B. Goldstein

发表

Mathematical and computational models of immune-receptor signalling

W. S. Hlavacek, J. Faeder, B. Goldstein, 2004, Nature Reviews Immunology.

Polyspecificity of T cell and B cell receptor recognition.

A. Perelson, R. Greenspan, D. Krakauer, 2007, Seminars in immunology.

Optimal strategies in immunology III. The IgM-IgG switch

A. Perelson, S. Rocklin, B. Goldstein, 1980, Journal of mathematical biology.

Investigation of Early Events in FcεRI-Mediated Signaling Using a Detailed Mathematical Model1

W. S. Hlavacek, I. Reischl, M. Blinov, 2003, The Journal of Immunology.

A Mechanistic Model of Early FcεRI Signaling: Lipid Rafts and the Question of Protection from Dephosphorylation

B. Goldstein, D. Barua, 2012, PloS one.

The kinetics of bivalent ligand-bivalent receptor aggregation: ring formation and the breakdown of the equivalent site approximation.

B. Goldstein, C. Wofsy, R. Posner, 1995, Mathematical biosciences.

The complexity of complexes in signal transduction

James R Faeder, Byron Goldstein, Michael L Blinov, 2003, Biotechnology and bioengineering.

A network model of early events in epidermal growth factor receptor signaling that accounts for combinatorial complexity.

W. S. Hlavacek, M. Blinov, J. Faeder, 2006, Bio Systems.

A Theoretical and Experimental Study of Competition Between Solution and Surface Receptors for Ligand in a Biacore Flow Cell

Daniel Coombs, Byron Goldstein, David G Myszka, 2006, Bulletin of mathematical biology.

Effective rate models for receptors distributed in a layer above a surface: application to cells and Biacore.

Byron Goldstein, B. Goldstein, C. Wofsy, 2002, Biophysical journal.

Extending the range of rate constants available from BIACORE: interpreting mass transport-influenced binding data.

D G Myszka, M. Dembo, B. Goldstein, 1998, Biophysical journal.

Effective rate models for the analysis of transport-dependent biosensor data.

T Mason, B. Goldstein, C. Wofsy, 1999, Mathematical biosciences.

The effect of receptor density on the forward rate constant for binding of ligands to cell surface receptors.

J. Erickson, B. Goldstein, B. Baird, 1987, Biophysical journal.

Degranulation of human basophils: quantitative analysis of histamine release and desensitization, due to a bivalent penicilloyl hapten.

M. Dembo, B. Goldstein, L. Lichtenstein, 1979, Journal of immunology.

Crosslinking and gelation between linear polymers: DNA-antibody complexes in systemic lupus erythematosus

F. W. Wiegel, B. Geurts, B. Goldstein, 1987 .

Cross-linking of Fc gamma receptors and surface antibodies. Theory and application.

B. Goldstein, C. Wofsy, 1990, Journal of immunology.

Analysis of cholera toxin-ganglioside interactions by flow cytometry.

Byron Goldstein, John P Nolan, Rhiannon L. Nolan, 2002, Biochemistry.

Effect of Concentration and Intermolecular Forces on the Sedimentation of Polystyrene Spheres

B. Zimm, B. Goldstein, 1971 .

Interactions of low density lipoprotein receptors with coated pits on human fibroblasts: estimate of the forward rate constant and comparison with the diffusion limit.

B. Goldstein, C. Wofsy, B Goldstein, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Signaling Using a Detailed Mathematical Model RI-Mediated ε Investigation of Early Events in Fc

W. S. Hlavacek, L. Blinov, I. Reischl, 2012 .

Qualitative characteristics of histamine release from human basophils by covalently cross-linked IgE.

M. Dembo, B. Goldstein, H. Metzger, 1981, Journal of immunology.

Exploiting the difference between intrinsic and extrinsic kinases: implications for regulation of signaling by immunoreceptors.

B. Goldstein, H. Metzger, C. Wofsy, 1997, Journal of immunology.

Theory of hapten binding to IgM: the question of repulsive interactions between binding sites.

B. Goldstein, B Goldstein, 1975, Biophysical chemistry.

Interaction of Interleukin-2 with its Cell Surface Receptors: Interpretation of Equilibrium Binding Experiments via Scatchard Plots

A. Perelson, B. Goldstein, 1992 .

T cell activation: kinetic proofreading, serial engagement and cell adhesion

B. Goldstein, D. Coombs, 2005 .

Activated TCRs remain marked for internalization after dissociation from pMHC

B. Goldstein, D. Coombs, C. Wofsy, 2002, Nature Immunology.

Analysis of coated pit recycling on human fibroblasts

B. Goldstein, C. Wofsy, 2007, Cell Biochemistry and Biophysics.

Solution assembly of cytokine receptor ectodomain complexes

Kirk W. Johnson, B. Goldstein, T. Laue, 1995 .

The Fc segment of IgE influences the kinetics of dissociation of a symmetrical bivalent ligand from cyclic dimeric complexes.

B. Goldstein, B. Baird, K. Subramanian, 1996, Biochemistry.

Bivalent ligand dissociation kinetics from receptor-bound immunoglobulin E: evidence for a time-dependent increase in ligand rebinding at the cell surface.

J. Erickson, B. Goldstein, R. Posner, 1991, Biochemistry.

Test of a theory relating to the cross-linking of IgE antibody on the surface of human basophils.

M. Dembo, B. Goldstein, D. MacGlashan, 1985, Journal of immunology.

Rule-based modeling of biochemical networks

William S. Hlavacek, Michael L. Blinov, Byron Goldstein, 2005, Complex..

PhosphorylationInteractions May Persist beyond LAT RI e Kinetic Proofreading of Ligand-Fc

J. Faeder, B. Goldstein, J. Oliver, 2007 .

Soluble MD2 increases TLR4 levels on the epithelial cell surface.

B. Goldstein, E. Hong-Geller, Sabine Lauer, 2009, Cellular immunology.

The distribution of cell surface proteins on spreading cells. Comparison of theory with experiment.

F. W. Wiegel, B. Goldstein, 1988, Biophysical journal.

Kinetics of Multivalent Antigen DNP-BSA Binding to IgE-FcεRI in Relationship to the Stimulated Tyrosine Phosphorylation of FcεRI

Byron Goldstein, Barbara Baird, David Holowka, 1998, The Journal of Immunology.

Some invariant properties of IgE-mediated basophil activation and desensitization.

M. Dembo, B. Goldstein, L. Lichtenstein, 1979, Journal of immunology.

Quantitative aspects of receptor aggregation.

B. Goldstein, H. Metzger, C. Wofsy, 1994, Advances in experimental medicine and biology.

Stimulated Tyrosine Phosphorylation of Fc RI in Relationship to the ε Binding to IgE-Fc Kinetics of Multivalent Antigen DNP-BSA

B. Goldstein, B. Baird, D. Holowka, 2013 .

Some quantitative aspects of the passive sensitization of human basophils.

M. Dembo, B. Goldstein, F. Malveaux, 1979, Journal of immunology.

Dissociation kinetics of bivalent ligand-immunoglobulin E aggregates in solution.

J. Erickson, B. Goldstein, R. Posner, 1991, Biochemistry.

Reply to Hybble

B. Goldstein, C. Wofsy, 1997 .

The influence of transport on the kinetics of binding to surface receptors: application to cells and BIAcore

B. Goldstein, D. Coombs, C. Wofsy, 1999, Journal of molecular recognition : JMR.

Aggregation of IgE-receptor complexes on rat basophilic leukemia cells does not change the intrinsic affinity but can alter the kinetics of the ligand-IgE interaction.

D. Conrad, B. Goldstein, R. Posner, 1992, Biochemistry.

Anomalies in sedimentation. I. Stability theory of sedimenting entanglements in the “tight‐bending” limit

B. Zimm, B. Goldstein, 1973, Biopolymers.

Investigation of early events in Fc epsilon RI-mediated signaling using a detailed mathematical model.

James R Faeder, Byron Goldstein, Michael L Blinov, 2003, Journal of immunology.

One lyn molecule is sufficient to initiate phosphorylation of aggregated high-affinity IgE receptors.

B. Goldstein, H. Metzger, C. Wofsy, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Effects of the geometry of the immunological synapse on the delivery of effector molecules.

B. Goldstein, D. Coombs, 2004, Biophysical journal.

Interpretation of Scatchard plots for aggregating receptor systems.

B. Goldstein, C. Wofsy, 1992, Mathematical biosciences.

Modeling and Simulation of Aggregation of Membrane Protein LAT with Molecular Variability in the Number of Binding Sites for Cytosolic Grb 2-SOS 1-Grb 2

Alan S. Perelson, Byron Goldstein, Ambarish Nag, 2012 .

Combinatorial complexity and dynamical restriction of network flows in signal transduction.

M L Blinov, W S Hlavacek, M. Blinov, 2004, Systems biology.

Histamine Release Due to Bivalent Penicilloyl Haptens Control by the Number of Cross-Linked IgE Antibodies on the Basophil Plasma Membrane

M. Dembo, B. Goldstein, L. Lichtenstein, 1978, The Journal of Immunology.

Kinetic Proofreading of Ligand-FcεRI Interactions May Persist beyond LAT Phosphorylation1

J. Faeder, B. Goldstein, J. Oliver, 2007, The Journal of Immunology.

Kinetics of Tyrosine Phosphorylation When IgE Dimers Bind to FCε Receptors on Rat Basophilic Leukemia Cells (*)

B. Goldstein, H. Metzger, C. Wofsy, 1995, The Journal of Biological Chemistry.

Implications of epidermal growth factor (EGF) induced egf receptor aggregation.

K Lund, H. Wiley, B. Goldstein, 1992, Biophysical journal.

The effect of co-operativity on the equilibrium binding of symmetric bivalent ligands to antibodies: theoretical results with application to histamine release from basophils.

B. Goldstein, C. Wofsy, 1987, Molecular immunology.

Theory of equilibrium binding of asymmetric bivalent haptens to cell surface antibody: application to histamine release from basophils.

M. Dembo, B. Goldstein, C. Wofsy, 1978, Journal of immunology.

Histamine release due to bivalent penicilloyl haptens the relation of activation and desensitization of basophils to dynamic aspects of ligand binding to cell surface antibody.

M. Dembo, B. Goldstein, L. Lichtenstein, 1979, Journal of immunology.

Competition between solution and cell surface receptors for ligand. Dissociation of hapten bound to surface antibody in the presence of solution antibody.

D. Torney, J. Erickson, B. Goldstein, 1989, Biophysical journal.

Kinetic analysis of histamine release due to covalently linked IgE dimers.

M. Dembo, B. Goldstein, A. Kagey‐Sobotka, 1982, Molecular immunology.

A model of cell activation and desensitization by surface immunoglobin: The case of histamine release from human basophils

M. Dembo, B. Goldstein, 1980, Cell.

T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell.

Daniel Coombs, Byron Goldstein, B. Goldstein, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Guidelines for visualizing and annotating rule-based models.

Bin Hu, Jin Yang, James R Faeder, 2011, Molecular bioSystems.

BioNetGen: software for rule-based modeling of signal transduction based on the interactions of molecular domains

William S. Hlavacek, Michael L. Blinov, Byron Goldstein, 2004, Bioinform..

Recombinant interleukin-2 analogs. Dynamic probes for receptor structure.

B. Goldstein, K. Smith, J. Murphy, 1992, Journal of Biological Chemistry.

Calculations show substantial serial engagement of T cell receptors.

B. Goldstein, D. Coombs, C. Wofsy, 2001, Biophysical journal.

Supplementary information for Activated TCRs remain marked for internalization after dissociation from pMHC

Daniel Coombs, Alexis M. Kalergis, Byron Goldstein, 2022 .

Solution assembly of the pseudo‐high affinity and intermediate affinity interleukin‐2 receptor complexes

B. Goldstein, T. Laue, Zining Wu, 2008, Protein science : a publication of the Protein Society.

Solution Assembly of a Soluble, Heteromeric, High Affinity Interleukin-2 Receptor Complex (*)

B. Goldstein, T. Laue, Zining Wu, 1995, The Journal of Biological Chemistry.

Mathematical Modeling of Syk Activation in Allergen-Stimulated Mast Cells and Basophils

A. Nag, M. Blinov, J. Faeder, 2012 .

A Detailed Mathematical Model Predicts That Serial Engagement of IgE–FcεRI Complexes Can Enhance Syk Activation in Mast Cells

Michael L. Blinov, Byron Goldstein, Ambarish Nag, 2010, The Journal of Immunology.

Kinetic proofreading model.

Daniel Coombs, James R Faeder, Byron Goldstein, 2008, Advances in experimental medicine and biology.

Equilibrium thermodynamics of cell-cell adhesion mediated by multiple ligand-receptor pairs.

Daniel Coombs, Byron Goldstein, Micah Dembo, 2004, Biophysical journal.

A Biophysical Model of Cell Adhesion Mediated by Immunoadhesin Drugs and Antibodies

R. Gutenkunst, Michael Loran Dustin, B. Goldstein, 2010, PloS one.

On the mechanism of hemolytic plaque inhibition.

C DeLisi, C. DeLisi, B. Goldstein, 1974, Immunochemistry.

Signal transduction by FcεRI: Analysis of the early molecular events

B. Goldstein, H. Metzger, C. Wofsy, 1999 .

Diffusion Limited Reactions

Byron Goldstein, David Torney, Harold Levine, 2007, SIAM J. Appl. Math..

Mathematical Modeling of Receptor-Mediated Endocytosis

R. Klausner, B. Goldstein, C. Wofsy, 1985 .

Effect of preferential insertion of LDL receptors near coated pits

B. Goldstein, C. Wofsy, H. Echavarría-Heras, 1985, Cell Biophysics.

Diffusion-limited forward rate constants in two dimensions. Application to the trapping of cell surface receptors by coated pits.

B. Goldstein, C. Wofsy, R. Griego, 1984, Biophysical journal.

Combinatorial diversity of Syk recruitment driven by its multivalent engagement with FcεRIγ

S. Gnanakaran, B. Goldstein, D. Lidke, 2019, Molecular biology of the cell.

Molecular aspects of multivalent engagement between Syk and FcεRIγ

S. Gnanakaran, B. Goldstein, D. Lidke, 2018, bioRxiv.

Taste of sugar at the membrane: thermodynamics and kinetics of the interaction of a disaccharide with lipid bilayers.

S Gnanakaran, Anurag Sethi, Byron Goldstein, 2013, Biophysical journal.

SYMPOSIUM ON COMPUTATIONAL CELL BIOLOGY AGENDA

M. Blinov, J. Faeder, B. Goldstein, 2005 .

Approximating the effects of diffusion on reversible reactions at the cell surface: ligand-receptor kinetics.

M. Dembo, B. Goldstein, M Dembo, 1995, Biophysical journal.

Modeling the early signaling events mediated by FcepsilonRI.

William S. Hlavacek, Michael L. Blinov, Byron Goldstein, 2002, Molecular immunology.

Equilibrium theory for the clustering of bivalent cell surface receptors by trivalent ligands. Application to histamine release from basophils.

A S Perelson, A. Perelson, B. Goldstein, 1984, Biophysical journal.

Equilibrium theory for the binding of bivalent antibodies to regularly spaced sites on a DNA molecule

F. W. Wiegel, B. Goldstein, 1987, Biopolymers.

Forward rate constants for receptor clusters. Variational methods for upper and lower bounds.

F. W. Wiegel, B. Goldstein, B Goldstein, 1984, Biophysical chemistry.

Membrane-mediated regulation of the intrinsically disordered CD3ϵ cytoplasmic tail of the TCR.

S Gnanakaran, Anurag Sethi, Byron Goldstein, 2015, Biophysical journal.

Binding mechanisms of PEGylated ligands reveal multiple effects of the PEG scaffold.

B. Goldstein, Raibatak Das, B. Baird, 2008, Biochemistry.

Kinetic proofreading of ligand-FcepsilonRI interactions may persist beyond LAT phosphorylation.

J. Faeder, B. Goldstein, J. Oliver, 2007, Journal of immunology.

Cross-linking of IgE-receptor complexes at the cell surface: a fluorescence method for studying the binding of monovalent and bivalent haptens to IgE.

J. Erickson, B. Goldstein, B. Baird, 1986, Molecular immunology.

Quantifying Intramolecular Binding in Multivalent Interactions: A Structure-Based Synergistic Study on Grb2-Sos1 Complex

Anurag Sethi, Byron Goldstein, S. Gnanakaran, 2011, PLoS Comput. Biol..

Antigen-specific desensitization of human basophils.

M. Dembo, B. Goldstein, L. Lichtenstein, 1979, Journal of immunology.

Effect of membrane flow on the capture of receptors by coated pits. Theoretical results.

B. Goldstein, C. Wofsy, H. Echavarría-Heras, 1988, Biophysical journal.

Analysis of the role of the interleukin-2 receptor gamma chain in ligand binding.

Byron Goldstein, David G Myszka, B. Goldstein, 2002, Biochemistry.

The hemolytic plaque assay: theory for finite layers.

A. Perelson, B. Goldstein, 1977, Biophysical Chemistry.

The time development of direct hemolytic plaques: implications for the binding of IgM to cell surface haptens.

B. Goldstein, L. J. Rubinstein, S. Esrig, 1985, Molecular immunology.

The electrophoretic hemolytic plaque assay -- theory.

A S Perelson, A. Perelson, B. Goldstein, 1976, Biophysical chemistry.

Immunodiffusion in gels containing erythrocyte antigen. I. Theory for diffusion of antiserum from a circular well.

C DeLisi, C. DeLisi, B. Goldstein, 1975, Journal of theoretical biology.

Aggregation of membrane proteins by cytosolic cross-linkers: theory and simulation of the LAT-Grb2-SOS1 system.

James R Faeder, Byron Goldstein, Ambarish Nag, 2009, Biophysical journal.

Modeling and Simulation of Aggregation of Membrane Protein LAT with Molecular Variability in the Number of Binding Sites for Cytosolic Grb2-SOS1-Grb2

Alan S. Perelson, Byron Goldstein, Ambarish Nag, 2012, PloS one.

'On-the-fly' or 'generate-first' modeling?

Jin Yang, William S. Hlavacek, Michael L. Blinov, 2005, Nature Biotechnology.

A thermodynamic model of binding of flexible bivalent haptens to antibody.

M. Dembo, B. Goldstein, 1978, Immunochemistry.

Theory of equilibrium binding of symmetric bivalent haptens to cell surface antibody: application to histamine release from basophils.

M. Dembo, B. Goldstein, M Dembo, 1978, Journal of immunology.

Kinetic proofreading in receptor-mediated transduction of cellular signals: Receptor aggregation, partially activated receptors, and cytosolic messengers

Byron Goldstein, William S Hlavacek, B. Goldstein, 2002, Bulletin of mathematical biology.

Simultaneous cross-linking by two nontriggering bivalent ligands causes synergistic signaling of IgE Fc epsilon RI complexes.

B. Goldstein, R. Posner, B. Baird, 1995, Journal of immunology.

Kinetics of multivalent antigen DNP-BSA binding to IgE-Fc epsilon RI in relationship to the stimulated tyrosine phosphorylation of Fc epsilon RI.

B. Goldstein, B. Baird, D. Holowka, 1998, Journal of immunology.

Kinetic proofreading models for cell signaling predict ways to escape kinetic proofreading

William S. Hlavacek, Byron Goldstein, B. Goldstein, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Estimating the Probability of Polyreactive Antibodies 4E10 and 2F5 Disabling a gp41 Trimer after T Cell-HIV Adhesion

Bin Hu, Byron Goldstein, S. Munir Alam, 2014, PLoS Comput. Biol..

Evidence for p55-p75 heterodimers in the absence of IL-2 from Scatchard plot analysis.

A S Perelson, I. Kevrekidis, A. Perelson, 1992, International immunology.

Altered patterns of tyrosine phosphorylation and Syk activation for sterically restricted cyclic dimers of IgE-Fc epsilonRI.

B. Goldstein, B. Baird, D. Holowka, 1997, Biochemistry.

Quantification and Modeling of Tripartite CD2-, CD58FC Chimera (Alefacept)-, and CD16-mediated Cell Adhesion*

Daniel Coombs, Byron Goldstein, Adrian Whitty, 2007, Journal of Biological Chemistry.

Shuttling of initiating kinase between discrete aggregates of the high affinity receptor for IgE regulates the cellular response.

B. Goldstein, H. Metzger, C. Wofsy, 1997, Proceedings of the National Academy of Sciences of the United States of America.

A quantitative approach to signal transduction.

B. Goldstein, H. Metzger, C. Wofsy, 1999, Immunology letters.

Progress Toward Understanding the Molecular Details and Consequences of IgE-Receptor Crosslinking

J. Erickson, B. Goldstein, A. Menon, 2018 .

Analysis of Ligand Binding and Cross-Linking of Receptors in Solution and on Cell Surfaces

J. Erickson, B. Goldstein, R. Posner, 1991 .

Dynamics of signal transduction after aggregation of cell-surface receptors: studies on the type I receptor for IgE.

B. Goldstein, H. Metzger, C. Wofsy, 1994, Proceedings of the National Academy of Sciences of the United States of America.

A network model of early events in epidermal growth factor receptor signaling that accounts for combinatorial complexity.

M. Blinov, J. Faeder, B. Goldstein, 2006, Bio Systems.

Lattice Boltzmann Simulation of Diffusion-Convection Systems with Surface Chemical Reaction

Byron Goldstein, Xiaoyi He, B. Goldstein, 2000 .

Shaping the response: the role of FcεRI and Syk expression levels in mast cell signaling.

James R Faeder, Byron Goldstein, Ambarish Nag, 2010, IET systems biology.

Crosslinking of surface antibodies and Fc sub. gamma. receptors: Theory and application

B. Goldstein, C. Wofsy, 1991 .

Theory of a Helix‐to‐Coil Transition in a Triple‐Stranded Macromolecule

C. DeLisi, B. Goldstein, 1969 .

Theory of melting of the triple helix poly (A + 2U) for a 1 : 2 mixture of Poly A to Poly U

B. Goldstein, 1973 .

Why is it so hard to dissociate multivalent antigens from cell-surface antibodies?

B. Goldstein, C. Wofsy, 1996, Immunology today.

A Biophysical Model of Cell Adhesion Mediated by Immunoadhesin Drugs and Antibodies

R. Gutenkunst, Michael Loran Dustin, B. Goldstein, 2010, PloS one.

Combinatorial complexity and dynamical restriction of network flows in signal transduction.

M. Blinov, J. Faeder, B. Goldstein, 2004, Systems biology.

Transport effects on surface–volume biological reactions

D. Cohen, B. Goldstein, B Goldstein, 1999, Journal of mathematical biology.