H. Phillips

发表

Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis.

Thomas D. Wu, K. Aldape, Z. Modrušan, 2006, Cancer cell.

Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma.

Se Hoon Kim, K. Aldape, D. Cahill, 2013, Cancer cell.

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma.

R. Wilson, C. Perou, K. Aldape, 2010, Cancer cell.

Differential Gene Expression in Glioblastoma Defined by ADC Histogram Analysis: Relationship to Extracellular Matrix Molecules and Survival

S. Nelson, T. Cloughesy, H. Phillips, 2012, American Journal of Neuroradiology.

Vascular endothelial growth factor messenger ribonucleic acid expression in the primate ovary.

H. Phillips, A. Zeleznik, N. Ferrara, 1992, Endocrinology.

Characterization of a multicomponent receptor for GDNF

A. Buj-Bello, C. Henderson, A. Goddard, 1996, Nature.

Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin.

Zhaoshi Jiang, Somasekar Seshagiri, Franklin Peale, 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

A multigene predictor of outcome in glioblastoma.

K. Aldape, M. Gilbert, M. Mehta, 2010, Neuro-oncology.

BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease

Steven A. Johnson, H. Phillips, M. Armanini, 1991, Neuron.

Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System

Heidi Phillips, D. Sulzer, I. Fariñas, 2000, Neuron.

Neurturin Exerts Potent Actions on Survival and Function of Midbrain Dopaminergic Neurons

J. Milbrandt, H. Phillips, R. Vandlen, 1998, The Journal of Neuroscience.

Rescue of NGF-deficient mice II: basal forebrain cholinergic projections require NGF for target innervation but not guidance.

H. Phillips, B. Davis, K. Albers, 2004, Brain research. Molecular brain research.

Neurotrophic‐4/5 is a survival factor for embryonic midbrain dopaminergic neurons in enriched cultures

H. Phillips, L. Berkemeier, A. Rosenthal, 1994 .

The Glial Cell Line-Derived Neurotrophic Factor Family Receptor Components Are Differentially Regulated within Sensory Neurons after Nerve Injury

S. McMahon, G. Michael, H. Phillips, 2000, The Journal of Neuroscience.

GFRα1 Is an Essential Receptor Component for GDNF in the Developing Nervous System and Kidney

I. Fariñas, A. Davies, H. Phillips, 1998, Neuron.

Neurotrophin‐3 reverses experimental cisplatin‐induced peripheral sensory neuropathy

H. Phillips, W. Gao, F. Hefti, 1995, Annals of neurology.

Development of neurotrophic factor therapy for Alzheimer's disease.

L. Goodman, H. Phillips, P. Godowski, 1996, Ciba Foundation symposium.

DMD057513 1110..1116

H. Phillips, R. Carano, B. Alicke, 2014 .

Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria

M. Westphal, Z. Modrušan, H. Phillips, 2008, Oncogene.

Impact of Blood–Brain Barrier Integrity on Tumor Growth and Therapy Response in Brain Metastases

W. Wick, H. Phillips, F. Winkler, 2016, Clinical Cancer Research.

Persephin, a Novel Neurotrophic Factor Related to GDNF and Neurturin

R. Vejsada, C. Henderson, J. Milbrandt, 1998, Neuron.

Vascular endothelial growth factor is expressed in rat corpus luteum.

H. Phillips, N. Ferrara, D. Leung, 1990, Endocrinology.

Neurotrophins promote motor neuron survival and are present in embryonic limb bud

S. McMahon, C. Henderson, H. Phillips, 1993, Nature.

Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle

A. Björklund, H. Phillips, D. Kirik, 1999, The European journal of neuroscience.

Nomenclature of GPI-Linked Receptors for the GDNF Ligand Family

L. M. Goodman, J. Treanor, J. Milbrandt, 1997, Neuron.

Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis.

H. Phillips, N. Ferrara, L. Jakeman, 1993, Endocrinology.

Autoradiographic localization of relaxin binding sites in rat brain.

H. Phillips, P. Osheroff, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Trastuzumab uptake and its relation to efficacy in an animal model of HER2-positive breast cancer brain metastasis

H. Phillips, S. Kharbanda, Simon-Peter Williams, 2017, Breast Cancer Research and Treatment.

Heparin Coinfusion during Convection-Enhanced Delivery (CED) Increases the Distribution of the Glial-Derived Neurotrophic Factor (GDNF) Ligand Family in Rat Striatum and Enhances the Pharmacological Activity of Neurturin

Heidi Phillips, John F. Hamilton, H. Phillips, 2001, Experimental Neurology.

Truncated and Catalytic Isoforms of trkB are Co‐expressed in Neurons of Rat and Mouse CNS

S. McMahon, H. Phillips, J. Sutherland, 1995, The European journal of neuroscience.

Correlation of molecular subtypes with survival in AVAglio (bevacizumab [Bv] and radiotherapy [RT] and temozolomide [T] for newly diagnosed glioblastoma [GB]).

R. Bourgon, P. Hegde, W. Mason, 2014 .

Intense focal expression of vascular endothelial growth-factor messenger-RNA in human intracranial neoplasms - association with regions of necrosis.

M. Westphal, H. Phillips, N. Ferrara, 1993, International journal of oncology.

Ultrastructural localization of LH-RH-immunoreactive synapses in the hamster accessory olfactory bulb

H. Phillips, B. Ho, J. Linner, 1982, Brain Research.

Compositions and methods for the diagnosis and treatment of a tumor

Thomas D. Wu, G. Frantz, K. Hillan, 2000 .

Hypoxia and oxygenation induce a metabolic switch between pentose phosphate pathway and glycolysis in glioma stem-like cells

M. Westphal, Z. Modrušan, T. Sandmann, 2013, Acta Neuropathologica.

Csk and BatK Show Opposite Temporal Expression in the Rat CNS: Consistent with its Late Expression in Development, BatK Induces Differentiation of PC12 Cells

H. Phillips, M. Armanini, I. Caras, 1997, The European journal of neuroscience.

Sensory and Motor Neuron-derived Factor. A NOVEL HEREGULIN VARIANT HIGHLY EXPRESSED IN SENSORY AND MOTOR NEURONS (*)

H. Phillips, M. Armanini, W. Ho, 1995, The Journal of Biological Chemistry.

A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor

Barbara Moffat, Heidi Phillips, C. Henderson, 1997, Nature.

A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor (Nature (1997) 387 (717-721))

C. Henderson, N. Asai, H. Phillips, 1998 .

Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation.

Jerry J. Lou, T. Cloughesy, L. Liau, 2013, Neuro-oncology.

A regulatory network of canonical nuclear factor-κB activation predicts high-grade glioma outcome

K. Aldape, M. Bredel, G. Harsh, 2007 .

Molecular Characterization and Distribution of Vascular Endothelial Growth Factor

H. Phillips, N. Ferrara, D. Leung, 1991 .

Regulation of Hippocampal Synaptic Plasticity by the Tyrosine Kinase Receptor, REK7/EphA5, and its Ligand, AL-1/Ephrin-A5

H. Phillips, W. Gao, M. Armanini, 1998, Molecular and Cellular Neuroscience.

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

M. Scott, H. Phillips, M. Noll, 1996, Nature.

A deletion truncating the gonadotropin-releasing hormone gene is responsible for hypogonadism in the hpg mouse.

P. Seeburg, R. Zoeller, A. Mason, 1986, Science.

Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family.

P. Seeburg, R. Sprengel, M. Köhler, 1989, Science.

Hippocampal dysfunction and behavioral deficit in the water maze in mice: An unresolved issue?

H. Phillips, Simon-Peter Williams, R. Gerlai, 2002, Brain Research Bulletin.

Widespread expression of BDNF but not NT3 by target areas of basal forebrain cholinergic neurons.

H. Phillips, A. Rosenthal, J. Hains, 1990, Science.

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

Bing Li, Napoleone Ferrara, J. Winer, 1993, Nature.

Development of a gene expression-based prognostic signature for IDH wild-type glioblastoma.

C. Brennan, R. Bourgon, M. Weller, 2020, Neuro-oncology.

Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma

L. Rangell, H. Phillips, H. Koeppen, 2016, Drug Metabolism and Disposition.

Reply to T.J. Kruser et al.

R. Bourgon, W. Mason, M. Taphoorn, 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Patients With Proneural Glioblastoma May Derive Overall Survival Benefit From the Addition of Bevacizumab to First-Line Radiotherapy and Temozolomide: Retrospective Analysis of the AVAglio Trial.

R. Bourgon, P. Hegde, W. Mason, 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H glioma

M. Hedehus, A. Daemen, F. Peale, 2014, Proceedings of the National Academy of Sciences.

Distribution of the Phosphatidylinositol 3-Kinase Inhibitors Pictilisib (GDC-0941) and GNE-317 in U87 and GS2 Intracranial Glioblastoma Models—Assessment by Matrix-Assisted Laser Desorption Ionization Imaging

H. Phillips, R. Carano, B. Alicke, 2014, Drug Metabolism and Disposition.

Identifying the mesenchymal molecular subtype of glioblastoma using quantitative volumetric analysis of anatomic magnetic resonance images.

Benjamin M Ellingson, Timothy F Cloughesy, Albert Lai, 2013, Neuro-oncology.

Molecular subclassification of diffuse gliomas: Seeing order in the chaos

C. Brennan, J. Huse, H. Phillips, 2011, Glia.

TMEFF2 Is a PDGF-AA Binding Protein with Methylation-Associated Gene Silencing in Multiple Cancer Types Including Glioma

Thomas D. Wu, H. Phillips, H. Koeppen, 2011, PloS one.

A distinct subset of glioma cell lines with stem cell‐like properties reflects the transcriptional phenotype of glioblastomas and overexpresses CXCR4 as therapeutic target

M. Westphal, Z. Modrušan, H. Phillips, 2011, Glia.

NFKBIA deletion in glioblastomas.

K. Aldape, D. Scholtens, H. Vogel, 2011, The New England journal of medicine.

A hierarchy of self-renewing tumor-initiating cell types in glioblastoma.

Serban Nacu, Manfred Westphal, Zora Modrusan, 2010, Cancer cell.

Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma.

Jane Fridlyand, Justin Chen, Bruno M Costa, 2010, Cancer research.

Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma

Zora Modrusan, K. Aldape, Z. Modrušan, 2007, Proceedings of the National Academy of Sciences.

Renal and neuronal abnormalities in mice lacking GDNF

I. Fariñas, H. Phillips, L. Reichardt, 1996, Nature.

G-protein-coupled receptorof Kaposi ’ ssarcoma-associated herpesvirusisaviraloncogene andangiogenesisactivator

C. Henderson, N. Asai, Masahide Takahashi, 1997 .

Cardiotrophin-1, a Cytokine Present in Embryonic Muscle, Supports Long-Term Survival of Spinal Motoneurons

R. Vejsada, H. Phillips, D. Pennica, 1996, Neuron.

Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growth

K. Aldape, J. Costello, H. Phillips, 2007, Proceedings of the National Academy of Sciences.

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system.

D. Sulzer, I. Fariñas, A. Abeliovich, 2000, Neuron.

Anatomic localization of O6-methylguanine DNA methyltransferase (MGMT) promoter methylated and unmethylated tumors: A radiographic study in 358 de novo human glioblastomas

Robert J. Harris, Albert Lai, Whitney B. Pope, 2012, NeuroImage.

Regulation of Learning by EphA Receptors: a Protein Targeting Study

J. Winer, H. Phillips, R. Gerlai, 1999, The Journal of Neuroscience.

Synchronous Onset of NGF and TrkA Survival Dependence in Developing Dorsal Root Ganglia

M. Barbacid, H. Phillips, W. Snider, 1996, The Journal of Neuroscience.

GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle.

C. Henderson, A. Davies, H. Phillips, 1994, Science.

Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR.

M. Barbacid, F. Rice, Richard J Smeyne, 1998, Developmental biology.

The LHRH family of peptide messengers in the frog nervous system.

Y. Jan, W. Branton, H. Phillips, 1986, Progress in brain research.

Immunocytochemical localization of LHRH in central olfactory pathways of hamster

H. Phillips, G. Kozlowski, B. Kerdelhué, 1980, Brain Research.

Expression and coexpression of Trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets

S. McMahon, H. Phillips, M. Armanini, 1994, Neuron.

Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons

S. McMahon, H. Phillips, A. Levinson, 1994, Cell.

Differential dependency of cutaneous mechanoreceptors on neurotrophins, trk receptors, and P75 LNGFR.

A. Fagan, M. Barbacid, F. Rice, 1997, Developmental biology.

Expression of the trk family of neurotrophin receptors in developing and adult dorsal root ganglion neurons.

H. Phillips, M. Armanini, 1996, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Therapeutic Use of Neurotrophic Factors

J. Treanor, H. Phillips, W. Gao, 1995 .

Expression of vascular endothelial growth factor does not promote transformation but confers a growth advantage in vivo to Chinese hamster ovary cells.

J. Winer, H. Phillips, A. Rowland, 1993, The Journal of clinical investigation.

3D micro-CT imaging of the postmortem brain

Heidi Phillips, H. D'Arceuil, A. Crespigny, 2008, Journal of Neuroscience Methods.

Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent

G. V. Vande Woude, H. Phillips, M. Starovasnik, 2013, Proceedings of the National Academy of Sciences.

Molecular cloning and expression of a novel adhesion molecule, SC1

H. Phillips, Angela L. Lee, I. Kubota, 1991, Neuron.

Identification and Analysis of In Vivo VEGF Downstream Markers Link VEGF Pathway Activity with Efficacy of Anti-VEGF Therapies

Matthew J. Brauer, C. James, P. Hegde, 2013, Clinical Cancer Research.

Mammalian-Cell-Produced Neurturin (NTN) Is More Potent Than Purified Escherichia coli-Produced NTN

Weng Tao, M. Hoane, H. Phillips, 2000, Experimental Neurology.

Chapter 3.2.7 Protein targeting in the functional analysis of EphA receptors: the use of immunoadhesins

J. Winer, H. Phillips, P. Williams, 1999 .

Protein targeting in the analysis of learning and memory: a potential alternative to gene targeting

N. Bruggen, H. Phillips, Simon-Peter Williams, 1998, Experimental Brain Research.

Disruption of a Single Allele of the Nerve Growth Factor Gene Results in Atrophy of Basal Forebrain Cholinergic Neurons and Memory Deficits

H. Phillips, S. Spencer, C. Crowley, 1997 .

Rescue of NGF-deficient mice I: transgenic expression of NGF in skin rescues mice lacking endogenous NGF.

H. Phillips, B. Davis, K. Albers, 2004, Brain research. Molecular brain research.

Identification and purification of an irreversible presynaptic neurotoxin from the venom of the spider Hololena curta.

Y. Jan, L. Jan, H. Phillips, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Immunocytochemical localization in rat brain of a prolactin release-inhibiting sequence of gonadotropin-releasing hormone prohormone

P. Seeburg, H. Phillips, K. Nikolics, 1985, Nature.

Spider toxins selectively block calcium currents in drosophila

W. Branton, L. Byerly, H. Phillips, 1989, Neuron.

TGF beta 2 and TGF beta 3 are potent survival factors for midbrain dopaminergic neurons.

H. Phillips, A. Rosenthal, K. Poulsen, 1994, Neuron.

Targeting the PI3K Pathway in the Brain—Efficacy of a PI3K Inhibitor Optimized to Cross the Blood–Brain Barrier

J. Sarkaria, H. Phillips, S. Kharbanda, 2012, Clinical Cancer Research.

Impaired water maze learning performance without altered dopaminergic function in mice heterozygous for the GDNF mutation

H. Phillips, L. Powell-Braxton, R. Gerlai, 2001, The European journal of neuroscience.

TGFβ2 and TGFβ3 are potent survival factors for midbrain dopaminergic neurons

H. Phillips, A. Rosenthal, K. Poulsen, 1994, Neuron.

A hierarchy of self-renewing tumor-initiating cell types in glioblastoma.

S. Vandenberg, M. Prados, Serban Nacu, 2010, Cancer cell.

Reply to T.J. Kruser et al.

R. Bourgon, W. Mason, M. Taphoorn, 2016, Journal of Clinical Oncology.

Patients With Proneural Glioblastoma May Derive Overall Survival Benefit From the Addition of Bevacizumab to First-Line Radiotherapy and Temozolomide: Retrospective Analysis of the AVAglio Trial.

R. Bourgon, P. Hegde, W. Mason, 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Disruption of a Single Allele of the Nerve Growth Factor Gene Results in Atrophy of Basal Forebrain Cholinergic Neurons and Memory Deficits

H. Phillips, S. Spencer, C. Crowley, 1997, The Journal of Neuroscience.