X. Ji

发表

Structural basis for the aldolase and epimerase activities of Staphylococcus aureus dihydroneopterin aldolase.

Yue Li, Honggao Yan, J. Błaszczyk, 2007, Journal of molecular biology.

A Potent Germline-like Human Monoclonal Antibody Targets a pH-Sensitive Epitope on H7N9 Influenza Hemagglutinin

Wei Li, D. Dimitrov, X. Ji, 2017, Cell Host & Microbe.

Crystallographic and modeling studies of RNase III suggest a mechanism for double-stranded RNA cleavage.

D. Court, J. Błaszczyk, X. Ji, 2001, Structure.

Structural basis for RNA recognition by NusB and NusE in the initiation of transcription antitermination

D. Court, X. Ji, A. Altieri, 2011, Nucleic acids research.

Structural Insight into the Mechanism of Double-Stranded RNA Processing by Ribonuclease III

D. Court, J. Gan, X. Ji, 2006, Cell.

The absorption edge of protein-bound mercury and a double-edge strategy for HgMAD data acquisition.

J. Błaszczyk, X. Ji, X. Chen, 2001, Acta crystallographica. Section D, Biological crystallography.

Molecular motions and conformational changes of HPPK

D. Covell, O. Keskin, X. Ji, 2002, Proteins.

Crystal structure of the broadly cross-reactive HIV-1-neutralizing Fab X5 and fine mapping of its epitope.

D. Burton, D. Dimitrov, X. Ji, 2004, Biochemistry.

JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity.

K. M. Davies, X. Ji, Shivendra V. Singh, 2003, Molecular cancer therapeutics.

Irreversible Inhibition of Glutathione S-Transferase by Phenethyl Isothiocyanate (PEITC), a Dietary Cancer Chemopreventive Phytochemical

X. Ji, Shivendra V. Singh, M. Dyba, 2016, PloS one.

Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug.

D. Townsend, K. Tew, X. Ji, 2004, Molecular pharmacology.

Role of arginine 216 in catalytic activity of murine Alpha class glutathione transferases mGSTAl-1 and mGSTA2-2 toward carcinogenic diol epoxides of polycyclic aromatic hydrocarbons.

S. Srivastava, X. Ji, C. Herzog, 2001, Carcinogenesis.

A spring-loaded state of NusG in its functional cycle is suggested by X-ray crystallography and supported by site-directed mutants.

D. Court, W. Guo, X. Ji, 2003, Biochemistry.

The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X

X. Ji, He Song, 2019, Nature Communications.

The Functional Cycle of Rnt1p: Five Consecutive Steps of Double-Stranded RNA Processing by a Eukaryotic RNase III.

Yun-Xing Wang, X. Ji, X. Fang, 2017, Structure.

Nitric Oxide (NO) Releasing Poly ADP-ribose Polymerase 1 (PARP-1) Inhibitors Targeted to Glutathione S-Transferase P1-Overexpressing Cancer Cells

X. Ji, L. Anderson, J. Saavedra, 2014, Journal of medicinal chemistry.

Contribution of tyrosine 6 to the catalytic mechanism of isoenzyme 3-3 of glutathione S-transferase.

G. Gilliland, X. Ji, R. Armstrong, 1992, The Journal of biological chemistry.

Tyrosine 115 participates both in chemical and physical steps of the catalytic mechanism of a glutathione S-transferase.

G. Gilliland, X. Ji, R. Armstrong, 1993, The Journal of biological chemistry.

First-sphere and second-sphere electrostatic effects in the active site of a class mu gluthathione transferase.

W. J. Stevens, G. Gilliland, X. Ji, 1996, Biochemistry.

Activity of four allelic forms of glutathione S-transferase hGSTP1-1 for diol epoxides of polycyclic aromatic hydrocarbons.

S. Srivastava, X. Ji, Y. Awasthi, 1997, Biochemical and biophysical research communications.

Structure and function of residue 104 and water molecules in the xenobiotic substrate-binding site in human glutathione S-transferase P1-1.

J. Błaszczyk, X. Ji, B. Xiao, 1999, Biochemistry.

Active Site Architecture of Polymorphic Forms of Human GlutathioneS-Transferase P1-1 Accounts for Their Enantioselectivity and Disparate Activity in the Glutathione Conjugation of 7β,8α-Dihydroxy-9α, 10α-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene

S. Srivastava, X. Ji, Shivendra V. Singh, 1997 .

Growth Arrest by the Antitumor Steroidal Lactone Withaferin A in Human Breast Cancer Cells Is Associated with Down-regulation and Covalent Binding at Cysteine 303 of β-Tubulin*

A. Marcus, P. Wipf, X. Ji, 2013, The Journal of Biological Chemistry.

Crystal structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, a potential target for the development of novel antimicrobial agents.

Honggao Yan, X. Ji, B. Xiao, 1999, Structure.

Crystallization and preliminary X-ray diffraction studies of NusG, a protein shared by the transcription and translation machines.

D. E. Anderson, W. Guo, X. Ji, 2002, Acta crystallographica. Section D, Biological crystallography.

Structural and biochemical analyses of shikimate dehydrogenase AroE from Aquifex aeolicus: implications for the catalytic mechanism.

Yue Li, Honggao Yan, J. Gan, 2007, Biochemistry.

Fusion Proteins as Alternate Crystallization Paths to Difficult Structure Problems

G. Gilliland, X. Ji, K. Keeling, 1994 .

Structure of RapA, a Swi2/Snf2 protein that recycles RNA polymerase during transcription.

A. Joachimiak, J. Gan, X. Ji, 2008, Structure.

Therapeutic Potential of Leelamine, a Novel Inhibitor of Androgen Receptor and Castration-Resistant Prostate Cancer

X. Ji, Shivendra V. Singh, Krishna B Singh, 2018, Molecular Cancer Therapeutics.

Role of protein conformational dynamics in the catalysis by 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.

Honggao Yan, X. Ji, 2011, Protein and peptide letters.

Structural basis for Dicer-like function of an engineered RNase III variant and insights into the reaction trajectory of two-Mg2+-ion catalysis

X. Ji, S. Dharavath, G. Shaw, 2022, RNA biology.

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of macrophage growth locus A (MglA) protein from Francisella tularensis.

X. Ji, D. Waugh, B. P. Austin, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

Overproduction of a Dominant Mutant of the Conserved Era GTPase Inhibits Cell Division in Escherichia coli

Daniel P. Haeusser, N. Costantino, D. Court, 2020, Journal of Bacteriology.

Structural basis for non-catalytic and catalytic activities of ribonuclease III.

X. Ji, 2006, Acta crystallographica. Section D, Biological crystallography.

Allosteric Activation of Bacterial Swi2/Snf2 (Switch/Sucrose Non-fermentable) Protein RapA by RNA Polymerase

Yun-Xing Wang, X. Ji, M. Kashlev, 2015, The Journal of Biological Chemistry.

Active site architecture of polymorphic forms of human glutathione S-transferase P1-1 accounts for their enantioselectivity and disparate activity in the glutathione conjugation of 7beta,8alpha-dihydroxy-9alpha,10alpha-ox y-7,8,9,10-tetrahydrobenzo(a)pyrene.

S. Srivastava, X. Ji, B. Nanduri, 1997, Biochemical and biophysical research communications.

Crystal structure of Mycobacterium tuberculosis shikimate kinase in complex with shikimic acid and an ATP analogue.

Yue Li, Honggao Yan, J. Gan, 2006, Biochemistry.

Dual-Target Inhibitors of the Folate Pathway Inhibit Intrinsically Trimethoprim-Resistant DfrB Dihydrofolate Reductases.

J. Pelletier, X. Ji, J. Toulouse, 2020, ACS medicinal chemistry letters.

Tubulin β Cysteine 303 of Down-regulation and Covalent Binding at Cancer Cells Is Associated with Lactone Withaferin A in Human Breast Growth Arrest by the Antitumor Steroidal Signal Transduction

A. Marcus, P. Wipf, X. Ji, 2014 .

The three-dimensional structure of a glutathione S-transferase from the mu gene class. Structural analysis of the binary complex of isoenzyme 3-3 and glutathione at 2.2-A resolution.

G L Gilliland, G. Gilliland, X. Ji, 1992, Biochemistry.

Characterization of four orthologs of stringent starvation protein A.

X. Ji, Mi Li, K. M. Routzahn, 2003, Acta crystallographica. Section D, Biological crystallography.

Structural Basis for the Function of Stringent Starvation Protein A as a Transcription Factor*

X. Ji, Mi Li, D. Jin, 2005, Journal of Biological Chemistry.

Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New design with improved properties.

Yue Li, Honggao Yan, X. Ji, 2012, Bioorganic & medicinal chemistry.

Unusual Conformational Changes in 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase as Revealed by X-ray Crystallography and NMR*

Honggao Yan, J. Błaszczyk, X. Ji, 2001, The Journal of Biological Chemistry.

Mechanism of differential catalytic efficiency of two polymorphic forms of human glutathione S-transferase P1-1 in the glutathione conjugation of carcinogenic diol epoxide of chrysene.

S. Srivastava, X. Ji, S. Srivastava, 1997, Archives of biochemistry and biophysics.

Structure and function of Rnt1p: An alternative to RNAi for targeted RNA degradation

X. Ji, S. Abou Elela, 2018, Wiley interdisciplinary reviews. RNA.

A stepwise model for double‐stranded RNA processing by ribonuclease III

D. Court, J. Gan, X. Ji, 2007, Molecular microbiology.

The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X

X. Ji, He Song, 2019, Nature Communications.

The molecular mechanism of dsRNA processing by a bacterial Dicer.

X. Ji, Shuo Gu, He Song, 2019, Nucleic acids research.

RNase III: Genetics and function; structure and mechanism.

N. Costantino, D. Court, J. Gan, 2013, Annual review of genetics.

The mechanism of RNase III action: how dicer dices.

X. Ji, 2008, Current topics in microbiology and immunology.

Intermediate states of ribonuclease III in complex with double-stranded RNA.

D. Court, J. Gan, X. Ji, 2005, Structure.

Noncatalytic assembly of ribonuclease III with double-stranded RNA.

D. Court, J. Błaszczyk, J. Gan, 2004, Structure.

Structure of a eukaryotic RNase III postcleavage complex reveals a double-ruler mechanism for substrate selection.

Mathieu Lavoie, X. Ji, S. Abou Elela, 2014, Molecular cell.

Snapshots along the reaction coordinate of an SNAr reaction catalyzed by glutathione transferase.

G L Gilliland, G. Gilliland, X. Ji, 1993, Biochemistry.

Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs.

H. Chakrapani, X. Ji, J. Saavedra, 2008, Bioorganic & medicinal chemistry.

Antitumor activity of JS-K [O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate] and related O2-aryl diazeniumdiolates in vitro and in vivo.

L. Jia, X. Ji, J. Saavedra, 2006, Journal of medicinal chemistry.

PABA/NO as an anticancer lead: analogue synthesis, structure revision, solution chemistry, reactivity toward glutathione, and in vitro activity.

K. M. Davies, J. Deschamps, L. Jia, 2006, Journal of medicinal chemistry.

Structure and function of the xenobiotic substrate-binding site and location of a potential non-substrate-binding site in a class pi glutathione S-transferase.

G L Gilliland, G. Gilliland, X. Ji, 1997, Biochemistry.

Structure of ERA in complex with the 3′ end of 16S rRNA: Implications for ribosome biogenesis

D. Court, X. Ji, J. Tropea, 2009, Proceedings of the National Academy of Sciences.

Structural insights into cell cycle control by essential GTPase Era.

X. Ji, 2016, Postepy biochemii.

The Era GTPase recognizes the GAUCACCUCC sequence and binds helix 45 near the 3′ end of 16S rRNA

D. Court, X. Ji, S. Tarasov, 2011, Proceedings of the National Academy of Sciences.

Crystal structure of ERA: a GTPase-dependent cell cycle regulator containing an RNA binding motif.

D. Court, X. Ji, X. Chen, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Purification, characterization and crystallization of ERA, an essential GTPase from Escherichia coli 1

D. Court, X. Ji, Su-min Chen, 1999, FEBS letters.

Allosteric regulation of E2:E3 interactions promote a processive ubiquitination machine

X. Ji, A. Weissman, Jess Li, 2013, The EMBO journal.

Three-dimensional structure, catalytic properties, and evolution of a sigma class glutathione transferase from squid, a progenitor of the lens S-crystallins of cephalopods.

G L Gilliland, G. Gilliland, X. Ji, 1995, Biochemistry.

Structure and function of the xenobiotic substrate binding site of a glutathione S-transferase as revealed by X-ray crystallographic analysis of product complexes with the diastereomers of 9-(S-glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene.

G L Gilliland, G. Gilliland, X. Ji, 1993, Biochemistry.

Is the critical role of loop 3 of Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase in catalysis due to loop-3 residues arginine-84 and tryptophan-89? Site-directed mutagenesis, biochemical, and crystallographic studies.

Yue Li, Honggao Yan, J. Błaszczyk, 2005, Biochemistry.

Catalytic center assembly of HPPK as revealed by the crystal structure of a ternary complex at 1.25 A resolution.

Honggao Yan, J. Błaszczyk, X. Ji, 2000, Structure.

Bisubstrate inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: Transition state analogs for high affinity binding.

X. Ji, G. Shi, S. Tarasov, 2020, Bioorganic & medicinal chemistry.

P6981, An Arylstibonic Acid, Is a Novel Low Nanomolar Inhibitor of cAMP Response Element-Binding Protein Binding to DNA

R. Shoemaker, X. Ji, C. Vinson, 2012, Molecular Pharmacology.

Structure and function of RapA: a bacterial Swi2/Snf2 protein required for RNA polymerase recycling in transcription.

X. Ji, D. Jin, G. Shaw, 2011, Biochimica et biophysica acta.

Guide RNA biogenesis involves a novel RNase III family endoribonuclease in Trypanosoma brucei.

S. Sze, J. Sacchettini, X. Ji, 2011, RNA.

Impact of antibody framework residue VH-71 on the stability of a humanised anti-MUC1 scFv and derived immunoenzyme

D. Newton, S. Rybak, X. Ji, 2004, British Journal of Cancer.

Reaction trajectory of pyrophosphoryl transfer catalyzed by 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.

Yue Li, Honggao Yan, J. Błaszczyk, 2004, Structure.

Survival of BRCA2-Deficient Cells Is Promoted by GIPC3, a Novel Genetic Interactor of BRCA2

D. Morrison, Xia Ding, X. Ji, 2017, Genetics.

Crystallographic and molecular dynamics simulation analysis of Escherichia coli dihydroneopterin aldolase

Yue Li, Honggao Yan, J. Błaszczyk, 2014, Cell & Bioscience.

Structure and activity of Yersinia pestis 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase as a novel target for the development of antiplague therapeutics.

Yue Li, Honggao Yan, J. Błaszczyk, 2007, Acta crystallographica. Section D, Biological crystallography.

Allosteric activation of E2-RING finger-mediated ubiquitylation by a structurally defined specific E2-binding region of gp78.

Yien Che Tsai, Ranabir Das, X. Ji, 2009, Molecular cell.

Crystal structure of a murine glutathione S-transferase in complex with a glutathione conjugate of 4-hydroxynon-2-enal in one subunit and glutathione in the other: evidence of signaling across the dimer interface.

X. Ji, B. Xiao, B. Nanduri, 1999, Biochemistry.

Redesign of a four-helix bundle protein by phage display coupled with proteolysis and structural characterization by NMR and X-ray crystallography.

Yawen Bai, Andrey V Kajava, Wuhong Pei, 2002, Journal of molecular biology.

A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation

Michelle E. Clapp, R. Chari, X. Ji, 2021, PLoS biology.

Structural enzymology and inhibition of the bi‐functional folate pathway enzyme HPPK–DHPS from the biowarfare agent Francisella tularensis

Yue Li, Honggao Yan, X. Ji, 2014, The FEBS journal.

Impact of low-frequency hotspot mutation R282Q on the structure of p53 DNA-binding domain as revealed by crystallography at 1.54 Å resolution

X. Ji, Yawen Bai, Yu-Hong Tan, 2008, Acta crystallographica. Section D, Biological crystallography.

A Glutathione S-Transferase π-Activated Prodrug Causes Kinase Activation Concurrent with S-Glutathionylation of Proteins

D. Townsend, K. Tew, X. Ji, 2006, Molecular Pharmacology.

Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B*

X. Ji, A. Weissman, Jess Li, 2015, The Journal of Biological Chemistry.

A structurally unique E2-binding domain activates ubiquitination by the ERAD E2, Ubc7p, through multiple mechanisms.

X. Ji, A. Weissman, Jess Li, 2013, Molecular cell.

Structural basis for binding of RNA and cofactor by a KsgA methyltransferase.

D. Court, X. Ji, J. Tropea, 2009, Structure.

Modular mutagenesis of exons 1, 2, and 8 of a glutathione S-transferase from the mu class. Mechanistic and structural consequences for chimeras of isoenzyme 3-3.

G. Gilliland, X. Ji, R. Armstrong, 1992, Biochemistry.

Location of a potential transport binding site in a sigma class glutathione transferase by x-ray crystallography.

G L Gilliland, G. Gilliland, X. Ji, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Biochemical and Biological Studies of Mouse APOBEC3

X. Ji, A. Rein, Silvia Sánchez-Martínez, 2014, Journal of Virology.

Essential roles of a dynamic loop in the catalysis of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.

Yue Li, Honggao Yan, J. Błaszczyk, 2004, Biochemistry.

Dynamic roles of arginine residues 82 and 92 of Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: crystallographic studies.

Honggao Yan, Yue Li, Honggao Yan, 2003, Biochemistry.

Structural basis for catalytic differences between alpha class human glutathione transferases hGSTA1-1 and hGSTA2-2 for glutathione conjugation of environmental carcinogen benzo[a]pyrene-7,8-diol-9,10-epoxide.

S. Srivastava, X. Ji, S. Amin, 2004, Biochemistry.

Structure-based design of anticancer prodrug PABA/NO

X. Ji, Shivendra V. Singh, J. Saavedra, 2008, Drug design, development and therapy.

Dissecting the nucleotide binding properties of Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase with fluorescent 3'(2)'-o-anthraniloyladenosine 5'-triphosphate.

J. Zeikus, Honggao Yan, X. Ji, 2000, Biochimica et biophysica acta.

Structure and activity of PPX/GppA homologs from Escherichia coli and Helicobacter pylori

X. Ji, D. Jin, He Song, 2019, The FEBS journal.

The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X

X. Ji, He Song, 2019, Nature Communications.

Crystal structure of DEAD-box RNA helicase DDX3X at pre-unwound state

X. Ji, He Song, 2019 .

P6981, An Arylstibonic Acid, Is a Novel Low Nanomolar Inhibitor of cAMP Response Element-Binding Protein Binding to DNA

R. Shoemaker, X. Ji, C. Vinson, 2012, Molecular Pharmacology.

Structural basis for binding of RNA and cofactor by a KsgA methyltransferase.

D. Court, X. Ji, J. Tropea, 2009, Structure.

Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes.

P. Reinemer, G. Kleywegt, G. Gilliland, 1993, Journal of molecular biology.

Allosteric activation of E2-RING finger-mediated ubiquitylation by a structurally defined specific E2-binding region of gp78.

X. Ji, A. Weissman, A. Altieri, 2009, Molecular cell.

Guide RNA biogenesis involves a novel RNase III family endoribonuclease in Trypanosoma brucei.

S. Sze, J. Sacchettini, X. Ji, 2011, RNA.