J. Tavis

发表

Changes in Gene Expression during Pegylated Interferon and Ribavirin Therapy of Chronic Hepatitis C Virus Distinguish Responders from Nonresponders to Antiviral Therapy

Matthew J. Stephens, Milton W. Taylor, L. Brodsky, 2007, Journal of Virology.

Genome-Wide Networks of Amino Acid Covariances Are Common among Viruses

R. Aurora, J. Tavis, M. Donlin, 2012, Journal of Virology.

Herpes simplex virus 2 VP22 phosphorylation induced by cellular and viral kinases does not influence intracellular localization.

J. Tavis, B. Geiss, L. Morrison, 2004, Virology.

Multiple effects of silymarin on the hepatitis C virus lifecycle

J. Tavis, Y. Nahmias, S. Polyak, 2010, Hepatology.

Immune evasion versus recovery after acute hepatitis C virus infection from a shared source

J. Tavis, D. Lewinsohn, H. Rosen, 2005, The Journal of experimental medicine.

A Functional Interplay between Human Immunodeficiency Virus Type 1 Protease Residues 77 and 93 Involved in Differential Regulation of Precursor Autoprocessing and Mature Protease Activity

J. Tavis, P. S. Ho, M. Donlin, 2015, PloS one.

Host Factor-Targeted Hepatitis B Virus Therapies

A. Bertoletti, J. Tavis, A. Gehring, 2014, Intervirology.

β-Thujaplicinol inhibits hepatitis B virus replication by blocking the viral ribonuclease H activity.

J. Tavis, Yuan Hu, A. Huang, 2013, Antiviral research.

Hydroxylated Tropolones Inhibit Hepatitis B Virus Replication by Blocking Viral Ribonuclease H Activity

J. Tavis, S. L. Le Grice, Craig J. Thomas, 2014, Antimicrobial Agents and Chemotherapy.

Predicted structure of the hepatitis B virus polymerase reveals an ancient conserved protein fold

J. Tavis, D. Bradley, Razia Tajwar, 2022, bioRxiv.

A research agenda for curing chronic hepatitis B virus infection

C. Rice, F. Chisari, B. McMahon, 2018, Hepatology.

Differential In Vitro Effects of Intravenous versus Oral Formulations of Silibinin on the HCV Life Cycle and Inflammation

J. Tavis, S. Polyak, N. Oberlies, 2011, PloS one.

Hepadnaviral Genomic Replication

Matthew P. Badtke, J. Tavis, 2009 .

Evidence for activation of the hepatitis B virus polymerase by binding of its RNA template

J. Tavis, D. Ganem, Don Ganem, 1996, Journal of virology.

polymerase by binding of its RNA template . Evidence for activation of the hepatitis B virus

J. Tavis, D. Ganem, 1996 .

How further suppression of virus replication could improve current HBV treatment

J. Tavis, Yuan Hu, A. Gehring, 2013, Expert review of anti-infective therapy.

Sexual transmission of hepatitis C virus among monogamous heterosexual couples: The HCV partners study

M. Alter, T. Levin, E. Murphy, 2013, Hepatology.

Hepatitis B virus genetic diversity has minimal impact on sensitivity of the viral ribonuclease H to inhibitors.

J. Tavis, M. Donlin, M. J. Meyers, 2016, Antiviral research.

Contribution of Genome-Wide HCV Genetic Differences to Outcome of Interferon-Based Therapy in Caucasian American and African American Patients

R. Aurora, J. Tavis, A. Wahed, 2010, PloS one.

Pretreatment Sequence Diversity Differences in the Full-Length Hepatitis C Virus Open Reading Frame Correlate with Early Response to Therapy

Milton W. Taylor, R. Aurora, J. Tavis, 2007, Journal of Virology.

Pre-P Is a Secreted Glycoprotein Encoded as an N-Terminal Extension of the Duck Hepatitis B Virus Polymerase Gene

J. Tavis, A. Jilbert, F. Cao, 2008, Journal of Virology.

3,7-Dihydroxytropolones Inhibit Initiation of Hepatitis B Virus Minus-Strand DNA Synthesis

E. Gallicchio, J. Tavis, S. L. Le Grice, 2020, Molecules.

The Duck Hepatitis B Virus Polymerase Is Activated by Its RNA Packaging Signal, ɛ

J. Tavis, Y. Gong, B. Massey, 1998, Journal of Virology.

Hepadnavirus reverse transcription initiates within the stem-loop of the RNA packaging signal and employs a novel strand transfer

J. Tavis, D. Ganem, S. Perri, 1994, Journal of virology.

Nucleotide sequence of the human polyomavirus AS virus, an antigenic variant of BK virus

J. Tavis, S. Gardner, R. Frisque, 1989, Journal of virology.

Substrate specificity of the herpes simplex virus type 2 UL13 protein kinase.

J. Tavis, L. Morrison, Gina L. Cano-Monreal, 2008, Virology.

Herpes simplex virus 2 UL13 protein kinase disrupts nuclear lamins.

K. Wylie, J. Tavis, L. Morrison, 2009, Virology.

Prospects for personalizing antiviral therapy for hepatitis C virus with pharmacogenetics

R. Aurora, J. Tavis, M. Donlin, 2011, Genome Medicine.

A general method for nested RT-PCR amplification and sequencing the complete HCV genotype 1 open reading frame

J. Tavis, E. Yao, the Virahep-C Study Group, 2005, Virology Journal.

Suppression of mRNA accumulation by the duck hepatitis B virus reverse transcriptase.

J. Tavis, F. Cao, 2006, Virology.

Identification of 4-isopropyl–thiotropolone as a novel anti-microbial: regioselective synthesis, NMR characterization, and biological evaluation

J. Tavis, M. Donlin, Mohamed Elagawany, 2018, RSC advances.

Inhibition of hepatitis B virus replication by N‐hydroxyisoquinolinediones and related polyoxygenated heterocycles

J. Tavis, F. Bailly, L. Morrison, 2017, Antiviral research.

Design, synthesis, and biological evaluation of novel sulfamoylbenzamide derivatives as HBV capsid assembly modulators

P. Zhan, Xinyong Liu, J. Tavis, 2022, Bioorganic Chemistry.

Effects of Troponoids on Mitochondrial Function and Cytotoxicity

J. Tavis, R. Murelli, B. Rogers, 2021, Antimicrobial agents and chemotherapy.

Troponoids Can Inhibit Growth of the Human Fungal Pathogen Cryptococcus neoformans

J. Tavis, M. Donlin, M. J. Meyers, 2017, Antimicrobial Agents and Chemotherapy.

Hepatitis B virus reverse transcriptase and its many roles in hepadnaviral genomic replication.

J. Pollack, J. Tavis, D. Ganem, 1994, Infectious agents and disease.

Efficacy and cytotoxicity in cell culture of novel &agr;‐hydroxytropolone inhibitors of hepatitis B virus ribonuclease H

J. Tavis, R. Murelli, J. Daw, 2017, Antiviral research.

In Vitro Enzymatic and Cell Culture-Based Assays for Measuring Activity of HBV RNaseH Inhibitors.

J. Tavis, E. Lomonosova, 2017, Methods in molecular biology.

Establishment of a Replicon System for Bourbon Virus and Identification of Small Molecules that Efficiently Inhibit Virus Replication

J. Tavis, J. Qiu, Xiaomei Wang, 2020, bioRxiv.

Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Journal of medicinal chemistry.

Translation of Duck Hepatitis B Virus Reverse Transcriptase by Ribosomal Shunting

J. Tavis, F. Cao, N. Sen, 2004, Journal of Virology.

Purification and enzymatic characterization of the hepatitis B virus ribonuclease H, a new target for antiviral inhibitors.

J. Tavis, E. Lomonosova, G. Lu, 2016, Antiviral research.

The hepatitis B virus polymerase.

J. Tavis, Jianming Hu, Daniel N. Clark, 2021, The Enzymes.

The hepatitis B virus ribonuclease H as a drug target.

J. Tavis, E. Lomonosova, 2015, Antiviral research.

Simplex Virus Replication Superfamily Enzymes Suppress Herpes Inhibitors of Nucleotidyltransferase

J. Tavis, K. L. Davis, L. Morrison, 2014 .

The Hepatitis B Virus Ribonuclease H Is Sensitive to Inhibitors of the Human Immunodeficiency Virus Ribonuclease H and Integrase Enzymes

S. Sarafianos, R. Aurora, J. Tavis, 2013, PLoS pathogens.

The GB Virus C (GBV-C) NS3 Serine Protease Inhibits HIV-1 Replication in a CD4+ T Lymphocyte Cell Line without Decreasing HIV Receptor Expression

J. Tavis, S. L. George, Dino Varmaz, 2012, PloS one.

Converting the JCV T antigen Rb binding domain to that of SV40 does not alter JCV's limited transforming activity but does eliminate viral viability.

J. Tavis, R. Frisque, P. Trowbridge, 1994, Virology.

Establishment of a Replicon Reporter of the Emerging Tick-Borne Bourbon Virus and Use It for Evaluation of Antivirals

J. Tavis, J. Qiu, Xiaomei Wang, 2020, Frontiers in Microbiology.

RNA Elements Directing Translation of the Duck Hepatitis B Virus Polymerase via Ribosomal Shunting

J. Tavis, F. Cao, 2011, Journal of Virology.

Silencing HBV transcription with SMC5/6: has a path been found?

J. Tavis, R. Chauhan, 2021, Gut.

Efficient Inhibition of Hepatitis B Virus (HBV) Replication and cccDNA Formation by HBV Ribonuclease H Inhibitors during Infection

J. Tavis, R. Chauhan, M. J. Meyers, 2021, Antimicrobial agents and chemotherapy.

HBV replication inhibitors.

J. Tavis, Claire Pierra Rouvière, C. Dousson, 2020, Antiviral research.

NVR 3-778 Plus Pegylated Interferon-α Treatment for Chronic Hepatitis B Viral Infections: Could 1 + 1 = 3?

J. Tavis, E. Lomonosova, 2018, Gastroenterology.

Efficacy of hepatitis B virus ribonuclease H inhibitors, a new class of replication antagonists, in FRG human liver chimeric mice

J. Sagartz, J. Tavis, R. Murelli, 2018, Antiviral research.

Discovery and optimization of benzenesulfonamides-based hepatitis B virus capsid modulators via contemporary medicinal chemistry strategies.

P. Zhan, Xinyong Liu, J. Tavis, 2020, European journal of medicinal chemistry.

Altered DNA binding and replication activities of JC virus T-antigen mutants.

J. Tavis, R. Frisque, 1991, Virology.

Hepatitis B virus replication is blocked by a 2-hydroxyisoquinoline-1,3(2H,4H)-dione (HID) inhibitor of the viral ribonuclease H activity.

J. Tavis, F. Bailly, M. J. Meyers, 2014, Antiviral research.

Inhibitors of Nucleotidyltransferase Superfamily Enzymes Suppress Herpes Simplex Virus Replication

J. Tavis, K. L. Davis, L. Morrison, 2014, Antimicrobial Agents and Chemotherapy.

Synthetic α-Hydroxytropolones Inhibit Replication of Wild-Type and Acyclovir-Resistant Herpes Simplex Viruses

J. Tavis, L. Morrison, M. Korom, 2016, Antimicrobial Agents and Chemotherapy.

Synthetic Derivatives of Ciclopirox are Effective Inhibitors of Cryptococcus neoformans

J. Tavis, M. Donlin, D. Bradley, 2021, ACS omega.

Synthesis of Polyoxygenated Tropolones and their Antiviral Activity Against Hepatitis B Virus and Herpes Simplex Virus-1.

J. Tavis, L. Morrison, R. Murelli, 2022, Chemistry.

Amide-containing α-hydroxytropolones as inhibitors of hepatitis B virus replication.

E. Gallicchio, J. Tavis, M. Donlin, 2020, Antiviral research.

Synthesis and biological assessment of 3,7-dihydroxytropolones.

E. Gallicchio, J. Tavis, S. L. Le Grice, 2017, Organic & biomolecular chemistry.

Metal coordinating inhibitors of Rift Valley fever virus replication

J. Tavis, M. Donlin, Grigoris Zoidis, 2022, bioRxiv.

Divergent synthesis of a thiolate-based α-hydroxytropolone library with a dynamic bioactivity profile

J. Tavis, L. Morrison, M. Donlin, 2019, RSC advances.

Alpha-hydroxytropolones are noncompetitive inhibitors of human RNase H1 that bind to the active site and modulate substrate binding

J. Tavis, N. Pozzi, Razia Tajwar, 2022, The Journal of biological chemistry.

Recent Advances in Hepatitis B Treatment

J. Tavis, Grigoris Zoidis, Vasiliki Pardali, 2021, Pharmaceuticals.

A global scientific strategy to cure hepatitis B.

Joan M. Block, J. Fellay, F. Chisari, 2019, The lancet. Gastroenterology & hepatology.

Inhibition of HBV replication by N‐hydroxyisoquinolinedione and N‐hydroxypyridinedione ribonuclease H inhibitors

J. Tavis, R. Rijnbrand, M. Sofia, 2019, Antiviral research.

Synthesis and Evaluation of Troponoids as a New Class of Antibiotics

P. Adegboyega, J. Tavis, M. Donlin, 2018, ACS omega.

Synergistic Interactions between Hepatitis B Virus RNase H Antagonists and Other Inhibitors

A. Zlotnick, J. Tavis, E. Lomonosova, 2016, Antimicrobial Agents and Chemotherapy.

Hepatitis B virus nucleocapsid envelopment does not occur without genomic DNA synthesis

J. Tavis, V. Bruss, T. Gerelsaikhan, 1996, Journal of virology.

Relationship between viral DNA synthesis and virion envelopment in hepatitis B viruses

J. Tavis, D. Ganem, Y. Wei, 1996, Journal of virology.

The Duck Hepatitis B Virus Reverse Transcriptase Functions as a Full-length Monomer*

J. Tavis, Zhian Zhang, 2006, Journal of Biological Chemistry.

Sequences in the terminal protein and reverse transcriptase domains of the hepatitis B virus polymerase contribute to RNA binding and encapsidation

J. Tavis, F. Cao, S. Jones, 2014, Journal of viral hepatitis.

PrimingBinding, RNA Packaging, and Protein Polymerase Sequences Required for Viral Comparative Analysis of Hepatitis B Virus

Scott A. Jones, J. Tavis, Jianming Hu, 2014 .

Comparative Analysis of Hepatitis B Virus Polymerase Sequences Required for Viral RNA Binding, RNA Packaging, and Protein Priming

Scott A. Jones, J. Tavis, Jianming Hu, 2013, Journal of Virology.

An interdomain RNA binding site on the hepadnaviral polymerase that is essential for reverse transcription.

Matthew P. Badtke, J. Tavis, Jianming Hu, 2009, Virology.

Identification of an Essential Molecular Contact Point on the Duck Hepatitis B Virus Reverse Transcriptase

Matthew P. Badtke, J. Tavis, F. Cao, 2005, Journal of Virology.

Identiﬁcation of an Essential Molecular Contact Point on the Duck Hepatitis B Virus Reverse Transcriptase

Matthew P. Badtke, J. Tavis, F. Cao, 2005 .

and Yunhao Gong Activated by Its RNA Packaging Signal , ? The Duck Hepatitis B Virus Polymerase Is

J. Tavis, Y. Gong, B. Massey, 1998 .

Expression of functional hepatitis B virus polymerase in yeast reveals it to be the sole viral protein required for correct initiation of reverse transcription.

J. Tavis, D. Ganem, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Evidence that the first strand-transfer reaction of duck hepatitis B virus reverse transcription requires the polymerase and that strand transfer is not needed for the switch of the polymerase to the elongation mode of DNA synthesis.

J. Tavis, E. Yao, Y. Gong, 2000, The Journal of general virology.

Combining genetic and biochemical approaches to identify functional molecular contact points

Matthew P. Badtke, J. Tavis, F. Cao, 2006, Biological Procedures Online.

Localization of duck hepatitis B virus polymerase within cells.

J. Tavis, E. Yao, 2004, Methods in molecular medicine.

Evidence that the RNAseH activity of the duck hepatitis B virus is unable to act on exogenous substrates

J. Tavis, E. Yao, Y. Gong, 2001, BMC Microbiology.

The Majority of Duck Hepatitis B Virus Reverse Transcriptase in Cells Is Nonencapsidated and Is Bound to a Cytoplasmic Structure

J. Tavis, N. Chen, E. Yao, 2000, Journal of Virology.

RNA sequences controlling the initiation and transfer of duck hepatitis B virus minus-strand DNA

J. Tavis, D. Ganem, 1995, Journal of virology.

Assessing immunological and virological responses in the liver: Implications for the cure of chronic hepatitis B virus infection

F. Zoulim, J. Tavis, T. Pollicino, 2022, JHEP reports : innovation in hepatology.

Biographical Feature: William S. M. Wold, Ph.D., 1944–2021

J. Tavis, L. Morrison, C. Bellone, 2021, Journal of virology.

Detection and characterization of cytoplasmic hepatitis B virus reverse transcriptase.

J. Tavis, F. Cao, 2004, The Journal of general virology.

The duck hepatitis B virus polymerase and core proteins accumulate in different patterns from their common mRNA.

J. Tavis, H. Schaller, E. Yao, 2003, Virology.

Kinetics of Synthesis and Turnover of the Duck Hepatitis B Virus Reverse Transcriptase*

J. Tavis, E. Yao, 2003, The Journal of Biological Chemistry.

Chemical Approaches to Inhibiting the Hepatitis B Virus Ribonuclease H.

J. Tavis, Grigoris Zoidis, M. J. Meyers, 2019, ACS infectious diseases.

APOBEC3B edits HBV DNA and inhibits HBV replication during reverse transcription

J. Tavis, Jie-Li Hu, X. Cai, 2018, Antiviral research.

Genetic and biochemical diversity in the HCV NS5B RNA polymerase in the context of interferon α plus ribavirin therapy

J. Tavis, M. Donlin, F. Cao, 2011, Journal of viral hepatitis.

Association of Hepatitis B Virus Covalently Closed Circular DNA and Human APOBEC3B in Hepatitis B Virus-Related Hepatocellular Carcinoma

J. Tavis, Jie-Li Hu, Yuan Hu, 2016, PloS one.

Hepatitis C Virus Diversity and Evolution in the Full Open-Reading Frame during Antiviral Therapy

R. Aurora, J. Tavis, M. Donlin, 2008, PloS one.

Temporal Regulation of Herpes Simplex Virus Type 2 VP22 Expression and Phosphorylation

J. Tavis, B. Geiss, L. Morrison, 2001, Journal of Virology.

Antigenic and transforming properties of the DB strain of the human polyomavirus BK virus.

J. Tavis, R. Frisque, F. White, 1990, Virology.

Genome-wide hepatitis C virus amino acid covariance networks can predict response to antiviral therapy in humans.

R. Aurora, J. Tavis, M. Donlin, 2008, The Journal of clinical investigation.

Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response.

P. Klenerman, R. Bartenschlager, J. Tavis, 2009, The Journal of clinical investigation.

HCV Genome-Wide Genetic Analyses in Context of Disease Progression and Hepatocellular Carcinoma

J. Tavis, M. Donlin, A. D. Di Bisceglie, 2014, PloS one.

Human pegivirus (GB virus C) NS3 protease activity inhibits induction of the type I interferon response and is not inhibited by HCV NS3 protease inhibitors.

J. Tavis, S. L. George, Adnan Y. Chowdhury, 2014, Virology.

Coordinated evolution among hepatitis C virus genomic sites is coupled to host factors and resistance to interferon

Gilberto Vaughan, Joseph C. Forbi, Yuri Khudyakov, 2012, Silico Biol..

Host-specific HCV evolution and response to the combined interferon and ribavirin therapy

Gilberto Vaughan, Joseph C. Forbi, Yuri Khudyakov, 2011, 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW).

Evidence for action of ribavirin through the hepatitis C virus RNA polymerase

J. Tavis, M. Donlin, A. Lyra, 2009, Journal of viral hepatitis.

A Novel Unsupervised Method to Identify Genes Important in the Anti-viral Response: Application to Interferon/Ribavirin in Hepatitis C Patients

Milton W. Taylor, L. Brodsky, Takuma Tsukahara, 2007, PloS one.

Design, synthesis and evaluation of heteroaryldihydropyrimidine analogues bearing spiro ring as hepatitis B virus capsid protein inhibitors.

P. Zhan, Xinyong Liu, J. Tavis, 2021, European journal of medicinal chemistry.

Endonuclease Activity Inhibition of the NS1 Protein of Parvovirus B19 as a Novel Target for Antiviral Drug Development

J. Tavis, N. Horton, J. Qiu, 2018, Antimicrobial Agents and Chemotherapy.

Diversity of the hepatitis C virus NS5B gene during HIV co-infection

J. Sobel, J. Blackard, J. Tavis, 2020, PloS one.

Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Journal of medicinal chemistry.

A mid-throughput HBV replication inhibition assay capable of detecting ribonuclease H inhibitors.

J. Tavis, Nathan L. Ponzar, Qilan Li, 2021, Journal of virological methods.

Shedding light on RNaseH: a promising target for hepatitis B virus (HBV)

J. Tavis, Nathan L. Ponzar, Tiffany C. Edwards, 2019, Expert opinion on therapeutic targets.

Separation of near full-length hepatitis C virus quasispecies variants from a complex population.

J. Tavis, A. D. Di Bisceglie, Xiaofeng Fan, 2007, Journal of virological methods.

A Cell-Based Assay for RNA Synthesis by the HCV Polymerase Reveals New Insights on Mechanism of Polymerase Inhibitors and Modulation by NS5A

K. Bhardwaj, J. Tavis, R. Ct, 2011, PloS one.

Subgenomic Reporter RNA System for Detection of Alphavirus Infection in Mosquitoes

J. Tavis, B. Geiss, I. Sánchez-Vargas, 2013, PloS one.

Antiviral Evaluation of Dispirotripiperazines against Hepatitis B Virus.

S. Ekins, J. Tavis, O. Riabova, 2023, Journal of medicinal chemistry.

In vitro evaluation of tropolone absorption, metabolism, and clearance.

J. Tavis, Molly E. Woodson, Ryan P. Murelli, 2023, Antiviral research.

An interdomain RNA binding site on the hepadnaviral polymerase that is essential for reverse transcription.

Matthew P. Badtke, J. Tavis, Jianming Hu, 2009, Virology.

Role of HVR1 sequence similarity in the cross-genotypic neutralization of HCV

J. Ball, J. Tavis, R. Urbanowicz, 2020, Virology journal.

Identification and assessment of the 1,6-dihydroxy-pyridin-2-one moiety as privileged scaffold for HBV ribonuclease H inhibition.

J. Tavis, Grigoris Zoidis, Vasiliki Pardali, 2024, Antiviral research.