Margrith E. Mattmann

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Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels

O. McManus, C. Lindsley, R. Kass, 2013, Proceedings of the National Academy of Sciences.

An integrated chemical biology approach reveals the mechanism of action of HIV replication inhibitors.

Nicholas D. P. Cosford, Li Yang, Peter Teriete, 2017, Bioorganic & medicinal chemistry.

Potent and Selective Modulation of the RhlR Quorum Sensing Receptor by Using Non‐native Ligands: An Emerging Target for Virulence Control in Pseudomonas aeruginosa

Margrith E. Mattmann, H. Blackwell, Joseph D. Moore, 2015, Chembiochem : a European journal of chemical biology.

Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator.

O. McManus, C. Lindsley, Haibo Yu, 2012, Bioorganic & medicinal chemistry letters.

Identification of Positive Allosteric Modulators VU0155094 (ML397) and VU0422288 (ML396) Reveals New Insights into the Biology of Metabotropic Glutamate Receptor 7

Bruce J. Melancon, K. Gregory, Z. Xiang, 2014, ACS chemical neuroscience.

Control of Quorum Sensing by a Burkholderia pseudomallei Multidrug Efﬂux Pump (cid:1)

Margrith E. Mattmann, H. Blackwell, H. Suga, 2007 .

Control of Quorum Sensing by a Burkholderia pseudomallei Multidrug Efflux Pump

Margrith E. Mattmann, H. Blackwell, H. Suga, 2007, Journal of bacteriology.

Inhibition of Akt with small molecules and biologics: historical perspective and current status of the patent landscape

Sydney L. Stoops, C. Lindsley, Margrith E. Mattmann, 2011, Expert opinion on therapeutic patents.

Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012.

Bruce J. Melancon, D. Sheffler, C. Lindsley, 2012, Bioorganic & medicinal chemistry letters.

Isovaleryl-homoserine lactone, an unusual branched-chain quorum-sensing signal from the soybean symbiont Bradyrhizobium japonicum

Helen E Blackwell, E. Greenberg, G. Pessi, 2011, Proceedings of the National Academy of Sciences.

Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions

Anna L. Blobaum, G. Macdonald, H. Lavreysen, 2013, Drug Metabolism and Disposition.

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Anna L. Blobaum, G. Macdonald, H. Lavreysen, 2013 .

DMD052662 2066..2075

Anna L. Blobaum, G. Macdonald, H. Lavreysen, 2013 .

Small molecules that modulate quorum sensing and control virulence in Pseudomonas aeruginosa.

Margrith E. Mattmann, H. Blackwell, 2010, The Journal of organic chemistry.

Modulation of bacterial quorum sensing with synthetic ligands: systematic evaluation of N-acylated homoserine lactones in multiple species and new insights into their mechanisms of action.

Helen E Blackwell, Margrith E. Mattmann, H. Blackwell, 2007, Journal of the American Chemical Society.

Recent progress in the discovery of small molecules for the treatment of amyotrophic lateral sclerosis (ALS)

Margrith E. Mattmann, N. Cosford, A. Limpert, 2013, Beilstein journal of organic chemistry.

Potent and Selective Synthetic Modulators of a Quorum Sensing Repressor in Pseudomonas aeruginosa Identified from Second‐Generation Libraries of N‐Acylated L‐Homoserine Lactones

Margrith E. Mattmann, H. Blackwell, Patrick M. Shipway, 2011, Chembiochem : a European journal of chemical biology.

Evaluation of a focused library of N-aryl L-homoserine lactones reveals a new set of potent quorum sensing modulators.

Margrith E. Mattmann, H. Blackwell, Grant D. Geske, 2008, Bioorganic & medicinal chemistry letters.

Comparative Analyses of N‐Acylated Homoserine Lactones Reveal Unique Structural Features that Dictate Their Ability to Activate or Inhibit Quorum Sensing

Margrith E. Mattmann, H. Blackwell, Grant D. Geske, 2008, Chembiochem : a European journal of chemical biology.

Synthetic ligands that activate and inhibit a quorum-sensing regulator in Pseudomonas aeruginosa.

E. Greenberg, Margrith E. Mattmann, H. Blackwell, 2008, Bioorganic & medicinal chemistry letters.

Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells

Betty L. Slinger, Margrith E. Mattmann, H. Blackwell, 2022, Nature Chemical Biology.

Comparative Analyses of N‐Acylated Homoserine Lactones Reveal Unique Structural Features that Dictate Their Ability to Activate or Inhibit Quorum Sensing

Margrith E. Mattmann, H. Blackwell, Grant D. Geske, 2008, Chembiochem : a European journal of chemical biology.

Inhibition of Akt with small molecules and biologics: historical perspective and current status of the patent landscape

Sydney L. Stoops, C. Lindsley, Margrith E. Mattmann, 2011, Expert opinion on therapeutic patents.

Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe molecule.

D. Sheffler, C. Lindsley, Margrith E. Mattmann, 2013, Bioorganic & medicinal chemistry letters.

H. Lavreysen, C. Lindsley, Margrith E. Mattmann, 2013, Drug Metabolism and Disposition.

DMD052662 2066..2075

H. Lavreysen, C. Lindsley, Margrith E. Mattmann, 2013 .