C. Hopkins

发表

Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels

O. McManus, C. Lindsley, R. Kass, 2013, Proceedings of the National Academy of Sciences.

ACS chemical neuroscience molecule spotlight on viibryd (Vilazodone).

C. Hopkins, 2011, ACS chemical neuroscience.

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

Tudor I. Oprea, Jennifer E. Golden, Joshua A. Bittker, 2015, Cell.

Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe.

Charles C Hong, Craig W Lindsley, C. Lindsley, 2013, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4).

Kari A. Johnson, C. Lindsley, C. Hopkins, 2009, Bioorganic & medicinal chemistry letters.

Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats.

Anna L. Blobaum, S. Jadhav, C. Lindsley, 2011, Journal of medicinal chemistry.

Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers.

Anna L. Blobaum, J. Javitch, C. Lindsley, 2016, ACS chemical neuroscience.

The antipsychotic potential of muscarinic allosteric modulation.

C. Lindsley, C. Hopkins, E. Lebois, 2010, Drug news & perspectives.

"Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology.

P Jeffrey Conn, Craig W Lindsley, C. Lindsley, 2011, Biochemistry.

Identification and Characterization of a Compound That Protects Cardiac Tissue from Human Ether-à-go-go-related Gene (hERG)-related Drug-induced Arrhythmias*

J. Balser, C. Lindsley, Beiyan Zou, 2012, The Journal of Biological Chemistry.

Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4).

Anna L. Blobaum, C. Lindsley, C. Hopkins, 2016, Bioorganic & medicinal chemistry letters.

Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels.

C. Hopkins, Krystian A. Kozek, C. Weaver, 2018, ACS chemical neuroscience.

Identification and Characterization of ML352: A Novel, Noncompetitive Inhibitor of the Presynaptic Choline Transporter

R. Blakely, O. McManus, C. Lindsley, 2015, ACS chemical neuroscience.

DMH1, a Novel BMP Small Molecule Inhibitor, Increases Cardiomyocyte Progenitors and Promotes Cardiac Differentiation in Mouse Embryonic Stem Cells

C. Hopkins, J. Hao, C. Hong, 2012, PloS one.

Synthesis of 2,3-diarylsubstituted indazoles utilizing a Suzuki cross-coupling/deprotection/N-arylation sequence.

C. Lindsley, C. Hopkins, J. Salovich, 2010, Tetrahedron letters.

Synthesis of 6,7-disubstituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation

C. Hopkins, Nicola Collar, 2005 .

An improved method for the synthesis of 6-substituted-5H-pyrrolo[2,3-b] pyrazines via palladium-catalyzed heteroannulation using microwave heating

C. Hopkins, Nicola Collar, 2004 .

6-Substituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation from N-(3-chloropyrazin-2-yl)-methanesulfonamide and alkynes

C. Hopkins, Nicola Collar, 2004 .

Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.

J. P. Kennedy, C. Lindsley, C. Hopkins, 2010, Bioorganic & medicinal chemistry letters.

Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992

Amanda M. Duran, Anna L. Blobaum, J. Meiler, 2018, Molecular Pharmacology.

Inward rectifier potassium (Kir) channels in the soybean aphid Aphis glycines: Functional characterization, pharmacology, and toxicology.

C. Hopkins, A. Michel, J. Denton, 2018, Journal of insect physiology.

PIK3C3 Inhibition Promotes Sensitivity to Colon Cancer Therapy by Inhibiting Cancer Stem Cells

C. Hopkins, P. Dhawan, D. Oupický, 2021, Cancers.

An insecticide resistance-breaking mosquitocide targeting inward rectifier potassium channels in vectors of Zika virus and malaria

J. Bloomquist, C. Hopkins, Reed M. Johnson, 2016, Scientific Reports.

Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models.

C. Lindsley, C. Hopkins, M. Bubser, 2018, ACS chemical neuroscience.

Blocking the Rac1-TRPC5 pathway protects human podocytes

C. Hopkins, Fan Zhang, M. Emani, 2021 .

Specific Activin Receptor–Like Kinase 3 Inhibitors Enhance Liver Regeneration

C. Lindsley, C. Hopkins, C. Hong, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Validation of an improved scale for rating l-DOPA-induced dyskinesia in the mouse and effects of specific dopamine receptor antagonists

C. Hopkins, M. Cenci, I. Sebastianutto, 2016, Neurobiology of Disease.

Discovery, Synthesis, SAR Development of a Series of N -4-(2,5-dioxopyrrolidin-1-yl)-phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu 4 ) with Oral Efficacy in an anti-Parkinsonian Animal Model

Colleen, Y. Smith, C. Lindsley, 2011 .

Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonism.

D. Sheffler, C. Lindsley, C. Hopkins, 2013, Bioorganic & medicinal chemistry letters.

Inhibitors of the bone morphogenetic protein (BMP) signaling pathway: a patent review (2008-2015)

C. Hopkins, 2016, Expert opinion on therapeutic patents.

Pharmacological Inhibition of Inward Rectifier Potassium Channels Induces Lethality in Larval Aedes aegypti

C. Hopkins, J. Denton, P. Piermarini, 2018, Insects.

Discovery and Characterization of a Potent and Selective Inhibitor of Aedes aegypti Inward Rectifier Potassium Channels

C. Hopkins, K. Lovell, Emily L. Days, 2014, PloS one.

Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.

Bruce J. Melancon, Anna L. Blobaum, D. Sheffler, 2013, Bioorganic & medicinal chemistry letters.

LJ000328, a novel ALK2/3 kinase inhibitor, represses hepcidin and significantly improves the phenotype of IRIDA

C. Hopkins, C. Hong, M. Roth, 2019, Haematologica.

Bidirectional Influence of Limbic GIRK Channel Activation on Innate Avoidance Behavior

C. Hopkins, Haichang Luo, K. Wickman, 2021, The Journal of Neuroscience.

Synthesis and structure-activity relationships of a series of 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter.

R. Blakely, C. Lindsley, C. Hopkins, 2015, Bioorganic & Medicinal Chemistry Letters.

Novel pyrazinone inhibitors of mast cell tryptase: synthesis and SAR evaluation.

M. Mathieu, C. Hopkins, S. Jackson, 2004, Bioorganic & medicinal chemistry letters.

Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator.

O. McManus, C. Lindsley, Haibo Yu, 2012, Bioorganic & medicinal chemistry letters.

Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.

J. P. Kennedy, C. Lindsley, C. Hopkins, 2010, Bioorganic & medicinal chemistry letters.

Identification of Positive Allosteric Modulators VU0155094 (ML397) and VU0422288 (ML396) Reveals New Insights into the Biology of Metabotropic Glutamate Receptor 7

Bruce J. Melancon, K. Gregory, Z. Xiang, 2014, ACS chemical neuroscience.

Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase.

M. Mathieu, C. Hopkins, S. Kaye, 2005, Bioorganic & medicinal chemistry letters.

Extended Probe Characterization: Development of an M4 PAM with Improved Activity and Brain Exposure, while Avoiding Species Bias

Julie L. Engers, Bruce J. Melancon, D. Sheffler, 2013 .

Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu4 positive allosteric modulators that mitigate CYP1A2 induction liability.

Alison R. Gregro, Julie L. Engers, Anna L. Blobaum, 2018, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS).

C. Lindsley, C. Hopkins, P. Conn, 2010, Bioorganic & medicinal chemistry letters.

Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core.

Alison R. Gregro, Julie L. Engers, Bruce J. Melancon, 2016, Bioorganic & medicinal chemistry letters.

Development of N-4,6-pyrimidine-N-alkyl-N'-phenyl ureas as orally active inhibitors of lymphocyte specific tyrosine kinase.

C. Hopkins, A. Gołębiowski, T. A. Brugel, 2006, Bioorganic & medicinal chemistry letters.

Eliciting Renal Failure in Mosquitoes with a Small-Molecule Inhibitor of Inward-Rectifying Potassium Channels

C. Hopkins, K. Lovell, K. Beyenbach, 2013, PloS one.

ACS chemical neuroscience molecule spotlight on Telcagepant (MK-0974).

C. Hopkins, 2011, ACS chemical neuroscience.

Solution-phase parallel synthesis and SAR of homopiperazinyl analogs as positive allosteric modulators of mGlu₄.

Anna L. Blobaum, C. Lindsley, C. Hopkins, 2011, ACS combinatorial science.

ACS chemical neuroscience molecule spotlight on Lorcaserin.

C. Hopkins, 2010, ACS chemical neuroscience.

From dopamine 4 to sigma 1: Synthesis, SAR and biological characterization of a piperidine scaffold of σ1 modulators.

C. Hopkins, D. Murry, Manishika Sharma, 2022, European journal of medicinal chemistry.

Discovery and Characterization of 2-Nitro-5-(4-(phenylsulfonyl)piperazin-1-yl)- N-(pyridin-4-ylmethyl)anilines as Novel Inhibitors of the Aedes aegypti Kir1 ( AeKir1) Channel.

C. Hopkins, J. Denton, P. Piermarini, 2019, ACS infectious diseases.

Convenient synthesis of 4-amino-3,5-disubstituted pyrazoles in one step from the corresponding diketo oximes

C. Hopkins, T. Majid, Nicola Collar, 2004 .

Iterative experimental and virtual high-throughput screening identifies metabotropic glutamate receptor subtype 4 positive allosteric modulators

Jens Meiler, Mariusz Butkiewicz, Ralf Mueller, 2012, Journal of Molecular Modeling.

Convenient Synthesis of 4‐Amino‐3,5‐disubstituted Pyrazoles in One‐Step from the Corresponding Diketo Oximes.

C. Hopkins, Nicola Collar, B. L. Pedgrift, 2004 .

The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease.

Bruce J. Melancon, Z. Xiang, O. McManus, 2011, ACS chemical neuroscience.

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators.

C. Hopkins, Sushil Kumar, N. Gautam, 2019, Bioorganic & medicinal chemistry letters.

Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903.

C. Hopkins, Anna Greka, Corey R Hopkins, 2019, Bioorganic & medicinal chemistry letters.

Metabotropic glutamate receptor 4 (mGlu4)-positive allosteric modulators for the treatment of Parkinson's disease: historical perspective and review of the patent literature

C. Lindsley, C. Hopkins, 2012, Expert opinion on therapeutic patents.

Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery.

Bruce J. Melancon, A. Christopoulos, C. Lindsley, 2012, Journal of medicinal chemistry.

Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkins

Anna L. Blobaum, Y. Smith, S. Jadhav, 2011, Journal of medicinal chemistry.

Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics.

A. Robichaud, C. Lindsley, C. Hopkins, 2011, ACS chemical neuroscience.

Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).

P Jeffrey Conn, Craig W Lindsley, Colleen M Niswender, 2009, Journal of medicinal chemistry.

mGluR4-positive allosteric modulation as potential treatment for Parkinson's disease.

C. Lindsley, C. Hopkins, C. Niswender, 2009, Future medicinal chemistry.

Efficient Synthesis of 1,4-Dihydro-2H-isoquinoline-3,5,8-triones via Cyclobutene Ring Expansion.

P. Wipf, C. Hopkins, 1999, The Journal of organic chemistry.

Biomimetic Synthesis of Lignans

C. Lindsley, C. Hopkins, G. Sulikowski, 2011 .

The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu4 PAM development candidate.

Alison R. Gregro, Andrew S. Felts, Anna L. Blobaum, 2019, Bioorganic & medicinal chemistry letters.

Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu4).

Julie L. Engers, Anna L. Blobaum, C. Lindsley, 2018, Journal of medicinal chemistry.

Discovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4).

Anna L. Blobaum, J. Macor, C. Lindsley, 2016, ACS chemical neuroscience.

Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors.

K. Gregory, C. Lindsley, C. Hopkins, 2016, Chemical reviews.

Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4.

C. Lindsley, C. Hopkins, P. Conn, 2010, ACS chemical neuroscience.

Structure-Activity Relationships for the N-Me- Versus N-H-Amide Modification to Macrocyclic ent-Verticilide Antiarrhythmics.

C. Hopkins, B. Knollmann, N. Schley, 2022, ACS medicinal chemistry letters.

ACS chemical neuroscience molecule spotlight on BMS-708163.

C. Hopkins, 2012, ACS chemical neuroscience.

ACS chemical neuroscience molecule spotlight on Valdoxen.

C. Hopkins, 2010, ACS chemical neuroscience.

Bone morphogenetic protein signaling promotes tumorigenesis in a murine model of high-grade glioma.

L. Chambless, C. Hopkins, H. Moses, 2016, Neuro-oncology.

Discovery, Characterization, and Structure–Activity Relationships of an Inhibitor of Inward Rectifier Potassium (Kir) Channels with Preference for Kir2.3, Kir3.X, and Kir7.1

C. Lindsley, C. Hopkins, C. Weaver, 2011, Front. Pharmacol..

Identification and characterization of a first-generation inhibitor of claudin-1 in colon cancer progression and metastasis.

C. Hopkins, P. Dhawan, D. Murry, 2023, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction.

Charles C Hong, C. Hopkins, C. Hong, 2012, ACS chemical neuroscience.

Discovery and characterization of benzyloxy piperidine based dopamine 4 receptor antagonists.

C. Hopkins, A. Vadukoot, Viktoriya Mashinson, 2021, Bioorganic & medicinal chemistry letters.

Selective α7 nicotinic receptor agonists and positive allosteric modulators for the treatment of schizophrenia – a review

C. Hopkins, Kirsten Antonio-Tolentino, 2020, Expert opinion on investigational drugs.

Separation of Cdc25 dual specificity phosphatase inhibition and DNA cleaving activities in a focused library of analogs of the antitumor antibiotic Dnacin

P. Wipf, C. Hopkins, J. Lazo, 2002 .

Inhibition of BMP Signaling Suppresses Metastasis in Mammary Cancer

J. Giltnane, C. Hopkins, H. Moses, 2014, Oncogene.

Identification of ML204, a Novel Potent Antagonist That Selectively Modulates Native TRPC4/C5 Ion Channels*

Melissa R. Miller, O. McManus, C. Lindsley, 2011, The Journal of Biological Chemistry.

In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors.

C. Lindsley, C. Hopkins, J. Hao, 2010, ACS chemical biology.

The Metabotropic Glutamate Receptor 4-Positive Allosteric Modulator VU0364770 Produces Efficacy Alone and in Combination with l-DOPA or an Adenosine 2A Antagonist in Preclinical Rodent Models of Parkinson's Disease

Anna L. Blobaum, M. Amalric, S. Jadhav, 2012, Journal of Pharmacology and Experimental Therapeutics.

Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis.

Jeff T Roesgen, C. Hopkins, R. Walter, 2006, Bioorganic & medicinal chemistry letters.

TRPC5 Channel Inhibition Protects Podocytes in Puromycin-Aminonucleoside Induced Nephrosis Models

C. Hopkins, Fan Zhang, M. Emani, 2021, Frontiers in Medicine.

ACS chemical neuroscience molecule spotlight on STX209 (arbaclofen).

C. Hopkins, 2011, ACS chemical neuroscience.

Application of small organic molecules reveals cooperative TGFβ and BMP regulation of mesothelial cell behaviors.

C. Hopkins, C. Hong, R. Thomason, 2011, ACS chemical biology.

mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome

Anna L. Blobaum, Z. Xiang, C. Lindsley, 2017, Science Translational Medicine.

A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models

E. Lander, C. Hopkins, M. Garrett, 2017, Science.

Discovery and Characterization of ML398, a Potent and Selective Antagonist of the D4 Receptor with in Vivo Activity.

C. Lindsley, C. Hopkins, M. Bubser, 2014, ACS medicinal chemistry letters.

ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels.

Anna L. Blobaum, J. Meiler, C. Lindsley, 2016, ACS chemical neuroscience.

Selective inhibition of the K(ir)2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133.

O. McManus, C. Lindsley, Haibo Yu, 2011, ACS chemical biology.

Discovery of Small Molecule Renal Outer Medullary Potassium (ROMK) Channel Inhibitors: A Brief History of Medicinal Chemistry Approaches To Develop Novel Diuretic Therapeutics.

C. Hopkins, Christopher D Aretz, A. Vadukoot, 2019, Journal of medicinal chemistry.

Novel Therapeutic Approaches to the Treatment of Parkinson’s Disease: An Overview and Update

C. Hopkins, 2016 .

Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain

Anna L. Blobaum, Qian Xu, Shaoqiu He, 2017, Proceedings of the National Academy of Sciences.

Discovery and Characterization of 2‐(Cyclopropanesulfonamido)‐N‐(2‐ethoxyphenyl)benzamide, ML382: a Potent and Selective Positive Allosteric Modulator of MrgX1

Xinzhong Dong, O. McManus, C. Lindsley, 2015, ChemMedChem.

Inhibition of the TRPC5 ion channel protects the kidney filter.

Craig W Lindsley, Antonio Riccio, C. Lindsley, 2013, The Journal of clinical investigation.

Discovery of VU2957 (Valiglurax): An mGlu4 Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson's Disease.

Julie L. Engers, Andrew S. Felts, Anna L. Blobaum, 2018, ACS medicinal chemistry letters.

Characterization of VU0468554, a New Selective Inhibitor of Cardiac G Protein–Gated Inwardly Rectifying K+ Channels

C. Hopkins, C. Weaver, K. Wickman, 2021, Molecular Pharmacology.

Reversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay.

Joseph J. Babcock, R. Neubig, O. McManus, 2013, Cellular signalling.

Return of D4 Dopamine Receptor Antagonists in Drug Discovery.

C. Lindsley, C. Hopkins, 2017, Journal of medicinal chemistry.

Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases.

C. Hopkins, Swagat Sharma, 2019, Journal of medicinal chemistry.

Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor.

Anna L. Blobaum, D. Sheffler, C. Lindsley, 2012, Bioorganic & medicinal chemistry letters.

Enantioselective synthesis of the AB-ring system of the antitumor antibiotic tetrazomine.

P. Wipf, C. Hopkins, 2001, The Journal of organic chemistry.

Is there a path forward for mGlu(2) positive allosteric modulators for the treatment of schizophrenia?

C. Hopkins, 2013, ACS chemical neuroscience.

Discovery, synthesis and biological characterization of a series of N-(1-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1H-pyrazol-5-yl)acetamide ethers as novel GIRK1/2 potassium channel activators.

C. Hopkins, Sushil Kumar, N. Gautam, 2021, RSC medicinal chemistry.

Identification of ML 204 , a Novel Potent Antagonist That Selectively Modulates Native TRPC 4 / C 5 Ion Channels *

Melissa R. Miller, O. McManus, C. Lindsley, 2011 .

KVA-D-88, a novel preferable phosphodiesterase 4B inhibitor, decreases cocaine-mediated reward properties in vivo.

C. Hopkins, K. Miczek, S. Buch, 2020, ACS chemical neuroscience.

Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and l-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist

C. Lindsley, C. Hopkins, P. Conn, 2015, Neuropharmacology.

Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K(v)7.2 (KCNQ2) channel pharmacology: identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a potent, brain penetrant K(v)7.2 channel inhibitor.

O. McManus, C. Lindsley, Beiyan Zou, 2012, Journal of medicinal chemistry.

ACS chemical neuroscience molecule spotlight on ELND006: another γ-secretase inhibitor fails in the clinic.

C. Hopkins, 2011, ACS chemical neuroscience.

Discovery, synthesis and characterization of a series of 7-aryl-imidazo[1,2-a]pyridine-3-ylquinolines as activin-like kinase (ALK) inhibitors.

Andrew S. Felts, Anna L. Blobaum, C. Lindsley, 2020, Bioorganic & medicinal chemistry letters.

Discovery, Synthesis, and Structure Activity Relationship of a Series of N-Aryl- bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener.

Haibo Yu, Meng Wu, Craig W Lindsley, 2011, ACS chemical neuroscience.

Further SAR on the (Phenylsulfonyl)piperazine Scaffold as Inhibitors of the Aedes aegypti Kir1 (AeKir) Channel and Larvicides

C. Hopkins, J. Denton, P. Piermarini, 2020, ChemMedChem.

Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu4) antagonist: unexpected 'molecular switch' from a closely related mGlu4 positive allosteric modulator.

C. Lindsley, C. Hopkins, C. Niswender, 2011, Bioorganic & medicinal chemistry letters.

VU0810464, a non‐urea G protein‐gated inwardly rectifying K+ (Kir3/GIRK) channel activator, exhibits enhanced selectivity for neuronal Kir3 channels and reduces stress‐induced hyperthermia in mice

C. Hopkins, C. Weaver, R. Morrison, 2019, British journal of pharmacology.

Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1/2 Potassium Channel Activators.

C. Hopkins, C. Weaver, R. Morrison, 2017, ACS chemical neuroscience.

Synthesis and SAR Studies of 1H-Pyrrolo[2,3-b]pyridine-2-carboxamides as Phosphodiesterase 4B (PDE4B) Inhibitors.

C. Hopkins, T. Kielian, Sushil Kumar, 2020, ACS medicinal chemistry letters.

ACS chemical neuroscience molecule spotlight on Saphris.

C. Hopkins, 2010, ACS Chemical Neuroscience.

The Metabotropic Glutamate Receptor 4-Positive Allosteric Modulator VU 0364770 Produces Efficacy Alone and in Combination with L-DOPA or an Adenosine 2 A Antagonist in Preclinical Rodent Models of Parkinson ’ s Disease

Anna L. Blobaum, M. Amalric, S. Jadhav, 2012 .

Chemical Modulation of Mutant mGlu1 Receptors Derived from Deleterious GRM1 Mutations Found in Schizophrenics

C. Lindsley, C. Hopkins, Hyekyung P. Cho, 2014, ACS chemical biology.

ACS chemical neuroscience molecule spotlight on Saredutant.

C. Hopkins, 2010, ACS chemical neuroscience.

A small molecule activator of KCNQ2 and KCNQ4 channels

Julie L. Engers, O. McManus, C. Lindsley, 2013 .

ACS chemical neuroscience molecule spotlight on RG1678.

C. Hopkins, 2011, ACS chemical neuroscience.

ACS chemical neuroscience molecule spotlight on Suvorexant.

C. Hopkins, 2012, ACS Chemical Neuroscience.

Julie L. Engers, Anna L. Blobaum, C. Lindsley, 2018, Journal of Medicinal Chemistry.

Novel Chemical Inhibitor of TRPC4 Channels

Julie L. Engers, Melissa R. Miller, O. McManus, 2011 .

Activation of Metabotropic Glutamate Receptor 7 Is Required for Induction of Long-Term Potentiation at SC-CA1 Synapses in the Hippocampus

C. Lindsley, C. Hopkins, P. Conn, 2015, The Journal of Neuroscience.

ACS chemical neuroscience molecule spotlight on semagacestat (LY450139).

C. Hopkins, 2010, ACS chemical neuroscience.

A potent and selective small molecule Kir2.1 inhibitor

O. McManus, C. Lindsley, Meng Wu, 2010 .

Discovery, synthesis and biological evaluation of a series of N-(phenylcarbamothioyl)-2-napthamides as inhibitors of Claudin-1.

C. Hopkins, P. Dhawan, A. Vadukoot, 2023, Bioorganic & Medicinal Chemistry.

Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators.

J. P. Kennedy, C. Lindsley, C. Hopkins, 2010, Bioorganic & medicinal chemistry letters.

Recent progress in the development of mGluR4 positive allosteric modulators for the treatment of Parkinson's disease.

C. Lindsley, C. Hopkins, C. Niswender, 2009, Current topics in medicinal chemistry.

ACS chemical neuroscience molecule spotlight on gilenya (fingolimod; FTY720).

C. Hopkins, 2011, ACS chemical neuroscience.

Abstract 2676: Inhibition of bmp signaling suppresses metastasis in mammary cancer

J. Giltnane, C. Hopkins, H. Moses, 2014 .

Virtual screening and biological evaluation of PPARγ antagonists as potential anti-prostate cancer agents.

C. Hopkins, Jeremy O. Jones, S. Almahmoud, 2021, Bioorganic & medicinal chemistry.

ACS chemical neuroscience molecule spotlight on Sabril.

C. Hopkins, 2010, ACS chemical neuroscience.

Human relevance of blocking the Rac1-TRPC5 pathway as a podocyte-protective strategy for progressive kidney diseases

C. Hopkins, Fan Zhang, M. Emani, 2020, bioRxiv.

ACS chemical neuroscience molecule spotlight on latuda (lurasidone; SM-13,496).

C. Hopkins, 2011, ACS chemical neuroscience.

Characterization of VU0468554, a New Selective Inhibitor of Cardiac G Protein – Gated Inwardly Rectifying K 1 Channels

C. Hopkins, C. Weaver, E. M. F. D. Velasco, 2021 .