing Wu, 2016, Nucleic acids research.

Fluorescent Aptaswitch for Detection of Lead Ions.

J. Gan, A. Chandrasekaran, Hehua Liu, 2022, ACS applied bio materials.

Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP

Cai-Guang Yang, J. Gan, Q. Ji, 2022, Nature Communications.

Crystal structure of Mycobacterium tuberculosis shikimate kinase in complex with shikimic acid and an ATP analogue.

Yue Li, Honggao Yan, J. Gan, 2006, Biochemistry.

Chemical and structural biology of nucleic acids and protein-nucleic acid complexes for novel drug discovery

J. Gan, Zhen Huang, J. Sheng, 2011 .

Novel RNA base pair with higher specificity using single selenium atom

J. Gan, Huiyan Sun, Zhen Huang, 2012, Nucleic acids research.

Structural Basis for the Selective Pb(II) Recognition of Metalloregulatory Protein PbrR691.

J. Gan, Wenquan Zhou, Weizhong Chen, 2016, Inorganic chemistry.

Resistance-Gene Directed Discovery of a Natural Product Herbicide with a New Mode of Action

S. Jacobsen, J. Gan, Shuguang Yuan, 2018, Nature.

Novel complex MAD phasing and RNase H structural insights using selenium oligonucleotides.

I. Weber, J. Gan, A. Chumanevich, 2014, Acta crystallographica. Section D, Biological crystallography.

Synthesis of 6-Se-guanosine RNAs for structural study.

J. Gan, J. Saloň, Zhen Huang, 2013, Organic letters.

Synthesis and crystal structure study of 2′-Se-adenosine-derivatized DNA

J. Gan, J. Saloň, Zhen Huang, 2010 .

Synthesis and crystal structure of 2'-se-modified guanosine containing DNA.

J. Gan, J. Saloň, Zhen Huang, 2010, The Journal of organic chemistry.

Structure‐Based DNA‐Targeting Strategies with Small Molecule Ligands for Drug Discovery

Zhen Huang, Jia Sheng, J. Gan, 2013, Medicinal research reviews.

DNA backbone interactions impact the sequence specificity of DNA sulfur-binding domains: revelations from structural analyses

Z. Deng, J. Gan, Geng Wu, 2020, Nucleic acids research.

Structural basis of Zn(II) induced metal detoxification and antibiotic resistance by histidine kinase CzcS in Pseudomonas aeruginosa

J. Gan, H. Sang, Weizhong Chen, 2017, PLoS pathogens.

Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein.

Tianlu Wang, Xiaolian Zhang, Wei Huang, 2015, Journal of the American Chemical Society.

Construction and structure studies of DNA-bipyridine complexes as versatile scaffolds for site-specific incorporation of metal ions into DNA

J. Gan, S. Ranganathan, M. Scalabrin, 2019, Journal of biomolecular structure & dynamics.

Rhein Inhibits AlkB Repair Enzymes and Sensitizes Cells to Methylated DNA Damage*

Yue Huang, Cai-Guang Yang, J. Gan, 2016, The Journal of Biological Chemistry.

Structural insights of non-canonical U•U pair and Hoogsteen interaction probed with Se atom

J. Gan, A. Soares, J. Saloň, 2013, Nucleic acids research.

Hydrogen bond formation between the naturally modified nucleobase and phosphate backbone

J. Gan, Wen Zhang, A. Soares, 2012, Nucleic acids research.

A stepwise model for double‐stranded RNA processing by ribonuclease III

D. Court, J. Gan, X. Ji, 2007, Molecular microbiology.

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.

Hualiang Jiang, Yue Huang, Cai-Guang Yang, 2019, Cancer cell.

Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1

S. Jaffrey, J. Gan, Jinbiao Ma, 2018, Nature Communications.

A DNA Structure Containing AgI -Mediated G:G and C:C Base Pairs.

Q. Luo, J. Gan, Jinbiao Ma, 2017, Angewandte Chemie.

Structural and functional studies of a noncanonical Dicer from Entamoeba histolytica

J. Gan, Jinbiao Ma, Xuhang Li, 2017, Scientific Reports.

RNase III: Genetics and function; structure and mechanism.

N. Costantino, D. Court, J. Gan, 2013, Annual review of genetics.

Intermediate states of ribonuclease III in complex with double-stranded RNA.

D. Court, J. Gan, X. Ji, 2005, Structure.

Noncatalytic assembly of ribonuclease III with double-stranded RNA.

D. Court, J. Błaszczyk, J. Gan, 2004, Structure.

Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5

Cheng Luo, Hu Zhou, Hualiang Jiang, 2014, Nucleic acids research.

Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease

J. Gan, Q. Ji, Yifei Zhang, 2019, PLoS biology.

RNA interference with DNA polymerase and synthesis

J. Gan, Zhen Huang, R. Abdur, 2014, Science China Chemistry.

Structural analysis of Phytophthora suppressor of RNA silencing 2 (PSR2) reveals a conserved modular fold contributing to virulence

J. Gan, Jinbiao Ma, Yuanchao Wang, 2019, Proceedings of the National Academy of Sciences.

Structural insights into the effects of 2′-5′ linkages on the RNA duplex

Li Li, Jia Sheng, J. Szostak, 2014, Proceedings of the National Academy of Sciences.

Structural insights into RNA duplexes with multiple 2΄-5΄-linkages

J. Gan, Zhipu Luo, Hehua Liu, 2016, Nucleic acids research.

Crystal structure of an RNA-cleaving DNAzyme

Jinzhong Lin, J. Gan, Jinbiao Ma, 2017, Nature Communications.

Zhanghua Wu, Q. Luo, J. Gan, 2020, Proceedings of the National Academy of Sciences.

Structural studies reveal a ring-shaped architecture of deep-sea vent phage NrS-1 polymerase

J. Gan, Jinbiao Ma, Yixi Zhang, 2020, Nucleic acids research.

Structural Analysis of the Hg(II)-Regulatory Protein Tn501 MerR from Pseudomonas aeruginosa

J. Gan, Jing Ma, Weizhong Chen, 2016, Scientific Reports.

Structural insights into the complex of trigger factor chaperone and ribosomal protein S7 from Mycobacterium tuberculosis.

J. Gan, C. Ji, Jixi Li, 2019, Biochemical and biophysical research communications.

OsChz1 acts as a histone chaperone in modulating chromatin organization and genome function in rice

Q. Luo, J. Gan, W. Shen, 2020, Nature Communications.

Structural insights into target DNA recognition by R2R3-MYB transcription factors

Q. Luo, J. Gan, A. Dong, 2019, Nucleic acids research.

Toxin–antitoxin operon kacAT of Klebsiella pneumoniae is regulated by conditional cooperativity via a W-shaped KacA–KacT complex

Z. Deng, Hong-Yu Ou, J. Gan, 2019, Nucleic acids research.

Structural Insight into the Mechanism of Staphylococcus aureus Stp1 Phosphatase.

Kunqian Yu, Kaixian Chen, Cai-Guang Yang, 2019, ACS infectious diseases.

Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR.

Cai-Guang Yang, J. Gan, L. Lan, 2017, Journal of the American Chemical Society.

Oxidation-sensing Regulator AbfR Regulates Oxidative Stress Responses, Bacterial Aggregation, and Biofilm Formation in Staphylococcus epidermidis*

Hualiang Jiang, Cai-Guang Yang, D. Qu, 2012, The Journal of Biological Chemistry.

Characterization of Gain-of-Function Mutant Provides New Insights into ClpP Structure.

Hualiang Jiang, Cai-Guang Yang, J. Gan, 2016, ACS chemical biology.

Structural and Molecular Mechanism of CdpR Involved in Quorum-Sensing and Bacterial Virulence in Pseudomonas aeruginosa

X. Deng, J. Gan, Jinbiao Ma, 2016, PLoS biology.

The transcription factor OsSUF4 interacts with SDG725 in promoting H3K36me3 establishment

Q. Luo, J. Gan, W. Shen, 2019, Nature Communications.

Structural insights into target DNA recognition by R2R3-type MYB transcription factor

Q. Luo, J. Gan, A. Dong, 2019 .

Identification and Characterization of a Novel Prokaryotic Peptide

D. Qu, J. Gan, Jinbiao Ma, 2015, The Journal of Biological Chemistry.

Short DNA Oligonucleotide as a Ag+ Binding Detector

J. Gan, A. Chandrasekaran, Hehua Liu, 2020, ACS omega.

Flexibility and stabilization of HgII-mediated C:T and T:T base pairs in DNA duplex

Q. Luo, J. Gan, Jinbiao Ma, 2016, Nucleic acids research.

Nucleic acid crystallization and phase determination facilitated by selenium functionalization

J. Gan, Wen Zhang, Cen Chen, 2017 .

A unique DNA-binding mode of African swine fever virus AP endonuclease

J. Gan, Jinbiao Ma, Jixi Li, 2020, Cell Discovery.

Acetylation of lysine 182 inhibits the ability of Mycobacterium tuberculosis DosR to bind DNA and regulate gene expression during hypoxia

J. Gan, Honghai Wang, Xuelian Zhang, 2018, Emerging Microbes & Infections.

Identification and characterization of chromosomal relBE toxin-antitoxin locus in Streptomyces cattleya DSM46488

Zixin Deng, Cui Tai, Hong-Yu Ou, 2016, Scientific Reports.

Crystal structure of an RNA-cleaving DNAzyme

Jinzhong Lin, J. Gan, Jinbiao Ma, 2017, Nature Communications.

The identification and characterization of a selected SAM-dependent methyltransferase ribozyme that is present in natural sequences

Dongrong Chen, A. Murchie, J. Gan, 2021, Nature Catalysis.

Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1

S. Jaffrey, J. Gan, Jinbiao Ma, 2017, Nature Communications.

Assessment of the structure-activity relationship and antileukemic activity of diacylpyramide compounds as human ClpP agonists.

Cai-Guang Yang, J. Gan, Tao Zhang, 2023, European journal of medicinal chemistry.

Structure of an isolated unglycosylated antibody CH2 domain

D. Dimitrov, J. Gan, P. Prabakaran, 2008, Acta crystallographica. Section D, Biological crystallography.

Histamine activates HinK to promote the virulence of Pseudomonas aeruginosa.

Cai-Guang Yang, J. Gan, Q. Cao, 2021, Science bulletin.

Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues

J. Gan, Jinbiao Ma, Suhua Li, 2019, Nature Communications.

Structure-Activity Relationships and Antileukemia Effects of the Tricyclic Benzoic Acid FTO Inhibitors.

Yue Huang, Cai-Guang Yang, J. Gan, 2022, Journal of medicinal chemistry.

Rational Design of RNA Demethylase FTO Inhibitors with Enhanced Antileukemia Drug-Like Properties.

Cai-Guang Yang, J. Gan, Ze Dong, 2023, Journal of medicinal chemistry.

Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1

Samie R Jaffrey, Jinbiao Ma, S. Jaffrey, 2017, Nature Communications.

Catalytic-state structure and engineering of Streptococcus thermophilus Cas9

J. Gan, Suwen Zhao, Q. Ji, 2020, Nature Catalysis.

Competition between Supramolecular Interaction and Protein–Protein Interaction in Protein Crystallization: Effects of Crystallization Method and Small Molecular Bridge

J. Gan, Jinbiao Ma, Rongting Hu, 2018 .

Synthesis of 6-Se-guanosine RNAs for structural study.

J. Gan, J. Saloň, Zhen Huang, 2013, Organic letters.

A DNA Structure Containing AgI -Mediated G:G and C:C Base Pairs.

Q. Luo, J. Gan, Jinbiao Ma, 2017, Angewandte Chemie.