B. Kastner

发表

Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion

H. Urlaub, Cyrille Girard, C. Will, 2012, Nature Communications.

GraFix: sample preparation for single-particle electron cryomicroscopy

Henning Urlaub, Bjoern Sander, Franz Herzog, 2008, Nature Methods.

Structure of spliceosomal snRNPs and their role in pre-mRNA splicing.

B. Kastner, R. Lührmann, R Lührmann, 1990, Biochimica et biophysica acta.

Purification and characterization of human autoantibodies directed to specific regions on U1RNA; recognition of native U1RNP complexes.

B. Kastner, R. Lührmann, R. Hoet, 1993, Nucleic acids research.

Isolation of S. cerevisiae snRNPs: comparison of U1 and U4/U6.U5 to their human counterparts.

B. Kastner, R. Lührmann, S. Esser, 1994, Science.

Induction of interferon-alpha by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjögren's syndrome autoantigen-associated RNA.

L. Rönnblom, B. Kastner, M. Eloranta, 2006, Arthritis and rheumatism.

U 1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR 7

S. Akira, B. Kastner, R. Schmid, 2005 .

Combined Biochemical and Electron Microscopic Analyses Reveal the Architecture of the Mammalian U2 snRNP

B. Kastner, A. Krämer, Angela Krämer, 1999, The Journal of cell biology.

Organization of core spliceosomal components U5 snRNA loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as revealed by electron cryomicroscopy.

Bjoern Sander, Monika M Golas, Holger Stark, 2006, Molecular cell.

Mapping the binding site of snurportin 1 on native U1 snRNP by cross-linking and mass spectrometry

C. Lenz, H. Urlaub, B. Kastner, 2010, Nucleic acids research.

Isolation and characterization of the small nucleolar ribonucleoprotein particle snR30 from Saccharomyces cerevisiae

B. Kastner, P. Fabrizio, P Fabrizio, 1995, The Journal of Biological Chemistry.

Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex

H. Stark, H. Urlaub, B. Kastner, 2018, Cell.

Molecular architecture of the human 17S U2 snRNP

H. Stark, H. Urlaub, C. Will, 2020, Nature.

Small nuclear ribonucleoprotein (RNP) U2 contains numerous additional proteins and has a bipartite RNP structure under splicing conditions

B. Kastner, R. Lührmann, J. Reichelt, 1993, Molecular and cellular biology.

Purification and Electron Microscopy of Spliceosomal snRNPs

B. Kastner, 1998 .

Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5′ splice site

H. Urlaub, C. Will, B. Kastner, 2015, RNA.

Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex

H. Stark, H. Urlaub, B. Kastner, 2018, Cell.

Structure of the small nuclear RNP particle U1: identification of the two structural protuberances with RNP-antigens A and 70K

B. Kastner, R. Lührmann, M. Bach, 1992, The Journal of cell biology.

snRNPs: Methods for Purification

B. Kastner, 2001 .

Electron microscopy of assembly intermediates of the snRNP core: morphological similarities between the RNA-free (E.F.G) protein heteromer and the intact snRNP core.

B. Kastner, R. Lührmann, G. Plessel, 1997, Journal of molecular biology.

Electron microscopy of small nuclear ribonucleoprotein (snRNP) particles U2 and U5: evidence for a common structure-determining principle in the major U snRNP family.

B. Kastner, R. Lührmann, M. Bach, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Electron microscopy of U1 small nuclear ribonucleoprotein particles: shape of the particle and position of the 5′ RNA terminus.

B. Kastner, R. Lührmann, 1989, The EMBO journal.

Purification of U small nuclear ribonucleoprotein particles.

B. Kastner, R. Lührmann, 1999, Methods in molecular biology.

The Preparation of HeLa Cell Nuclear Extracts

B. Kastner, K. Hartmuth, R. Lührmann, 2012 .

The ribosomal domain of the bacterial release factors. The carboxyl-terminal domain of the dimer of Escherichia coli ribosomal protein L7/L12 located in the body of the ribosome is important for release factor interaction.

W. Tate, K. McCaughan, B. Kastner, 1990, European journal of biochemistry.

ATPγS stalls splicing after B complex formation but prior to spliceosome activation

P. Dube, H. Urlaub, C. Will, 2016, RNA.

Cbf5p, a potential pseudouridine synthase, and Nhp2p, a putative RNA-binding protein, are present together with Gar1p in all H BOX/ACA-motif snoRNPs and constitute a common bipartite structure.

M. Mann, G. Neubauer, B. Kastner, 1998, RNA.

A doughnut‐shaped heteromer of human Sm‐like proteins binds to the 3′‐end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro

M. Wilm, B. Kastner, R. Lührmann, 1999, The EMBO journal.

The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome.

Henning Urlaub, Holger Stark, H. Stark, 2009, Molecular cell.

Spliceosomal U snRNP Core Assembly: Sm Proteins Assemble onto an Sm Site RNA Nonanucleotide in a Specific and Thermodynamically Stable Manner

B. Kastner, K. Hartmuth, R. Lührmann, 1999, Molecular and Cellular Biology.

Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation

H. Urlaub, H. Waldmann, C. Will, 2017, eLife.

A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity

H. Urlaub, C. Will, B. Kastner, 2016, Nature Communications.

3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core.

H. Stark, M. Golas, B. Kastner, 2010, Molecular cell.

U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7.

S. Akira, B. Kastner, R. Schmid, 2006, Blood.

Protein Stoichiometry of a Multiprotein Complex, the Human Spliceosomal U1 Small Nuclear Ribonucleoprotein

B. Kastner, R. Lührmann, A. Schmidt, 2005, Journal of Biological Chemistry.

Arrangement of RNA and proteins in the spliceosomal U1 small nuclear ribonucleoprotein particle

Holger Stark, H. Stark, P. Dube, 2001, Nature.

The yeast U5 snRNP coisolated with the U1 snRNP has an unexpected protein composition and includes the splicing factor Aar2p.

B. Kastner, R. Lührmann, P. Fabrizio, 2001, RNA.

The yeast U 5 snRNP coisolated with the U 1 snRNP has an unexpected protein composition and includes the splicing factor Aar 2 p

B. Kastner, R. Lührmann, P. Fabrizio, 2001 .

Cryo-EM structure of a human spliceosome activated for step 2 of splicing

H. Stark, H. Urlaub, C. Will, 2017, Nature.

Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy

H. Stark, M. Golas, B. Kastner, 2008, Nature Structural &Molecular Biology.

Electron microscopy of U4/U6 snRNP reveals a Y-shaped U4 and U6 RNA containing domain protruding from the U4 core RNP

B. Kastner, R. Lührmann, M. Bach, 1991, The Journal of cell biology.

Discriminatory RNP remodeling by the DEAD-box protein DED1.

T. Nilsen, B. Kastner, R. Lührmann, 2006, RNA.

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation

Henning Urlaub, Olexandr Dybkov, Holger Stark, 2017, Cell.

RNP)U2 Contains Numerous Additional Proteins andHasa Bipartite RNP Structure underSplicing Conditions

B. Kastner, J. Reichelt, K. Tyc, 1993 .

Functional organization of the Sm core in the crystal structure of human U1 snRNP

B. Kastner, R. Lührmann, S. Trowitzsch, 2010, The EMBO journal.

Immunological studies of Escherichia coli mutants lacking one or two ribosomal proteins

R. Hasenbank, B. Kastner, E. Dabbs, 2004, Molecular and General Genetics MGG.

Regulation of 3′ splice site selection after step 1 of splicing by spliceosomal C* proteins

C. Dienemann, H. Urlaub, Cyrille Girard, 2023, Science advances.

Composition and three‐dimensional EM structure of double affinity‐purified, human prespliceosomal A complexes

Henning Urlaub, Bjoern Sander, Monika M Golas, 2007, The EMBO journal.

Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation

H. Stark, H. Urlaub, C. Will, 2020, Science.

Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome.

H. Stark, H. Urlaub, C. Will, 2020, Molecular cell.

Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes.

H. Stark, C. Will, B. Kastner, 2019, Cold Spring Harbor perspectives in biology.

Localization of the release factor-2 binding site on 70 S ribosomes by immuno-electron microscopy.

W. Tate, B. Kastner, C. Trotman, 1990, Journal of molecular biology.

Molecular architecture of the human U4/U6.U5 tri-snRNP

H. Stark, H. Urlaub, B. Kastner, 2016, Science.

Molecular architecture of the Saccharomyces cerevisiae activated spliceosome

Henning Urlaub, Reinhard Rauhut, Ashwin Chari, 2016, Science.

Antisense-targeted immuno-EM localization of the pre-mRNA path in the spliceosomal C complex.

B. Kastner, R. Lührmann, E. Wolf, 2012, RNA.

Exon, intron and splice site locations in the spliceosomal B complex

H. Stark, B. Kastner, R. Lührmann, 2009, The EMBO journal.

Conservation of the Protein Composition and Electron Microscopy Structure of Drosophila melanogaster and Human Spliceosomal Complexes

Henning Urlaub, Nadine Herold, H. Urlaub, 2008, Molecular and Cellular Biology.

Protein Composition and Electron Microscopy Structure of Affinity-Purified Human Spliceosomal B Complexes Isolated under Physiological Conditions

Henning Urlaub, Holger Stark, Daniel Boehringer, 2006, Molecular and Cellular Biology.

Three-dimensional structure of a pre-catalytic human spliceosomal complex B

Bjoern Sander, Holger Stark, Daniel Boehringer, 2004, Nature Structural &Molecular Biology.

Protein localisation by electron microscopy reveals the architecture of the yeast spliceosomal B complex

B. Kastner, R. Lührmann, P. Fabrizio, 2015, The EMBO journal.

Structure of yeast U6 snRNPs: arrangement of Prp24p and the LSm complex as revealed by electron microscopy.

H. Stark, P. Dube, B. Kastner, 2008, RNA.

The 5' end of U2 snRNA is in close proximity to U1 and functional sites of the pre-mRNA in early spliceosomal complexes.

C. Will, B. Kastner, K. Hartmuth, 2007, Molecular cell.

Regulation of the interferon-alpha production induced by RNA-containing immune complexes in plasmacytoid dendritic cells.

L. Rönnblom, B. Kastner, M. Eloranta, 2009, Arthritis and rheumatism.

Arrangement of the subunits in the ribosome of Escherichia coli: demonstration by immunoelectron microscopy.

B. Kastner, G. Stöffler, B Kastner, 1981, Proceedings of the National Academy of Sciences of the United States of America.

A protein map of the yeast activated spliceosome as obtained by electron microscopy

B. Kastner, R. Lührmann, P. Fabrizio, 2016, RNA.

Complex Formation among Rat Pancreatic Secretory Proteins under Mild Alkaline pH Conditions

B. Kastner, H. Kern, R. Kleene, 1999, Digestion.

Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation

H. Urlaub, H. Waldmann, C. Will, 2017, eLife.

Discriminatory RNP remodeling by th eD EAD-box protei nD ED1

T. Nilsen, B. Kastner, P. Maroney, 2006 .

Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes.

H. Stark, C. Will, B. Kastner, 2019, Cold Spring Harbor perspectives in biology.

Structural insights into the cross-exon to cross-intron spliceosome switch

C. Will, B. Kastner, O. Dybkov, 2024, Nature.

Interferon in Plasmacytoid Dendritic Cells through Tlr7 U1 Small Nuclear Ribonucleoprotein Immune Complexes Induce Type I

S. Akira, B. Kastner, R. Schmid, 2022 .