D. Baker

发表

Pharmacophore development and application toward the identification of novel, small-molecule autotaxin inhibitors.

E. J. North, A. L. Howard, I. Wanjala, 2010, Journal of medicinal chemistry.

Subtype-Selective Antagonists of Lysophosphatidic Acid Receptors Inhibit Platelet Activation Triggered by the Lipid Core of Atherosclerotic Plaques

D. Baker, W. Siess, Enno Rother, 2003, Circulation.

Virtual screening approaches for the identification of non-lipid autotaxin inhibitors.

Daniel L Baker, Abby L Parrill, T. Pham, 2008, Bioorganic & medicinal chemistry.

G protein-coupled receptors: the evolution of structural insight.

D. Baker, A. Parrill, Samantha B. Gacasan, 2017, AIMS biophysics.

RNA-guided RNA modification: functional organization of the archaeal H/ACA RNP.

Daniel L Baker, D. Baker, R. Terns, 2005, Genes & development.

Synthesis and Characterization of 2-Decenoic Acid Modified Chitosan for Infection Prevention and Tissue Engineering

D. Baker, Tomoko Fujiwara, J. Bumgardner, 2021, Marine drugs.

Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors.

L. Pott, D. Baker, K. Liliom, 2001, The Biochemical journal.

Discovery and synthetic optimization of a novel scaffold for hydrophobic tunnel-targeted autotaxin inhibition.

D. Baker, A. Parrill, G. Tigyi, 2016, Bioorganic & medicinal chemistry.

Short-chain phosphatidates are subtype-selective antagonists of lysophosphatidic acid receptors.

D. Baker, A. Parrill, G. Tigyi, 2001, Molecular pharmacology.

The phospholipase A1 activity of lysophospholipase A-I links platelet activation to LPA production during blood coagulation[S]

D. Baker, K. Liliom, Y. Igarashi, 2011, Journal of Lipid Research.

Direct quantitative analysis of lysophosphatidic acid molecular species by stable isotope dilution electrospray ionization liquid chromatography-mass spectrometry.

Duane D. Miller, D. Baker, D. Desiderio, 2001, Analytical biochemistry.

Carba Analogs of Cyclic Phosphatidic Acid Are Selective Inhibitors of Autotaxin and Cancer Cell Invasion and Metastasis*

G. Mills, Y. Fujiwara, D. Baker, 2006, Journal of Biological Chemistry.

Autotaxin inhibition: challenges and progress toward novel anti-cancer agents.

D. Baker, A. Parrill, 2008, Anti-cancer agents in medicinal chemistry.

Identification of Darmstoff analogs as selective agonists and antagonists of lysophosphatidic acid receptors.

Duane D. Miller, Y. Fujiwara, D. Baker, 2006, Bioorganic & medicinal chemistry letters.

Structure and catalytic function of sphingosine kinases: analysis by site-directed mutagenesis and enzyme kinetics.

T. Pham, D. Baker, Melanie A Sparks, 2013, Biochimica et biophysica acta.

(S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity.

M. Gotoh, T. Pham, D. Baker, 2010, Cellular signalling.

Determination of protein-RNA interaction sites in the Cbf5-H/ACA guide RNA complex by mass spectrometric protein footprinting.

N. Seyfried, D. Baker, R. Terns, 2008, Biochemistry.

Autotaxin inhibition: development and application of computational tools to identify site-selective lead compounds.

D. Baker, A. Parrill, Derek D. Norman, 2013, Bioorganic & medicinal chemistry.

Gold nanorods carrying paclitaxel for photothermal-chemotherapy of cancer.

Xiaohua Huang, D. Baker, A. Parrill, 2013, Bioconjugate chemistry.

In vitro evaluation of loaded chitosan membranes for pain relief and infection prevention.

D. Baker, Tomoko Fujiwara, J. Bumgardner, 2021, Journal of biomedical materials research. Part B, Applied biomaterials.

Pharmacological Characterization of Phospholipid Growth‐Factor Receptors

Duane D. Miller, D. Baker, A. Parrill, 2000, Annals of the New York Academy of Sciences.

Stereochemical properties of lysophosphatidic acid receptor activation and metabolism.

D. Baker, K. Liliom, R. Bittman, 2002, Biochimica et biophysica acta.

Plasma lysophosphatidic acid concentration and ovarian cancer.

Daniel L Baker, Gabor Tigyi, D. Baker, 2002, JAMA.

GPCR homology model template selection benchmarking: Global versus local similarity measures.

Judith A Cole, Daniel L Baker, Abby L Parrill, 2019, Journal of molecular graphics & modelling.

Crystal structure of a Cbf5-Nop10-Gar1 complex and implications in RNA-guided pseudouridylation and dyskeratosis congenita.

D. Baker, R. Terns, M. Terns, 2006, Molecular cell.

Benzyl and Naphthalene Methylphosphonic Acid Inhibitors of Autotaxin with Anti‐invasive and Anti‐metastatic Activity

Duane D. Miller, James I. Fells, G. Mills, 2011, ChemMedChem.

Different Residues Mediate Recognition of 1-O-Oleyllysophosphatidic Acid and Rosiglitazone in the Ligand Binding Domain of Peroxisome Proliferator-activated Receptor γ*

Satoshi Yasuda, Hongbin Yuan, Daniel L Baker, 2006, Journal of Biological Chemistry.

Lysophosphatidic Acid Induces Neointima Formation Through PPARγ Activation

Chunxiang Zhang, G. Prestwich, D. Baker, 2004, The Journal of experimental medicine.

Multiple Mechanisms Linked to Platelet Activation Result in Lysophosphatidic Acid and Sphingosine 1-Phosphate Generation in Blood*

D. Baker, Y. Igarashi, Y. Yatomi, 2002, The Journal of Biological Chemistry.

Quantitative Analysis of Lysophosphatidic Acid in Human Blood Fractions

D. Baker, D. Desiderio, G. Tigyi, 2000, Annals of the New York Academy of Sciences.

Synthesis and pharmacological evaluation of second-generation phosphatidic acid derivatives as lysophosphatidic acid receptor ligands.

Duane D. Miller, Y. Fujiwara, D. Baker, 2006, Bioorganic & medicinal chemistry letters.

Molecular basis for lysophosphatidic acid receptor antagonist selectivity.

D. Baker, A. Parrill, G. Tigyi, 2002, Biochimica et biophysica acta.

Application of computational methods for class A GPCR Ligand discovery.

D. Baker, A. Parrill, G. Szwabowski, 2023, Journal of molecular graphics & modelling.

Structure-based pharmacophore modeling 1. Automated random pharmacophore model generation.

D. Baker, A. Parrill, J. Cole, 2023, Journal of molecular graphics & modelling.

Ligand-based G Protein Coupled Receptor pharmacophore modeling: Assessing the role of ligand function in model development.

D. Baker, A. Parrill, D. Bowman, 2021, Journal of molecular graphics & modelling.

Benchmarking GPCR homology model template selection in combination with de novo loop generation

Abby L. Parrill, Chandler K Sears, Daniel L. Baker, 2020, Journal of Computer-Aided Molecular Design.

A benchmark study of loop modeling methods applied to G protein-coupled receptors

Judith A Cole, Lee H Wink, Daniel L Baker, 2019, Journal of Computer-Aided Molecular Design.

Optimization of a pipemidic acid autotaxin inhibitor.

H. Bostic, A. L. Howard, I. Wanjala, 2010, Journal of medicinal chemistry.

Hits of a High-Throughput Screen Identify the Hydrophobic Pocket of Autotaxin/Lysophospholipase D As an Inhibitory Surface

Duane D. Miller, James I. Fells, Y. Fujiwara, 2013, Molecular Pharmacology.

Mice with transgenic overexpression of lipid phosphate phosphatase-1 display multiple organotypic deficits without alteration in circulating lysophosphatidate level.

D. Baker, J. Yue, G. Tigyi, 2004, Cellular signalling.

Highly Potent Non-Carboxylic Acid Autotaxin Inhibitors Reduce Melanoma Metastasis and Chemotherapeutic Resistance of Breast Cancer Stem Cells.

Duane D. Miller, T. Pham, D. Baker, 2017, Journal of medicinal chemistry.

Synthesis and pharmacological evaluation of the stereoisomers of 3-carba cyclic-phosphatidic acid.

Duane D. Miller, G. Mills, M. Gotoh, 2010, Bioorganic & medicinal chemistry letters.

Characterization of non-lipid autotaxin inhibitors.

A. L. Howard, I. Wanjala, T. Pham, 2010, Bioorganic & medicinal chemistry.

Autotaxin structure-activity relationships revealed through lysophosphatidylcholine analogs.

E. J. North, D. Baker, A. Parrill, 2009, Bioorganic & medicinal chemistry.

Identification of Edg1 Receptor Residues That Recognize Sphingosine 1-Phosphate*

S. Spiegel, D. Baker, A. Parrill, 2000, The Journal of Biological Chemistry.

Synthesis of photoactivatable analogues of lysophosphatidic acid and covalent labeling of plasma proteins.

D. Baker, R. Bittman, G. Tigyi, 2006, The Journal of organic chemistry.

2-Heptylcyclopropane-1-Carboxylic Acid Disperses and Inhibits Bacterial Biofilms

D. Baker, J. Jennings, Michael R Harris, 2021, Frontiers in Microbiology.

Autotaxin inhibitors: a perspective on initial medicinal chemistry efforts

D. Baker, A. Parrill, 2010, Expert opinion on therapeutic patents.

Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif

Duane D. Miller, James I. Fells, T. Pham, 2014, The FEBS journal.

Phospholipase D2-dependent inhibition of the nuclear hormone receptor PPARgamma by cyclic phosphatidic acid.

Chunxiang Zhang, F. Re, Y. Fujiwara, 2010, Molecular cell.

Self-docking and cross-docking simulations of G protein-coupled receptor-ligand complexes: Impact of ligand type and receptor activation state.

D. Baker, A. Parrill, Brittany N. Thomas, 2021, Journal of molecular graphics & modelling.

Structure-activity relationships of autotaxin inhibition

D. Baker, A. Parrill, Lauren E. Ragle, 2017 .

Computational identification and experimental characterization of substrate binding determinants of nucleotide pyrophosphatase/phosphodiesterase 7

I. Wanjala, T. Pham, D. Baker, 2011, BMC Biochemistry.

Ligand-based autotaxin pharmacophore models reflect structure-based docking results.

Daniel L Baker, Abby L Parrill, D. Baker, 2011, Journal of molecular graphics & modelling.

Structure-based pharmacophore modeling 2. Developing a novel framework for structure-based pharmacophore model generation and selection.

Bernie J. Daigle, D. Baker, A. Parrill, 2023, Journal of molecular graphics & modelling.

Structural Features of EDG1 Receptor‐Ligand Complexes Revealed by Computational Modeling and Mutagenesis

S. Spiegel, D. Baker, A. Parrill, 2000, Annals of the New York Academy of Sciences.

(S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity.

M. Gotoh, T. Pham, D. Baker, 2010, Cellular signalling.

Hits of a High-Throughput Screen Identify the Hydrophobic Pocket of Autotaxin/Lysophospholipase D As an Inhibitory Surface

Duane D. Miller, James I. Fells, Y. Fujiwara, 2013, Molecular Pharmacology.