H. Rhim

Byung-Hwan Lee, Sun-Hye Choi, S. Hwang, 2012, The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology.

Modifications of aliphatic side chain of 20(S)-ginsenoside RG3 cause an enhancement or loss of brain Na+ channel current inhibitions.

Byung-Hwan Lee, Sun-Hye Choi, S. Nah, 2008, Biological & pharmaceutical bulletin.

Inhibitory effect of ginsenosides on NMDA receptor-mediated signals in rat hippocampal neurons.

S. Nah, H. Rhim, T. Oh, 2002, Biochemical and biophysical research communications.

The transcription factor STAT2 enhances proteasomal degradation of RCAN1 through the ubiquitin E3 ligase FBW7.

H. Rhim, K. Chung, Joo-Heon Yoon, 2012, Biochemical and biophysical research communications.

Monitoring of Intracellular Tau Aggregation Regulated by OGA/OGT Inhibitors

H. Rhim, Y. Kim, G. Nam, 2015, International journal of molecular sciences.

Analgesic effect of highly reversible ω-conotoxin FVIA on N type Ca2+ channels

H. Rhim, H. Suh, J. Kim, 2010, Molecular pain.

The Novel Cellular Mechanism of Human 5-HT6 Receptor through an Interaction with Fyn*

J. Baik, H. Rhim, E. Kostenis, 2007, Journal of Biological Chemistry.

Discovery of aryl-biphenyl-2-ylmethylpiperazines as novel scaffolds for 5-HT(7) ligands and role of the aromatic substituents in binding to the target receptor.

B. Roth, H. Choo, H. Rhim, 2013, Bioorganic & medicinal chemistry.

Acutely elevated O-GlcNAcylation suppresses hippocampal activity by modulating both intrinsic and synaptic excitability factors

H. Rhim, Hongik Hwang, 2019, Scientific Reports.

Synthesis and SAR of N-Chlorophenyl Substituted Piperrazinylethyl-aminomethylpyrazoles as 5-HT 3A Inhibitors

Byung-Hwan Lee, S. Nah, H. Rhim, 2009 .

Modulation of Ca(v)3.1 T-type Ca2+ channels by the ran binding protein RanBPM.

H. Rhim, Y. Han, K. Chung, 2009, Biochemical and biophysical research communications.

Effects of Gintonin-enriched fraction on the gene expression of six lysophosphatidic receptor subtypes

Byung-Hwan Lee, Sun-Hye Choi, S. Nah, 2021, Journal of ginseng research.

Direct Interaction and Functional Coupling between Human 5-HT6 Receptor and the Light Chain 1 Subunit of the Microtubule-Associated Protein 1B (MAP1B-LC1)

H. Rhim, E. Hur, K. Chung, 2014, PloS one.

Amyloid-β Oligomers May Impair SNARE-Mediated Exocytosis by Direct Binding to Syntaxin 1a.

H. Rhim, Y. Shin, Yoosoo Yang, 2015, Cell reports.

Synthesis and SAR studies of a novel series of T-type calcium channel blockers.

H. Rhim, Jung-Ha Lee, S. Park, 2006, Bioorganic & medicinal chemistry.

Synthesis and biological activity of 3,4-dihydroquinazolines for selective T-type Ca2+ channel blockers.

H. Rhim, S. Park, Yong Sup Lee, 2005, Bioorganic & medicinal chemistry letters.

Protective Effects of Gintonin on Reactive Oxygen Species-Induced HT22 Cell Damages: Involvement of LPA1 Receptor-BDNF-AKT Signaling Pathway

Sun-Hye Choi, S. Nah, H. Rhim, 2021, Molecules.

Dyrk1A Phosphorylates α-Synuclein and Enhances Intracellular Inclusion Formation*

T. Iwatsubo, H. Rhim, M. Hasegawa, 2006, Journal of Biological Chemistry.

Central administration of afzelin extracted from Ribes fasciculatum improves cognitive and memory function in a mouse model of dementia

H. Rhim, Bonggi Lee, So-Young Oh, 2021, Scientific Reports.

Human glycine α1 receptor inhibition by quercetin is abolished or inversed by α267 mutations in transmembrane domain 2

Byung-Hwan Lee, Sun-Hye Choi, S. Nah, 2007, Brain Research.

Ginseng gintonin, aging societies, and geriatric brain diseases

Sun-Hye Choi, S. Nah, H. Rhim, 2020, Integrative medicine research.

Ginseng saponins induce store‐operated calcium entry in Xenopus oocytes

Byung-Hwan Lee, S. Nah, H. Rhim, 2004, British journal of pharmacology.

Synthesis and evaluation of alpha,alpha'-disubstituted phenylacetate derivatives for T-type calcium channel blockers.

H. Rhim, E. Roh, K. Shin, 2008, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of 1,3-dioxoisoindoline-5-carboxamide derivatives as T-type calcium channel blockers.

M. Doddareddy, H. Choo, Y. Cho, 2007, Bioorganic & Medicinal Chemistry Letters.

Deletion of PLCγ1 in GABAergic neurons increases seizure susceptibility in aged mice

H. Rhim, Yong Ryoul Yang, P. Suh, 2019, Scientific Reports.

Synthesis and Biological Evaluation of Isophthalamide Derivatives as T-type Calcium Channel Blockers

H. Choo, Y. Cho, H. Rhim, 2008 .

The biochemical activation of T-type Ca2+ channels in HEK293 cells stably expressing alpha1G and Kir2.1 subunits.

S. Nah, H. Rhim, Y. Han, 2004, Biochemical and biophysical research communications.

Synthesis and biological evaluation of novel T-type Ca2+ channel blockers.

M. Doddareddy, Y. Cho, H. Rhim, 2004, Bioorganic & medicinal chemistry.

Lead discovery and optimization of T-type calcium channel blockers.

M. Doddareddy, H. Rhim, A. Pae, 2007, Bioorganic & medicinal chemistry.

An inhibitory compound against the interaction between Gα(s) and the third intracellular loop region of serotonin receptor subtype 6 (5-HT(6)) disrupts the signaling pathway of 5-HT(6)

H. Rhim, Y. Yu, Y. Choi, 2007, Experimental & Molecular Medicine.

Prospects of Marine Sterols against Pathobiology of Alzheimer’s Disease: Pharmacological Insights and Technological Advances

H. Rhim, Md Jamal Uddin, R. Dash, 2021, Marine drugs.

Intracellular Calcium Mobilization Induces Immediate Early Genepip92 via Src and Mitogen-activated Protein Kinase in Immortalized Hippocampal Cells*

M. G. Lee, H. Rhim, K. Chung, 2001, The Journal of Biological Chemistry.

Amyloid-b Oligomers May Impair SNARE-Mediated Exocytosis by Direct Binding to Syntaxin 1 a Graphical Abstract Highlights

H. Rhim, Y. Shin, Yoosoo Yang, 2015 .

Pharmacological Inhibition of O-GlcNAc Transferase Promotes mTOR-Dependent Autophagy in Rat Cortical Neurons

H. Rhim, M. Rahman, Hongik Hwang, 2020, Brain sciences.

Promising Modulatory Effects of Autophagy on APP Processing as a Potential Treatment for Alzheimer's Disease

Md. Rezanur Rahman, H. Rhim, Md Jamal Uddin, 2020 .

Activation of NMDA receptors increases proliferation and differentiation of hippocampal neural progenitor cells

Suk-Ho Lee, H. Rhim, H. Son, 2007, Journal of Cell Science.

Stilbene derivatives as human 5-HT(6) receptor antagonists from the root of Caragana sinica.

H. Rhim, K. Chung, S. Kim, 2010, Biological & pharmaceutical bulletin.

Ginseng Gintonin Activates the Human Cardiac Delayed Rectifier K+ Channel: Involvement of Ca2+/Calmodulin Binding Sites

Ho-Chul Shin, Byung-Hwan Lee, Sun-Hye Choi, 2014, Molecules and cells.

Ginsenoside Rg3 activates human KCNQ1 K+ channel currents through interacting with the K318 and V319 residues: a role of KCNE1 subunit.

Byung-Hwan Lee, Sun-Hye Choi, S. Hwang, 2009, European journal of pharmacology.

5-Hydroxytryptamine 6 Receptor (5-HT6R)-Mediated Morphological Changes via RhoA-Dependent Pathways

H. Choo, H. Rhim, Mikyoung Park, 2017, Molecules and cells.

Structure of ginseng major latex-like protein 151 and its proposed lysophosphatidic acid-binding mechanism.

Sun-Hye Choi, Hyeon-Joong Kim, S. Nah, 2015, Acta crystallographica. Section D, Biological crystallography.

Physical Interaction of Jab1 with Human Serotonin 6 G-protein-coupled Receptor and Their Possible Roles in Cell Survival*

J. Baik, H. Rhim, I. Kang, 2010, The Journal of Biological Chemistry.

Functional Interaction of Neuronal Cav1.3 L-type Calcium Channel with Ryanodine Receptor Type 2 in the Rat Hippocampus*

J. Baik, S. Nah, H. Rhim, 2007, Journal of Biological Chemistry.

Recovery from Posttraumatic Stress Requires Dynamic and Sequential Shifts in Amygdalar Connectivities

I. Lyoo, G. Kim, H. Rhim, 2017, Neuropsychopharmacology.

Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation

Jung Hoon Jung, H. Rhim, Su-Jeong Kim, 2017, Scientific Reports.

Parkin Ubiquitinates and Promotes the Degradation of RanBP2*

H. Rhim, K. Chung, D. Min, 2006, Journal of Biological Chemistry.

Ginsenoside Rk1 is a novel inhibitor of NMDA receptors in cultured rat hippocampal neurons

S. Nah, H. Rhim, S. Ko, 2019, Journal of ginseng research.

Growth inhibition of human cancer cells in vitro by T-type calcium channel blockers.

H. Rhim, S. Seo, Jae Yeol Lee, 2006, Bioorganic & medicinal chemistry letters.

Emerging Potential of Naturally Occurring Autophagy Modulator against Neurodegeneration.

Md. Rezanur Rahman, H. Rhim, M. Uddin, 2020, Current pharmaceutical design.

Gintonin, a ginseng-derived exogenous lysophosphatidic acid receptor ligand, enhances blood-brain barrier permeability and brain delivery.

Sun-Hye Choi, Hyeon-Joong Kim, S. Nah, 2018, International journal of biological macromolecules.

Effect of Acute and Chronic Electroconvulsive Shock on 5-Hydroxytrypamine 6 Receptor Immunoreactivity in Rat Hippocampus

Sun-Hye Choi, H. Rhim, Seungwoo Kang, 2014, Experimental neurobiology.

Synthesis and structure activity relationship studies of 2‐amino‐4‐arylysulfonyl‐5,6,7,8‐tetrahydroquinazolines as 5‐HT 6 receptor antagonists

H. Choo, H. Rhim, G. Nam, 2023, Bulletin of the Korean Chemical Society.

Effect of the Gintonin-Enriched Fraction on Glucagon-Like-Protein-1 Release

Sun-Hye Choi, S. Hwang, S. Nah, 2021, Molecules.

Resveratrol inhibits glycine receptor-mediated ion currents.

Byung-Hwan Lee, Sun-Hye Choi, S. Hwang, 2014, Biological & pharmaceutical bulletin.

Elevated O-GlcNAcylation induces an antidepressant-like phenotype and decreased inhibitory transmission in medial prefrontal cortex

H. Rhim, M. Rahman, ChiHye Chung, 2020, Scientific Reports.

Discovery of β-Arrestin Biased Ligands of 5-HT7R.

H. Choo, H. Rhim, Jihye Seong, 2018, Journal of medicinal chemistry.

Cholecystokinin-8S-induced intracellular calcium signaling in acutely isolated periaqueductal gray neurons of the rat.

H. Rhim, Yu-Mi Yang, Jun‐mo Chung, 2007, Biological & pharmaceutical bulletin.

An increase in voltage‐gated sodium channel current elicits microglial activation followed inflammatory responses in vitro and in vivo after spinal cord injury

H. Rhim, T. Yune, Jee Youn Lee, 2013, Glia.

Cyclin Y, a novel actin-binding protein, regulates spine plasticity through the cofilin-actin pathway

H. Rhim, D. Jo, Mikyoung Park, 2020, Progress in Neurobiology.

Synthesis and biological evaluation of 4-nitroindole derivatives as 5-HT2A receptor antagonists.

Ambily Nath Indu Viswanath, H. Rhim, A. Pae, 2015, Bioorganic & medicinal chemistry.

Ginseng gintonin attenuates the disruptions of brain microvascular permeability and microvascular endothelium junctional proteins in an APPswe/PSEN-1 double-transgenic mouse model of Αlzheimer's disease

Sun-Hye Choi, S. Nah, H. Rhim, 2021, Experimental and therapeutic medicine.

Elevated O-GlcNAcylation induces an antidepressant-like phenotype and decreased inhibitory transmission in medial prefrontal cortex

H. Rhim, M. Rahman, ChiHye Chung, 2020, Scientific Reports.

Ginseng and ginsenoside Rg3, a newly identified active ingredient of ginseng, modulate Ca2+ channel currents in rat sensory neurons.

S. Nah, H. Rhim, Hyeno Kim, 2002, European journal of pharmacology.

Effects of quercetin on human α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated ion currents.

Byung-Hwan Lee, Sun-Hye Choi, S. Hwang, 2010, Biological & pharmaceutical bulletin.

Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, potentiates ATP-gated P2X1 receptor channel currents

Byung-Hwan Lee, Sun-Hye Choi, S. Hwang, 2013, Molecules and cells.

Identification of disulfide cross-linked tau dimer responsible for tau propagation

Dong Jin Kim, H. Rhim, Young‐Tae Chang, 2015, Scientific Reports.

ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned human 5-HT6 receptors.

F. Bordi, H. Rhim, G. Tarzia, 2011, European journal of pharmacology.

Differential Effects of Quercetin and Quercetin Glycosides on Human α7 Nicotinic Acetylcholine Receptor-Mediated Ion Currents

Byung-Hwan Lee, Sun-Hye Choi, S. Hwang, 2016, Biomolecules & therapeutics.

Effects of ginsenoside Rg3 on α9α10 nicotinic acetylcholine receptor-mediated ion currents.

Byung-Hwan Lee, Sun-Hye Choi, S. Hwang, 2013, Biological & pharmaceutical bulletin.

Quercetin enhances human α7 nicotinic acetylcholine receptor-mediated ion current through interactions with Ca2+ binding sites

Byung-Hwan Lee, Sun-Hye Choi, S. Hwang, 2010, Molecules and cells.

A role for Leu247 residue within transmembrane domain 2 in ginsenoside-mediated α7 nicotinic acetylcholine receptor regulation

Byung-Hwan Lee, Sun-Hye Choi, S. Hwang, 2009, Molecules and cells.

Mutations of arginine 222 in pre-transmembrane domain I of mouse 5-HT(3A) receptor abolish 20(R)- but not 20(S)-ginsenoside Rg(3) inhibition of 5-HT-mediated ion currents.

Byung-Hwan Lee, Sun-Hye Choi, S. Nah, 2007, Biological & pharmaceutical bulletin.

GABAB receptor-mediated ERK1/2 phosphorylation via a direct interaction with CaV1.3 channels

H. Rhim, Bo-Hye Im, 2012, Neuroscience Letters.

Gintonin Attenuates D-Galactose-Induced Hippocampal Senescence by Improving Long-Term Hippocampal Potentiation, Neurogenesis, and Cognitive Functions

Sun-Hye Choi, Hyeon-Joong Kim, S. Nah, 2018, Gerontology.

Ginsenoside Rg3 Inhibits Human Kv1.4 Channel Currents by Interacting with the Lys531 Residue

Byung-Hwan Lee, Sun-Hye Choi, S. Nah, 2008, Molecular Pharmacology.

Gintonin influences the morphology and motility of adult brain neurons via LPA receptors

Sun-Hye Choi, Hyeon-Joong Kim, S. Nah, 2020, Journal of ginseng research.

Synthesis and biological evaluation of (phenylpiperazinyl-propyl)arylsulfonamides as selective 5-HT(2A) receptor antagonists.

H. Rhim, A. Pae, W. Park, 2010, Bioorganic & medicinal chemistry.

Stereospecificity of ginsenoside Rg3 action on ion channels.

Byung-Hwan Lee, S. Nah, H. Rhim, 2004, Molecules and cells.

Effects of dextrorotatory morphinans on brain Na+ channels expressed in Xenopus oocytes.

Byung-Hwan Lee, Sun-Hye Choi, S. Nah, 2007, European journal of pharmacology.

Visualization of the binding between gintonin, a Panax ginseng-derived LPA receptor ligand, and the LPA receptor subtypes and transactivation of the EGF receptor

Sun-Hye Choi, S. Hwang, S. Nah, 2021, Journal of ginseng research.

Preparation of Red Ginseng Marc-Derived Gintonin and Its Application as a Skin Nutrient

S. Hwang, S. Nah, H. Rhim, 2023, Nutrients.

Role of K+ Channels in Frequency Regulation of Spontaneous Action Potentials in Rat Pituitary GH3 Cells

W. Ho, Suk-Ho Lee, H. Rhim, 2003, Neuroendocrinology.

Molecular interaction between kisspeptin decapeptide analogs and a lipid membrane.

H. Rhim, J. Kim, Sungtae Yang, 2009, Archives of biochemistry and biophysics.

Physical and Functional Interaction between 5-HT6 Receptor and Nova-1

H. Rhim, Kyungjin Kim, Hongik Hwang, 2019, Experimental neurobiology.

Hypothalamic administration of sargahydroquinoic acid elevates peripheral thermogenic signaling and ameliorates high fat diet-induced obesity through the sympathetic nervous system

H. Rhim, Bonggi Lee, Hyeung‐Rak Kim, 2021, Scientific Reports.

HYP-1, a novel diamide compound, relieves inflammatory and neuropathic pain in rats

S. Nah, H. Rhim, Hwa‐Jung Kim, 2012, Pharmacology Biochemistry and Behavior.

Ginsenosides inhibit NMDA receptor-mediated epileptic discharges in cultured hippocampal neurons

H. Rhim, Sunoh Kim, 2004, Archives of pharmacal research.

Increased production of tumor necrosis factor-alpha induces apoptosis after traumatic spinal cord injury in rats.

H. Rhim, Y. Oh, M. Shin, 2003, Journal of Neurotrauma.

Effects of ginsenosides, active ingredients of Panax ginseng, on development, growth, and life span of Caenorhabditis elegans.

Sun-Hye Choi, S. Nah, H. Rhim, 2007, Biological & pharmaceutical bulletin.

Impaired long‐term memory and long‐term potentiation in N‐type Ca2+ channel‐deficient mice

H. Rhim, D. Jeon, H. Rhim, 2007, Genes, brain, and behavior.

Postsynaptic action mechanism of somatostatin on the membrane excitability in spinal substantia gelatinosa neurons of juvenile rats

S. J. Kim, H. Rhim, J. Kim, 2002, Neuroscience.

Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression.

H. Choo, H. Rhim, G. Keum, 2014, Bioorganic & Medicinal Chemistry.

Synthesis and Inhibition Effects on 5-HT 6 Receptor of Benzothiazole Derivatives

H. Rhim, F. Hayat, Euna Yoo, 2013 .

Effects of Gintonin-Enriched Fraction in an Atopic Dermatitis Animal Model: Involvement of Autotaxin Regulation.

Sun-Hye Choi, S. Hwang, Hyeon-Joong Kim, 2017, Biological & pharmaceutical bulletin.

Novel N-acyl-carbazole derivatives as 5-HT7R antagonists.

H. Rhim, J. Tae, Youngjae Kim, 2016, European journal of medicinal chemistry.

Aryl Biphenyl‐3‐ylmethylpiperazines as 5‐HT7 Receptor Antagonists

Xi-Ping Huang, B. Roth, Bongjin Moon, 2013, ChemMedChem.

The effects of ginsenoside Rg(3) on human Kv1.4 channel currents without the N-terminal rapid inactivation domain.

Sun-Hye Choi, S. Hwang, S. Nah, 2009, Biological & pharmaceutical bulletin.

Effects of ginsenoside Rg2 on the 5-HT3A receptor-mediated ion current in Xenopus oocytes.

S. Nah, H. Rhim, Seikwan Oh, 2003, Molecules and cells.

Synthesis and biological evaluation of arylsulfonylpiperazine derivatives as 5-HT6 receptor ligands

Y. Cho, H. Rhim, H. Koh, 2007 .

Functional human 5-HT6 receptor assay for high throughput screening of chemical ligands and binding proteins.

H. Rhim, A. Pae, E. Kostenis, 2008, Combinatorial chemistry & high throughput screening.

GABAB receptor-mediated ERK1/2 phosphorylation via a direct interaction with CaV1.3 channels

H. Rhim, Bo-Hye Im, 2012, Neuroscience Letters.

Transcranial focused ultrasound stimulation with high spatial resolution

A. Thielscher, H. Rhim, H. Lee, 2021, Brain Stimulation.