J. Whitsett

发表

SLICE: determining cell differentiation and lineage based on single cell entropy

M. Guo, Erik L. Bao, M. Wagner, 2016, Nucleic acids research.

Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway

J. Uddin, Y. Belkaid, J. Whitsett, 2004, Nature Immunology.

Tumor necrosis factor-alpha inhibits expression of pulmonary surfactant protein.

J. Whitsett, J. Wispé, J. C. Clark, 1990, The Journal of clinical investigation.

Surfactant protein A-polylysine conjugates for delivery of DNA to airway cells in culture.

J. Whitsett, G. Ross, R. Morris, 1995, Human gene therapy.

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

Fabian J Theis, D. Pe’er, A. Regev, 2020, Cell.

Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis.

B. Stripp, M. Guo, J. Whitsett, 2016, JCI insight.

Foxm1 regulates resolution of hyperoxic lung injury in newborns.

J. Whitsett, T. Kalin, V. Kalinichenko, 2015, American journal of respiratory cell and molecular biology.

Glucocorticoid Regulates Mesenchymal Cell Differentiation Required for Perinatal Lung Morphogenesis and Function.

M. Weirauch, A. Jobe, M. Guo, 2020, American journal of physiology. Lung cellular and molecular physiology.

Lung Gene Expression Analysis (LGEA): an integrative web portal for comprehensive gene expression data analysis in lung development

Ravi S. Misra, S. Bhattacharya, T. Mariani, 2017, Thorax.

Time-resolved proteome profiling of normal lung development.

Ronald J. Moore, Anil K. Shukla, J. Carson, 2018, American journal of physiology. Lung cellular and molecular physiology.

Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth

Samriddha Ray, S. Potter, H. Deshmukh, 2019, Nature Communications.

The S52F FOXF1 Mutation Inhibits STAT3 Signaling and Causes Alveolar Capillary Dysplasia.

P. Stankiewicz, P. Szafranski, J. Whitsett, 2019, American journal of respiratory and critical care medicine.

Building and Regenerating the Lung Cell by Cell.

J. Whitsett, Yan Xu, T. Kalin, 2019, Physiological reviews.

Neonatal Lung Disease Associated with TBX4 Mutations

Kevin R. Dufendach, J. Whitsett, D. Dawson, 2019, The Journal of pediatrics.

Integration of transcriptomic and proteomic data identifies biological functions in cell populations from human infant lung.

Ravi S. Misra, S. Bhattacharya, T. Mariani, 2019, American journal of physiology. Lung cellular and molecular physiology.

The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution.

Larry N. Singh, Timothy L. Tickle, Noor B. Dawany, 2019, Developmental cell.

Reconstructing differentiation networks and their regulation from time series single-cell expression data

Z. Bar-Joseph, B. Aronow, N. Kaminski, 2018, Genome research.

Developmental Cell Perspective The Pediatric Cell Atlas : Defining the Growth Phase of Human Development at Single-Cell Resolution

Timothy L. Tickle, Deanne M. Taylor, Jo Lynne Rokita, 2022 .

Foxa2 regulates alveolarization and goblet cell hyperplasia

K. Kaestner, F. Finkelman, J. Whitsett, 2004, Development.

β-Catenin Is Required for Specification of Proximal/Distal Cell Fate during Lung Morphogenesis*

W. Birchmeier, E. Morrisey, J. Whitsett, 2003, Journal of Biological Chemistry.

Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function.

Elizabeth A. Calle, Thiennu H. Vu, J. Epstein, 2014, Cell stem cell.

TTF-1 Phosphorylation Is Required for Peripheral Lung Morphogenesis, Perinatal Survival, and Tissue-specific Gene Expression*

Susan E Wert, Jeffrey A Whitsett, J. Whitsett, 2003, Journal of Biological Chemistry.

Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium.

J. Whitsett, Yan Xu, V. Besnard, 2013, Developmental biology.

Tissue Engineering for the Respiratory Epithelium: Cell-Based Therapies for Treatment of Lung Disease

J. Whitsett, V. Besnard, 2014 .

Functional Genomics of Lung Disease

S. Redline, N. Friedman, A. Regev, 2004 .

Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice.

T. Mak, H. Kubo, J. Whitsett, 2007, The Journal of clinical investigation.

Lung Cell-specific Expression of the Murine Surfactant Protein A (SP-A) Gene Is Mediated by Interactions between the SP-A Promoter and Thyroid Transcription Factor-1 (*)

J. Whitsett, K. Huelsman, M. Bruno, 1995, The Journal of Biological Chemistry.

Clara cell secretory protein: a determinant of PCB bioaccumulation in mammals.

B. Stripp, J. Whitsett, M. Nord, 1996, The American journal of physiology.

Thyroid Transcription Factor-1 and Cytokeratins 7 and 20 in Pulmonary and Breast Carcinoma

J. Whitsett, P. Bejarano, R. Baughman, 1998, Acta Cytologica.

Ablation of a Critical Surfactant Protein B Intramolecular Disulfide Bond in Transgenic Mice*

J. Whitsett, T. Weaver, D. Beck, 2000, The Journal of Biological Chemistry.

Human surfactant protein B: structure, function, regulation, and genetic disease.

J. Whitsett, T. Weaver, L. Nogee, 1995, Physiological reviews.

EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis.

Jeffrey A Whitsett, Cynthia Davidson, J. Whitsett, 2008, American journal of physiology. Lung cellular and molecular physiology.

Signaling pathways in the epithelial origins of pulmonary fibrosis

J. Whitsett, V. Davé, J. Hagood, 2010, Cell cycle.

Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycin.

K. G. Lewis, Bo Li, J. Whitsett, 2005, The American journal of pathology.

Systems Biology Approaches for Elucidation of the Transcriptional Regulation of Pulmonary Maturation

J. Whitsett, Yan Xu, 2016 .

Transcriptional Networks – Control of Lung Maturation

J. Whitsett, Yan Xu, 2012 .

Purification of a Cell-surface Receptor for Surfactant Protein A*

J. Whitsett, R. Abdolrasulnia, V. Shepherd, 1996, The Journal of Biological Chemistry.

Combined Inactivation of MYC and K-Ras Oncogenes Reverses Tumorigenesis in Lung Adenocarcinomas and Lymphomas

Dean W. Felsher, Jeffrey A. Whitsett, D. Felsher, 2008, PloS one.

Differential expression of thyroid transcription factor 1 in small cell lung carcinoma and Merkel cell tumor.

J. Whitsett, P. Cagle, J. Messina, 2000, Human pathology.

Surfactant chemical composition and biophysical activity in acute respiratory distress syndrome.

C. R. Reed, J. Whitsett, A. Fowler, 1991, The Journal of clinical investigation.

Ontogeny of Surfactant Proteins A and B in Human Amniotic Fluid as Indices of Fetal Lung Maturity

J. Whitsett, G. Pryhuber, W. Hull, 1991, Pediatric Research.

Vascular Endothelial Growth Factor-A Induces Prenatal Neovascularization and Alters Bronchial Development in Mice

J. Whitsett, A. Akeson, J. Greenberg, 2005, Pediatric Research.

Fatal familial lung disease caused by ABCA3 deficiency without identified ABCA3 mutations.

J. Whitsett, S. Wert, A. Golan, 2010, The Journal of pediatrics.

Tumor necrosis factor-alpha decreases surfactant protein B mRNA in murine lung.

J. Whitsett, G. Pryhuber, C. Bachurski, 1996, The American journal of physiology.

Role of Cystic Fibrosis Transmembrane Conductance Regulator in Pulmonary Clearance of Pseudomonas aeruginosa In Vivo1

D. Hassett, J. Whitsett, S. Wert, 2000, The Journal of Immunology.

In Pseudomonas aeruginosa Clearance of Conductance Regulator in Pulmonary Role of Cystic Fibrosis Transmembrane

D. Hassett, J. Whitsett, S. Wert, 2000 .

Gene Structure and Expression of Human Thyroid Transcription Factor-1 in Respiratory Epithelial Cells (*)

J. Whitsett, C. Boutell, M. Stahlman, 1995, The Journal of Biological Chemistry.

Expression of thyroid transcription factor-1(TTF-1) in fetal and neonatal human lung.

J. Whitsett, M. Stahlman, M. Gray, 1996, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Cis-active elements controlling lung cell-specific expression of human pulmonary surfactant protein B gene.

J. Whitsett, R. Bohinski, J. Huffman, 1993, The Journal of biological chemistry.

SP-B deficiency causes respiratory failure in adult mice.

J. Tichelaar, J. Whitsett, K. Melton, 2003, American journal of physiology. Lung cellular and molecular physiology.

Foxm1 transcription factor is required for lung fibrosis and epithelial‐to‐mesenchymal transition

J. Whitsett, T. Kalin, V. Kalinichenko, 2013, The EMBO journal.

Respiratory epithelial cells orchestrate pulmonary innate immunity

J. Whitsett, T. Alenghat, 2014, Nature Immunology.

Surfactant Protein D Regulates NF-κB and Matrix Metalloproteinase Production in Alveolar Macrophages via Oxidant-Sensitive Pathways1

J. Whitsett, T. Korfhagen, Mitsuhiro Yoshida, 2001, The Journal of Immunology.

CTGF disrupts alveolarization and induces pulmonary hypertension in neonatal mice: implication in the pathogenesis of severe bronchopulmonary dysplasia.

E. Bancalari, J. Whitsett, Shaoyi Chen, 2011, American journal of physiology. Lung cellular and molecular physiology.

EMC3 coordinates surfactant protein and lipid homeostasis required for respiration

J. Whitsett, Yan Xu, Xinhua Lin, 2017, The Journal of clinical investigation.

Ontogeny of α1-adrenergic receptors in the rat myocardium: Effects of hypothyroidism

J. Whitsett, A. Noguchi, 1982 .

Inhibition of the Growth Factor MDK/Midkine by a Novel Small Molecule Compound to Treat Non-Small Cell Lung Cancer

Motowo Nakajima, William Seibel, Sandra Nelson, 2013, PloS one.

Transgenic models for study of pulmonary development and disease.

J. Whitsett, T. Korfhagen, S. Wert, 1994, The American journal of physiology.

GATA-6 and Thyroid Transcription Factor-1 Directly Interact and Regulate Surfactant Protein-C Gene Expression*

J. Whitsett, H. Wan, S. Glasser, 2002, The Journal of Biological Chemistry.

Upstream Enhancer Activity in the Human Surfactant Protein B Gene Is Mediated by Thyroid Transcription Factor 1 (*)

J. Whitsett, C. Yan, Z. Sever, 1995, The Journal of Biological Chemistry.

Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung.

L. Lim, J. Whitsett, R. Costa, 1996, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Protein Kinase A Activation of the Surfactant Protein B Gene Is Mediated by Phosphorylation of Thyroid Transcription Factor 1*

J. Whitsett, C. Yan, 1997, The Journal of Biological Chemistry.

Regulation of Clara cell secretory protein gene transcription by thyroid transcription factor-1.

B. Stripp, J. Whitsett, L. Zhang, 1997, Biochimica et biophysica acta.

Trophoblastic cells of the hydatidiform mole contain a beta 1-subtype adrenergic receptor.

J. J. Moore, J. Whitsett, L. Workman, 1982, The Journal of clinical endocrinology and metabolism.

Adenoviral E3-14.7K protein in LPS-induced lung inflammation.

J. Whitsett, K. Harrod, A. D. Mounday, 2000, American journal of physiology. Lung cellular and molecular physiology.

Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development.

K. Kaestner, M. Goulding, J. Whitsett, 2009, Developmental biology.

Aminoglycoside suppression of a premature stop mutation in a Cftr–/– mouse carrying a human CFTR-G542X transgene

M. Evans, J. Whitsett, W. Colledge, 2002, Journal of Molecular Medicine.

Aquaporin 5-deficient mouse lungs are hyperresponsive to cholinergic stimulation

Carissa M Krane, J. Whitsett, J. Lorenz, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19

Konrad U. Förstner, Philipp H. Schiffer, D. Pe’er, 2020, Immunity.

Molecular determinants of lung development.

J. Rossant, T. Mariani, J. Epstein, 2013, Annals of the American Thoracic Society.

Summary Foxa 2 regulates alveolarization and goblet cell hyperplasia

K. Kaestner, F. Finkelman, J. Whitsett, 2022 .

Prenatal nicotine increases pulmonary alpha7 nicotinic receptor expression and alters fetal lung development in monkeys.

H. Sekhon, J. Whitsett, J. Pankow, 1999, The Journal of clinical investigation.

Potential role of Sox9 in patterning tracheal cartilage ring formation in an embryonic mouse model.

J. Whitsett, R. Elluru, 2004, Archives of otolaryngology--head & neck surgery.

Developmental aspects of alpha- and beta-adrenergic receptors.

J. J. Moore, J. Whitsett, A. Noguchi, 1982, Seminars in perinatology.

Effects of lung surfactant proteolipid SP-C on the organization of model membrane lipids: a fluorescence study.

J. Whitsett, J. Baatz, A. Horowitz, 1992, Biochimica et biophysica acta.

Chromosomal localization of three pulmonary surfactant protein genes in the mouse.

N. Copeland, N. Jenkins, J. Whitsett, 1992, Genomics.

SP-A enhances viral clearance and inhibits inflammation after pulmonary adenoviral infection.

J. Whitsett, B. Trapnell, T. Korfhagen, 1999, American journal of physiology. Lung cellular and molecular physiology.

Surfactant protein-A enhances respiratory syncytial virus clearance in vivo.

J. Whitsett, M. Bruno, T. Korfhagen, 1999, The Journal of clinical investigation.

Absence of SP-A modulates innate and adaptive defense responses to pulmonary influenza infection.

J. Whitsett, K. Hartshorn, T. Korfhagen, 2002, American journal of physiology. Lung cellular and molecular physiology.

Intersections between pulmonary development and disease.

J. Whitsett, H. Haitchi, Yutaka Maeda, 2011, American journal of respiratory and critical care medicine.

Domains of surfactant protein A that affect protein oligomerization, lipid structure and surface tension.

J. Whitsett, T. Korfhagen, N. Palaniyar, 2001, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

Dissociation, cellular isolation, and initial molecular characterization of neonatal and pediatric human lung tissues.

Jason R. Myers, Ravi S. Misra, S. Bhattacharya, 2018, American journal of physiology. Lung cellular and molecular physiology.

Expression of Thyroid Transcription Factor-1, Surfactant Proteins, Type I Cell–associated Antigen, and Clara Cell Secretory Protein in Pulmonary Hypoplasia

J. Whitsett, C. Langston, S. Wert, 2001 .

Hydrophobic surfactant proteins in lung function and disease.

J. Whitsett, T. Weaver, 2002, The New England journal of medicine.

Genetic disorders influencing lung formation and function at birth.

J. Whitsett, B. Trapnell, S. Wert, 2004, Human molecular genetics.

Sterol response element binding protein and thyroid transcription factor-1 (Nkx2.1) regulate Abca3 gene expression.

J. Whitsett, Yan Xu, V. Besnard, 2007, American journal of physiology. Lung cellular and molecular physiology.

Diseases of pulmonary surfactant homeostasis.

J. Whitsett, S. Wert, T. Weaver, 2015, Annual review of pathology.

Prolonged Survival in Hereditary Surfactant Protein B (SP-B) Deficiency Associated with a Novel Splicing Mutation

A. Hamvas, J. Whitsett, S. Guttentag, 2000, Pediatric Research.

Wntless is required for peripheral lung differentiation and pulmonary vascular development.

J. Whitsett, R. Lang, D. Sinner, 2013, Developmental biology.

A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration

E. Morrisey, J. Whitsett, F. DeMayo, 2008, Nature Genetics.

Fetal and Neonatal Lung Development: Clinical Correlates and Technologies for the Future

A. Jobe, J. Whitsett, S. Abman, 2016 .

Guided construction of single cell reference for human and mouse lung

Timothy L. Tickle, Ravi S. Misra, B. Aronow, 2022, bioRxiv.

Single Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell.

D. Kwiatkowski, S. Potter, M. Guo, 2020, American journal of respiratory and critical care medicine.

Identification of the lymphangioleiomyomatosis cell and its uterine origin

D. Kwiatkowski, S. Potter, M. Guo, 2019, bioRxiv.

Alveolar injury and regeneration following deletion of ABCA3.

Sydney E. Dautel, J. Whitsett, Yan Xu, 2017, JCI insight.

Transdifferentiation of ciliated cells during repair of the respiratory epithelium.

Kwon-Sik Park, J. Whitsett, A. Zorn, 2006, American journal of respiratory cell and molecular biology.

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

Masahiro Yoshida, Fabian J. Theis, Oliver Eickelberg, 2020, Nature Medicine.

Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation.

J. Whitsett, T. Korfhagen, J. Kitzmiller, 2015, The Journal of clinical investigation.

Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction

J. Whitsett, F. Costantini, J. Haigh, 2005, Nucleic Acids Research.

Ectopic respiratory epithelial cell differentiation in bronchiolised distal airspaces in idiopathic pulmonary fibrosis

J. Whitsett, L. Plantier, A. Guenther, 2011, Thorax.

Type I insulin-like growth factor receptor induces pulmonary tumorigenesis.

J. Whitsett, J. Petrik, K. Watson, 2009, Neoplasia.

Alveolar adenoma: a histochemical, immunohistochemical, and ultrastructural analysis of 17 cases.

W. Travis, J. Whitsett, M. Koss, 1999, Human pathology.

A mutation in the surfactant protein C gene associated with familial interstitial lung disease.

F. Askin, A. Hamvas, J. Whitsett, 2001, The New England journal of medicine.

ABCA3 mutations associated with pediatric interstitial lung disease.

J. Whitsett, M. Dean, S. Wert, 2005, American journal of respiratory and critical care medicine.

The Molecular Era of Surfactant Biology

J. Whitsett, 2014, Neonatology.

Simian virus 40 large T antigen directed by transcriptional elements of the human surfactant protein C gene produces pulmonary adenocarcinomas in transgenic mice.

J. Whitsett, J. C. Clark, M. Stahlman, 1992, Cancer research.

Production of immortalized distal respiratory epithelial cell lines from surfactant protein C/simian virus 40 large tumor antigen transgenic mice.

J. Whitsett, J. C. Clark, C. Bachurski, 1993, Proceedings of the National Academy of Sciences of the United States of America.

STAT3 regulates ABCA3 expression and influences lamellar body formation in alveolar type II cells.

J. Whitsett, Yan Xu, V. Besnard, 2008, American journal of respiratory cell and molecular biology.

Chapter Seventy-Three – Progenitor Cells in the Respiratory System

J. Whitsett, V. Besnard, 2007 .

Pulmonary-specific expression of SP-D corrects pulmonary lipid accumulation in SP-D gene-targeted mice.

J. Whitsett, Y. Ho, T. Korfhagen, 2000, American journal of physiology. Lung cellular and molecular physiology.

ALUNG February 22/2

J. Whitsett, T. Korfhagen, S. Fligiel, 2000 .

Regulation of mouse SP-B gene promoter by AP-1 family members.

J. Whitsett, Z. Sever-Chroneos, C. Bachurski, 1999, The American journal of physiology.

Regulation of mouse SP-B gene promoter by AP-1 family members.

J. Whitsett, Z. Sever-Chroneos, C. Bachurski, 1999, American journal of physiology. Lung cellular and molecular physiology.

Regulation of surfactant protein gene transcription.

J. Whitsett, S. Glasser, 1998, Biochimica et biophysica acta.

Limitations of retrovirus-mediated HSV-tk gene transfer to pulmonary adenocarcinoma cells in vitro and in vivo.

J. Whitsett, L. Zhang, K. Wikenheiser, 1997, Human gene therapy.

Transcriptional Control in the Developing Lung

J. Whitsett, T. Korfhagen, 1997 .

Pulmonary surfactant inhibits cationic liposome-mediated gene delivery to respiratory epithelial cells in vitro.

J. Whitsett, A. Horowitz, J. E. Duncan, 1997, Human Gene Therapy.

Tumor progression and cellular differentiation of pulmonary adenocarcinomas in SV40 large T antigen transgenic mice.

J. Whitsett, K. Wikenheiser, 1997, American journal of respiratory cell and molecular biology.

Hepatocyte nuclear factor 3 activates transcription of thyroid transcription factor 1 in respiratory epithelial cells

J. Whitsett, K. Ikeda, S. Wert, 1996, Molecular and cellular biology.

Tumor Necrosis Factor-α Inhibits Surfactant Protein C Gene Transcription (*)

J. Whitsett, G. Pryhuber, C. Bachurski, 1995, The Journal of Biological Chemistry.

Temporal-spatial distribution of SP-B and SP-C proteins and mRNAs in developing respiratory epithelium of human lung.

J. Whitsett, M. Stahlman, A. Khoor, 1994, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Structure and expression of the pulmonary surfactant protein SP-C gene in the mouse.

J. Whitsett, M. Bruno, T. Korfhagen, 1990, The Journal of biological chemistry.

Surfactant protein C precursor is palmitoylated and associates with subcellular membranes.

J. Whitsett, T. Weaver, C. Dey, 1992, Biochimica et Biophysica Acta.

Surfactant-associated protein inhibits phospholipid secretion from type II cells.

J. Whitsett, G. Ross, S. Dingle, 1987, Journal of applied physiology.

Structure and functions of a dimeric form of surfactant protein SP-C: a Fourier transform infrared and surfactometry study.

J. Whitsett, J. Baatz, D. Absolom, 1992, Chemistry and physics of lipids.

Transcriptional elements from the human SP-C gene direct expression in the primordial respiratory epithelium of transgenic mice.

J. Whitsett, T. Korfhagen, S. Wert, 1993, Developmental biology.

Glucocorticoids regulate surfactant protein synthesis in a pulmonary adenocarcinoma cell line.

A. Gazdar, T. Pilot‐Matias, J. Whitsett, 1989, The American journal of physiology.

Purification of canine surfactant-associated glycoproteins A. Identification of a collagenase-resistant domain.

J. Whitsett, Y. Kim, G. Ross, 1986, Biochimica et biophysica acta.

Surfactant protein SP-B induces ordering at the surface of model membrane bilayers.

J. Whitsett, J. Baatz, B. Elledge, 1990, Biochemistry.

Cis-acting sequences from a human surfactant protein gene confer pulmonary-specific gene expression in transgenic mice.

S. Potter, J. Whitsett, J. Stock, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Intracellular processing of pulmonary surfactant protein B in an endosomal/lysosomal compartment.

H. Geuze, J. Whitsett, W. Voorhout, 1992, The American journal of physiology.

Murine pulmonary surfactant SP-A gene: cloning, sequence, and transcriptional activity.

J. Whitsett, J. C. Clark, M. Bruno, 1992, The American journal of physiology.

Sequence, ontogeny, and cellular localization of murine surfactant protein B mRNA.

J. Whitsett, J. C. Clark, M. D'Amore-Bruno, 1992, The American journal of physiology.

Pulmonary Perspective Intersections between Pulmonary Development and Disease

J. Whitsett, H. Haitchi, Y. Maeda, 2011 .

VEGF enhances pulmonary vasculogenesis and disrupts lung morphogenesis in vivo

J. Whitsett, K. Peters, S. Wert, 1998, Developmental dynamics : an official publication of the American Association of Anatomists.

Surfactant proteins and thyroid transcription factor-1 in pulmonary and breast carcinomas.

R. Lauro, J. Whitsett, C. Fenoglio-Preiser, 1996, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

Determination of lung as the primary site of cerebral metastatic adenocarcinomas using monoclonal antibody to thyroid transcription factor-1

R. Warnick, J. Whitsett, P. Bejarano, 1998, Journal of Neuro-Oncology.

Transcriptional control in the developing lung. The Parker B. Francis lectureship.

J. Whitsett, T. Korfhagen, 1997, Chest.

Integrin α6β4 defines a novel lung epithelial progenitor cell: a step forward for cell-based therapies for pulmonary disease.

J. Whitsett, V. Kalinichenko, 2011, The Journal of clinical investigation.

Tissue Engineering for the Respiratory Epithelium: Is There a Future for Stem Cell Therapy in the Lung?

J. Whitsett, V. Besnard, 2008 .

GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium.

A. R. Thitoff, Kwon-Sik Park, J. Whitsett, 2008, The American journal of pathology.

Resident cellular components of the lung: developmental aspects.

J. Whitsett, W. Cardoso, 2008, Proceedings of the American Thoracic Society.

Peripheral airway cell differentiation in human lung cancer cell lines.

A. Gazdar, J. Mulshine, J. Whitsett, 1990, Cancer research.

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes.

H. Varmus, A. Koretsky, J. Tichelaar, 2001, Genes & development.

β‐catenin and Kras/Foxm1 signaling pathway are critical to restrict Sox9 in basal cells during pulmonary branching morphogenesis

J. Whitsett, T. Kalin, V. Kalinichenko, 2016, Developmental dynamics : an official publication of the American Association of Anatomists.

Cell type-resolved human lung lipidome reveals cellular cooperation in lung function

Anil K. Shukla, Jason R. Myers, Ravi S. Misra, 2018, Scientific Reports.

TGFBI functions similar to periostin but is uniquely dispensable during cardiac injury

J. Whitsett, J. Molkentin, S. Conway, 2017, PloS one.

Immunosuppressed surfactant protein A-deficient mice have increased susceptibility to Pneumocystis carinii infection.

J. Whitsett, T. Korfhagen, P. Walzer, 2001, The Journal of infectious diseases.

Modulating pulmonary inflammation

E. Morrisey, J. Whitsett, 2016, Science.

FOXM1 activates AGR2 and causes progression of lung adenomas into invasive mucinous adenocarcinomas

A. Warth, H. Dienemann, J. Whitsett, 2017, PLoS genetics.

Simian Virus 40 Large T Antigen Directed by Transcriptional Elements of the Human Surfactant Protein C Gene Produces Pulmonary Adenocarcinomas in Transgenic Mice 1

J. Whitsett, M. Stahlman, Jean C. Clark, 2006 .

Mucins and Mucus

J. Whitsett, M. McGuckin, D. Thornton, 2015 .

mechanisms of disease Pulmonary Alveolar Proteinosis

J. Whitsett, B. Trapnell, K. Nakata, 2003 .

Pulmonary alveolar proteinosis.

J. Whitsett, B. Trapnell, K. Nakata, 2003, The New England journal of medicine.

Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung.

J. Tichelaar, J. Whitsett, S. Wert, 2005, American journal of respiratory cell and molecular biology.

Interference with intraepithelial TNF-α signaling inhibits CD8(+) T-cell-mediated lung injury in influenza infection.

J. Whitsett, C. Ramana, M. Jamaluddin, 2010, Viral immunology.

Expression of surfactant protein B precursor and surfactant protein B mRNA in adenocarcinoma of the lung.

J. Whitsett, M. Stahlman, A. Khoor, 1997, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

36 – Trachea, Bronchi, and Lungs

J. Whitsett, R. Elluru, S. Wert, 2004 .

Subject Index, Volume 42, 1998

G. Nilsson, O. Larsson, M. Tsou, 1998, Acta Cytologica.

Contributor Index, Volume 42, 1998

G. Nilsson, O. Larsson, M. Tsou, 1998, Acta Cytologica.

YAP regulates alveolar epithelial cell differentiation and AGER via NFIB/KLF5/NKX2-1

J. Whitsett, Yan Xu, A. Sridharan, 2021, iScience.

Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung.

B. Stripp, J. Whitsett, Yan Xu, 2015, Journal of molecular cell biology.

GATA-6 Activates Transcription of Thyroid Transcription Factor-1*

J. Whitsett, M. Bruno, J. R. Shaw-white, 1999, The Journal of Biological Chemistry.

Activation of Sterol-response Element-binding Proteins (SREBP) in Alveolar Type II Cells Enhances Lipogenesis Causing Pulmonary Lipotoxicity*

J. Whitsett, Yan Xu, L. Plantier, 2012, The Journal of Biological Chemistry.

Foxa2 regulates leukotrienes to inhibit Th2-mediated pulmonary inflammation.

J. Whitsett, F. Luo, Xiaoju Tang, 2013, American journal of respiratory cell and molecular biology.

Genomics and proteomics of lung disease: conference summary.

John Quackenbush, Naftali Kaminski, Scott T Weiss, 2007, American journal of physiology. Lung cellular and molecular physiology.

Human Mn-superoxide dismutase in pulmonary epithelial cells of transgenic mice confers protection from oxygen injury.

J. Crapo, J. Whitsett, Ling-Yi L Chang, 1992, The Journal of biological chemistry.

Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis.

J. Whitsett, P. Vassalli, C. Vesin, 1995, The Journal of clinical investigation.

Arrested lung morphogenesis in transgenic mice bearing an SP-C-TGF-beta 1 chimeric gene.

J. Whitsett, L. Zhou, S. Wert, 1996, Developmental biology.

NHLBI Workshop Strategic Plan for Pediatric Respiratory Diseases Research An NHLBI Working Group Report

D. Gozal, N. Prabhakar, W. Teague, 2009 .

Differential effects of glucocorticoid on expression of surfactant proteins in a human lung adenocarcinoma cell line.

A. Gazdar, J. Whitsett, M. O’Reilly, 1988, Biochimica et biophysica acta.

In vitro sulfation of pulmonary surfactant-associated protein-35.

J. Whitsett, T. Weaver, K. Kropp, 1987, Biochimica et biophysica acta.

Activity of Pulmonary Surfactant Protein-D (SP-D) in Vivo Is Dependent on Oligomeric Structure*

J. Whitsett, T. Korfhagen, E. Crouch, 2001, The Journal of Biological Chemistry.

Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient mice.

G. Dranoff, J. Whitsett, R. Mulligan, 1996, The Journal of clinical investigation.

Surfactant metabolic consequences of overexpression of GM-CSF in the epithelium of GM-CSF-deficient mice.

A. Jobe, J. Whitsett, M. Ikegami, 1997, American journal of physiology. Lung cellular and molecular physiology.

Surfactant protein-B-deficient mice are susceptible to hyperoxic lung injury.

J. Whitsett, H. Iwamoto, C. Bachurski, 1999, American journal of respiratory cell and molecular biology.

Temporal/spatial expression of nuclear receptor coactivators in the mouse lung.

J. Whitsett, S. Wert, C. Yan, 2000, American journal of physiology. Lung cellular and molecular physiology.

Airway Epithelial KIF3A Regulates Th2 Responses to Aeroallergens

J. Whitsett, G. K. Khurana Hershey, A. Sridharan, 2016, The Journal of Immunology.

IL-1β Disrupts Postnatal Lung Morphogenesis in the Mouse

J. Whitsett, U. Lappalainen, K. Bry, 2007 .

Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis.

Thiennu H. Vu, J. Whitsett, N. Ferrara, 2007, Developmental biology.

Transient induction of TGF-alpha disrupts lung morphogenesis, causing pulmonary disease in adulthood.

J. Whitsett, K. Albertine, W. Hardie, 2004, American journal of physiology. Lung cellular and molecular physiology.

Respiratory epithelial cell expression of human transforming growth factor-alpha induces lung fibrosis in transgenic mice.

J. Whitsett, T. Korfhagen, J. McCarty, 1994, The Journal of clinical investigation.

IL-1beta disrupts postnatal lung morphogenesis in the mouse.

J. Whitsett, U. Lappalainen, K. Bry, 2007, American Journal of Respiratory Cell and Molecular Biology.

Disrupted pulmonary vascular development and pulmonary hypertension in transgenic mice overexpressing transforming growth factor-alpha.

J. Whitsett, W. Hardie, T. Korfhagen, 2003, American journal of physiology. Lung cellular and molecular physiology.

Conditional overexpression of connective tissue growth factor disrupts postnatal lung development.

E. Bancalari, J. Whitsett, Shaoyi Chen, 2010, American journal of respiratory cell and molecular biology.

Conditional disruption of mouse Klf5 results in defective eyelids with malformed meibomian glands, abnormal cornea and loss of conjunctival goblet cells.

J. Whitsett, H. Wan, Divya Gupta, 2011, Developmental biology.

Conditional recombination reveals distinct subsets of epithelial cells in trachea, bronchi, and alveoli.

J. Whitsett, A. Perl, S. Wert, 2005, American journal of respiratory cell and molecular biology.

Immunolocalization of Sonic Hedgehog (Shh) in Developing Mouse Lung

J. Whitsett, S. Wert, L. Miller, 2001, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Tumor necrosis factor-alpha inhibits surfactant protein C gene transcription.

J. Whitsett, G. Pryhuber, C. Bachurski, 1995, The Journal of biological chemistry.

Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis.

G. Dranoff, R. Bronson, M. Sadelain, 1994, Science.

Heterogeneity in Human Induced Pluripotent Stem Cell – derived Alveolar Epithelial Type II Cells Revealed with ABCA3/SFTPC Reporters

Ignacio S. Caballero, S. Russo, J. Whitsett, 2021 .

LungMAP Portal Ecosystem: Systems-Level Exploration of the Lung

V. B. Surya Prasath, Kevin A. Burns, Timothy L. Tickle, 2021, bioRxiv.

Resident Cellular Components of the Human Lung

W. Travis, R. Crystal, T. Colby, 2012 .

β-Adrenergic Receptors and Catecholamine Sensitive Adenylate Cyclase in Developing Rat Ventricular Myocardium: Effect of Thyroid Status

J. Whitsett, J. Pollinger, S. Matz, 1982, Pediatric Research.

II. Beta-adrenergic receptors and catecholamine sensitive adenylate cyclase in the developing rat lung.

J. Whitsett, M. Manton, K. Adams, 1981, Life sciences.

Developmental Aspects of β-Adrenergic Receptors and Catecholamine-Sensitive Adenylate Cyclase in Rat Myocardium

J. Whitsett, C. Darovec-Beckerman, 1981, Pediatric Research.

Surfactant protein-A binds group B streptococcus enhancing phagocytosis and clearance from lungs of surfactant protein-A-deficient mice.

W. Watford, J. Whitsett, G. Ross, 1999, American journal of respiratory cell and molecular biology.

Immunolocalization of Surfactant Protein-D (SP-D) in Human Fetal, Newborn, and Adult Tissues

J. Whitsett, M. Stahlman, W. Hull, 2002, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Surfactant Protein-D Regulates Soluble CD14 through Matrix Metalloproteinase-121

J. Whitsett, S. Shapiro, T. Korfhagen, 2005, The Journal of Immunology.

Pulmonary dysfunction in neonatal SP-B-deficient mice.

A. Jobe, J. Whitsett, H. Iwamoto, 1997, American journal of physiology. Lung cellular and molecular physiology.

Decreased lung compliance and air trapping in heterozygous SP-B-deficient mice.

A. Jobe, J. Whitsett, J. C. Clark, 1997, American journal of respiratory cell and molecular biology.

Rapamycin decreases airway remodeling and hyperreactivity in a transgenic model of noninflammatory lung disease.

J. Whitsett, W. Hardie, T. Korfhagen, 2011, Journal of applied physiology.

Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice.

J. Whitsett, W. Hardie, T. Korfhagen, 2009, American journal of respiratory cell and molecular biology.

CCSP deficiency does not alter surfactant homeostasis during adenoviral infection.

A. Jobe, J. Whitsett, K. Harrod, 1999, American journal of physiology. Lung cellular and molecular physiology.

Conditional expression of genes in the respiratory epithelium in transgenic mice: cautionary notes and toward building a better mouse trap.

J. Whitsett, A. Perl, Liqian Zhang, 2009, American journal of respiratory cell and molecular biology.

Regulation and function of CCSP during pulmonary Pseudomonas aeruginosa infection in vivo.

J. Whitsett, K. Harrod, S. Hayashida, 2000, American journal of physiology. Lung cellular and molecular physiology.

Clara cell secretory protein decreases lung inflammation after acute virus infection.

B. Stripp, J. Whitsett, K. Harrod, 1998, American journal of physiology. Lung cellular and molecular physiology.

IL-4 increases surfactant and regulates metabolism in vivo.

A. Jobe, J. Whitsett, G. Ross, 2000, American journal of physiology. Lung cellular and molecular physiology.

Surfactant protein-D and surfactant inhibit endotoxin-induced pulmonary inflammation.

Elizabeth A. Scoville, J. Whitsett, R. Scheule, 2007, Chest.

Surfactant protein-d enhances phagocytosis and pulmonary clearance of respiratory syncytial virus.

J. Whitsett, T. Korfhagen, E. Crouch, 2004, American journal of respiratory cell and molecular biology.

Genetics of Quorum Sensing Circuitry in Pseudomonas aeruginosa

D. Hassett, J. Whitsett, T. McDermott, 2002 .

Therapeutic Potential of Endothelial Progenitor Cells in Pulmonary Diseases.

J. Whitsett, T. Kalin, V. Kalinichenko, 2021, American journal of respiratory cell and molecular biology.

Chapter 1 – Molecular Determinants of Lung Morphogenesis

J. Whitsett, S. Wert, 2006 .

Efficient Transduction of Alveolar Type 2 Cells with Adeno-associated Virus for the Study of Lung Regeneration.

J. Whitsett, S. Wootton, J. Bridges, 2021, American journal of respiratory cell and molecular biology.

Genetic Disorders of Surfactant Dysfunction

J. Whitsett, S. Wert, L. Nogee, 2009, Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.

An MRI system for imaging neonates in the NICU: initial feasibility study

Jean A. Tkach, S. Merhar, C. Dumoulin, 2012, Pediatric Radiology.

Uterine deletion of Gp130 or Stat3 shows implantation failure with increased estrogenic responses.

S. Dey, J. Whitsett, Xiaofei Sun, 2013, Molecular endocrinology.

Neither SP-A nor NH2-terminal domains of SP-A can substitute for SP-D in regulation of alveolar homeostasis.

J. Whitsett, S. Shapiro, T. Korfhagen, 2006, American journal of physiology. Lung cellular and molecular physiology.

Alveolar macrophages and emphysema in surfactant protein‐D‐deficient mice

J. Whitsett, Mitsuhiro Yoshida, 2006, Respirology.

Pulmonary collectins and innate host defense of the lung.

J. Whitsett, A. Levine, 2001, Microbes and infection.

Surfactant Protein D Enhances Clearance of Influenza A Virus from the Lung In Vivo1

J. Whitsett, K. Hartshorn, T. Korfhagen, 2001, The Journal of Immunology.

Surfactant protein A-deficient mice are susceptible to group B streptococcal infection.

J. Whitsett, G. Ross, K. Huelsman, 1997, Journal of immunology.

Altered surfactant function and structure in SP-A gene targeted mice.

B. Stripp, A. Jobe, J. Whitsett, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity.

J. Whitsett, Yan Xu, S. Randell, 2014, American journal of respiratory and critical care medicine.

Alterations of the endogenous surfactant system in septic adult rats.

J. Whitsett, R. Veldhuizen, J. Malloy, 1997, American journal of respiratory and critical care medicine.

Surfactant replacement therapy for adult respiratory distress syndrome in children

J. Whitsett, R. Wilmott, Daniel A. Evans, 1996, Pediatric pulmonology.

Altered alveolar surfactant is an early marker of acute lung injury in septic adult sheep.

W. Sibbald, J. Whitsett, R. Qanbar, 1994, American journal of respiratory and critical care medicine.

FGF signaling is required for pulmonary homeostasis following hyperoxia.

J. Whitsett, A. Perl, I. Hokuto, 2004, American journal of physiology. Lung cellular and molecular physiology.

Prenatal, but Not Postnatal, Inhibition of Fibroblast Growth Factor Receptor Signaling Causes Emphysema*

J. Whitsett, A. Perl, I. Hokuto, 2003, The Journal of Biological Chemistry.

Surfactant protein deficiency in familial interstitial lung disease.

J. Whitsett, J. Tomashefski, R. Baughman, 2001, The Journal of pediatrics.

Immunolocalization of Transforming Growth Factor α and Epidermal Growth Factor Receptor in Lungs of Patients with Cystic Fibrosis

J. Whitsett, P. Bejarano, J. Yankaskas, 1999, Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.

HNF-3/Forkhead Homologue-4 (HFH-4) Is Expressed in Ciliated Epithelial Cells in the Developing Mouse Lung

J. Tichelaar, J. Whitsett, R. Costa, 1999, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Characteristics of surfactant from SP-A-deficient mice.

A. Jobe, J. Whitsett, M. Bruno, 1998, American journal of physiology. Lung cellular and molecular physiology.

Postnatal lung function and morphology in transgenic mice expressing transforming growth factor-alpha.

J. Whitsett, W. Hardie, K. Huelsman, 1997, The American journal of pathology.

Surfactant metabolism in surfactant protein A-deficient mice.

A. Jobe, J. Whitsett, M. Bruno, 1997, The American journal of physiology.

Posttranslational processing of surfactant protein C in rat type II cells.

J. Whitsett, W. Voorhout, T. Weaver, 1995, The American journal of physiology.

cDNA, deduced polypeptide structure and chromosomal assignment of human pulmonary surfactant proteolipid, SPL(pVal).

T. Pilot‐Matias, J. Whitsett, J. C. Clark, 1988, The Journal of biological chemistry.

Differential effects of epidermal growth factor and transforming growth factor-beta on synthesis of Mr = 35,000 surfactant-associated protein in fetal lung.

M. Lieberman, J. Whitsett, J. C. Clark, 1987, The Journal of biological chemistry.

Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis.

M. Medvedovic, J. Whitsett, W. Hardie, 2007, American journal of respiratory cell and molecular biology.

Comparison of the distinct effects of epidermal growth factor and betamethasone on the morphogenesis of the gas exchange region and differentiation of alveolar type II cells in lungs of fetal rhesus monkeys.

J. Whitsett, D. Styne, A. Tarantal, 1995, The Journal of pharmacology and experimental therapeutics.

Surfactant protein B inhibits endotoxin-induced lung inflammation.

A. Jobe, J. Whitsett, R. Epaud, 2003, American journal of respiratory cell and molecular biology.

Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy.

B. Rubin, J. Whitsett, B. Trapnell, 2010, American journal of respiratory and critical care medicine.

Surfactant enhances adenovirus-mediated gene expression in rabbit lungs.

A. Jobe, J. Whitsett, B. Trapnell, 1996, Gene therapy.

Granulocyte-macrophage colony-stimulating factor and pulmonary surfactant homeostasis.

J. Whitsett, J. A. Reed, 1998, Proceedings of the Association of American Physicians.

How Can the Pediatric Community Enhance Funding for Child Health Research?

T. Boat, J. Whitsett, 2021, JAMA pediatrics.

Immortalization of subpopulations of respiratory epithelial cells from transgenic mice bearing SV40 large T antigen.

J. Whitsett, J. Cuppoletti, J. C. Clark, 1994, The American journal of physiology.

The pulmonary collectins, SP-A and SP-D, orchestrate innate immunity in the lung.

J. Whitsett, F. McCormack, 2002, The Journal of clinical investigation.

Patient-derived granulocyte/macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primates.

J. Krischer, J. Whitsett, B. Trapnell, 2010, American journal of respiratory and critical care medicine.

Surfactant metabolism in SP-D gene-targeted mice.

A. Jobe, J. Whitsett, G. Ross, 2000, American journal of physiology. Lung cellular and molecular physiology.

Surfactant-associated protein A inhibits LPS-induced cytokine and nitric oxide production in vivo.

J. Taylor, J. Whitsett, T. Korfhagen, 2000, American journal of physiology. Lung cellular and molecular physiology.

A common mutation in the surfactant protein C gene associated with lung disease.

A. Hamvas, J. Whitsett, G. Deutsch, 2005, The Journal of pediatrics.

Forkhead Box m1 transcription factor is required for perinatal lung function

J. Whitsett, T. Kalin, V. Kalinichenko, 2008, Proceedings of the National Academy of Sciences.

A lungful of transcription factors

J. Whitsett, 1998, Nature Genetics.

Pulmonary malformation in transgenic mice expressing human keratinocyte growth factor in the lung.

J. Whitsett, T. Ulich, L. Zhou, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Expression of surfactant associated protein-A and Clara cell 10 kilodalton mRNA in neoplastic and non-neoplastic human lung tissue as detected by in situ hybridization.

J. Minna, W. Travis, A. Gazdar, 1992, Laboratory investigation; a journal of technical methods and pathology.

GM-CSF regulates protein and lipid catabolism by alveolar macrophages.

J. Whitsett, M. Ikegami, Z. Chroneos, 2001, American journal of physiology. Lung cellular and molecular physiology.

Surfactant protein D alters allergic lung responses in mice and human subjects.

J. Whitsett, G. K. Khurana Hershey, M. Rothenberg, 2008, The Journal of allergy and clinical immunology.

Intratracheal recombinant surfactant protein d prevents endotoxin shock in the newborn preterm lamb.

J. Whitsett, R. Scheule, W. Brondyk, 2006, American journal of respiratory and critical care medicine.

Localization of pulmonary surfactant protein D in kidney.

J. Whitsett, Y. Tomino, M. Ikegami, 2006 .

Surfactant protein-A-deficient mice are susceptible to Pseudomonas aeruginosa infection.

J. Whitsett, M. Bruno, T. Korfhagen, 1998, American journal of respiratory cell and molecular biology.

cis-acting elements that confer lung epithelial cell expression of the CC10 gene.

B. Stripp, J. Whitsett, D. Luse, 1992, The Journal of biological chemistry.

Airway Epithelial Differentiation and Mucociliary Clearance.

J. Whitsett, 2018, Annals of the American Thoracic Society.

Decreased surfactant protein A in patients with bacterial pneumonia.

J. Whitsett, R. Baughman, W. Hull, 1993, The American review of respiratory disease.

Role of Sonic hedgehog in patterning of tracheal–bronchial cartilage and the peripheral lung

J. Whitsett, Yan Xu, A. Perl, 2004, Developmental dynamics : an official publication of the American Association of Anatomists.

R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis

J. Whitsett, W. Scott, M. Mucenski, 2008, Development.

Temporal effects of Sprouty on lung morphogenesis.

G. Christofori, J. Whitsett, A. Perl, 2003, Developmental biology.

Surfactant protein A (SP-A) gene targeted mice.

J. Whitsett, T. Korfhagen, A. Levine, 1998, Biochimica et biophysica acta.

Binding and uptake of pulmonary surfactant protein (SP-A) by pulmonary type II epithelial cells.

J. Whitsett, R. Morris, G. Ciraolo, 1989, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Reversibility of Pulmonary Abnormalities by Conditional Replacement of Surfactant Protein D (SP-D) in Vivo *

J. Whitsett, T. Korfhagen, M. Ikegami, 2002, The Journal of Biological Chemistry.

Complementation of Pulmonary Abnormalities in SP-D(−/−) Mice with an SP-D/Conglutinin Fusion Protein*

J. Whitsett, K. Hartshorn, E. Crouch, 2002, The Journal of Biological Chemistry.

Congenital cystic adenomatoid malformation of the lung (CCAM): evaluation of the cellular components.

F. Askin, J. Whitsett, J. Jagirdar, 1999, Human pathology.

Forkhead transcription factor HFH-4 and respiratory epithelial cell differentiation.

J. Tichelaar, J. Whitsett, 1999, American journal of respiratory cell and molecular biology.

Resident Cellular Components of the Lung

J. Whitsett, W. Cardoso, 2012 .

Regulation of gene transcription in respiratory epithelial cells.

J. Whitsett, T. Korfhagen, 1996, American journal of respiratory cell and molecular biology.

80 – Surfactant Homeostasis: Composition and Function of Pulmonary Surfactant Lipids and Proteins

J. Whitsett, 2017 .

References Subscriptions Permissions Email Alerts Mice Macrophage Dysfunction and Susceptibility to Pulmonary Pseudomonas aeruginosa Infection in Surfactant Protein C-Deficient

D. Prows, J. Whitsett, G. Ross, 2013 .

MiceInfection in Surfactant Protein C-Deficient Pseudomonas aeruginosa to Pulmonary Macrophage Dysfunction and Susceptibility

D. Prows, J. Whitsett, G. Ross, 2008 .

Novel mutations in the gene encoding ATP binding cassette protein member A3 (ABCA3) resulting in fatal neonatal lung disease

F. Reinholt, A. Hamvas, J. Whitsett, 2007, Acta paediatrica.

Surfactant Proteins in Innate Host Defense of the Lung

J. Whitsett, 2005, Neonatology.

Genetic Disorders of Surfactant Homeostasis

J. Whitsett, Yan Xu, S. Wert, 2005, Neonatology.

Chapter 100 – Composition of Pulmonary Surfactant Lipids and Proteins

J. Whitsett, 2004 .

Genetic basis of familial interstitial lung disease: misfolding or function of surfactant protein C?

J. Whitsett, 2002, American journal of respiratory and critical care medicine.

Mutations in the surfactant protein C gene associated with interstitial lung disease.

F. Askin, A. Hamvas, J. Whitsett, 2002, Chest.

Lamellar Body Formation in Normal and Surfactant Protein B-Deficient Fetal Mice

J. Whitsett, M. Stahlman, T. Weaver, 2000, Laboratory Investigation.

S128 Soluble ADAM33 Causes Airway Remodelling To Promote Allergic Airway Inflammation

D. Davies, J. Whitsett, Elizabeth R. Davies, 2015 .

Immortalization of epithelial cells.

J. Whitsett, J. Jacobberger, R. Eckert, 1996, The American journal of physiology.

Lung Gene Expression Analysis Web Portal Version 3: Lung-at-a-Glance.

M. Guo, J. Whitsett, Yan Xu, 2021, American Journal of Respiratory Cell and Molecular Biology.

Surfactant Protein B (SP-B) −/− Mice Are Rescued by Restoration of SP-B Expression in Alveolar Type II Cells but Not Clara Cells*

J. Whitsett, Sui Lin, T. Weaver, 1999, The Journal of Biological Chemistry.

Rescue of SP-B Knockout Mice with a Truncated SP-B Proprotein

A. Jobe, J. Whitsett, H. Iwamoto, 1997, The Journal of Biological Chemistry.

proteinosis in GM-CSF-deficient mice Aerosolized GM-CSF ameliorates pulmonary alveolar

A. Jobe, J. Whitsett, M. Ikegami, 2016 .

GM-CSF regulates a PU.1-dependent transcriptional program determining the pulmonary response to LPS.

J. Whitsett, B. Trapnell, M. O’connor, 2007, American journal of respiratory cell and molecular biology.

Inhibitory Effects of Surfactant Protein A on Surfactant Phospholipid Hydrolysis by Secreted Phospholipases A21

M. Gelb, L. Touqui, J. Whitsett, 2003, The Journal of Immunology.

2 Secreted Phospholipases A Surfactant Phospholipid Hydrolysis by Inhibitory Effects of Surfactant Protein A on

M. Gelb, L. Touqui, J. Whitsett, 2003 .

Alveolar Macrophages by GM-CSF and PU.1 Organization Are Coordinately Regulated in Nonspecific Phagocytosis, and Cytoskeletal Endocytic Internalization of Adenovirus,

J. Whitsett, B. Trapnell, Y. Shibata, 2002 .

SP-D and GM-CSF regulate surfactant homeostasis via distinct mechanisms.

J. Whitsett, M. Ikegami, S. Wert, 2001, American journal of physiology. Lung cellular and molecular physiology.

Distinct changes in pulmonary surfactant homeostasis in common beta-chain- and GM-CSF-deficient mice.

C. Begley, J. Whitsett, G. Ross, 2000, American journal of physiology. Lung cellular and molecular physiology.

Granulocyte-Macrophage Colony-Stimulating Factor in the Innate Immune Response toPneumocystis carinii Pneumonia in Mice

J. Whitsett, Gary, R. Paine, 2000 .

Aerosolized GM-CSF ameliorates pulmonary alveolar proteinosis in GM-CSF-deficient mice.

W. Lu, A. Jobe, J. Whitsett, 1999, American journal of physiology. Lung cellular and molecular physiology.

GM-CSF-deficient mice are susceptible to pulmonary group B streptococcal infection.

J. Whitsett, A. Levine, J. A. Reed, 1999, The Journal of clinical investigation.

Aerosolized GM-CSF ameliorates pulmonary alveolar proteinosis in GM-CSF-deficient mice

A. Jobe, J. Whitsett, M. Ikegami, 1999 .

Adenovirus-mediated granulocyte-macrophage colony-stimulating factor improves lung pathology of pulmonary alveolar proteinosis in granulocyte-macrophage colony-stimulating factor-deficient mice.

J. Whitsett, A. Levine, C. Bachurski, 1998, Human gene therapy.

GM-CSF enhances lung growth and causes alveolar type II epithelial cell hyperplasia in transgenic mice.

G. Dranoff, J. Whitsett, S. Wert, 1997, American journal of physiology. Lung cellular and molecular physiology.

GM-CSF enhances lung growth and causes alveolar type II epithelial cell hyperplasia in transgenic mice.

G. Dranoff, J. Whitsett, S. Wert, 1997, American journal of physiology. Lung cellular and molecular physiology.

Surfactant metabolic consequences of overexpression of GM-CSF in the epithelium of GM-CSF-deficient mice.

A. Jobe, J. Whitsett, M. Ikegami, 1997, The American journal of physiology.

Surfactant metabolism in transgenic mice after granulocyte macrophage-colony stimulating factor ablation.

G. Dranoff, A. Jobe, J. Whitsett, 1996, The American journal of physiology.

A lung-specific neo-antigen elicits specific CD8+ T cell tolerance with preserved CD4+ T cell reactivity. Implications for immune-mediated lung disease.

M. Stoler, T. Braciale, J. Whitsett, 1996, The Journal of clinical investigation.

Review: The intersection of surfactant homeostasis and innate host defense of the lung: lessons from newborn infants

J. Whitsett, 2010, Innate immunity.

Hereditary disorders of surfactant homeostasis cause acute and chronic lung disease in infancy

J. Whitsett, 2008, Thorax.

The concentration of surfactant protein-A in amniotic fluid decreases in spontaneous human parturition at term

R. Romero, J. Whitsett, T. Chaiworapongsa, 2008, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

Amniotic fluid concentration of surfactant proteins in intra-amniotic infection

Chapter 2 – Hereditary Disorders of Alveolar Homeostasis in the Newborn

J. Whitsett, T. Weaver, 2008 .

Genetic disorders of surfactant homeostasis.

J. Whitsett, Yan Xu, S. Wert, 2005, Biology of the neonate.

Transient surfactant protein B deficiency in a term infant with severe respiratory failure.

M. W. Thompson, E. Bell, J. Klein, 1998, The Journal of pediatrics.

Roles of SP-A, SP-B, and SP-C in modulation of lipid uptake by pulmonary epithelial cells in vitro.

J. Whitsett, A. Horowitz, B. Moussavian, 1996, The American journal of physiology.

Lipid effects on aggregation of pulmonary surfactant protein SP-C studied by fluorescence energy transfer.

J. Whitsett, J. Baatz, A. Horowitz, 1993, Biochemistry.

Processing of hydrophobic pulmonary surfactant protein B in rat type II cells.

J. Whitsett, T. Weaver, 1989, The American journal of physiology.

cDNA and deduced amino acid sequence of human pulmonary surfactant-associated proteolipid SPL(Phe).

T. Pilot‐Matias, J. Whitsett, T. Korfhagen, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis.

J. Whitsett, W. Hardie, T. Korfhagen, 2010, The American journal of pathology.

Integrative Single Cell Multiomic Profiling Analysis Reveals HOX-PBX Gene Regulatory Network Contributing to the Survival of mTOR Hyperactive Cells

M. Guo, J. Whitsett, Yan Xu, 2022, bioRxiv.

Effects of TNF-alpha and phorbol ester on human surfactant protein and MnSOD gene transcription in vitro.

J. Whitsett, G. Pryhuber, J. Wispé, 1992, The American journal of physiology.

Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice.

M Ikegami, J. Whitsett, G. Ross, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Pulmonary Collectins

J. Whitsett, P. Kingma, Nicholas Guiot, 2021, Reference Module in Biomedical Sciences.

SP-D Loaded PLGA Nanoparticles as Drug Delivery System for Prevention and Treatment of Premature Infant's Lung Diseases.

J. Kost, J. Whitsett, Shani Attias Cohen, 2020, International journal of pharmaceutics.

Surfactant protein D regulates the cell surface expression of alveolar macrophage β2-integrins

J. Whitsett, T. Korfhagen, A. Senft, 2007 .

Correction of Pulmonary Abnormalities in Sftpd-/- Mice Requires the Collagenous Domain of Surfactant Protein D*

J. Whitsett, K. Hartshorn, F. McCormack, 2006, Journal of Biological Chemistry.

Surfactant protein D influences surfactant ultrastructure and uptake by alveolar type II cells.

J. Whitsett, T. Korfhagen, M. Ikegami, 2005, American journal of physiology. Lung cellular and molecular physiology.

ultrastructure and uptake by alveolar type II cells Surfactant protein D influences surfactant

J. Whitsett, T. Korfhagen, M. Ikegami, 2005 .

Diverse Roles of Lung Collectins in Pulmonary Innate Immunity

J. Whitsett, E. Crouch, 2003 .

The Role of Pulmonary Collectin N-terminal Domains in Surfactant Structure, Function, and Homeostasis in Vivo *

J. Whitsett, T. Korfhagen, N. Palaniyar, 2002, The Journal of Biological Chemistry.

Biophysical inhibition of synthetic phospholipid-lung surfactant apoprotein admixtures by plasma proteins.

J. Whitsett, R. Notter, J. Baatz, 1991, Chemistry and physics of lipids.

C/EBP (cid:1) is required for pulmonary cytoprotection during hyperoxia

J. Whitsett, Yan Xu, M. Ikegami, 2009 .

Persistent tachypnea and hypoxia in a 3-month-old term infant.

J. Whitsett, L. Young, G. Deutsch, 2006, The Journal of pediatrics.

Surfactant Composition and Function in Patients with ABCA3 Mutations

A. Hamvas, J. Whitsett, M. Dean, 2006, Pediatric Research.

This information is current as Infection Respiratory Epithelium during Adenoviral Stat 3 Is Required for Cytoprotection of the and

Kwon-Sik Park, J. Whitsett, Yan Xu, 2006 .

Expression of interleukin-6 by airway epithelial cells. Effects on airway inflammation and hyperreactivity in transgenic mice.

B. Stripp, R. Flavell, J. Whitsett, 1995, Chest.

Secretion of unprocessed human surfactant protein B in milk of transgenic mice

J. Whitsett, J. Rosen, N. Greenberg, 2004, Transgenic Research.

Pulmonary mastocytosis and enhanced lung inflammation in mice heterozygous null for the Foxf1 gene.

J. Whitsett, T. Kalin, V. Kalinichenko, 2008, American journal of respiratory cell and molecular biology.

The ontogeny and distribution of surfactant protein B in human fetuses and newborns.

J. Whitsett, M. Stahlman, M. Gray, 1992, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Intraamniotic Administration of an Adenoviral Vector for Gene Transfer to Fetal Sheep and Mouse Tissues

J. Whitsett, B. Trapnell, A. Holzinger, 1995, Pediatric Research.

Transforming growth factor-β inhibits surfactant protein A expression in vitro

J. Whitsett, M. O’Reilly, Jean C. Clark, 1992 .

Transforming growth factor-beta inhibits surfactant protein A expression in vitro.

J. Whitsett, M. O’Reilly, J. C. Clark, 1992, Biochimica et biophysica acta.

Lamellar body formation precedes pulmonary surfactant apoprotein expression during embryonic mouse lung development in vivo and in vitro.

H. Slavkin, J. Whitsett, P. Bringas, 1989, Differentiation; research in biological diversity.

Distinct effects of SP-A and SP-B on endocytosis of SP-C by pulmonary epithelial cells.

J. Whitsett, J. Baatz, A. Horowitz, 1997, The American journal of physiology.

Lectin activity of the major surfactant protein (SP-A) may participate in, but is not required for, binding to rat type II cells.

J. Whitsett, G. Ross, R. Morris, 1992, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Resident cellular components of the human lung: current knowledge and goals for research on cell phenotyping and function.

Scott H Randell, Christopher J Drake, Troy Stevens, 2008, Proceedings of the American Thoracic Society.

The β-adrenergic receptor in mammalian placenta: Species differences and ontogeny

J. Whitsett, John J. Moore, 1982 .

ß1-Adrenergic receptors in human neuroblastoma

J. J. Moore, C. L. Johnson, J. Whitsett, 1981, Brain Research.

beta-Adrenergic receptors in the developing rabbit lung.

J. J. Moore, J. Whitsett, M. Manton, 1981, The American journal of physiology.

Distinct effects of oxygen on surfactant protein B expression in bronchiolar and alveolar epithelium.

J. Whitsett, J. Wispé, M. Stahlman, 1992, The American journal of physiology.

Cardiovascular , Pulmonary and Renal Pathology Inhibition of PI 3 K by PX-866 Prevents Transforming Growth Factor-– Induced Pulmonary Fibrosis

J. Whitsett, W. Hardie, T. Korfhagen, 2010 .

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

Fabian J Theis, D. Pe’er, A. Regev, 2020, Nature Medicine.

surfactant treatment effects in preterm lambs Surfactant inhibition by plasma: gestational age and

A. Jobe, B. Yoder, J. Whitsett, 2015 .

Surfactant Replacement for Ventilator-Associated Pneumonia: A Preliminary Report

R. Henderson, J. Whitsett, E. Pattishall, 2002, Respiration.

Molecular Basis for Surfactant Function in ARDS

J. Whitsett, Liqian Zhang, 2001 .

Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated β1/β2-integrin trafficking

J. Whitsett, H. Grimes, K. Chang, 2013, Nature Communications.

Human Surfactant Protein-A Contains Blood Group A Antigenic Determinants

J. Whitsett, S. Dingle, M. Stahlman, 1992, Pediatric Research.

Understanding Interstitial Lung Disease: It's in the Mucus.

J. Whitsett, B. Dickey, 2017, American journal of respiratory cell and molecular biology.

Ontogeny of β-Adrenergic Receptors in the Rat Lung: Effects of Hypothyroidism

J. Whitsett, John J. Moore, J. Pollinger, 1982, Pediatric Research.

[3H]ouabain binding and Na+-K+-ATPase activity in human placenta.

J. Whitsett, E. Wallick, E. T. Wallick, 1980, The American journal of physiology.

Inhibition of surfactant release from isolated Type II cells by compound 48/80.

J. Whitsett, W. Rice, 1984, Biochimica et biophysica acta.

Forkhead box A2 transcription factor is expressed in all types of neuroendocrine lung tumors.

J. Whitsett, M. Stahlman, A. Khoor, 2004, Human pathology.

Temporal-Spatial Distribution of Hepatocyte Nuclear Factor-3β in Developing Human Lung and Other Foregut Derivatives

J. Whitsett, M. Stahlman, M. Gray, 1998, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Developmental expression of SP-A and SP-A mRNA in the proximal and distal respiratory epithelium in the human fetus and newborn.

J. Whitsett, M. Stahlman, A. Khoor, 1993, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Lung Deficiency During Bacterial Infection on the Distinct Effects of Surfactant Protein A or D and

J. Whitsett, T. Korfhagen, J. Fisher, 2000 .

Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells.

E. Morrisey, S. Russo, J. Whitsett, 2017, Cell stem cell.

Effect of cytochalasins on surfactant release from alveolar type II cells.

J. Whitsett, K. Osterhoudt, W. Rice, 1984, Biochimica et biophysica acta.

Interleukin-4 Enhances Pulmonary Clearance ofPseudomonas aeruginosa

J. Whitsett, G. Ross, W. Hull, 1998, Infection and Immunity.

Pseudomonas aeruginosa Clearance of Interleukin-4 Enhances Pulmonary

J. Whitsett, G. Ross, W. Hull, 1998 .

Pathogenesis, Presentation, Diagnosis, and Therapy

B. Rubin, J. Whitsett, B. Trapnell, 2010 .

Differences in localization of insulin receptors and adenylate cyclase in the human placenta.

C. L. Johnson, J. Whitsett, K. Hawkins, 1979, American journal of obstetrics and gynecology.

Use of transgenic mice to study autocrine-paracrine signaling in lung morphogenesis and differentiation.

J. Whitsett, L. Zhou, L. Zhou, 1996, Clinics in perinatology.

The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice

J. Whitsett, A. Pradhan, T. Kalin, 2017, Science Signaling.

FOXA3 Regulates Mucus Metaplasia And Innate Immunity In The Lung

J. Whitsett, C. Karp, T. Korfhagen, 2012, ATS 2012.

Foxa2 Programs Th2-Cell Mediated Innate Immunity In The Lung

J. Whitsett, Yan Xu, H. Wan, 2010, ATS 2010.

Structural relationships of the major glycoproteins from human alveolar proteinosis surfactant.

J. Whitsett, G. Ross, David Tannenbaum, 1987, Biochimica et biophysica acta.

Reduced Surfactant Protein C Expression in Full-Term Infants with Respiratory Distress Syndrome • 1776

J. Whitsett, S. Wert, L. Nogee, 1998, Pediatric Research.

Importance of hydrophobic apoproteins as constituents of clinical exogenous surfactants.

J. Whitsett, R. Notter, A. Venkitaraman, 1992, The American review of respiratory disease.

Increased expression of pulmonary surfactant proteins in oxygen-exposed rats.

J. Whitsett, J. Wispé, J. C. Clark, 1991, American journal of respiratory cell and molecular biology.

Biophysical and biological activity of a synthetic 8.7-kDa hydrophobic pulmonary surfactant protein SP-B.

J. Whitsett, B. Ohning, V. Sarin, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Glucocorticoid enhances surfactant proteolipid Phe and pVal synthesis and RNA in fetal lung.

J. Whitsett, J. C. Clark, T. Korfhagen, 1987, The Journal of biological chemistry.

Pulmonary pathology in thyroid transcription factor-1 deficiency syndrome.

J. Whitsett, R. Lindeman, A. Perez-Atayde, 2010, American journal of respiratory and critical care medicine.

C/EBP (cid:3) is required for lung maturation at birth

Yan Xu, J. Whitsett, H. Wan, 2006 .

3'-untranslated region of SP-B mRNA mediates inhibitory effects of TPA and TNF-alpha on SP-B expression.

J. Whitsett, G. Pryhuber, A. Panchal, 1994, The American journal of physiology.

Biophysical activity of synthetic phospholipids combined with purified lung surfactant 6000 dalton apoprotein.

J. Whitsett, R. Notter, D. Shapiro, 1987, Chemistry and physics of lipids.

Orphan G protein-coupled receptor GPR116 regulates pulmonary surfactant pool size.

J. Whitsett, Yan Xu, Matthias Mueller, 2013, American journal of respiratory cell and molecular biology.

Human GM-CSF autoantibodies and reproduction of pulmonary alveolar proteinosis.

J. Whitsett, B. Trapnell, R. Wood, 2009, The New England journal of medicine.

Surfactant Associated Protein (SAP‐35) in Amniotic Fluid FroMDiabetic and Nondiabetic Pregnancies

J. Whitsett, F. Mimouni, M. Miodovnik, 1987, Obstetrics and gynecology.

Induction of surfactant protein in fetal lung. Effects of cAMP and dexamethasone on SAP-35 RNA and synthesis.

J. Whitsett, J. C. Clark, T. Weaver, 1987, The Journal of biological chemistry.

Synthesis of surfactant-associated protein, 35,000 daltons, in fetal lung.

J. Whitsett, G. Ross, T. Weaver, 1986, Journal of applied physiology.

Immunologic Identification of a Pulmonary Surfactant-Associated Protein of Molecular Weight = 6000 Daltons

J. Whitsett, G. Ross, T. Weaver, 1986, Pediatric Research.

In vitro acetylation of rat pulmonary surfactant-associated glycoprotein(s) A primary translation products.

J. Whitsett, G. Ross, T. Weaver, 1986, Biochimica et biophysica acta.

Identification of canine pulmonary surfactant-associated glycoprotein A precursors.

J. Whitsett, G. Ross, T. Weaver, 1985, Journal of applied physiology.

Characteristics of Human Surfactant-Associated Glyoproteins A

J. Whitsett, G. Ross, T. Weaver, 1985, Pediatric Research.

Adenylate cyclase from human decidua parietalis.

C. L. Johnson, J. Whitsett, 1979, American journal of obstetrics and gynecology.

Surfactant protein‐A in bronchoalveolar lavage fluid from neonates with RDS on conventional and high‐frequency oscillatory ventilation

J. Whitsett, S. Abbasi, W. Hull, 1990, Pediatric pulmonology.

Surfactant protein B deficiency: antenatal diagnosis and prospective treatment with surfactant replacement.

H. Colten, A. Hamvas, J. Whitsett, 1994, The Journal of pediatrics.

Surfactant (beractant) therapy for infants with congenital diaphragmatic hernia on ECMO: evidence of persistent surfactant deficiency.

J. Whitsett, D. Bulas, K. Anderson, 1994, Journal of pediatric surgery.

Improved pulmonary outcome after exogenous surfactant therapy for respiratory failure in term infants requiring extracorporeal membrane oxygenation.

J. Whitsett, D. Bulas, G. Martin, 1993, The Journal of pediatrics.

exerciseof SP-A-deficient mice to hyperoxia or

I. Y. Haddad, A. Jobe, B. Yoder, 2015 .

Tolerance of SP-A-deficient mice to hyperoxia or exercise.

A. Jobe, J. Whitsett, T. Korfhagen, 2000, Journal of applied physiology.

Treatment responses to surfactants containing natural surfactant proteins in preterm rabbits.

A. Jobe, J. Whitsett, D. Absolom, 1993, The American review of respiratory disease.

Phospholipid binding and biophysical activity of pulmonary surfactant-associated protein (SAP)-35 and its non-collagenous COOH-terminal domains.

J. Whitsett, R. Notter, G. Ross, 1986, The Journal of biological chemistry.

Mesenchymal Wnt signaling promotes formation of sternum and thoracic body wall.

J. Whitsett, R. Lang, D. Sinner, 2015, Developmental biology.

Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates

N. Salomonis, H. Deshmukh, A. Jobe, 2021, bioRxiv.

The Role of Homodimers in Surfactant Protein B Function in Vivo *

J. Johansson, J. Whitsett, M. Ikegami, 2000, The Journal of Biological Chemistry.

Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice.

B. Stripp, J. Whitsett, J. C. Clark, 1995, Proceedings of the National Academy of Sciences of the United States of America.

The Collagen-like Region of Surfactant Protein A (SP-A) Is Required for Correction of Surfactant Structural and Functional Defects in the SP-A Null Mouse*

J. Whitsett, T. Korfhagen, N. Palaniyar, 2001, The Journal of Biological Chemistry.

Function and regulation of expression of pulmonary surfactant-associated proteins.

N. Hooper, A. Wittinghofer, J. Whitsett, 1991, The Biochemical journal.

Prenatal Exposure to Epidermal Growth Factor Attenuates Respiratory Distress Syndrome in Rhesus Infants

J. Whitsett, D. Styne, C. Plopper, 1994, Pediatric Research.

A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma.

John D Lambris, J. Lambris, J. Whitsett, 2006, The Journal of clinical investigation.

A lung tropic AAV vector improves survival in a mouse model of surfactant B deficiency

J. Whitsett, B. Thébaud, S. Wootton, 2020, Nature Communications.

Phorbol ester inhibits surfactant protein SP-A and SP-B expression.

J. Whitsett, M. O’Reilly, G. Pryhuber, 1990, The Journal of biological chemistry.

SARS-CoV-2 Receptor ACE2 is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Enriched in Specific Cell Subsets Across Tissues

Fabian J Theis, Alison Yu, Alex K. Shalek, 2020, SSRN Electronic Journal.

Acceleration of alveolar type II cell differentiation in fetal rhesus monkey lung by administration of EGF.

J. Whitsett, K. Pinkerton, J. S. St. George, 1992, The American journal of physiology.

TGFβ signaling inhibits goblet cell differentiation via SPDEF in conjunctival epithelium

Chia-Yang Liu, J. Whitsett, K. Wikenheiser-Brokamp, 2014, Development.

Spdef null mice lack conjunctival goblet cells and provide a model of dry eye.

H. Clevers, I. Gipson, J. Whitsett, 2013, The American journal of pathology.

Calcium Uptake and Binding by Membrane Fractions of Human Placenta: ATP-dependent Calcium Accumulation

J. Whitsett, R. Tsang, 1980, Pediatric Research.

Characteristics of the microvillus brush border of human placenta: insulin receptor localization in brush border membranes.

J. Whitsett, J. Lessard, 1978, Endocrinology.

Specializations in plasma membranes of the human placenta.

J. Whitsett, 1980, The Journal of pediatrics.

Distinct Effects of Surfactant Protein A or D Deficiency During Bacterial Infection on the Lung1

J. Whitsett, T. Korfhagen, M. Burhans, 2000, The Journal of Immunology.

MEG3 is increased in idiopathic pulmonary fibrosis and regulates epithelial cell differentiation.

J. Whitsett, Yan Xu, L. Hariri, 2018, JCI insight.

Beta-Adrenergic receptors and catecholamine-sensitive adenylate cyclase of the human placenta.

C. L. Johnson, J. Whitsett, A. Noguchi, 1980, The Journal of clinical endocrinology and metabolism.

Adenosine 3',5'-monophosphate (cAMP)-binding protein and cAMP-dependent protein kinase in human placenta.

J. J. Moore, J. Whitsett, J. V. Baker, 1983, The Journal of clinical endocrinology and metabolism.

cAMP-DEPENDENT PROTEIN KINASE AND cAMP, cGMP AND CALCIUM STIMULATED PHOSPHORYLATION IN HUMAN PLACENTA: COMPARISON OF CYTOSOL AND MEMBRANE FRACTIONS

J. Whitsett, John J. Moore, J. V. Baker, 1984 .

Kruppel-like factor 5 is required for formation and differentiation of the bladder urothelium.

J. Whitsett, Yan Xu, H. Haitchi, 2011, Developmental biology.

Surfactant Replacement Therapies in Children

J. Whitsett, Daniel A. Evans, 1997 .

β-Adrenergic Receptors in Pediatric Tumors: Uncoupled β1-Adrenergic Receptor in Ewing's Sarcoma

J. Whitsett, J. Neely, L. Workman, 1983 .

beta-Adrenergic receptors in pediatric tumors: uncoupled beta 1-adrenergic receptor in Ewing's sarcoma.

J. Whitsett, J. Neely, L. Workman, 1983, Journal of the National Cancer Institute.

Utility of surfactant protein B precursor and thyroid transcription factor 1 in differentiating adenocarcinoma of the lung from malignant mesothelioma.

J. Whitsett, P. Cagle, M. Stahlman, 1999, Human pathology.

Temporal and spatial regulation of VEGF-A controls vascular patterning in the embryonic lung.

J. Whitsett, A. Akeson, Diane Wiginton, 2003, Developmental biology.

Monoclonal antibody to thyroid transcription factor-1: production, characterization, and usefulness in tumor diagnosis.

J. Whitsett, A. Holzinger, P. Bejarano, 1996, Hybridoma.

The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis

R. Lauro, J. Whitsett, R. di Lauro, 1994, Molecular and cellular biology.

Overexpression of manganese superoxide dismutase (MnSOD) in whole lung or alveolar type II cells of MnSOD transgenic mice does not provide intrinsic lung irradiation protection

C. Epstein, J. Whitsett, J. Greenberger, 2001, International journal of cancer.

GATA6 regulates differentiation of distal lung epithelium.

Jeffrey A Whitsett, M. Lu, Honghua Yang, 2002, Development.

GATA-6 Activates Transcription of Surfactant Protein A*

E. Morrisey, J. Whitsett, M. Bruno, 2000, The Journal of Biological Chemistry.

Thy-1 signals through PPARγ to promote lipofibroblast differentiation in the developing lung.

N. Ambalavanan, J. Whitsett, J. Hagood, 2012, American journal of respiratory cell and molecular biology.

Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner

J. Whitsett, Wei Lin, S. Ang, 2007, Development.

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

Kyle J. Gaulton, David S. Fischer, Malte D. Luecken, 2021, Nature Medicine.

Molecular Determinants of Lung Morphogenesis

J. Whitsett, S. Wert, D. Swarr, 2019, Kendig's Disorders of the Respiratory Tract in Children.

Transcription Factors Regulating Embryonic Development of Pulmonary Vasculature.

J. Whitsett, T. Kalin, V. Kalinichenko, 2018, Advances in anatomy, embryology, and cell biology.

Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction

J. Whitsett, F. Costantini, J. Haigh, 2005, Nucleic acids research.

Identification of the Surfactant Protein A Receptor 210 as the Unconventional Myosin 18A*

J. Shabanowitz, D. Hunt, J. Whitsett, 2005, Journal of Biological Chemistry.

Stage-specific regulation of respiratory epithelial cell differentiation by Foxa1.

K. Kaestner, J. Whitsett, V. Besnard, 2005, American journal of physiology. Lung cellular and molecular physiology.

SINCERA: A Pipeline for Single-Cell RNA-Seq Profiling Analysis

Hui Wang, Yan Xu, Minzhe Guo, 2015, PLoS Comput. Biol..

Foxm1 Mediates Cross Talk between Kras/Mitogen-Activated Protein Kinase and Canonical Wnt Pathways during Development of Respiratory Epithelium

J. Whitsett, T. Kalin, V. Kalinichenko, 2012, Molecular and Cellular Biology.

Deletion of Forkhead Box M1 Transcription Factor from Respiratory Epithelial Cells Inhibits Pulmonary Tumorigenesis

J. Whitsett, T. Kalin, V. Kalinichenko, 2009, PloS one.

Cell-specific conditional deletion of Pten in the uterus results in differential phenotypes.

S. Dey, J. Whitsett, V. Besnard, 2011, Gynecologic oncology.

LungMAP: The Molecular Atlas of Lung Development Program

Scott M. Palmer, James P. Carson, Naftali Kaminski, 2017, American journal of physiology. Lung cellular and molecular physiology.

The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future

G. Vunjak‐Novakovic, E. Morrisey, M. Guo, 2020, Cell Stem Cell.

SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production.

Susan E Wert, Hans Clevers, Jeffrey A Whitsett, 2009, The Journal of clinical investigation.

Sox17 influences the differentiation of respiratory epithelial cells.

Kwon-Sik Park, J. Whitsett, A. Zorn, 2006, Developmental biology.

TAZ Interacts with TTF-1 and Regulates Expression of Surfactant Protein-C*

M. Yaffe, Kwon-Sik Park, M. Zannini, 2004, Journal of Biological Chemistry.

Active epithelial Hippo signaling in idiopathic pulmonary fibrosis.

B. Stripp, J. Whitsett, Yan Xu, 2018, JCI insight.

Gsh‐4 encodes a LIM‐type homeodomain, is expressed in the developing central nervous system and is required for early postnatal survival.

J. Whitsett, Gurparkash Singh, M. Weinstein, 1994, The EMBO journal.

Genome-wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells

J. Whitsett, E. Metzakopian, S. Ang, 2015, Development.

Sox17 Promotes Cell Cycle Progression and Inhibits TGF-β/Smad3 Signaling to Initiate Progenitor Cell Behavior in the Respiratory Epithelium

J. Whitsett, A. Zorn, J. Wells, 2009, PloS one.

Synthesis and processing of the precursor for human mangano-superoxide dismutase.

J. Whitsett, J. Wispé, J. C. Clark, 1989, Biochimica et biophysica acta.

Compensatory Roles of Foxa1 and Foxa2 during Lung Morphogenesis*

Jeffrey A Whitsett, K. Kaestner, J. Whitsett, 2005, Journal of Biological Chemistry.

SPDEF Inhibits Prostate Carcinogenesis by Disrupting a Positive Feedback Loop in Regulation of the Foxm1 Oncogene

M. Medvedovic, J. Whitsett, T. Kalin, 2014, PLoS genetics.

Sox2 Is Required for Maintenance and Differentiation of Bronchiolar Clara, Ciliated, and Goblet Cells

J. Whitsett, R. Lang, V. Besnard, 2009, PloS one.

Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity

A. Regev, A. Nicholson, A. Brazma, 2021, Nature Communications.

Postnatal Alveologenesis Depends on FOXF1 Signaling in c-KIT+ Endothelial Progenitor Cells.

M. Guo, J. Whitsett, Yan Xu, 2019, American journal of respiratory and critical care medicine.

Increased expression of FoxM1 transcription factor in respiratory epithelium inhibits lung sacculation and causes Clara cell hyperplasia.

J. Whitsett, H. Park, V. Kalinichenko, 2010, Developmental biology.

Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation.

D. Warburton, Y. Mishina, J. Whitsett, 2008, The American journal of pathology.

Beta-catenin regulates differentiation of respiratory epithelial cells in vivo.

A. R. Thitoff, J. Whitsett, Yan Xu, 2005, American journal of physiology. Lung cellular and molecular physiology.

Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung.

W. Birchmeier, M. Lu, E. Morrisey, 2005, Developmental biology.

Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development.

J. Whitsett, G. Gusarova, R. Costa, 2004, American journal of physiology. Lung cellular and molecular physiology.

Early restriction of peripheral and proximal cell lineages during formation of the lung

Susan E. Wert, Andras Nagy, Jeffrey A. Whitsett, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Fusion of lung lobes and vessels in mouse embryos heterozygous for the forkhead box f1 targeted allele.

L. Lim, J. Whitsett, R. Costa, 2002, American journal of physiology. Lung cellular and molecular physiology.

Intrinsic and innate defenses in the lung: intersection of pathways regulating lung morphogenesis, host defense, and repair.

Jeffrey A Whitsett, J. Whitsett, 2002, The Journal of clinical investigation.

Defects in pulmonary vasculature and perinatal lung hemorrhage in mice heterozygous null for the Forkhead Box f1 transcription factor.

Simon C Watkins, D. Stolz, L. Lim, 2001, Developmental biology.

Hepatocyte nuclear factor‐3β limits cellular diversity in the developing respiratory epithelium and alters lung morphogenesis in vivo

J. Whitsett, R. Costa, S. Wert, 1997, Developmental dynamics : an official publication of the American Association of Anatomists.

Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung.

S. Werner, J. Whitsett, L. Williams, 1994, The EMBO journal.

The pulmonary surfactant system matures upon pipping in the freshwater turtle Chelydra serpentina.

J. Whitsett, C. Daniels, S. Orgeig, 2002, The Journal of experimental biology.

Expression of Thyroid Transcription Factor-1, Surfactant Proteins, Type I Cell–associated Antigen, and Clara Cell Secretory Protein in Pulmonary Hypoplasia

J. Whitsett, C. Langston, S. Wert, 2001, Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.

Expression of Thyroid Transcription Factor-1 in Congenital Cystic Adenomatoid Malformation of the Lung

F. Askin, J. Whitsett, S. Wert, 2000, Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.

Transgenic Mouse Models for the Study of Growth Factor Signaling During Lung Morphogenesis

J. Whitsett, T. Korfhagen, 2000 .

Molecular mechanisms controlling lung morphogenesis

J. Whitsett, A. Perl, 1999, Clinical genetics.

Molecular mechanisms controlling lung morphogenesis

J. Whitsett, A. Perl, 1999 .

Transgenic Models of Lung Development and Disease

J. Whitsett, T. Korfhagen, 1999 .

Retinoic acid-receptor activation of SP-B gene transcription in respiratory epithelial cells.

J. Whitsett, M. Ghaffari, Xin Zeng, 1998, American journal of physiology. Lung cellular and molecular physiology.

Retinoic acid-receptor activation of SPB gene transcription in respiratory epithelial cells

J. Whitsett, M. Ghaffari, Xin Zeng, 1998 .

Functional Genomic Responses to Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and CFTRΔ508 in the Lung*

J. Whitsett, Yan Xu, Jean C. Clark, 2006, Journal of Biological Chemistry.

Blastocyst complementation reveals that NKX2‐1 establishes the proximal‐peripheral boundary of the airway epithelium

J. Whitsett, T. Kalin, V. Kalinichenko, 2021, Developmental dynamics : an official publication of the American Association of Anatomists.

Inhibition of alveolarization and altered pulmonary mechanics in mice expressing GATA-6.

Jeffrey A Whitsett, J. Whitsett, M. Ikegami, 2003, American journal of physiology. Lung cellular and molecular physiology.

Thyroid transcription factor (TTF) ‐1 regulates the expression of midkine (MK) during lung morphogenesis

J. Whitsett, M. Mucenski, Paul R. Reynolds, 2003, Developmental dynamics : an official publication of the American Association of Anatomists.

GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1.

J. Whitsett, B. Trapnell, Y. Shibata, 2001, Immunity.

Single cell transcriptomic profiling identifies molecular phenotypes of newborn human lung cells

John M. Ashton, Jason R. Myers, Ravi S. Misra, 2020, bioRxiv.

Intestinal commensal bacteria mediate lung mucosal immunity and promote resistance of newborn mice to infection

H. Deshmukh, J. Whitsett, G. Worthen, 2017, Science Translational Medicine.

Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life

David I. Wilson, Jeffrey A. Whitsett, Stephen T. Holgate, 2016, JCI insight.

A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma.

J. Whitsett, M. Wills-Karp, G. Silverman, 2011, The Journal of allergy and clinical immunology.

Transcriptional Regulation of the Murine Surfactant Protein-A Gene by B-Myb*

J. Whitsett, G. Ross, M. Bruno, 1999, The Journal of Biological Chemistry.

Alveolar development and disease.

J. Whitsett, T. Weaver, 2015, American journal of respiratory cell and molecular biology.

Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues.

J. Whitsett, V. Besnard, S. Wert, 2004, Gene expression patterns : GEP.

Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model.

J. Tichelaar, J. Whitsett, J. Everitt, 2005, Carcinogenesis.

Sox17 regulates organ lineage segregation of ventral foregut progenitor cells.

K. Kaestner, J. Whitsett, A. Lowy, 2009, Developmental cell.

GATA-6 is required for maturation of the lung in late gestation.

E. Morrisey, J. Whitsett, Cong Liu, 2002, American journal of physiology. Lung cellular and molecular physiology.

FGF-10 disrupts lung morphogenesis and causes pulmonary adenomas in vivo.

J. Tichelaar, J. Whitsett, J. C. Clark, 2001, American journal of physiology. Lung cellular and molecular physiology.

Correction of lethal intestinal defect in a mouse model of cystic fibrosis by human CFTR.

J. Whitsett, R. Frizzell, S. Wert, 1994, Science.

C/EBPα is required for lung maturation at birth

J. Whitsett, Yan Xu, H. Wan, 2006 .

Conditional deletion of Pten causes bronchiolar hyperplasia.

A. R. Thitoff, J. Whitsett, V. Davé, 2008, American journal of respiratory cell and molecular biology.

SP-A deficiency in primate model of bronchopulmonary dysplasia with infection. In situ mRNA and immunostains.

J. Whitsett, S. Seidner, J. Coalson, 1995, American journal of respiratory and critical care medicine.

Increased synthesis and mRNA of surfactant protein A in oxygen-exposed rats.

J. Whitsett, J. Wispé, J. C. Clark, 1989, American journal of respiratory cell and molecular biology.

injurylung and during endotoxin-mediated lung STAT-3 regulates surfactant phospholipid homeostasis

J. Whitsett, G. Loudos, P. Argyriou, 2015 .

STAT-3 regulates surfactant phospholipid homeostasis in normal lung and during endotoxin-mediated lung injury.

J. Whitsett, M. Ikegami, A. Falcone, 2008, Journal of applied physiology.

Midkine Is Regulated by Hypoxia and Causes Pulmonary Vascular Remodeling*

P. Reynolds, J. Whitsett, T. L. Le Cras, 2004, Journal of Biological Chemistry.

Sox17 is required for normal pulmonary vascular morphogenesis.

P. Thurner, J. Whitsett, Yan Xu, 2014, Developmental biology.

Cell- and tissue-based therapies for lung disease

J. Whitsett, V. Kalinichenko, D. Swarr, 2020 .

FOXM1 Promotes Allergen-Induced Goblet Cell Metaplasia and Pulmonary Inflammation

J. Whitsett, T. Kalin, V. Kalinichenko, 2012, Molecular and Cellular Biology.

Foxm1 transcription factor is critical for proliferation and differentiation of Clara cells during development of conducting airways.

Susan E Wert, Jeffrey A Whitsett, J. Whitsett, 2012, Developmental biology.

Inflammation Cell Metaplasia and Pulmonary FOXM 1 Promotes Allergen-Induced Goblet

Yufang, Tanya, J. Whitsett, 2012 .

Sox2 activates cell proliferation and differentiation in the respiratory epithelium.

J. Whitsett, V. Besnard, M. Bruno, 2011, American journal of respiratory cell and molecular biology.

Notch and basal cells take center stage during airway epithelial regeneration.

J. Whitsett, V. Kalinichenko, 2011, Cell stem cell.

Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010.

M. Krasnow, D. Radisky, B. Hogan, 2011, Proceedings of the American Thoracic Society.

Conditional depletion of airway progenitor cells induces peribronchiolar fibrosis.

D. Riethmacher, J. Whitsett, A. Perl, 2011, American journal of respiratory and critical care medicine.

Complete Tracheal Ring Deformity: A Translational Genomics Approach to Pathogenesis.

J. Whitsett, J. Harley, K. Kaufman, 2019, American journal of respiratory and critical care medicine.

Endodermal Wnt signaling is required for tracheal cartilage formation.

J. Whitsett, D. Sinner, J. Snowball, 2015, Developmental biology.

Kruppel-like factor 5 is not required for K-RasG12D lung tumorigenesis, but represses ABCG2 expression and is associated with better disease-specific survival.

C. Gilks, J. Whitsett, Yan Xu, 2010, The American journal of pathology.

Kruppel-like factor 5 is required for perinatal lung morphogenesis and function

J. Whitsett, Yan Xu, H. Wan, 2008, Development.

Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung.

Takeshi Nagayasu, Tomoshi Tsuchiya, Jeffrey A Whitsett, 2012, The Journal of clinical investigation.

Surfactant content in children with inflammatory lung disease.

M. Pollack, J. Whitsett, C. Stroud, 1996, Critical care medicine.

Elastase activity and surfactant protein concentration in tracheal aspirates from neonates receiving synthetic surfactant.

J. Whitsett, W. Long, J. Gerdes, 1992, The Journal of pediatrics.

Surfactant protein A concentrations in tracheal aspirate fluid from infants requiring extracorporeal membrane oxygenation.

J. Whitsett, G. Taylor, B. Short, 1990, The Journal of pediatrics.

Biologic characteristics of four Ewing's sarcomas.

J. Whitsett, J. Neely, E. Ballard, 1985, Cancer genetics and cytogenetics.

Muscarinic Cholinergic Receptors in Developing Rat Lung

J. Whitsett, B. Hollinger, 1984, Pediatric Research.

KLF5 controls glutathione metabolism to suppress p190-BCR-ABL+ B-cell lymphoblastic leukemia

K. Stegmaier, K. Komurov, G. Alexe, 2018, Oncotarget.

GM-CSF in the lung protects against lethal influenza infection.

J. Whitsett, T. Allen, D. Pérez, 2011, American journal of respiratory and critical care medicine.

Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity.

B. Stripp, R. Flavell, J. Whitsett, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Training for an academic career in neonatal medicine.

J. Whitsett, 1993, Clinics in perinatology.

ABCA3 gene mutations in newborns with fatal surfactant deficiency.

J. Whitsett, M. Dean, S. Wert, 2004, The New England journal of medicine.

Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease.

Susan E Wert, Jeffrey A Whitsett, J. Whitsett, 2010, Annual review of medicine.

C/EBP{alpha} is required for pulmonary cytoprotection during hyperoxia.

Shawn Grant, Jeffrey A Whitsett, J. Whitsett, 2009, American journal of physiology. Lung cellular and molecular physiology.

Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA

B. Rubin, J. Whitsett, T. Smolarek, 2008, The Journal of experimental medicine.

TGF-α perturbs surfactant homeostasis in vivo

J. Whitsett, W. Hardie, T. Korfhagen, 2005 .

Gm-CSF regulates pulmonary surfactant homeostasis and alveolar macrophage-mediated innate host defense.

J. Whitsett, B. Trapnell, 2002, Annual review of physiology.

Granulocyte-Macrophage Colony-Stimulating Factor in the Innate Immune Response to Pneumocystis carinii Pneumonia in Mice1

J. Whitsett, G. Ross, R. Paine, 2000, The Journal of Immunology.

Pneumonia in Mice Pneumocystis carinii Immune Response to Colony-Stimulating Factor in the Innate Granulocyte-Macrophage

J. Whitsett, G. Ross, R. Paine, 2000 .

Clearance of SP-C and recombinant SP-C in vivo and in vitro.

A. Jobe, J. Whitsett, M. Ikegami, 1998, American journal of physiology. Lung cellular and molecular physiology.

Clearance of SPC and recombinant SPC in vivo and in vitro

A. Jobe, J. Whitsett, M. Ikegami, 1998 .

Interleukin-4 alters epithelial cell differentiation and surfactant homeostasis in the postnatal mouse lung.

J. Whitsett, J. Rankin, S. Wert, 1997, American journal of respiratory cell and molecular biology.

Requirement of the collagenous domain for carbohydrate processing and secretion of a surfactant protein, SP-A.

J. Whitsett, M. O’Reilly, L. Nogee, 1988, Biochimica et biophysica acta.

Epithelial SCAP/INSIG/SREBP Signaling Regulates Multiple Biological Processes during Perinatal Lung Maturation

J. Whitsett, Yan Xu, V. Besnard, 2014, PloS one.

Conditional deletion of Abca3 in alveolar type II cells alters surfactant homeostasis in newborn and adult mice.

J. Whitsett, Yan Xu, V. Besnard, 2010, American journal of physiology. Lung cellular and molecular physiology.

Conditional deletion of Abca 3 in alveolar type II cells alters surfactant homeostasis in newborn and adult mice

J. Whitsett, Yan Xu, V. Besnard, 2010 .

Expression of ABCA3 in Developing Lung and Other Tissues

J. Whitsett, Yan Xu, V. Besnard, 2007, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Conditional control of gene expression in the respiratory epithelium: A cautionary note.

J. Whitsett, A. Perl, 2006, American journal of respiratory cell and molecular biology.

Foxa2 is required for transition to air breathing at birth.

Jeffrey A Whitsett, K. Kaestner, J. Whitsett, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Conditional gene expression in the respiratory epithelium of the mouse

Jeffrey A. Whitsett, Anne-Karina T. Perl, J. Tichelaar, 2002, Transgenic Research.

Altered stability of pulmonary surfactant in SP-C-deficient mice

P. Sly, J. Whitsett, G. Ross, 2001, Proceedings of the National Academy of Sciences of the United States of America.

cAMP-Dependent Protein Kinase and Protein Phosphorylation in Developing Rat Lung

J. Whitsett, S. Matz, C. Darovec-Beckerman, 1983, Pediatric Research.

Conservation of Surfactant Protein A: Evidence for a Single Origin for Vertebrate Pulmonary Surfactant

J. Whitsett, C. Daniels, S. Orgeig, 1998, Journal of Molecular Evolution.

Commentary on the Truncated Splice Variant of the GM-CSF Receptor Beta-Chain in Peripheral Blood Serves as Severity Biomarker of Respiratory Failure in Newborns

A. Jobe, J. Whitsett, 2021, Neonatology.

Pulmonary dysfunction in neonatal SP-B-deficient mice.

A. Jobe, J. Whitsett, J. C. Clark, 1997, The American journal of physiology.

Enhancement of biophysical activity of lung surfactant extracts and phospholipid-apoprotein mixtures by surfactant protein A.

J. Whitsett, R. Notter, A. Venkitaraman, 1990, Chemistry and physics of lipids.

In defense of the lung: surfactant protein A and surfactant protein D.

J. Whitsett, P. Kingma, 2006, Current opinion in pharmacology.

A novel PI3K inhibitor iMDK suppresses non-small cell lung Cancer cooperatively with A MEK inhibitor.

J. Whitsett, Y. Naomoto, Katsuya Kato, 2015, Experimental cell research.

Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis.

Jeffrey A Whitsett, J. Whitsett, W. Hardie, 2009, American journal of respiratory cell and molecular biology.

Conditional Expression of Fibroblast Growth Factor-7 in the Developing and Mature Lung*

J. Tichelaar, J. Whitsett, W. Lu, 2000, The Journal of Biological Chemistry.

Differential roles of STAT3 in the initiation and growth of lung cancer

J. Whitsett, S. Shapiro, G. Xiao, 2014, Oncogene.

Developmental aspects of the upper airway: report from an NHLBI Workshop, March 5-6, 2009.

David Paydarfar, Raanan Arens, David Wootton, 2009, Proceedings of the American Thoracic Society.

VEGF causes pulmonary hemorrhage, hemosiderosis, and air space enlargement in neonatal mice.

J. Whitsett, K. Albertine, T. L. Le Cras, 2004, American journal of physiology. Lung cellular and molecular physiology.

Transient induction of TGF-α disrupts lung morphogenesis, causing pulmonary disease in adulthood

J. Whitsett, K. Albertine, W. Hardie, 2004 .

Fibroblast Growth Factor 18 Influences Proximal Programming during Lung Morphogenesis*

J. Tichelaar, J. Whitsett, N. Itoh, 2002, The Journal of Biological Chemistry.

GM-CSF modulates pulmonary resistance to influenza A infection.

J. Tichelaar, J. Whitsett, Z. Sever-Chroneos, 2011, Antiviral research.

Glucocorticoid enhances pulmonary surfactant protein B gene transcription.

J. Whitsett, M. O’Reilly, J. C. Clark, 1991, The American journal of physiology.

Stat-3 is required for pulmonary homeostasis during hyperoxia.

S. Akira, K. Takeda, J. Whitsett, 2004, The Journal of clinical investigation.

Transcriptional control of lung morphogenesis.

Jeffrey A Whitsett, J. Whitsett, V. Davé, 2007, Physiological reviews.

Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma.

J. Whitsett, M. Holtzman, W. Hardie, 2011, American journal of physiology. Lung cellular and molecular physiology.

‘LungGENS’: a web-based tool for mapping single-cell gene expression in the developing lung

M. Guo, J. Whitsett, Yan Xu, 2015, Thorax.

Surface tension influences cell shape and phagocytosis in alveolar macrophages.

J. Whitsett, M. Ikegami, T. Weaver, 2006, American journal of physiology. Lung cellular and molecular physiology.

Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth

Samriddha Ray, S. Potter, H. Deshmukh, 2019, Nature Communications.

Allelic heterogeneity in hereditary surfactant protein B (SP-B) deficiency.

J. Whitsett, S. Wert, L. Nogee, 2000, American journal of respiratory and critical care medicine.

Perforin-independent CD8(+) T-cell-mediated cytotoxicity of alveolar epithelial cells is preferentially mediated by tumor necrosis factor-alpha: relative insensitivity to Fas ligand.

T. Braciale, J. Whitsett, J A Whitsett, 1999, American journal of respiratory cell and molecular biology.

HNF-3/forkhead homologue-4 influences lung morphogenesis and respiratory epithelial cell differentiation in vivo.

J. Tichelaar, L. Lim, J. Whitsett, 1999, Developmental biology.

Bronchopulmonary dysplasia

P. Davis, J. Aschner, A. Jobe, 2019, Nature Reviews Disease Primers.

Diffuse lung disease in children: Summary of a scientific conference

A. Hamvas, J. Whitsett, W. Balch, 2014, Pediatric pulmonology.

Foxa2 Programs Th2 Cell-Mediated Innate Immunity in the Developing Lung

J. Whitsett, Yan Xu, H. Wan, 2010, The Journal of Immunology.

Klf5 regulates lineage formation in the pre-implantation mouse embryo

J. Whitsett, J. Wells, Suh-Chin J. Lin, 2010, Development.

Klf 5 regulates lineage formation in the preimplantation mouse embryo

J. Whitsett, J. Wells, Suh-Chin J. Lin, 2010 .

Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity.

B. Stripp, R. Flavell, J. Whitsett, 1994, The Journal of clinical investigation.

MechanismsRemodeling in Asthma: Therapeutic Implications of

Richard J Martin, J. Whitsett, Ji-hang Ju, 2015 .

Uncoupling of Airway Inflammation and Bronchial Hyperreactivity

B. Stripp, R. Flavell, J. Whitsett, 1994 .

Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia.

Matthew R. Jones, J. Whitsett, Bryanne E. Robson, 2008, American journal of respiratory cell and molecular biology.

Transcriptional Adaptation to Cystic Fibrosis Transmembrane Conductance Regulator Deficiency*

B. Aronow, J. Whitsett, Yan Xu, 2003, The Journal of Biological Chemistry.

Pneumocystis carinii alters surfactant protein A concentrations in bronchoalveolar lavage fluid.

J. Whitsett, R. Baughman, W. Hull, 1995, The Journal of laboratory and clinical medicine.

CDC42 is required for structural patterning of the lung during development.

J. Whitsett, W. Xu, Yi Zheng, 2013, Developmental biology.

Transcriptional regulation of perinatal lung maturation.

J. Whitsett, Yohei Matsuzaki, 2006, Pediatric clinics of North America.

TGF‐β1 perturbs vascular development and inhibits epithelial differentiation in fetal lung in vivo

J. Whitsett, M. Stahlman, M. Gray, 2001, Developmental dynamics : an official publication of the American Association of Anatomists.

VEGF receptor 2 (KDR) protects airways from mucus metaplasia through a Sox9-dependent pathway.

J. Whitsett, L. Qiang, J. Que, 2021, Developmental cell.

Epithelial Gpr 116 regulates pulmonary alveolar homeostasis via G q / 11 signaling

J. Whitsett, K. Seuwen, W. Miller, 2018 .

Epithelial Gpr116 regulates pulmonary alveolar homeostasis via Gq/11 signaling.

J. Whitsett, K. Seuwen, W. Miller, 2017, JCI insight.

Reversal of lung lesions in transgenic transforming growth factor alpha mice by expression of mutant epidermal growth factor receptor.

J. Whitsett, W. Hardie, K. Huelsman, 1996, American journal of respiratory cell and molecular biology.

SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells.

J. Whitsett, N. Shroyer, Jeffrey Whitsett, 2010, Experimental cell research.

SPDEF regulates goblet cell hyperplasia in the airway epithelium.

Kwon-Sik Park, J. Whitsett, H. Wan, 2007, The Journal of clinical investigation.

Strategic plan for pediatric respiratory diseases research: an NHLBI working group report.

Rosalind J Wright, G. Redding, D. Gozal, 2009, Proceedings of the American Thoracic Society.

Strategic plan for pediatric respiratory diseases research: An NHLBI working group report

Rosalind J Wright, G. Redding, D. Gozal, 2009, Pediatric pulmonology.

EMC3 regulates mesenchymal cell survival via control of the mitotic spindle assembly

J. Whitsett, Xinhua Lin, C. Ansong, 2022, iScience.

Spatially-Resolved Proteomics: Rapid Quantitative Analysis of Laser Capture Microdissected Alveolar Tissue Samples

James P. Carson, Richard A. Corley, Namasivayam Ambalavanan, 2016, Scientific Reports.

CUL2 Is Required for the Activity of Hypoxia-inducible Factor and Vasculogenesis*

Xiufang Pan, Jeffrey A Whitsett, J. Whitsett, 2008, Journal of Biological Chemistry.

Lung at a Glance: an integrative web toolset of lung ontology, imaging and single cell omics

Yan Xu, Shuyang Zhao, Minzhe Guo, 2020, bioRxiv.

TGF-alpha perturbs surfactant homeostasis in vivo.

J. Whitsett, W. Hardie, T. Korfhagen, 2005, American journal of physiology. Lung cellular and molecular physiology.

Genetic element from human surfactant protein SP-C gene confers bronchiolar-alveolar cell specificity in transgenic mice.

J. Whitsett, M. Bruno, T. Korfhagen, 1991, The American journal of physiology.

Normal lung development and function after Sox9 inactivation in the respiratory epithelium

R. Kist, J. Whitsett, A. Perl, 2005, Genesis.

Retinoic Acid Stimulation of the Human Surfactant Protein B Promoter Is Thyroid Transcription Factor 1 Site-dependent*

J. Whitsett, M. Ghaffari, Cong Yan, 2000, The Journal of Biological Chemistry.

Structure and organization of the gene encoding human pulmonary surfactant proteolipid SP-B.

T. Pilot‐Matias, J. Whitsett, S. Glasser, 1989, DNA.

Stat3 Is Required for Cytoprotection of the Respiratory Epithelium during Adenoviral Infection1

Kwon-Sik Park, J. Whitsett, Yan Xu, 2006, The Journal of Immunology.

Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors

Johan Ericson, Mali Salmon-Divon, Heidi Dvinge, 2012, Development.

A systems approach to mapping transcriptional networks controlling surfactant homeostasis

Minlu Zhang, Pooja Kadambi, Jeffrey A Whitsett, 2010, BMC Genomics.

Nuclear localization domain of thyroid transcription factor-1 in respiratory epithelial cells.

J. Whitsett, M. Ghaffari, X. Zeng, 1997, The Biochemical journal.

Aberrant processing of surfactant protein C in hereditary SP-B deficiency.

J. Whitsett, L. Nogee, S. Profitt, 1995, The American journal of physiology.

Wild-type levels of the mouse Forkhead Box f1 gene are essential for lung repair.

Simon C Watkins, Yan Zhou, D. Stolz, 2002, American journal of physiology. Lung cellular and molecular physiology.

Endocytic Internalization of Adenovirus, Nonspecific Phagocytosis, and Cytoskeletal Organization Are Coordinately Regulated in Alveolar Macrophages by GM-CSF and PU.11

J. Whitsett, B. Trapnell, Y. Shibata, 2002, The Journal of Immunology.

Hyaline Membrane Disease and Surfactant Protein, SAP-35, in Diabetes in Pregnancy

J. Whitsett, L. Nogee, M. McMahan, 1988, American journal of perinatology.

COMPARISON OF MEASURED AND CALCUIATED SERUM BILIRUBIN BINDING CAPACITY (BBC)-A DANGER EXPOSED

J. Whitsett, A. Y. Sweet, E. Brown, 1977, Pediatric Research.

C/EBPalpha is required for lung maturation at birth.

J. Whitsett, Yan Xu, H. Wan, 2006, Development.

Down the primrose path: petechiae in a neonate exposed to herbal remedy for parturition.

J. Whitsett, K. Wedig, 2008, The Journal of pediatrics.

Lung calcium-dependent phospholipid-binding proteins: structure and function.

J. Whitsett, G. Zografi, P. Deluca, 1991, Biochimica et biophysica acta.

Activation of cAMP dependent protein kinase during surfactant release from type II pneumocytes.

J. Whitsett, C. Dion, W. Hull, 1985, Experimental lung research.

Partial SP-B deficiency perturbs lung function and causes air space abnormalities.

J. Whitsett, K. Melton, M. Ikegami, 2005, American journal of physiology. Lung cellular and molecular physiology.

Compound SFTPB 1549C→GAA (121ins2) and 457delC heterozygosity in severe congenital lung disease and surfactant protein B (SP‐B) deficiency

J. Whitsett, C. Houdayer, J. Elion, 1999, Human mutation.

Impact of advances in physiology, biochemistry, and molecular biology on pulmonary disease in neonates.

J. Whitsett, M. Stahlman, 1998, American journal of respiratory and critical care medicine.

Pulmonary surfactant surface tension influences alveolar capillary shape and oxygenation.

J. Whitsett, M. Ikegami, T. Weaver, 2009, American journal of respiratory cell and molecular biology.

Vitamin C prevents the effects of prenatal nicotine on pulmonary function in newborn monkeys.

H. Sekhon, J. Whitsett, E. Spindel, 2005, American journal of respiratory and critical care medicine.

Surfactant Protein-D Regulates Surfactant Phospholipid Homeostasis in Vivo *

Susan E. Wert, James H. Fisher, Jeffrey A. Whitsett, 1998, The Journal of Biological Chemistry.

Transcriptional Programs Controlling Perinatal Lung Maturation

Susan E. Wert, Leah Rae Donahue, Jeffrey A. Whitsett, 2012, PloS one.

Effects of surfactant-associated protein SP-B synthetic analogs on the structure and surface activity of model membrane bilayers.

J. Whitsett, J. Baatz, D. Absolom, 1991, Chemistry and physics of lipids.

Structure and function of the mouse surfactant protein B gene.

J. Whitsett, R. Bohinski, K. Foss, 1995, American Journal of Physiology.

Surfactant protein-D regulates the postnatal maturation of pulmonary surfactant lipid pool sizes.

J. Whitsett, R. Scheule, T. Korfhagen, 2009, Journal of applied physiology.

Relationships among surfactant fraction lipids, proteins and biophysical properties in the developing rat lung.

J. Whitsett, P. Farrell, R. Notter, 1990, Biochimica et biophysica acta.

Intracellular and oligomeric forms of surfactant-associated apolipoproteins(s) A in the rat.

J. Whitsett, G. Ross, T. Weaver, 1985, Biochimica et biophysica acta.

Reversibility of lung inflammation caused by SP-B deficiency.

J. Whitsett, M. Ikegami, T. Weaver, 2005, American journal of physiology. Lung cellular and molecular physiology.

In vitro translation, post-translational processing and secretion of pulmonary surfactant protein B precursors.

A. Gazdar, T. Pilot‐Matias, J. Whitsett, 1989, Biochimica et biophysica acta.

Genomic Profile of Matrix and Vasculature Remodeling in TGF-α–Induced Pulmonary Fibrosis

M. Medvedovic, J. Whitsett, W. Hardie, 2007 .

CCAAT/enhancer binding protein-α regulates the protease/antiprotease balance required for bronchiolar epithelium regeneration.

J. Whitsett, Yan Xu, M. Ikegami, 2012, American journal of respiratory cell and molecular biology.

Gene expression and biological processes influenced by deletion of Stat3 in pulmonary type II epithelial cells

Jeffrey A Whitsett, J. Whitsett, Yan Xu, 2007, BMC Genomics.

IGF1R controls mechanosignaling in myofibroblasts required for pulmonary alveologenesis

J. Whitsett, Hua He, J. Snowball, 2021, JCI insight.

Cell type-resolved human lung lipidome reveals cellular cooperation in lung function

John M. Ashton, Anil K. Shukla, Jason R. Myers, 2018, Scientific Reports.

Kruppel-like factor 5 (KLF5) is critical for conferring uterine receptivity to implantation

S. Dey, J. Whitsett, H. Wan, 2012, Proceedings of the National Academy of Sciences.

Ontogeny of Adenylate Cyclase Activity in the Rat Lung: Guanine Nucleotides and Cytosolic Factors

J. Whitsett, W. Rice, C. Darovec-Beckerman, 1983, Pediatric Research.

Dosing and formulation of antenatal corticosteroids for fetal lung maturation and gene expression in rhesus macaques

M. Kemp, A. Jobe, J. Whitsett, 2019, Scientific Reports.

Skeletal demineralization and fractures caused by fetal magnesium toxicity

J. Whitsett, E. Schorry, K. Wedig, 2006, Journal of Perinatology.

Calcineurin/Nfat signaling is required for perinatal lung maturation and function.

J. Neilson, G. Crabtree, J. Whitsett, 2006, The Journal of clinical investigation.

Deletion of Scap in Alveolar Type II Cells Influences Lung Lipid Homeostasis and Identifies a Compensatory Role for Pulmonary Lipofibroblasts*

J. Whitsett, Yan Xu, V. Besnard, 2009, Journal of Biological Chemistry.

In Vivo Generation of Lung and Thyroid Tissues from Embryonic Stem Cells using Blastocyst Complementation.

M. Guo, J. Whitsett, Yan Xu, 2020, American journal of respiratory and critical care medicine.

PARP-2 Interacts with TTF-1 and Regulates Expression of Surfactant Protein-B*

J. Whitsett, V. Davé, V. Schreiber, 2006, Journal of Biological Chemistry.

Inhibition of hSP-B promoter in respiratory epithelial cells by a dominant negative retinoic acid receptor.

J. Whitsett, M. Ghaffari, Cong Yan, 1999, American journal of physiology. Lung cellular and molecular physiology.

Pneumonitis and Emphysema in sp-C Gene Targeted Mice*

J. Whitsett, M. Ikegami, M. Stahlman, 2003, The Journal of Biological Chemistry.

Surfactant Protein B Corrects Oxygen-Induced Pulmonary Dysfunction in Heterozygous Surfactant Protein B–Deficient Mice

J. Whitsett, J. Baatz, M. Ikegami, 1999, Pediatric Research.

Gene structure of the pulmonary surfactant proteins SP-A, SP-B and SP-C

J. Whitsett, 1991 .

Thyroid transcription factor‐1, hepatocyte nuclear factor‐3β and surfactant protein A and B in the developing chick lung

J. Whitsett, K. Yutzey, Xin Zeng, 1998, Journal of anatomy.

Bronchoalveolar lavage fluid surfactant protein-A and surfactant protein-D are inversely related to inflammation in early cystic fibrosis.

Margaret W Leigh, Jeffrey A Whitsett, J. Whitsett, 2003, American journal of respiratory and critical care medicine.

Preferential uptake of small-aggregate fraction of pulmonary surfactant in vitro.

J. Whitsett, M. Ikegami, S. Wert, 1997, The American journal of physiology.

DURATION-DEPENDENT CYTOPROTECTIVE VERSUS INFLAMMATORY EFFECTS OF LUNG EPITHELIAL FIBROBLAST GROWTH FACTOR-7 EXPRESSION

J. Tichelaar, J. Whitsett, M. Sartor, 2007, Experimental lung research.

Surfactant protein-d inhibits lung inflammation caused by ventilation in premature newborn lambs.

J. Whitsett, R. Scheule, M. Ikegami, 2010, American journal of respiratory and critical care medicine.

In Vivo Measurements of Changes in Respiratory Mechanics with Age in Mice Deficient in Surfactant Protein D

Peter D Sly, Jeffrey A Whitsett, P. Sly, 2003, Pediatric Research.

Deficiency of SP-B reveals protective role of SP-C during oxygen lung injury.

P. Sly, J. Whitsett, G. Ross, 2002, Journal of applied physiology.

Transgenic models for study of lung morphogenesis and repair: Parker B. Francis lecture.

J. Tichelaar, J. Whitsett, J. C. Clark, 2001, Chest.

Two SP-C genes encoding human pulmonary surfactant proteolipid.

T. Pilot‐Matias, J. Whitsett, T. Korfhagen, 1988, The Journal of biological chemistry.

SAM-pointed domain ETS factor mediates epithelial cell–intrinsic innate immune signaling during airway mucous metaplasia

J. Whitsett, R. Hegde, C. Karp, 2012, Proceedings of the National Academy of Sciences.

Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation.

P. Howarth, S. Holgate, D. Davies, 2011, American journal of respiratory and critical care medicine.

Increased expression of thyroid transcription factor-1 (TTF-1) in respiratory epithelial cells inhibits alveolarization and causes pulmonary inflammation.

Susan E Wert, Shioko Kimura, Jeffrey A Whitsett, 2002, Developmental biology.

Early Development of the Mammalian Lung-Branching Morphogenesis

E. Morrisey, A. Jobe, J. Whitsett, 2016 .

Pulmonary Vascular Development

A. Jobe, J. Whitsett, S. Abman, 2016 .

Congenital Malformations of the Lung

A. Jobe, J. Whitsett, K. Wikenheiser-Brokamp, 2016 .

Effect of surfactant-associated protein-A (SP-A) on the activity of lipid extract surfactant.

J. Whitsett, F. Possmayer, J. Chung, 1989, Biochimica et biophysica acta.

Surfactant peptides stimulate uptake of phosphatidylcholine by isolated cells.

J. Whitsett, J. Baatz, S. Wert, 1989, Biochimica et biophysica acta.

GENETIC MODELS FOR THE STUDY OF AUTOCRINE-PARACRINE SIGNALING IN LUNG DEVELOPMENT AND REPAIR

J. Whitsett, T. Korfhagen, 2000 .

Alterations of surfactant lipid turnover in silicosis: evidence of a role for surfactant-associated protein A (SP-A).

O. Lesur, J. Whitsett, A. Cantin, 1995, International journal of experimental pathology.

Human cystic fibrosis transmembrane conductance regulator directed to respiratory epithelial cells of transgenic mice

B. Stripp, J. Whitsett, James M. Wilson, 1992, Nature genetics.

Thyroid dependent maturation of -adrenergic receptors in the rat lung

J. Whitsett, H. Needelman, K. Adams, 1980 .

GM-CSF, via PU.1, regulates alveolar macrophage FcγR-mediated phagocytosis and the IL-18/IFN-γ–mediated molecular connection between innate and adaptive immunity in the lung

J. Whitsett, B. Trapnell, Y. Shibata, 2002 .

GM-CSF, via PU.1, regulates alveolar macrophage Fcgamma R-mediated phagocytosis and the IL-18/IFN-gamma -mediated molecular connection between innate and adaptive immunity in the lung.

J. Whitsett, B. Trapnell, Y. Shibata, 2002, Blood.

Nuclear Factor of Activated T Cells Regulates Transcription of the Surfactant Protein D Gene (Sftpd) via Direct Interaction with Thyroid Transcription Factor-1 in Lung Epithelial Cells*

Jeffrey A. Whitsett, J. Whitsett, V. Davé, 2004, Journal of Biological Chemistry.

Maternal Synchronization of Gestational Length and Lung Maturation

S. Murray, L. Donahue, J. Whitsett, 2011, PloS one.

The lung-specific CC10 gene is regulated by transcription factors from the AP-1, octamer, and hepatocyte nuclear factor 3 families

B. Stripp, J. Whitsett, D. Luse, 1993, Molecular and cellular biology.

Surfactant proteins and cell markers in the respiratory epithelium of the amphibian, Ambystoma mexicanum.

J. Whitsett, S. Wert, L. D. Miller, 2001, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

Clara cell secretory protein decreases lung inflammation after acute virus infection

B. Stripp, J. Whitsett, K. Harrod, 1998 .

Clearance of SP-C and recombinant SP-C in vivo and in vitro.

A. Jobe, J. Whitsett, M. Ikegami, 1998, The American journal of physiology.

Respiratory Disease Syndrome-Hyaline Membrane Disease

J. Whitsett, 2008 .

Failure to detect surfactant protein-specific antibodies in sera of premature infants treated with survanta, a modified bovine surfactant.

J. Whitsett, W. Hull, S. Luse, 1991, Pediatrics.

Ontogeny of alpha 1-adrenergic receptors in the rat myocardium: effects of hypothyroidism.

J. Whitsett, A. Noguchi, 1982, European Journal of Pharmacology.

Decreased Surfadant Protein A in Patients with Baderial Pneumonia

J. Whitsett, R. Baughman, W. Hull, 1993 .

Generation of Pulmonary Endothelial Progenitor Cells for Cell-Based Therapy Using Interspecies Mouse-Rat Chimeras.

M. Guo, J. Whitsett, Yan Xu, 2021, American journal of respiratory and critical care medicine.

Keratinocyte growth factor stimulates CFTR-independent fluid secretion in the fetal lung in vitro.

R. W. Graeff, J. Whitsett, P. McCray, 1996, The American journal of physiology.

Conditional Deletion Of Abca3 In Alveolar Type II Cells Alters Surfactant Homeostasis In Newborn And Adult Mice

J. Whitsett, Yan Xu, V. Besnard, 2010, ATS 2010.

An integrated cell atlas of the lung in health and disease

Malte D. Luecken, Y. Bossé, M. Krasnow, 2023, Nature Medicine.

Genome-wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells

J. Whitsett, E. Metzakopian, S. Ang, 2015, Journal of Cell Science.

Single-cell multiomic analysis identifies a HOX-PBX gene network regulating the survival of lymphangioleiomyomatosis cells

M. Guo, J. Whitsett, Yan Xu, 2023, Science advances.

A portion of the human surfactant protein A (SP-A) gene locus consists of a pseudogene.

J. Whitsett, M. Bruno, T. Korfhagen, 1991, American journal of respiratory cell and molecular biology.

Production of human surfactant protein C in milk of transgenic mice

J. Whitsett, J. Rosen, N. Greenberg, 1995, Transgenic Research.

Identification of surfactant proteolipid SP-B in human surfactant and fetal lung.

J. Whitsett, T. Weaver, W. Hull, 1988, Journal of applied physiology.

Serial changes in surfactant-associated proteins in lung and serum before and after onset of ARDS.

J. Whitsett, K. Steinberg, T. Martin, 1999, American journal of respiratory and critical care medicine.

Evaluation of the efficacy and safety of in vitro, adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA.

J. Whitsett, B. Trapnell, J. Cuppoletti, 1994, Human gene therapy.

Effects of dimaprit on growth and differentiation of human promyelocytic cell line, HL-60.

C. L. Johnson, J. Whitsett, B. Lampkin, 1985, Life sciences.

Histamine H2 receptor desensitization in HL-60 human promyelocytic leukemia cells.

C. L. Johnson, J. Whitsett, D. Sawutz, 1984, The Journal of pharmacology and experimental therapeutics.

Adenoviral-mediated gene transfer of human surfactant protein B to respiratory epithelial cells.

J. Whitsett, B. Trapnell, J. Whitsett, 1994, American journal of respiratory cell and molecular biology.

Safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lungs of nonhuman primates.

G. Boivin, J. Whitsett, B. Trapnell, 1996, Human gene therapy.

Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity

A. Regev, A. Nicholson, A. Brazma, 2020, Nature Communications.

SURFACTANT PROTEIN (SP) B DEFICIENCY IN NEONATES WITH SEVERE RESPIRATORY FAILURE. • 2044

J. Whitsett, S. Wert, L. Nogee, 1996, Pediatric Research.

Structure and function of pulmonary surfactant proteins.

J. Whitsett, T. Weaver, 1988, Seminars in perinatology.

Dosing and formulation of antenatal corticosteroids for fetal lung maturation and gene expression in rhesus macaques

M. Kemp, A. Jobe, J. Whitsett, 2019, Scientific Reports.

Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010.

M. Krasnow, D. Radisky, B. Hogan, 2011, Proceedings of the American Thoracic Society.

SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production.

H. Clevers, J. Whitsett, Yan Xu, 2009, The Journal of clinical investigation.

A favourable prognostic marker for EGFR mutant non-small cell lung cancer: immunohistochemical analysis of MUC5B

T. Nagayasu, N. Yamasaki, Keitaro Matsumoto, 2015, BMJ Open.

Kruppel-like factor 5 (KLF5) is critical for conferring uterine receptivity to implantation

S. Dey, J. Whitsett, H. Wan, 2012, Proceedings of the National Academy of Sciences.

Notch and basal cells take center stage during airway epithelial regeneration.

J. Whitsett, V. Kalinichenko, 2011, Cell Stem Cell.

Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors

Paul Bertone, H. Dvinge, J. Whitsett, 2012, Development.

Transcription Factors Regulating Embryonic Development of Pulmonary Vasculature.

J. Whitsett, V. Kalinichenko, Craig S Bolte, 2018, Advances in anatomy, embryology, and cell biology.

Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease.

J. Whitsett, S. Wert, T. Weaver, 2010, Annual review of medicine.

Compensatory Roles of Foxa1 and Foxa2 during Lung Morphogenesis*

K. Kaestner, J. Whitsett, Yan Xu, 2005, Journal of Biological Chemistry.

Foxm1 regulates resolution of hyperoxic lung injury in newborns.

J. Whitsett, V. Kalinichenko, H. Xia, 2015, American journal of respiratory cell and molecular biology.

Pulmonary mastocytosis and enhanced lung inflammation in mice heterozygous null for the Foxf1 gene.

J. Whitsett, V. Kalinichenko, L. Meliton, 2008, American journal of respiratory cell and molecular biology.

Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung.

B. Stripp, J. Whitsett, Yan Xu, 2015, Journal of molecular cell biology.

The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution.

Larry N. Singh, Timothy L. Tickle, Noor B. Dawany, 2019, Developmental cell.

Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling

Gurjit K. Khurana, J. Whitsett, W. Hardie, 2010 .

Epithelial Gpr116 regulates pulmonary alveolar homeostasis via Gq/11 signaling.

J. Whitsett, K. Seuwen, W. Miller, 2017, JCI insight.

Mesenchymal Wnt signaling promotes formation of sternum and thoracic body wall.

J. Whitsett, R. Lang, D. Sinner, 2015, Developmental biology.

SARS-CoV-2 Entry Genes Are Most Highly Expressed in Nasal Goblet and Ciliated Cells within Human Airways

Fabian J Theis, D. Pe’er, A. Regev, 2020, Nature Medicine.

STAT-3 regulates surfactant phospholipid homeostasis in normal lung and during endotoxin-mediated lung injury.

J. Whitsett, M. Ikegami, A. Falcone, 2008, Journal of applied physiology.

Activation of Sterol-response Element-binding Proteins (SREBP) in Alveolar Type II Cells Enhances Lipogenesis

J. Whitsett, V. Besnard, A. Postle, 2012 .

Alveolar Epithelial Stat3, Il-6 Family Cytokines, and Host Defense during Escherichia Coli Pneumonia Materials and Methods

Matthew R. Jones, J. Whitsett, Bryanne E. Robson, 2022 .

Systems biology evaluation of cell-free amniotic fluid transcriptome of term and preterm infants to detect fetal maturity

Yan Xu, N. Salomonis, L. Muglia, 2015, BMC Medical Genomics.

GM-CSF modulates pulmonary resistance to influenza A infection.

J. Tichelaar, J. Whitsett, Z. Sever-Chroneos, 2011, Antiviral research.

GATA6 regulates differentiation of distal lung epithelium.

M. Lu, Honghua Yang, E. Morrisey, 2002, Development.

SP-A enhances viral clearance and inhibits inflammation after pulmonary adenoviral infection.

J. Whitsett, B. Trapnell, J. Whitsett, 1999, American journal of physiology. Lung cellular and molecular physiology.

The Molecular Era of Surfactant Biology

J. Whitsett, 2014, Neonatology.

Persistence of replication-deficient adenovirus-mediated gene transfer in lungs of immune-deficient (nu/nu) mice.

J. Whitsett, B. Trapnell, Xiaoyun Hu, 1995, Human gene therapy.

Series Introduction: Intrinsic and innate defenses in the lung: intersection of pathways regulating lung morphogenesis, host defense, and repair

J. Whitsett, 2002 .

Klf 5 regulates lineage formation in the preimplantation mouse embryo

J. Whitsett, J. Wells, Suh-Chin J. Lin, 2022 .

The beta-adrenergic receptor in human placenta: receptor subtype analysis (beta 1 and beta 2) and partial characterization of the solubilized receptor.

J. J. Moore, J. Whitsett, 1981, Placenta. Supplement.

ACINAR DYSPLASIA IS ASSOCIATED WITH THE ABSENCE OF TTF-1 AND HNF-3β EXPRESSION DURING HUMAN LUNG DEVELOPMENT. † 2117

J. Whitsett, C. Langston, S. Wert, 1996, Pediatric Research.

In vivo evaluation of the safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lung.

J. Whitsett, B. Trapnell, J. Whitsett, 1994, Human gene therapy.

Thyroid transcription factor , a regulator of lung specific surfactant protein-B gene Expression in carcinomas and diagnostic utility

J. Whitsett, P. Bejarano, R. Baughman, 1995 .

Cell Lines Peripheral Airway Cell Differentiation in Human Lung Cancer

A. Gazdar, J. Mulshine, J. Whitsett, 2006 .

Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation.

P. Howarth, S. Holgate, D. Davies, 2011, American journal of respiratory and critical care medicine.

Heterogeneity in Human iPSC-derived Alveolar Epithelial Type II Cells Revealed with ABCA3/SFTPC Reporters.

Ignacio S. Caballero, S. Russo, Jessie Huang, 2021, American journal of respiratory cell and molecular biology.

Surfactant protein D alters allergic lung responses in mice and human subjects.

J. Whitsett, G. K. Khurana Hershey, M. Rothenberg, 2008, The Journal of allergy and clinical immunology.

Effect of lead on renal responsiveness to antidiuretic hormone in young rats.

J. Whitsett, L. Kleinman, D. R. Johnson, 1980, Toxicology and applied pharmacology.

Disorders of lung morphogenesis.

J. Whitsett, 2006, Paediatric respiratory reviews.

Pulmonary surfactant surface tension influences alveolar capillary shape and oxygenation.

J. Whitsett, M. Ikegami, T. Weaver, 2009, American journal of respiratory cell and molecular biology.