G. Lefranc

E. Chouery, A. Mégarbané, G. Lefranc, 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Part 3 – TRDJ

M. Lefranc, G. Lefranc, 2001 .

Part 4 – TRDV

M. Lefranc, G. Lefranc, 2001 .

Homozygous stop mutation in the SNX10 gene in a consanguineous Iraqi boy with osteopetrosis and corpus callosum hypoplasia.

E. Chouery, A. Mégarbané, G. Lefranc, 2013, European journal of medical genetics.

First genomic sequence of a human Ig variable lambda gene belonging to subgroup III.

M. Lefranc, G. Lefranc, L. Buluwela, 1990, Nucleic acids research.

Atypical hemolytic uremic syndrome in the Tunisian population

G. Lefranc, M. López-Trascasa, P. Sánchez-Corral, 2011, International Urology and Nephrology.

QUANTITATIVE STUDIES OF Gm ALLOTYPES:V. SIMULTANEOUS PRESENCE OF LATENT Gm ALLOTYPES AND DEFICIENT Gm GENES IN A FAMILY WITH HYPOGAMMAGLOBULINAEMIC PROBANDS

G. Lefranc, M. Daveau, J. Salier, 1980, Journal of immunogenetics.

Part 2 – TRBD

M. Lefranc, G. Lefranc, 2001 .

Electron Microscopic Findings in Skin Biopsies from Patients with Infantile Osteopetrosis and Neuronal Storage Disease

J. Alroy, A. Mégarbané, G. Lefranc, 2007, Ultrastructural pathology.

The Role of Recent Admixture in Forming the Contemporary West Eurasian Genomic Landscape

R. J. Herrera, S. Myers, C. Buresi, 2015, Current Biology.

Synthetic review on the different anthropological aspects of hemoglobinopathies in Tunisia

G. Lefranc, J. Chibani, A. Khelil, 2012 .

Hemoglobinopathies in North Africa: A Review

G. Lefranc, J. Ben Chibani, S. Denden, 2010, Hemoglobin.

Mutations in OSTM1 (Grey Lethal) Define a Particularly Severe Form of Autosomal Recessive Osteopetrosis With Neural Involvement

A. Mégarbané, E. Lanino, G. Lefranc, 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Human IgG Allotypes Co‐Occurring in More than One IgG Subclass

M. Lefranc, G. Lefranc, E. Loghem, 1982, Vox sanguinis.

A novel homozygous mutation in Recombination Activating Gene 2 in two relatives with different clinical phenotypes: Omenn syndrome and Hyper-IgM syndrome

L. Notarangelo, Yu Nee Lee, R. Geha, 2012 .

Definition of the human immunoglobulin variable lambda (IGLV) gene subgroups

M. Lefranc, G. Lefranc, A. Blancher, 1990, European journal of immunology.

Phenotypic functional activities of monocyte change during crosstalk with breast cancer cell and enhancing effect of metformin of IFN-γ-associated antitumor cytokine production

G. Lefranc, N. Lamb, Anne Fernandez, 2020, bioRxiv.

IMGT, the international ImMunoGeneTics information system®

V. Giudicelli, M. Lefranc, G. Lefranc, 2004, Nucleic acids research.

IMGT, the international ImMunoGeneTics information system (cid:1)

V. Giudicelli, M. Lefranc, G. Lefranc, 2004 .

Molecular analysis of the T17 immunoglobulin CH multigene deletion (del A1-GP-G2-G4-E)

V. Wiebe, M. Lefranc, G. Lefranc, 1994, Human Genetics.

Molecular and biochemical characterization of JAK3 deficiency in a patient with severe combined immunodeficiency over 20 years after bone marrow transplantation: implications for treatment

R. Badolato, J. Loiselet, J. O’Shea, 1998, British Journal of Haematology.

IMGT, the international ImMunoGeneTics database

J. Bodmer, R. Bontrop, V. Giudicelli, 2000, Nucleic Acids Res..

Inherited deletion of immunoglobulin heavy chain constant region genes in normal human individuals

M. Lefranc, G. Lefranc, T. Rabbitts, 1982, Nature.

Restriction fragment haplotypes in the human immunoglobulin IGHG locus and their correlation with the Gm polymorphism

M. Lefranc, G. Lefranc, J. Dugoujon, 1988, European journal of immunology.

Alteration of Sarcoplasmic Reticulum Ca2+ Release in Skeletal Muscle from Calpain 3-Deficient Mice

C. Viero, G. Lefranc, N. Bourg, 2010, International journal of cell biology.

Deep dermatophytosis and inherited CARD9 deficiency.

R. Hay, J. Casanova, C. Picard, 2013, The New England journal of medicine.

Novel and recurrent STAT3 mutations in hyper-IgE syndrome patients from different ethnic groups.

J. Kere, A. Mégarbané, G. Lefranc, 2008, Molecular immunology.

Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C gamma genes.

M. Lefranc, G. Lefranc, P. Fort, 1986, Nucleic acids research.

IMGT®, the international ImMunoGeneTics information system® 25 years on

Patrice Duroux, Marie-Paule Lefranc, Sophia Kossida, 2014, Nucleic Acids Res..

NF‐NF‐κBB‐dependent expression of the antiapoptotic factor c‐FLIP is regulated by calpain 3, the protein involved in limb‐girdle muscular dystrophy type 2A

Hanns Lochmuller, Gérard Lefranc, Isabelle Richard, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

IMGT®, the international ImMunoGeneTics information system®

Jérôme Lane, Patrice Duroux, Marie-Paule Lefranc, 2004, Nucleic Acids Res..

Haplotype Diversity and Linkage Disequilibrium at Human G6PD: Recent Origin of Alleles That Confer Malarial Resistance

Andrew G. Clark, Scott M. Williams, Giovanni Destro-Bisol, 2001, Science.

Synthesis of the T cell receptor chains

M. Lefranc, G. Lefranc, 2001 .

Progressive pseudorheumatoid dysplasia in North and West Africa: Clinical description in ten patients with mutations of WISP3

E. Chouery, A. Mégarbané, G. Lefranc, 2017 .

[C3 complement polymorphism in patients suffering from obstructive chronic bronchopneumopathy in Tunisia].

G. Lefranc, J. Ben Chibani, S. Denden, 2007, Annales de biologie clinique.

Joining the Pillars of Hercules: mtDNA Sequences Show Multidirectional Gene Flow in the Western Mediterranean

D. Comas, J. Bertranpetit, G. Lefranc, 2003, Annals of human genetics.

The Role of Recent Admix ture in Forming the Contemporary West Eurasian Genomic Landscape Highlights

R. J. Herrera, S. Myers, C. Buresi, 2015 .

Erratum: The role of recent admixture in forming the contemporary west Eurasian genomic landscape (Current Biology (2015) 25 (2518-2526))

R. J. Herrera, S. Myers, C. Buresi, 2015 .

Calpain 3 deficiency is associated with myonuclear apoptosis and profound perturbation of the IκBα/NF-κB pathway in limb-girdle muscular dystrophy type 2A

J. Beckmann, J. Loiselet, G. Lefranc, 1999, Nature Medicine.

Heterochromatic Genes Undergo Epigenetic Changes and Escape Silencing in Immunodeficiency, Centromeric Instability, Facial Anomalies (ICF) Syndrome

A. Mégarbané, G. Lefranc, M. Claustres, 2011, PloS one.

Synthesis of the immunoglobulin chains

M. Lefranc, G. Lefranc, 2001 .

Chromosomal localization, organization of the loci, and potential repertoire

M. Lefranc, G. Lefranc, 2001 .

Exon duplication and triplication in the human T-cell receptor gamma constant region genes and RFLP in French, Lebanese, Tunisian, and Black African populations

C. Buresi, M. Lefranc, G. Lefranc, 2004, Immunogenetics.

CHAPTER 4 – Immunoglobulin Lambda (IGL) Genes of Human and Mouse

Gérard Lefranc, Marie-Paule Lefranc, M. Lefranc, 2004 .

A multigene deletion in the human IGH constant region locus involves highly homologous hot spots of recombination.

M. Lefranc, G. Lefranc, G. Keyeux, 1989, Genomics.

DNA analysis of the immunoglobulin IGHG loci in a Mandenka population from eastern Senegal: correlation with Gm haplotypes and hypotheses for the evolution of the Ig CH region

A. Langaney, A. Sanchez‐Mazas, M. Lefranc, 1996, Human Genetics.

A human immunoglobulinIGHG3 allele (Gmb0, b1, c3, c5, u) with anIGHG4 converted region and three hinge exons

M. Lefranc, G. Lefranc, S. Huck, 2006, Immunogenetics.

Molecular characterization of a ring chromosome 14 showing that the PI locus is centromeric to the D14S1 and IGH loci

M. Lefranc, G. Lefranc, S. Gilgenkrantz, 1989, Human Genetics.

Human immunoglobulin heavy‐chain multigene deletions in healthy individuals

M. Lefranc, G. Lefranc, G. Lefranc, 1987, FEBS letters.

Gene conversion in human immunoglobulin γ locus shown by unusual location of IgG allotypes

M. Lefranc, G. Lefranc, A. Helal, 1986 .

IMGT-Choreography for immunogenetics and immunoinformatics

Marie-Paule Lefranc, Véronique Giudicelli, Denys Chaume, 2004, Silico Biol..

Transcriptomic study in women with trisomy 21 identifies a possible role of the GTPases of the immunity-associated proteins (GIMAP) in the protection of breast cancer

A. Mégarbané, G. Lefranc, A. Rebillat, 2020, Scientific Reports.

Evidence for balancing selection from nucleotide sequence analyses of human G6PD.

S. Tishkoff, J. Loiselet, G. Lefranc, 2002, American journal of human genetics.

Human Gm, Km, and Am allotypes and their molecular characterization: a remarkable demonstration of polymorphism.

Gérard Lefranc, Marie-Paule Lefranc, M. Lefranc, 2012, Methods in molecular biology.

Common and uncommon immunoglobulin haplotypes among Lebanese communities

J. Loiselet, J. Lalouel, G. Lefranc, 1978, Human Genetics.

Asymptomatic deficiency in the peptide transporter associated to antigen processing (TAP)

M. Bonneville, X. Saulquin, G. Lefranc, 2002, Clinical and experimental immunology.

A novel homozygous mutation in recombination activating gene 2 in 2 relatives with different clinical phenotypes: Omenn syndrome and hyper-IgM syndrome.

L. Notarangelo, R. Geha, J. Chou, 2012, The Journal of allergy and clinical immunology.

Dock8 Functions as an Adaptor That Links Toll-like Receptor– Myd88 Signaling to B Cell Activation Hhs Public Access

Alessandro Plebani, Rima Wakim, Kate Fitzgerald, 2022 .

Immunologic reconstitution in severe combined immunodeficiency following transplantation with parental bone marrow.

R. Geha, G. Lefranc, J. Serre, 1976, Pediatrics.

A novel deletion in ZBTB24 in a Lebanese family with immunodeficiency, centromeric instability, and facial anomalies syndrome type 2

E. Chouery, A. Mégarbané, G. Lefranc, 2012, Clinical genetics.

Facial cutaneo-mucosal venous malformations can develop independently of mutation of TEK gene but may be associated with excessive expression of Src and p-Src

G. Lefranc, Moudjahed Saleh Al-Ddafari, M. Aribi, 2017, Journal of Negative Results in BioMedicine.

Multiple independent molecular etiology for limb-girdle muscular dystrophy type 2A patients from various geographical origins.

J. Beckmann, J. Burgunder, J. Loiselet, 1997, American journal of human genetics.

Plasmacytoid dendritic cell depletion in DOCK8 deficiency: rescue of severe herpetic infections with IFN-α 2b therapy.

Douglas R. McDonald, R. Geha, W. Al-Herz, 2014, The Journal of allergy and clinical immunology.

Calpain 3 deficiency is associated with myonuclear apoptosis and profound perturbation of the IkBa/NF-kB pathway in limb-girdle muscular dystrophy type 2A

J. Beckmann, J. Loiselet, G. Lefranc, 1999, Nature Medicine.

Detection of Sp110 by Flow Cytometry and Application to Screening Patients for Veno-occlusive Disease with Immunodeficiency

L. Notarangelo, R. Geha, J. Chou, 2017, Journal of Clinical Immunology.

HLA-C molecular characterization of a Lebanese population and genetic structure of 39 populations from Europe to India-Pakistan.

A. Mégarbané, A. Sanchez‐Mazas, G. Lefranc, 2006, Tissue antigens.

The IGLVA gene as a STS in the human immunoglobulin lambda light chain variable gene locus (located at 22q11)

M. Lefranc, G. Lefranc, P. Chuchana, 1991, Nucleic acids research.

An STS in the human T cell receptor gamma locus (located at 7p14-15).

M. Lefranc, G. Lefranc, P. Chuchana, 1990, Nucleic acids research.

Association Analysis of IL10, TNF-α, and IL23R-IL12RB2 SNPs with Behçet’s Disease Risk in Western Algeria

G. Lefranc, M. Barat‐Houari, I. Touitou, 2013, Front. Immunol..

Loss of Calpain 3 Proteolytic Activity Leads to Muscular Dystrophy and to Apoptosis-Associated Iκbα/Nuclear Factor κb Pathway Perturbation in Mice

J. Beckmann, G. Lefranc, N. Bourg, 2000, The Journal of cell biology.

[Familial Mediterranean Fever (FMF): from diagnosis to treatment].

A. Mégarbané, J. Loiselet, G. Lefranc, 2004, Sante.

Gm, Am and Km immunoglobulin allotypes of two populations in Tunisia

M. Lefranc, G. Lefranc, E. Loghem, 2004, Human Genetics.

Part 4 – TRBV

M. Lefranc, G. Lefranc, 2001 .

Population Structure in the Mediterranean Basin: A Y Chromosome Perspective

D. Goldstein, V. Pascali, Mark George Thomas, 2006, Annals of human genetics.

Plasmacytoid Dendritic Cell Depletion in DOCK8 Deficiency: Rescue of Severe Herpetic Infections with Interferon Alpha-2b Therapy

Douglas R. McDonald, R. Geha, W. Al-Herz, 2014 .

Update in chronic obstructive pulmonary disease: role of antioxidant and metabolizing gene polymorphisms

G. Lefranc, S. Denden, A. Kassab, 2011, Experimental lung research.

Association of GSTM1 and GSTT1 Polymorphisms with Chronic Obstructive Pulmonary Disease in a Tunisian Population

G. Lefranc, J. Ben Chibani, S. Denden, 2010, Biochemical Genetics.

Relationship between glutathione S-transferase P1 polymorphisms and chronic obstructive pulmonary disease in a Tunisian population.

G. Lefranc, J. Ben Chibani, S. Denden, 2010, Genetics and molecular research : GMR.

IMGT-ONTOLOGY for immunogenetics and immunoinformatics

Marie-Paule Lefranc, Véronique Giudicelli, Denys Chaume, 2003, Silico Biol..

Alu insertion polymorphisms in NW Africa and the Iberian Peninsula: evidence for a strong genetic boundary through the Gibraltar Straits

M. Stoneking, M. Batzer, A. Sajantila, 2000, Human Genetics.

Molecular study of six families originating from the Middle-East and presenting with autosomal recessive osteopetrosis.

E. Chouery, A. Mégarbané, G. Lefranc, 2007, European journal of medical genetics.

T cell receptor structural and biological properties

M. Lefranc, G. Lefranc, 2001 .

Part 3 – TRBJ

M. Lefranc, G. Lefranc, 2001 .

Thymoquinone Potently Enhances the Activities of Classically Activated Macrophages Pulsed with Necrotic Jurkat Cell Lysates and the Production of Antitumor Th1-/M1-Related Cytokines.

G. Lefranc, M. Aribi, F. Mennechet, 2018, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Genetic screening of fourteen mutations in Jordanian familial Mediterranean fever patients.

E. Chouery, A. Mégarbané, J. Loiselet, 2000, Human mutation.

IMGT® Homo sapiens IG and TR Loci, Gene Order, CNV and Haplotypes: New Concepts as a Paradigm for Jawed Vertebrates Genome Assemblies

M. Lefranc, G. Lefranc, 2022, Biomolecules.

DOCK8 and STAT3 dependent inhibition of IgE isotype switching by TLR9 ligation in human B cells.

R. Geha, W. Al-Herz, T. Chatila, 2017, Clinical immunology.

TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin

É. Pardoux, G. Lefranc, I. Touitou, 2017, Journal of immunology research.

[Alpha 1 antitrypsin polymorphism associated to asthma and emphysema in a central Tunisian population].

G. Lefranc, J. Ben Chibani, A. Haj-Khélil, 2008, Annales de biologie clinique.

Combined Analysis of EPHX1, GSTP1, GSTM1 and GSTT1 Gene Polymorphisms in Relation to Chronic Obstructive Pulmonary Disease Risk and Lung Function Impairment

G. Lefranc, S. Denden, M. Hassine, 2011, Disease markers.

Lack of TEK Gene Mutation in Patients with Cutaneomucosal Venous Malformations from the North-Western Region of Algeria

G. Lefranc, M. Barat‐Houari, I. Touitou, 2013, Genetics research international.

Ichthyosis follicularis, alopecia, and photophobia (IFAP) syndrome: Report of a new family with additional features and review

A. Mégarbané, G. Lefranc, H. Mégarbané, 2004, American journal of medical genetics. Part A.

Three‐dimensional analysis demonstrates the presence of exocrine cytoplasmic vela between endocrine cells and basal lamina in the stomach of mammals

G. Lefranc, P. Piloquet, G. Lefranc, 1991, Biology of the cell.

First genomic sequence of a human Ig variable lambda gene belonging to subgroup I. Functional genes, pseudogenes and vestigial sequences are interspersed in the IGLV locus.

M. Lefranc, G. Lefranc, A. Blancher, 1989, Nucleic acids research.

Admixture and sexual bias in the population settlement of La Réunion Island (Indian Ocean).

D. Comas, G. Lefranc, F. Calafell, 2008, American journal of physical anthropology.

Metformin partially reverses the inhibitory effect of co-culture with ER-/PR-/HER2+ breast cancer cells on biomarkers of monocyte antitumor activity

G. Lefranc, N. Lamb, Anne Fernandez, 2020, PloS one.

Transcriptomic study in women with trisomy 21 identifies a possible role of the GTPases of the immunity-associated proteins (GIMAP) in the protection of breast cancer

A. Mégarbané, G. Lefranc, A. Rebillat, 2020, Scientific Reports.

IMGT unique numbering for MHC groove G-DOMAIN and MHC superfamily (MhcSF) G-LIKE-DOMAIN.

Quentin Kaas, Gérard Lefranc, Elodie Duprat, 2005, Developmental and comparative immunology.

Part 1 – TRDC

M. Lefranc, G. Lefranc, 2001 .

The human immunoglobulin pseudo-gamma IGHGP gene shows no major structural defect.

G Lefranc, M. Lefranc, G. Lefranc, 1988, Nucleic acids research.

Epidermodysplasia verruciformis as a manifestation of ARTEMIS deficiency in a young adult.

R. Geha, J. Chou, M. Massaad, 2017, The Journal of allergy and clinical immunology.

HUMAN INVASIVE DERMATOPHYTIC DISEASE IS CAUSED BY INBORN ERRORS OF CARD9

J. Casanova, C. Picard, G. Lefranc, 2012 .

Combination of metformin with sodium selenite induces a functional phenotypic switch of human GM-CSF monocyte-derived macrophages.

G. Lefranc, N. Lamb, Anne Fernandez, 2019, International immunopharmacology.

HLA markers in six Lebanese religious subpopulations.

J. Loiselet, G. Lefranc, A. Jacquard, 2008, Tissue antigens.

TRISOMY 4 ASSOCIATED WITH ACUTE LYMPHOCYTIC LEUKAEMIA

G. Lefranc, P. Moreau, N. Milpied, 1991, British journal of haematology.

Immunoglobulin structural and biological properties

M. Lefranc, G. Lefranc, 2001 .

POLD3 deficiency is associated with severe combined immunodeficiency, neurodevelopmental delay, and hearing impairment.

M. Mustapha, E. Chouery, A. Mégarbané, 2023, Clinical immunology.

Deletion, insertion, and restriction site polymorphism of the T-cell receptor gamma variable locus in French, Lebanese, Tunisian, and Black African populations

C. Buresi, M. Lefranc, G. Lefranc, 2006, Immunogenetics.

SacI polymorphism defined by human T-cell receptor gamma (TCRG) variable gene V11.

M. Lefranc, G. Lefranc, P. Chuchana, 1989, Nucleic Acids Research.

Regulation of the immunoglobulin gene transcription.

M. Lefranc, G. Lefranc, G. Lefranc, 1990, Biochimie.

Polymorphism of MHC class III genes: definition of restriction fragment linkage groups and evidence for frequent deletions and duplications

M. Lefranc, G. Lefranc, M. Abbal, 1988, Human Genetics.

IMGT, the international ImMunoGeneTics information system®

Marie-Paule Lefranc, Véronique Giudicelli, Denys Chaume, 2004, Nucleic Acids Res..

Loss of Calpain 3 Proteolytic Activity Leads to Muscular Dystrophy and to Apoptosis-Associated Iκbα/Nuclear Factor κb Pathway Perturbation in Mice

J. Beckmann, G. Lefranc, N. Bourg, 2000, The Journal of cell biology.

Detection of Sp110 by Flow Cytometry and Application to Screening Patients for Veno-occlusive Disease with Immunodeficiency

L. Notarangelo, R. Geha, J. Chou, 2017, Journal of Clinical Immunology.

DOCK8 functions as an adaptor that links Toll-like receptor–MyD88 signaling to B cell activation

Douglas R. McDonald, L. Notarangelo, A. Plebani, 2012, Nature Immunology.

IMGT®, the international ImMunoGeneTics information system® 25 years on

V. Giudicelli, M. Lefranc, P. Duroux, 2014, Nucleic Acids Res..

A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency.

Toshiro K. Ohsumi, R. Geha, J. Chou, 2013, The Journal of allergy and clinical immunology.

Novel and recurrent STAT3 mutations in hyper-IgE syndrome patients from different ethnic groups.

J. Kere, A. Mégarbané, G. Lefranc, 2008, Molecular immunology.

Ultrastructural identification of round‐granule EC cells in rabbit fundic mucosa

G. Lefranc, P. Piloquet, G. Pradal, 1988, Biology of the cell.

Admixture and sexual bias in the population settlement of La Réunion Island (Indian Ocean).

D. Comas, G. Lefranc, F. Calafell, 2008, American journal of physical anthropology.