C. Will

发表

Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion

H. Urlaub, Cyrille Girard, C. Will, 2012, Nature Communications.

Molecular Architecture of the Multiprotein Splicing Factor SF3b

Bjoern Sander, Monika M Golas, Holger Stark, 2003, Science.

The Spliceosome: Design Principles of a Dynamic RNP Machine

C. Will, R. Lührmann, M. Wahl, 2009, Cell.

Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds.

C. Will, R. Lührmann, Peter G. Smith, 2018, Molecular cell.

Spliceosome structure and function.

C. Will, R. Lührmann, 2011, Cold Spring Harbor perspectives in biology.

Dynamic protein-protein interaction wiring of the human spliceosome.

Ulrich Stelzl, Atanas Kamburov, Arndt Grossmann, 2012, Molecular cell.

Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method

M. Wilm, H. Urlaub, C. Will, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Affinity purification of spliceosomal and small nuclear ribonucleoprotein complexes.

C. Will, R. Lührmann, P. Fabrizio, 2013 .

Minor spliceosome components are predominantly localized in the nucleus

C. Will, R. Lührmann, M. Nymark, 2008, Proceedings of the National Academy of Sciences.

Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment.

Henning Urlaub, H. Urlaub, C. Will, 2006, RNA.

Splicing of a rare class of introns by the U12-dependent spliceosome

C. Will, R. Lührmann, Cindy L Will, 2005, Biological chemistry.

Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD‐box protein

Henning Urlaub, Marc Gentzel, M. Wilm, 2002, The EMBO journal.

Structural Basis of Splicin g Modulation by Antitumor Macrolide Compounds Graphical Abstract Highlights

C. Will, Peter G. Smith, N. Larsen, 2022 .

The Sm-core mediates the retention of partially-assembled spliceosomal snRNPs in Cajal bodies until their full maturation

Cyrille Girard, C. Will, R. Lührmann, 2018, Nucleic acids research.

An ancient mechanism for splicing control: U11 snRNP as an activator of alternative splicing.

C. Will, R. Lührmann, M. Frilander, 2010, Molecular cell.

U1 snRNP-ASF/SF2 interaction and 5' splice site recognition: characterization of required elements.

M. Garcia-Blanco, C. Will, R. Lührmann, 1995, Nucleic acids research.

Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation

H. Urlaub, C. Will, R. Lührmann, 2010, Nature Structural &Molecular Biology.

Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors.

C. Will, R. Lührmann, J. Manley, 1993, Nucleic acids research.

Molecular architecture of the human 17S U2 snRNP

H. Stark, H. Urlaub, C. Will, 2020, Nature.

Multiple protein–protein interactions converging on the Prp38 protein during activation of the human spliceosome

U. Stelzl, C. Will, R. Lührmann, 2016, RNA.

Unbiased screen of human transcriptome reveals an unexpected role of 3′UTRs in translation initiation

Zefeng Wang, H. Urlaub, C. Will, 2021, bioRxiv.

Orcadian Regulation of RNA Polymerases and Nuclease Sensitivity in Rat Liver Nuclei

C. Will, N. Horseman, 1984 .

5-Fluorouracil augmentation of dihydrofolate reductase gene transcripts containing intervening sequences in methotrexate-resistant KB cells.

C. Will, B. Dolnick, 1986, Molecular pharmacology.

In vitro reconstitution of mammalian U2 and U5 snRNPs active in splicing: Sm proteins are functionally interchangeable and are essential for the formation of functional U2 and U5 snRNPs.

B. Sproat, C. Will, R. Lührmann, 1995, The EMBO journal.

Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5′ splice site

H. Urlaub, C. Will, B. Kastner, 2015, RNA.

SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing

H. Urlaub, C. Will, R. Lührmann, 2017, Nucleic acids research.

5-Fluorouracil inhibits dihydrofolate reductase precursor mRNA processing and/or nuclear mRNA stability in methotrexate-resistant KB cells.

C. Will, B. Dolnick, 1989, The Journal of biological chemistry.

Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1‐like protein

C. Will, R. Lührmann, D. Schümperli, 2001, The EMBO journal.

Puri ® ed U 7 snRNPs lack the Sm proteins D 1 and D 2 but contain Lsm 10 , a new 14 kDa Sm D 1-like protein

C. Will, R. Pillai, R. L. hrmann, 2022 .

Small Nuclear Rnps (Snrnps)

C. Will, R. Lührmann, 2002 .

Protein functions in premRNA splicing

C. Will, 1997 .

The human U4/U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p.

J. Lauber, William Arbuthnot Sir Lane, C. Will, 1997, RNA.

Semiquantitative Proteomic Analysis of the Human Spliceosome via a Novel Two-Dimensional Gel Electrophoresis Method

Henning Urlaub, H. Urlaub, C. Will, 2011, Molecular and Cellular Biology.

The [U4/U6.U5] tri-snRNP-specific 27K protein is a novel SR protein that can be phosphorylated by the snRNP-associated protein kinase.

J. Lauber, C. Will, R. Lührmann, 1997, RNA.

ATPγS stalls splicing after B complex formation but prior to spliceosome activation

P. Dube, H. Urlaub, C. Will, 2016, RNA.

Protein functions in pre-mRNA splicing.

C. Will, R. Lührmann, R Lührmann, 1997, Current opinion in cell biology.

Functional spliceosomal A complexes can be assembled in vitro in the absence of a penta-snRNP.

C. Will, K. Hartmuth, R. Lührmann, 2006, RNA.

the absence of a penta-snRNP Functional spliceosomal A complexes can be assembled in vitro in

C. Will, K. Hartmuth, R. Lührmann, 2006 .

In vitro reconstitution of mammalian U1 snRNPs active in splicing: the U1-C protein enhances the formation of early (E) spliceosomal complexes.

C. Will, R. Lührmann, W. V. van Venrooij, 1996, Nucleic acids research.

Nuclear Pre-mRNA Splicing

C. Will, R. Lührmann, P. Fabrizio, 1995 .

5-Fluorouracil augmentation of dihydrofolate reductase RNA containing contiguous exon and intron sequences in KB7B cells.

C. Will, B. Dolnick, 1987, The Journal of biological chemistry.

Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly

Divita Garg, C. Will, R. Lührmann, 2020, Nature Communications.

Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation

H. Urlaub, H. Waldmann, C. Will, 2017, eLife.

The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.

Henning Urlaub, Thomas Tuschl, Reinhard Rauhut, 2004, RNA.

A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity

H. Urlaub, C. Will, B. Kastner, 2016, Nature Communications.

Identification of an evolutionarily divergent U11 small nuclear ribonucleoprotein particle in Drosophila.

Jürgen Brosius, Claudia Schneider, J. Brosius, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Human U4/U6.U5 and U4atac/U6atac.U5 Tri-snRNPs Exhibit Similar Protein Compositions

C. Will, E. Makarov, R. Lührmann, 2002, Molecular and Cellular Biology.

Identification of both shared and distinct proteins in the major and minor spliceosomes.

C. Will, R. Lührmann, R. Reed, 1999, Science.

Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing.

Utz Fischer, Daniel Schümperli, Gunter Meister, 2003, Genes & development.

Spliceosomal UsnRNP biogenesis, structure and function.

C. Will, R. Lührmann, R Lührmann, 2001, Current opinion in cell biology.

Isolation of an active step I spliceosome and composition of its RNP core

H. Urlaub, C. Will, R. Lührmann, 2008, Nature.

Protein–protein interactions and 5'-splice-site recognition in mammalian mRNA precursors

M. Garcia-Blanco, C. Will, R. Lührmann, 1994, Nature.

Smu1 and RED are required for activation of spliceosomal B complexes assembled on short introns

Panagiotis K. Papasaikas, J. Valcárcel, Sandra Keiper, 2019, Nature Communications.

13 Spliceosome Structure and Function

C. Will, R. Lührmann, 2006 .

Major conformational change in the complex SF3b upon integration into the spliceosomal U11/U12 di-snRNP as revealed by electron cryomicroscopy.

Bjoern Sander, Monika M Golas, Holger Stark, 2005, Molecular cell.

Conserved Loop I of U5 Small Nuclear RNA Is Dispensable for Both Catalytic Steps of Pre-mRNA Splicing in HeLa Nuclear Extracts

C. Will, R. Lührmann, I. Mattaj, 1999, Molecular and Cellular Biology.

Cryo-EM structure of a human spliceosome activated for step 2 of splicing

H. Stark, H. Urlaub, C. Will, 2017, Nature.

Small Nuclear Ribonucleoprotein Remodeling During Catalytic Activation of the Spliceosome

Henning Urlaub, Marc Gentzel, M. Wilm, 2002, Science.

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation

Henning Urlaub, Olexandr Dybkov, Holger Stark, 2017, Cell.

Protein composition of mammalian spliceosomal snRNPs

C. Will, R. Lührmann, S. Behrens, 1993, Molecular Biology Reports.

Structural insights into how Prp5 proofreads the pre-mRNA branch site

H. Stark, H. Urlaub, C. Will, 2021, Nature.

A novel U2 and U11/U12 snRNP protein that associates with the pre‐mRNA branch site

Claudia Schneider, G. Neubauer, M. Wilm, 2001, The EMBO journal.

Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis.

Henning Urlaub, Bjoern Sander, Monika M Golas, 2010, RNA.

Regulation of 3′ splice site selection after step 1 of splicing by spliceosomal C* proteins

C. Dienemann, H. Urlaub, Cyrille Girard, 2023, Science advances.

Composition and three‐dimensional EM structure of double affinity‐purified, human prespliceosomal A complexes

Henning Urlaub, Bjoern Sander, Monika M Golas, 2007, The EMBO journal.

U2 snRNA-Protein Contacts in Purified Human 17S U2 snRNPs and in Spliceosomal A and B Complexes

C. Will, K. Hartmuth, R. Lührmann, 2006, Molecular and Cellular Biology.

Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation

H. Stark, H. Urlaub, C. Will, 2020, Science.

Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome.

H. Stark, H. Urlaub, C. Will, 2020, Molecular cell.

Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes.

H. Stark, C. Will, B. Kastner, 2019, Cold Spring Harbor perspectives in biology.

HSPC117 Is the Essential Subunit of a Human tRNA Splicing Ligase Complex

D. Söll, K. Mechtler, C. Will, 2011, Science.

Conservation of the Protein Composition and Electron Microscopy Structure of Drosophila melanogaster and Human Spliceosomal Complexes

Henning Urlaub, Nadine Herold, H. Urlaub, 2008, Molecular and Cellular Biology.

Protein Composition and Electron Microscopy Structure of Affinity-Purified Human Spliceosomal B Complexes Isolated under Physiological Conditions

Henning Urlaub, Holger Stark, Daniel Boehringer, 2006, Molecular and Cellular Biology.

A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing

M. Wilm, H. Urlaub, C. Will, 2004, The EMBO journal.

Inhibition of RNA Helicase Brr2 by the C-Terminal Tail of the Spliceosomal Protein Prp8

C. Will, R. Lührmann, M. Wahl, 2013, Science.

The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes

Henning Urlaub, H. Urlaub, C. Will, 2015, Nature Structural &Molecular Biology.

Exon definition complexes contain the tri-snRNP and can be directly converted into B-like precatalytic splicing complexes.

J. Tazi, H. Urlaub, C. Will, 2010, Molecular cell.

The human U5 snRNP-specific 100-kD protein is an RS domain-containing, putative RNA helicase with significant homology to the yeast splicing factor Prp28p.

C. Will, R. Lührmann, T. Achsel, 1997, RNA.

Rational Design of Cyclic Peptide Inhibitors of U2AF Homology Motif (UHM) Domains To Modulate Pre-mRNA Splicing.

Divita Garg, C. Will, R. Lührmann, 2016, Journal of medicinal chemistry.

Characterization of novel SF 3 b and 17 S U 2 snRNP proteins , including a human Prp 5 p homologue and an SF 3 b DEAD-box protein

M. Wilm, H. Urlaub, C. Will, 2022 .

The Prp19 Complex Directly Functions in Mitotic Spindle Assembly

C. Will, R. Lührmann, O. Gruss, 2013, PloS one.

Molecular Architecture of the Human Prp19/CDC5L Complex

Henning Urlaub, Wolfgang Fischle, H. Urlaub, 2010, Molecular and Cellular Biology.

, Dmitry Prp 19 / CDC 5 L Complex Molecular Architecture of the Human

H. Urlaub, C. Will, I. Lemm, 2010 .

Multiple RNA–RNA tertiary interactions are dispensable for formation of a functional U2/U6 RNA catalytic core in the spliceosome

C. Will, K. Hartmuth, R. Lührmann, 2018, Nucleic acids research.

The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated Bact complex

H. Urlaub, C. Will, R. Lührmann, 2017, Genes & development.

U6atac snRNA stem-loop interacts with U12 p65 RNA binding protein and is functionally interchangeable with the U12 apical stem-loop III

A. Komar, C. Will, G. Shukla, 2016, Scientific Reports.

Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans

C. Will, R. Lührmann, M. Wahl, 2014, RNA biology.

The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA.

H. Urlaub, C. Will, R. Lührmann, 2012, Genes & development.

unwinding by blocking Brr 2 loading onto the U 4 snRNA The Prp 8 RNase H-like domain inhibits Brr 2-mediated U 4 / U 6 snRNA Material Supplemental

H. Urlaub, C. Will, R. Lührmann, 2012 .

The U11-48K Protein Contacts the 5′ Splice Site of U12-Type Introns and the U11-59K Protein

C. Will, R. Lührmann, M. Frilander, 2008, Molecular and Cellular Biology.

The 5' end of U2 snRNA is in close proximity to U1 and functional sites of the pre-mRNA in early spliceosomal complexes.

C. Will, B. Kastner, K. Hartmuth, 2007, Molecular cell.

Spliceosomal A and B Complexes Human 17 S U 2 snRNPs and in U 2 snRNA-Protein Contacts in Purified

Nastaran, C. Will, K. Hartmuth, 2006 .

RNP Remodeling With DExH/D Boxes

C. Will, R. Lührmann, 2001, Science.

The U11/U12 snRNP 65K protein acts as a molecular bridge, binding the U12 snRNA and U11‐59K protein

C. Will, R. Lührmann, H. Benecke, 2005, The EMBO journal.

pre-mRNA splicing interaction network involved in branch point definition during Biochemical and NMR analyses of an SF3b155-p14-U2AF-RNA

C. Will, R. Lührmann, G. Stier, 2007 .

Biochemical and NMR analyses of an SF3b155-p14-U2AF-RNA interaction network involved in branch point definition during pre-mRNA splicing.

C. Will, R. Lührmann, G. Stier, 2006, RNA.

The U 11 / U 12 snRNP 65 K protein acts as a molecular bridge , binding the U 12 snRNA and U 1159 K protein

C. Will, R. Lührmann, H. Benecke, 2005 .

Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations.

Henning Urlaub, Olexandr Dybkov, Almudena Ponce-Salvatierra, 2016, Molecular cell.

Mutation(s) of the thymidylate synthase gene of human adenocarcinoma cells causes a thymidylate synthase-negative phenotype that can be attenuated by exogenous folates.

P. Houghton, C. Will, J. Houghton, 1992, Cancer research.

Characterization of lipid storage associated proteins induced in crop tissue by prolactin

C. Will, N. Horseman, 1984, Journal of Comparative Physiology B.

Molecular biology. RNP remodeling with DExH/D boxes.

C. Will, R. Lührmann, 2001, Science.

Conformational Change in the Protein Complex SF3b upon Integration into the Spliceosomal U11/U12 di-snRNP as Revealed by Electron Cryomicroscopy

H. Stark, M. Golas, C. Will, 2005, Microscopy and Microanalysis.

Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation

H. Urlaub, H. Waldmann, C. Will, 2017, eLife.

doi:10.1038/nsmb.2951 The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to

C. Will, Inessa De, Sergey Bessonov, 2015 .

Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes.

H. Stark, C. Will, B. Kastner, 2019, Cold Spring Harbor perspectives in biology.

Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds.

C. Will, Peter G. Smith, N. Larsen, 2018, Molecular cell.

The association of the U1‐specific 70K and C proteins with U1 snRNPs is mediated in part by common U snRNP proteins.

C. Will, R. Luhrmann, W. J. Venrooij, 1994, The EMBO journal.

Molecular Architecture of the Human Prp19/CDC5L Complex

H. Urlaub, C. Will, I. Lemm, 2010, Molecular and Cellular Biology.