A. Marchand

发表

E. Falkenauer, A. Marchand, 2001 .

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication.

A. Marchand, A. Voet, M. de Maeyer, 2010, Nature chemical biology.

Identification of 1-((2,4-Dichlorophenethyl)Amino)-3-Phenoxypropan-2-ol, a Novel Antibacterial Compound Active against Persisters of Pseudomonas aeruginosa

M. Fauvart, J. Michiels, A. Marchand, 2017, Antimicrobial Agents and Chemotherapy.

Discovery of a new Mycobacterium tuberculosis thymidylate synthase X inhibitor with a unique inhibition profile

P. Herdewijn, A. Marchand, H. Myllykallio, 2017, Biochemical pharmacology.

Synthesis and in vitro evaluation of 2-amino-4-N-piperazinyl-6-(3,4-dimethoxyphenyl)-pteridines as dual immunosuppressive and anti-inflammatory agents.

P. Herdewijn, A. Marchand, Ling-Jie Gao, 2011, Bioorganic & medicinal chemistry letters.

Novel Class of Chikungunya Virus Small Molecule Inhibitors That Targets the Viral Capping Machinery

T. Langer, B. Coutard, A. Marchand, 2020, Antimicrobial Agents and Chemotherapy.

Synthesis of 1,5‐Anhydrohexitol Building Blocks for Oligonucleotide Synthesis

P. Herdewijn, A. Aerschot, A. Marchand, 2003, Current protocols in nucleic acid chemistry.

A broad influenza virus inhibitor acting via IMP dehydrogenase and in synergism with ribavirin.

L. Naesens, A. Marchand, E. Vanderlinden, 2021, Antiviral research.

Therapeutic Discovery Identi fi cation and Characterization of MEL-3 , a Novel AR Antagonist That Suppresses Prostate Cancer Cell Growth

F. Claessens, A. Marchand, A. Voet, 2012 .

Elucidation of the Mode of Action of a New Antibacterial Compound Active against Staphylococcus aureus and Pseudomonas aeruginosa

K. Marchal, N. Verstraeten, M. Fauvart, 2016, PloS one.

Synthesis, Structure–Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication

A. Marchand, R. Hilgenfeld, E. Decroly, 2022, Molecules.

Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects

O. Feron, A. Marchand, C. Corbet, 2018, Nature Communications.

Identification of novel FLT3 kinase inhibitors.

A. Marchand, I. Lahortiga, K. Jacobs, 2013, European journal of medicinal chemistry.

Differential antiviral activities of RSV inhibitors in human airway epithelium

A. Marchand, J. Neyts, M. Boon, 2018, bioRxiv.

Differential antiviral activities of respiratory syncytial virus (RSV) inhibitors in human airway epithelium

A. Marchand, J. Neyts, M. Boon, 2018, The Journal of antimicrobial chemotherapy.

Identification of drugs that restore primary cilium expression in cancer cells

A. Marchand, S. Munck, J. Swinnen, 2016, Oncotarget.

Loratadine, an antihistaminic drug, suppresses the proliferation of endometrial stromal cells by inhibition of TRPV2.

A. Marchand, Sara Kerselaers, T. Voets, 2022, European journal of pharmacology.

Identification of Fungicidal 2,6-Disubstituted Quinolines with Activity against Candida Biofilms

A. Marchand, B. Cammue, D. Bardiot, 2012, Molecules.

ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model

A. Marchand, C. Liu, J. Neyts, 2021, bioRxiv.

The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir

P. Maes, A. Marchand, J. Neyts, 2022, bioRxiv.

Identification and Characterization of MEL-3, a Novel AR Antagonist That Suppresses Prostate Cancer Cell Growth

Sebastian Munck, Annemieke Verstuyf, Arnout Voet, 2012, Molecular Cancer Therapeutics.

Chapter 10 – Clustering Microarray Data with Evolutionary Algorithms

Emanuel Falkenauer, E. Falkenauer, A. Marchand, 2003 .

Synthetic strategy and antiviral evaluation of diamide containing heterocycles targeting dengue and yellow fever virus

J. Rozenski, A. Marchand, J. Neyts, 2016, European journal of medicinal chemistry.

Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells.

Antony E. Fernandes, O. Feron, A. Marchand, 2013, Bioorganic & medicinal chemistry.

Synthesis of D‐Altritol Nucleosides with a 3′‐O‐Tert‐Butyldimethylsilyl Protecting Group

P. Herdewijn, A. Marchand, M. Abramov, 2004, Nucleosides, nucleotides & nucleic acids.

5-(Trifluoromethyl)-beta-l-2'-deoxyuridine, the L-enantiomer of trifluorothymidine: stereospecific synthesis and antiherpetic evaluations.

A. Marchand, M. Pregnolato, J. Sommadossi, 2001, Bioorganic & medicinal chemistry.

Diels-Alder adducts from flavonoid

A. Marchand, G. Massiot, A. Duflos, 2007 .

Identification of novel Ebola virus inhibitors using biologically contained virus

P. Maes, A. Marchand, P. Chaltin, 2021, bioRxiv.

Identification of novel Ebola virus inhibitors using biologically contained virus.

P. Maes, A. Marchand, P. Chaltin, 2022, Antiviral research.

Antibacterial Activity of 1-[(2,4-Dichlorophenethyl)amino]-3-Phenoxypropan-2-ol against Antibiotic-Resistant Strains of Diverse Bacterial Pathogens, Biofilms and in Pre-clinical Infection Models

M. Fauvart, J. Michiels, A. Marchand, 2017, Front. Microbiol..

Synthesis and Antiviral Evaluation of Unnatural β-L-Enantiomers of 3′-Fluoro- and 3′-Azido-2,3′-dideoxyguanosine Derivatives

A. Marchand, J. Imbach, G. Gosselin, 2000, Nucleosides, nucleotides & nucleic acids.

Stereospecific synthesis of unnatural β-L-enantiomers of 2-chloroadenine pentofuranonucleoside derivatives

A. Marchand, J. Imbach, C. Mathé, 1999 .

Inhibition of MDR1 gene expression by chimeric HNA antisense oligonucleotides.

P. Herdewijn, A. Marchand, Dong Xu, 2004, Nucleic acids research.

Small-Molecule Inhibitors of the LEDGF/p75 Binding Site of Integrase Block HIV Replication and Modulate Integrase Multimerization

Stephen M. Shaw, A. Marchand, S. Butler, 2012, Antimicrobial Agents and Chemotherapy.

Multimerizationand Modulate Integrase Binding Site of Integrase Block HIV Small-Molecule Inhibitors of the LEDGF/p75

Stephen M. Shaw, A. Marchand, Z. Debyser, 2012 .

Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release

A. Marchand, T. Voets, P. Reeh, 2015, Proceedings of the National Academy of Sciences.

Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects

A. Marchand, C. Corbet, P. Chaltin, 2018, Nature Communications.

LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 – 2014)

A. Marchand, M. de Maeyer, Z. Debyser, 2014, Expert opinion on therapeutic patents.

Antitumor activity of pyridoisoquinoline derivatives F91873 and F91874, novel multikinase inhibitors with activity against the anaplastic lymphoma kinase

J. Annereau, C. Bailly, A. Marchand, 2009, Anti-cancer drugs.

Discovery of Indole Derivatives as Novel and Potent Dengue Virus Inhibitors.

A. Marchand, J. Neyts, K. Dallmeier, 2018, Journal of medicinal chemistry.

H1PVAT is a novel and potent early-stage inhibitor of poliovirus replication that targets VP1.

A. Marchand, J. Neyts, Javier Martin, 2014, Antiviral research.

Repurposing as a means to increase the activity of amphotericin B and caspofungin against Candida albicans biofilms.

A. Marchand, B. Cammue, P. Chaltin, 2014, The Journal of antimicrobial chemotherapy.

Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice

G. Berx, A. Marchand, P. Van Vlierberghe, 2021, The Journal of experimental medicine.

Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease

J. Winderickx, T. V. Van Dooren, C. Hoogenraad, 2018, Molecular Neurodegeneration.

The β2-adrenergic receptor in the apical membrane of intestinal enterocytes senses sugars to stimulate glucose uptake from the gut

J. Thevelein, J. Tavernier, A. Marchand, 2023, Frontiers in Cell and Developmental Biology.

1-((2,4-Dichlorophenethyl)Amino)-3-Phenoxypropan-2-ol Kills Pseudomonas aeruginosa through Extensive Membrane Damage

K. Marchal, M. Fauvart, J. Michiels, 2018, Front. Microbiol..

Antifungal carbazoles.

A. Marchand, B. Cammue, P. Chaltin, 2009, Current medicinal chemistry.

A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction

Peggy Geluykens, R. Bartenschlager, A. Marchand, 2021, Nature.

Effective Small Molecule Antibacterials from a Novel Anti-Protein Secretion Screen

S. Karamanou, A. Marchand, J. Anné, 2021, Microorganisms.

Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates

Gregory D. Gromowski, A. Barrett, D. Beasley, 2023, Nature.

2-(2-oxo-morpholin-3-yl)-acetamide derivatives as broad-spectrum antifungal agents.

A. Marchand, L. Maes, C. Taborda, 2015, Journal of medicinal chemistry.

Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease

J. Winderickx, T. V. Van Dooren, C. Hoogenraad, 2018, Molecular Neurodegeneration.

Small-molecule antibiotic inhibitors of post-translational protein secretion

S. Karamanou, A. Marchand, J. Anné, 2020, bioRxiv.

Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development

M. Scholle, A. Marchand, J. Deval, 2021, Antiviral Research.

Synthesis of a Pyridoxine–Peptide Based Delivery System for Nucleotides

P. Herdewijn, R. Busson, A. Marchand, 2007, Chemistry & biodiversity.

Inhibitors of the integrase–transportin-SR2 interaction block HIV nuclear import

A. Marchand, Z. Debyser, Lieve Dirix, 2018, Retrovirology.

Inhibitors of the integrase–transportin-SR2 interaction block HIV nuclear import

A. Marchand, Z. Debyser, Lieve Dirix, 2018, Retrovirology.

Identification and characterization of 4-[4-(3-phenyl-2-propen-1-yl)-1-piperazinyl]-5H-pyrimido[5,4-b]indole derivatives as Salmonella biofilm inhibitors.

A. Marchand, S. D. De Keersmaecker, J. Vanderleyden, 2012, FEMS immunology and medical microbiology.

Discovery of JNJ-1802, a First-in-Class Pan-Serotype Dengue Virus NS4B Inhibitor.

A. Marchand, T. Jonckers, D. Bardiot, 2024, Journal of medicinal chemistry.