A. D. de Vos

发表

Structural and mutational analysis of affinity-inert contact residues at the growth hormone-receptor interface.

J. Wells, K. Pearce, M. Ultsch, 1996, Biochemistry.

Convergent solutions to binding at a protein-protein interface.

W. Delano, J. Wells, M. Ultsch, 2000, Science.

The crystal structures of EDA-A1 and EDA-A2: splice variants with distinct receptor specificity.

Minhong Yan, Vishva M Dixit, A. D. de Vos, 2003, Structure.

The structure of human lymphotoxin (tumor necrosis factor-beta) at 1.9-A resolution.

S R Sprang, S. Sprang, M. Ultsch, 1992, The Journal of biological chemistry.

Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5.

M. Ultsch, R. Kelley, A. D. de Vos, 1999, Molecular cell.

Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity.

T. Clackson, J. Wells, M. Ultsch, 1998, Journal of molecular biology.

Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex.

M. Sliwkowski, A. D. de Vos, D. Leahy, 2004, Cancer cell.

Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors.

A. D. de Vos, V. Dixit, A. Goddard, 2000, Science.

VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface.

A. D. de Vos, Y. Muller, B. Cunningham, 1998, Structure.

The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 A resolution: multiple copy flexibility and receptor binding.

B. Keyt, A. D. de Vos, Y. Muller, 1997, Structure.

Nerve growth factor: structure and function

A. D. de Vos, C. Wiesmann, A. D. Vos, 2001, Cellular and Molecular Life Sciences CMLS.

Structure and function of human growth hormone: implications for the hematopoietins.

J. Wells, A. D. de Vos, J A Wells, 1993, Annual review of biophysics and biomolecular structure.

Crystal structure of the complex between VEGF and a receptor-blocking peptide.

A. D. de Vos, B. Cunningham, H. Christinger, 1998, Biochemistry.

The Ca2+ ion and membrane binding structure of the Gla domain of Ca-prothrombin fragment 1.

A. D. de Vos, A. Tulinsky, M. Soriano-garcia, 1994, Biochemistry.

The Crystal Structure of Placental Growth Factor in Complex with Domain 2 of Vascular Endothelial Growth Factor Receptor-1*

A. D. de Vos, H. Christinger, G. Fuh, 2004, Journal of Biological Chemistry.

Determination of residues involved in ligand binding and signal transmission in the human IFN-alpha receptor 2.

A. D. de Vos, S. Marsters, A. Ashkenazi, 1999, Journal of immunology.

Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution.

M. Ultsch, R. Kelley, A. D. de Vos, 1992, Biochemistry.

Hinge bending within the cytokine receptor superfamily revealed by the 2.4 Å crystal structure of the extracellular domain of rabbit tissue factor

R. Kelley, A. D. de Vos, Y. Muller, 1998, Protein science : a publication of the Protein Society.

Crystals of human growth hormone-receptor complexes. Extracellular domains of the growth hormone and prolactin receptors and a hormone mutant designed to prevent receptor dimerization.

M. Ultsch, A. D. de Vos, Abraham M. de Vos, 1993, Journal of molecular biology.

Crystallization of human c-H-ras oncogene products.

S. Kim, A. D. de Vos, E. Ohtsuka, 1988, Journal of molecular biology.

Suppressor of Fused Regulates Gli Activity through a Dual Binding Mechanism

M. Ultsch, A. D. de Vos, F. D. de Sauvage, 2004, Molecular and Cellular Biology.

Crystals of the complex between human growth hormone and the extracellular domain of its receptor.

M. Ultsch, A. D. de Vos, A. Kossiakoff, 1991, Journal of molecular biology.

Crystallization of ovine placental lactogen in a 1:2 complex with the extracellular domain of the rat prolactin receptor.

A. D. de Vos, A. Kossiakoff, H. Christinger, 1998, Acta crystallographica. Section D, Biological crystallography.

The crystal structure of affinity-matured human growth hormone at 2 A resolution.

M. Ultsch, A. D. de Vos, W. Somers, 1994, Journal of molecular biology.

Structure-function study of the extracellular domain of the human IFN-alpha receptor (hIFNAR1) using blocking monoclonal antibodies: the role of domains 1 and 2.

S. Bass, A. D. de Vos, A. Chuntharapai, 1998, Journal of immunology.

KDR (VEGF Receptor 2) Is the Major Mediator for the Hypotensive Effect of VEGF

A. D. de Vos, Renhui Yang, A. Ogasawara, 2002, Hypertension.

Sensitive ELISA for interleukin-6. Detection of IL-6 in biological fluids: synovial fluids and sera.

A. D. de Vos, A. D. de Vos, L. Aarden, 1991, Journal of immunological methods.

The crystal structure of the extracellular domain of human tissue factor refined to 1.7 A resolution.

M. Ultsch, A. D. de Vos, Y. Muller, 1996, Journal of molecular biology.

Structure of the extracellular domain of human tissue factor: location of the factor VIIa binding site.

M. Ultsch, R. Kelley, A. D. de Vos, 1994, Biochemistry.

Crystal structure of a sweet tasting protein thaumatin I, at 1.65 A resolution.

S. Kim, Sung-Hou Kim, A. D. de Vos, 1992, Journal of molecular biology.

Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen.

A. D. de Vos, H. Christinger, G. Fuh, 1999, Journal of molecular biology.

Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site.

A. D. de Vos, B. Li, Y. Muller, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.

M. Ultsch, A. D. de Vos, A. Kossiakoff, 1992, Science.

Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule.

K. Clauser, M. Ultsch, A. D. de Vos, 1991, Science.

Three-dimensional structure of thaumatin I, an intensely sweet protein.

S. Kim, M. Hatada, A. D. de Vos, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Crystal structures of two intensely sweet proteins.

S. Kim, Sung-Hou Kim, A. D. de Vos, 1989, Trends in biochemical sciences.

Putting two and two together: crystal structure of the FGF-receptor complex.

A. D. de Vos, C. Wiesmann, Christian Wiesmann, 1999, Structure.

Crystal structures at 2.2 A resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP.

S H Kim, S. Kim, M. Milburn, 1991, Journal of molecular biology.

Three-dimensional structure of an oncogene protein: catalytic domain of human c-H-ras p21.

S H Kim, S. Kim, M. Milburn, 1988, Science.

Mutations of ovine and bovine placental lactogens change, in different ways, the biological activity mediated through homologous and heterologous lactogenic receptors.

O. Livnah, A. D. de Vos, J. Djiane, 2001, The Journal of endocrinology.

Hematopoietic receptor complexes.

A. D. de Vos, J. Wells, J. Wells, 1996, Annual review of biochemistry.

Structural plasticity in a remodeled protein-protein interface.

S. Atwell, M. Ultsch, A. D. de Vos, 1997, Science.

Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites.

C. Schiffer, M. Ultsch, A. D. de Vos, 2002, Journal of molecular biology.

Ligand-binding sites in Ig-like domains of receptor tyrosine kinases

A. D. de Vos, Y. Muller, C. Wiesmann, 2000, Journal of Molecular Medicine.

Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC.

S. Bass, M. Ultsch, A. D. de Vos, 1999, Journal of molecular biology.

Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states.

M. Champe, A. D. de Vos, N. Skelton, 1999, Journal of molecular biology.

Structure of ras proteins.

S. Kim, M. Milburn, L. Tong, 1989, Science.

Vascular Endothelial Growth Factor–Induced Genes in Human Umbilical Vein Endothelial Cells: Relative Roles of KDR and Flt-1 Receptors

A. D. de Vos, P. Williams, M. Gerritsen, 2002, Arteriosclerosis, thrombosis, and vascular biology.

X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis.

S. Kim, M. Milburn, L. Tong, 1992, Proceedings of the National Academy of Sciences of the United States of America.

IL‐17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL‐17F, and implications for receptor binding

R. Kelley, A. D. de Vos, A. Gurney, 2001, The EMBO journal.

A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL.

M. Ultsch, R. Kelley, A. D. de Vos, 2000, Biochemistry.

Structural basis for cytokine hormone-receptor recognition and receptor activation.

A. D. de Vos, A. Kossiakoff, 1998, Advances in protein chemistry.

Comprehensive functional maps of the antigen-binding site of an anti-ErbB2 antibody obtained with shotgun scanning mutagenesis.

Sachdev S Sidhu, Leonard G Presta, L. Presta, 2002, Journal of molecular biology.

Comparison of the intermediate complexes of human growth hormone bound to the human growth hormone and prolactin receptors

M. Ultsch, A. D. de Vos, W. Somers, 1994, Protein science : a publication of the Protein Society.

Receptor-selective Variants of Human Vascular Endothelial Growth Factor

A. D. de Vos, M. Gerritsen, G. Fuh, 2000, The Journal of Biological Chemistry.

Crystallization of the receptor binding domain of vascular endothelial growth factor

B. Keyt, A. D. de Vos, Y. Muller, 1996, Proteins.

Vascular Endothelial Cell Growth Factor-Driven Endothelial Tube Formation Is Mediated by Vascular Endothelial Cell Growth Factor Receptor-2, a Kinase Insert Domain-Containing Receptor

A. D. de Vos, M. Gerritsen, G. Fuh, 2001, Arteriosclerosis, thrombosis, and vascular biology.

Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 A resolution.

M. Ultsch, A. D. de Vos, P. Godowski, 1998, Structure.

The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1.

K. Garcia, A. D. de Vos, G. Fuh, 2000, The Journal of biological chemistry.

Probing the mechanism of staphylococcal nuclease with unnatural amino acids: kinetic and structural studies.

P. Schultz, A. D. de Vos, E. C. Murphy, 1993, Science.

Crystal structure of human insulin-like growth factor-1: detergent binding inhibits binding protein interactions.

J Liu, M. Ultsch, A. D. de Vos, 2001, Biochemistry.

Molecular recognition in biological systems: from activation to inhibition.

T. Hynes, A. D. de Vos, A. Kossiakoff, 1993, Biochemical Society Transactions.

Variations on ligand-receptor complexes.

A. D. de Vos, C. Wiesmann, A. D. Vos, 2000 .