S. Okuda

发表

FKBP12.6-Mediated Stabilization of Calcium-Release Channel (Ryanodine Receptor) as a Novel Therapeutic Strategy Against Heart Failure

M. Yano, T. Ohkusa, M. Suetsugu, 2002, Circulation.

Assessment of the aortic valve annular geometry by real-time three-dimensional transthoracic echocardiography: comparison with two-dimensional transthoracic echocardiography and multidetector computed tomography

M. Yano, M. Matsuzaki, S. Okuda, 2014, Journal of Echocardiography.

Enhanced binding of calmodulin to RyR2 corrects arrhythmogenic channel disorder in CPVT-associated myocytes.

M. Yano, Shigeki Kobayashi, Takeshi Yamamoto, 2014, Biochemical and biophysical research communications.

Prevalence and characteristics of transesophageal echocardiography-related esophageal mucosal injury in patients with atrial fibrillation who underwent pulmonary vein isolation.

M. Yano, S. Okuda, N. Tanaka, 2022, International journal of cardiology.

Urinary 8‐hydroxy‐2′‐deoxyguanosine reflects symptomatic status and severity of systolic dysfunction in patients with chronic heart failure

M. Yano, Shigeki Kobayashi, M. Matsuzaki, 2011, European journal of heart failure.

Urinary 8-hydroxy-2'-deoxyguanosine as a novel biomarker for predicting cardiac events and evaluating the effectiveness of carvedilol treatment in patients with chronic systolic heart failure.

M. Yano, Shigeki Kobayashi, M. Matsuzaki, 2012, Circulation journal : official journal of the Japanese Circulation Society.

Impact of intraoperative transesophageal echocardiography in cardiac and thoracic aortic surgery: experience in 1011 cases.

M. Matsuzaki, S. Okuda, K. Murata, 2009, Journal of cardiology.

Echocardiographic features of acute-phase microscopic polyangiitis in Japanese patients: A single-centre retrospective study.

M. Yano, Shigeki Kobayashi, S. Okuda, 2021, Modern rheumatology.

Is the ratio of transmitral peak E-wave velocity to color flow propagation velocity useful for evaluating the severity of heart failure in atrial fibrillation?

M. Matsuzaki, S. Okuda, K. Murata, 2002, Circulation journal : official journal of the Japanese Circulation Society.

Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction.

M. Yano, Shigeki Kobayashi, Takeshi Yamamoto, 2010, Biochemical and biophysical research communications.

Dantrolene prevents ventricular tachycardia by stabilizing the ryanodine receptor in pressure- overload induced failing hearts.

M. Yano, Shigeki Kobayashi, Takeshi Yamamoto, 2019, Biochemical and biophysical research communications.

Low-dose β-blocker in combination with milrinone safely improves cardiac function and eliminates pulsus alternans in patients with acute decompensated heart failure.

M. Yano, Shigeki Kobayashi, M. Matsuzaki, 2012, Circulation journal : official journal of the Japanese Circulation Society.

Stabilizing cardiac ryanodine receptor prevents the development of cardiac dysfunction and lethal arrhythmia in Ca2+/calmodulin-dependent protein kinase IIδc transgenic mice.

M. Yano, Shigeki Kobayashi, Takeshi Yamamoto, 2020, Biochemical and biophysical research communications.

New data on catecholaminergic polymorphic ventricular tachycardia in Japan: from the bench to the bedside.

M. Yano, S. Okuda, 2013, Circulation journal : official journal of the Japanese Circulation Society.

[Guidelines for treatment of chronic heart failure (JCS 2010)].

M. Yano, S. Okuda, 2011, Nihon rinsho. Japanese journal of clinical medicine.

An oxidative stress biomarker, urinary 8-hydroxy-2'-deoxyguanosine, predicts cardiovascular-related death after steroid therapy for patients with active cardiac sarcoidosis.

M. Yano, Shigeki Kobayashi, M. Matsuzaki, 2016, International journal of cardiology.

G790del mutation in DSC2 alone is insufficient to develop the pathogenesis of ARVC in a mouse model

M. Yano, Shigeki Kobayashi, Takeshi Yamamoto, 2019, Biochemistry and biophysics reports.

Urinary 8-hydroxy-2'-deoxyguanosine as a novel biomarker of inflammatory activity in patients with cardiac sarcoidosis.

M. Yano, Shigeki Kobayashi, M. Matsuzaki, 2015, International journal of cardiology.

Localized Doxorubicin-Induced Cardiomyopathy Complicated With Shower Emboli Originating From Apical Intramural Thrombi.

M. Yano, Shigeki Kobayashi, S. Okuda, 2017, Circulation journal : official journal of the Japanese Circulation Society.

Ryanodine receptor-bound calmodulin is essential to protect against catecholaminergic polymorphic ventricular tachycardia.

M. Yano, Shigeki Kobayashi, Takeshi Yamamoto, 2019, JCI insight.

Abstract 14124: A Marked Increase in Myocardial Oxidative Stress Associated With Sympathetic Hyperactivity is Related to Transient Myocardial Dysfunction in Patients With Takotsubo Cardiomyopathy

M. Yano, Shigeki Kobayashi, S. Okuda, 2015 .

Dantrolene, a therapeutic agent for malignant hyperthermia, inhibits catecholaminergic polymorphic ventricular tachycardia in a RyR2(R2474S/+) knock-in mouse model.

M. Yano, Shigeki Kobayashi, Takeshi Yamamoto, 2010, Circulation journal : official journal of the Japanese Circulation Society.

Correction of impaired calmodulin binding to RyR2 as a novel therapy for lethal arrhythmia in the pressure-overloaded heart failure.

M. Yano, Shigeki Kobayashi, Takeshi Yamamoto, 2017, Heart rhythm.

Successful treatment with intravenous cyclophosphamide for anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis associated with myelodysplastic syndrome

T. Kanda, M. Yano, S. Okuda, 2017, Scandinavian journal of rheumatology.

Simultaneous Doppler tracing of transmitral inflow and mitral annular velocity as an estimate of elevated left ventricular filling pressure in patients with atrial fibrillation.

M. Matsuzaki, S. Okuda, K. Murata, 2012, Circulation journal : official journal of the Japanese Circulation Society.

Mutation-linked, excessively tight interaction between the calmodulin binding domain and the C-terminal domain of the cardiac ryanodine receptor as a novel cause of catecholaminergic polymorphic ventricular tachycardia.

M. Yano, Shigeki Kobayashi, Takeshi Yamamoto, 2018, Heart rhythm.

Application of a Miniaturized Biplane Transesophageal Echocardiographic Probe in Adults

M. Matsuzaki, S. Okuda, K. Murata, 2004 .

Transcatheter and percutaneous procedures for huge pelvic arteriovenous malformations causing high-output heart failure.

M. Yano, S. Okuda, N. Matsunaga, 2015, Journal of cardiology cases.

A Low-Dose β1-Blocker Effectively and Safely Slows the Heart Rate in Patients with Acute Decompensated Heart Failure and Rapid Atrial Fibrillation

M. Yano, Shigeki Kobayashi, M. Matsuzaki, 2013, Cardiology.

CaMKII-mediated phosphorylation of RyR2 plays a crucial role in aberrant Ca2+ release as an arrhythmogenic substrate in cardiac troponin T-related familial hypertrophic cardiomyopathy.

M. Yano, Shigeki Kobayashi, Takeshi Yamamoto, 2018, Biochemical and biophysical research communications.

Valsartan Restores Sarcoplasmic Reticulum Function With No Appreciable Effect on Resting Cardiac Function in Pacing-Induced Heart Failure

M. Yano, T. Ohkusa, M. Kohno, 2004, Circulation.

AT1 receptor antagonist restores cardiac ryanodine receptor function, rendering isoproterenol-induced failing heart less susceptible to Ca2+ -leak induced by oxidative stress.

M. Yano, T. Ohkusa, Takeshi Yamamoto, 2006, Circulation journal : official journal of the Japanese Circulation Society.

A Low-Dose β1-Blocker in Combination with Milrinone Improves Intracellular Ca2+ Handling in Failing Cardiomyocytes by Inhibition of Milrinone-Induced Diastolic Ca2+ Leakage from the Sarcoplasmic Reticulum

M. Yano, Shigeki Kobayashi, Takeshi Yamamoto, 2015, PloS one.

Enhancing calmodulin binding to cardiac ryanodine receptor completely inhibits pressure-overload induced hypertrophic signaling

M. Yano, Shigeki Kobayashi, Takeshi Yamamoto, 2020, Communications biology.

Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts.

M. Yano, T. Ohkusa, Shigeki Kobayashi, 2008, Cardiovascular research.

Correction of Defective Interdomain Interaction Within Ryanodine Receptor by Antioxidant Is a New Therapeutic Strategy Against Heart Failure

M. Yano, T. Ohkusa, Shigeki Kobayashi, 2005, Circulation.

Defective Regulation of Interdomain Interactions Within the Ryanodine Receptor Plays a Key Role in the Pathogenesis of Heart Failure

M. Yano, T. Ohkusa, Shigeki Kobayashi, 2005, Circulation.

Malnutrition and Frailty Are Critical Determinants of 6-Month Outcome in Hospitalized Elderly Patients With Heart Failure Harboring Surgically Untreated Functional Mitral Regurgitation

Takeshi Yamamoto, S. Okuda, Y. Ikeda, 2021, Frontiers in Cardiovascular Medicine.

Can transthoracic Doppler echocardiography predict the discrepancy between left ventricular end-diastolic pressure and mean pulmonary capillary wedge pressure in patients with heart failure?

M. Matsuzaki, S. Okuda, K. Murata, 2005, Circulation journal : official journal of the Japanese Circulation Society.

Recombinant Atrial Natriuretic Peptide Prevents Aberrant Ca2+ Leakage through the Ryanodine Receptor by Suppressing Mitochondrial Reactive Oxygen Species Production Induced by Isoproterenol in Failing Cardiomyocytes

M. Yano, Shigeki Kobayashi, Takeshi Yamamoto, 2016, PloS one.

Addition of a β1-Blocker to Milrinone Treatment Improves Cardiac Function in Patients with Acute Heart Failure and Rapid Atrial Fibrillation

M. Yano, Shigeki Kobayashi, S. Okuda, 2019, Cardiology.

Kinetics of left ventricular rotation during exercise and its relation to exercise tolerance in atrial fibrillation: assessment by two-dimensional speckle tracking echocardiography

M. Yano, Takeshi Yamamoto, S. Okuda, 2014, Journal of Echocardiography.

Mutation-Linked Defective Interdomain Interactions Within Ryanodine Receptor Cause Aberrant Ca2+ Release Leading to Catecholaminergic Polymorphic Ventricular Tachycardia

M. Yano, Shigeki Kobayashi, Takeshi Yamamoto, 2011, Circulation.

Propranolol Prevents the Development of Heart Failure by Restoring FKBP12.6-Mediated Stabilization of Ryanodine Receptor

M. Yano, T. Ohkusa, M. Suetsugu, 2002, Circulation.

Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor.

M. Yano, Shigeki Kobayashi, Takeshi Yamamoto, 2009, Journal of the American College of Cardiology.

Inter-Technique Consistency and Prognostic Value of Intra-Procedural Angiographic and Echocardiographic Assessment of Aortic Regurgitation After Transcatheter Aortic Valve Implantation.

P. Serruys, M. Yano, S. Okuda, 2018, Circulation journal : official journal of the Japanese Circulation Society.

Catecholaminergic Polymorphic Ventricular Tachycardia Is Caused by Mutation-Linked Defective Conformational Regulation of the Ryanodine Receptor

M. Yano, T. Ohkusa, Shigeki Kobayashi, 2010, Circulation research.

Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca(2+) release in heart failure.

M. Yano, Shigeki Kobayashi, Takeshi Yamamoto, 2010, Cardiovascular Research.

Urinary 8-Hydroxy-2′-Deoxyguanosine as a Myocardial Oxidative Stress Marker Is Associated With Ventricular Tachycardia in Patients With Active Cardiac Sarcoidosis

M. Yano, Shigeki Kobayashi, S. Okuda, 2017, Circulation. Cardiovascular imaging.

The impact of geriatric nutritional risk index on one-year outcomes in hospitalized elderly patients with heart failure

Takeshi Yamamoto, S. Okuda, Y. Ikeda, 2023, Frontiers in Cardiovascular Medicine.

RyR2-targeting therapy prevents left ventricular remodeling and ventricular tachycardia in post-infarction heart failure.

M. Yano, Shigeki Kobayashi, Takeshi Yamamoto, 2023, Journal of molecular and cellular cardiology.

Enhancing calmodulin binding to cardiac ryanodine receptor completely inhibits pressure-overload induced hypertrophic signaling

M. Yano, Shigeki Kobayashi, Takeshi Yamamoto, 2020, Communications Biology.

Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts.

M. Yano, Shigeki Kobayashi, Takeshi Yamamoto, 2012, Cardiovascular research.

A new cardioprotective agent, JTV519, improves defective channel gating of ryanodine receptor in heart failure.

M. Yano, T. Ohkusa, M. Kohno, 2003, American journal of physiology. Heart and circulatory physiology.

Nuclear translocation of calmodulin in pathological cardiac hypertrophy originates from ryanodine receptor bound calmodulin.

D. Bers, M. Yano, Shigeki Kobayashi, 2018, Journal of molecular and cellular cardiology.

Dantrolene prevents hepatic steatosis by reducing cytoplasmic Ca2+ level and ER stress

M. Yano, Shigeki Kobayashi, Takeshi Yamamoto, 2020, Biochemistry and biophysics reports.

Stabilization of RyR2 maintains right ventricular function, reduces the development of ventricular arrhythmias, and improves prognosis in pulmonary hypertension.

M. Yano, Shigeki Kobayashi, Takeshi Yamamoto, 2022, Heart rhythm.

Enhanced binding of calmodulin to RyR2 corrects arrhythmogenic channel disorder in CPVT-associated myocytes.

M. Yano, Shigeki Kobayashi, Takeshi Yamamoto, 2014, Biochemical and biophysical research communications.

Does a ripple of Ca(2+) leak develop into a rogue wave that can trigger pathological hypertrophy?

M. Yano, S. Okuda, 2014, Journal of the American College of Cardiology.

Heterogeneity of apex-to-base dispersion in diastolic lengthening is related to impaired global left ventricular relaxation in patients with hypertrophic cardiomyopathy

M. Matsuzaki, S. Okuda, K. Murata, 2011, Journal of echocardiography.