T. Voyno-Yasenetskaya

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G Protein &bgr;&ggr; Subunits Stimulate p114RhoGEF, a Guanine Nucleotide Exchange Factor for RhoA and Rac1: Regulation of Cell Shape and Reactive Oxygen Species Production

J. Niu, J. Profirovic, Haiyun Pan, 2003 .

Interaction between the Gα Subunit of Heterotrimeric G12 Protein and Hsp90 Is Required for Gα12 Signaling*

R. Vaiskunaite, T. Voyno-Yasenetskaya, T. Kozasa, 2001, The Journal of Biological Chemistry.

T‐cadherin modulates endothelial barrier function

J. Profirovic, T. Voyno-Yasenetskaya, Jingyan Han, 2009, Journal of cellular physiology.

RhoA Interaction with Inositol 1,4,5-Trisphosphate Receptor and Transient Receptor Potential Channel-1 Regulates Ca2+ Entry

T. Voyno-Yasenetskaya, A. Malik, R. Minshall, 2003, Journal of Biological Chemistry.

Gα Minigenes Expressing C-terminal Peptides Serve as Specific Inhibitors of Thrombin-mediated Endothelial Activation*

H. Hamm, T. Voyno-Yasenetskaya, J. Vanhauwe, 2001, The Journal of Biological Chemistry.

Thrombin Induces Proteinase-activated Receptor-1 Gene Expression in Endothelial Cells via Activation of Gi-linked Ras/Mitogen-activated Protein Kinase Pathway*

H. Hamm, T. Voyno-Yasenetskaya, A. Malik, 1999, The Journal of Biological Chemistry.

Thrombin-Induced NF- B Activation and ICAM-1 Transcription in Endothelial Cells

T. Voyno-Yasenetskaya, A. Malik, R. Ye, 2002 .

Galpha(q) and Gbetagamma regulate PAR-1 signaling of thrombin-induced NF-kappaB activation and ICAM-1 transcription in endothelial cells.

T. Voyno-Yasenetskaya, A. Malik, R. Ye, 2002, Circulation research.

Gα12/Gα13 Subunits of Heterotrimeric G Proteins Mediate Parathyroid Hormone Activation of Phospholipase D in UMR-106 Osteoblastic Cells

T. Voyno-Yasenetskaya, P. Stern, Amareshwar T. K. Singh, 2005 .

Carboxyl-terminal mutations of Gq alpha and Gs alpha that alter the fidelity of receptor activation.

B. Conklin, H. Bourne, T. Voyno-Yasenetskaya, 1996, Molecular pharmacology.

T-cadherin activates Rac1 and Cdc42 and changes endothelial permeability

T. Voyno-Yasenetskaya, V. Tkachuk, Y. Parfyonova, 2009, Biochemistry (Moscow).

Low density lipoprotein- and high density lipoprotein-mediated signal transduction and exocytosis in alveolar type II cells.

T. Voyno-Yasenetskaya, L. Dobbs, S. Erickson, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of Apoptosis by α-Subunits of G12 and G13 Proteins via Apoptosis Signal-regulating Kinase-1*

T. Voyno-Yasenetskaya, H. Ichijo, M. Faure, 1998, The Journal of Biological Chemistry.

Vascular Signal Transduction and Atherosclerosis

V. Tertov, T. Voyno-Yasenetskaya, V. Tkachuk, 1990, Annals of the New York Academy of Sciences.

Melatonin mt1 and MT2 receptors stimulate c-Jun N-terminal kinase via pertussis toxin-sensitive and -insensitive G proteins.

T. Voyno-Yasenetskaya, E. Stanbridge, Y. Wong, 2002, Cellular signalling.

T-cadherin is located in the nucleus and centrosomes in endothelial cells.

T. Voyno-Yasenetskaya, V. Tkachuk, A. Andreeva, 2009, American journal of physiology. Cell physiology.

Lipopolysaccharide Stimulates Platelet Secretion and Potentiates Platelet Aggregation via TLR4/MyD88 and the cGMP-Dependent Protein Kinase Pathway1

T. Voyno-Yasenetskaya, Jingyan Han, Emily J. Welch, 2009, The Journal of Immunology.

Gα13-mediated transformation and apoptosis are permissively dependent on basal ERK activity

J. Niu, R. Vaiskunaite, T. Voyno-Yasenetskaya, 2003 .

G alpha 13-mediated transformation and apoptosis are permissively dependent on basal ERK activity.

J. Niu, R. Vaiskunaite, T. Voyno-Yasenetskaya, 2003, American journal of physiology. Cell physiology.

Regulation of apoptosis signal‐regulating kinase 1 degradation by Gα13

T. Voyno-Yasenetskaya, A. Andreeva, M. Kutuzov, 2007 .

Guanine nucleotide‐dependent, pertussis toxin‐insensitive regulation of phosphoinositide turnover by bradykinin in bovine pulmonary artery endothelial cells

J. Stewart, T. Voyno-Yasenetskaya, V. Tkachuk, 1989, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

G-protein-coupled-receptor activation of the smooth muscle calponin gene.

T. Voyno-Yasenetskaya, S. Orlov, N. Dulin, 2001, The Biochemical journal.

cGMP-Dependent Protein Kinase Pathway Aggregation via TLR4/MyD88 and the Secretion and Potentiates Platelet Lipopolysaccharide Stimulates Platelet

T. Voyno-Yasenetskaya, Jingyan Han, Emily J. Welch, 2009 .

G Proteins and Na+/H+ Exchange

T. Voyno-Yasenetskaya, 1998, Neurosignals.

Gα12 Differentially Regulates Na+-H+ Exchanger Isoforms*

D. Barber, T. Voyno-Yasenetskaya, Xia Lin, 1996, The Journal of Biological Chemistry.

Acylation of Gα13 is important for its interaction with thrombin receptor, transforming activity and actin stress fiber formation

T. Voyno-Yasenetskaya, E. Ponimaskin, S. Offermanns, 2000, FEBS letters.

G a q and G bg Regulate PAR-1 Signaling of Thrombin-Induced NF- k B Activation and ICAM-1 Transcription in Endothelial Cells

T. Voyno-Yasenetskaya, A. Malik, R. Ye, 2002 .

48 NOVEL MECHANISM OF G-PROTEIN-DEPENDENT PHOSPHORYLATION OF VASODILATOR-STIMULATED PHOSPHOPROTEIN.

J. Niu, J. Profirovic, T. Voyno-Yasenetskaya, 2004, Journal of Investigative Medicine.

RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain.

R. Bodnar, J. Niu, T. Voyno-Yasenetskaya, 2002, The Biochemical journal.

Regulator of G Protein Signaling RGS3T Is Localized to the Nucleus and Induces Apoptosis*

J. Niu, T. Voyno-Yasenetskaya, N. Dulin, 2000, The Journal of Biological Chemistry.

Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling.

R. Vaiskunaite, T. Voyno-Yasenetskaya, T. Kozasa, 2001, The Journal of biological chemistry.

Mutant alpha subunits of G12 and G13 proteins induce neoplastic transformation of Rat-1 fibroblasts.

H. Bourne, T. Voyno-Yasenetskaya, A. Pace, 1994, Oncogene.

Morphogenic Signaling in Neurons Via Neurotransmitter Receptors and Small GTPases

D. Richter, M. Schachner, T. Voyno-Yasenetskaya, 2007, Molecular Neurobiology.

Constitutive Activation of NF-κB and Secretion of Interleukin-8 Induced by the G Protein-coupled Receptor of Kaposi's Sarcoma-associated Herpesvirus Involve Gα13 and RhoA*

T. Voyno-Yasenetskaya, P. Xie, R. Ye, 2001, The Journal of Biological Chemistry.

Cyclic AMP-independent Activation of Protein Kinase A by Vasoactive Peptides*

J. Niu, T. Voyno-Yasenetskaya, N. Dulin, 2001, The Journal of Biological Chemistry.

Regulation of surfactant secretion in alveolar type II cells.

T. Voyno-Yasenetskaya, A. Andreeva, M. Kutuzov, 2007, American journal of physiology. Lung cellular and molecular physiology.

Zyxin is involved in thrombin signaling via interaction with PAR‐1 receptor

J. Niu, J. Profirovic, T. Voyno-Yasenetskaya, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A Novel Mechanism of G Protein-dependent Phosphorylation of Vasodilator-stimulated Phosphoprotein*

J. Niu, J. Profirovic, T. Voyno-Yasenetskaya, 2005, Journal of Biological Chemistry.

Requirement of Gβγ and c-Src in D2 Dopamine Receptor-Mediated Nuclear Factor-κB Activation

T. Voyno-Yasenetskaya, R. Ye, Ming Yang, 2003 .

cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells.

H. Bourne, T. Voyno-Yasenetskaya, M. Faure, 1994, The Journal of biological chemistry.

G Protein Subunit Gα13 Binds to Integrin αIIbβ3 and Mediates Integrin “Outside-In” Signaling

T. Voyno-Yasenetskaya, P. Flevaris, Haixia Gong, 2010, Science.

A ubiquitous membrane fusion protein αSNAP: a potential therapeutic target for cancer, diabetes and neurological disorders?

T. Voyno-Yasenetskaya, A. Andreeva, M. Kutuzov, 2006, Expert opinion on therapeutic targets.

Potent Transforming Activity of the G13 α Subunit Defines a Novel Family of Oncogenes

T. Voyno-Yasenetskaya, J. Gutkind, N. Xu, 1994 .

Gα12 and Gα13 Regulate Extracellular Signal-regulated Kinase and c-Jun Kinase Pathways by Different Mechanisms in COS-7 Cells*

N. Ahn, H. Bourne, T. Voyno-Yasenetskaya, 1996, The Journal of Biological Chemistry.

Gα13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis

Guoquan Liu, Jingyan Han, J. Profirovic, 2009, Angiogenesis.

RhoGDI-1 Modulation of the Activity of Monomeric RhoGTPase RhoA Regulates Endothelial Barrier Function in Mouse Lungs

J. Niu, T. Voyno-Yasenetskaya, J. Miyoshi, 2007, Circulation research.

Novel Mechanisms of G Protein-Dependent Regulation of Endothelial Nitric-Oxide Synthase

J. Profirovic, R. Vaiskunaite, T. Voyno-Yasenetskaya, 2006, Molecular Pharmacology.

Heterotrimeric G‐proteins associate with microtubules during differentiation in PC12 pheochromocytoma cells

T. Hope, T. Voyno-Yasenetskaya, T. Sarma, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation

J. Niu, R. Vaiskunaite, T. Voyno-Yasenetskaya, 2001, Current Biology.

5-HT7 Receptor Is Coupled to Gα Subunits of Heterotrimeric G12-Protein to Regulate Gene Transcription and Neuronal Morphology

D. Richter, M. Schachner, T. Voyno-Yasenetskaya, 2005, The Journal of Neuroscience.

G alpha 13 stimulates Na-H exchange.

B. Conklin, H. Bourne, D. Barber, 1994, The Journal of biological chemistry.

A novel regulator of angiogenesis in endothelial cells: 5-hydroxytriptamine 4 receptor

J. Profirovic, T. Voyno-Yasenetskaya, M. Ushio-Fukai, 2012, Angiogenesis.

Galpha12 differentially regulates Na+-H+ exchanger isoforms.

D. Barber, T. Voyno-Yasenetskaya, X. Lin, 1996, The Journal of biological chemistry.

Gα12 is targeted to the mitochondria and affects mitochondrial morphology and motility

T. Voyno-Yasenetskaya, A. Andreeva, M. Kutuzov, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Scaffolding proteins in G-protein signaling

T. Voyno-Yasenetskaya, A. Andreeva, M. Kutuzov, 2007, Journal of molecular signaling.

Subunits Stimulate p 114 RhoGEF , a Guanine Nucleotide Exchange Factor for RhoA and Rac 1 Regulation of Cell Shape and Reactive Oxygen Species Production

J. Niu, J. Profirovic, Haiyun Pan, 2003 .

5-Hydroxytryptamine 4(a) Receptor Is Coupled to the Gα Subunit of Heterotrimeric G13 Protein*

D. Richter, J. Profirovic, R. Vaiskunaite, 2002, The Journal of Biological Chemistry.

Differential Expression of Adenosine Receptors in Human Endothelial Cells: Role of A2B Receptors in Angiogenic Factor Regulation

T. Voyno-Yasenetskaya, I. Biaggioni, L. Belardinelli, 2002, Circulation research.

Monitoring Receptor-Mediated Changes of Intracellular cAMP Level by Using Ion Channels and Fluorescent Proteins as Biosensors

T. Voyno-Yasenetskaya, A. Zeug, E. Ponimaskin, 2007 .

Protein Kinase A-mediated Phosphorylation of the Gα13 Switch I Region Alters the Gαβγ13-G Protein-coupled Receptor Complex and Inhibits Rho Activation*

T. Voyno-Yasenetskaya, G. L. Le Breton, T. Kozasa, 2003, The Journal of Biological Chemistry.

Protein kinase A-mediated phosphorylation of the Galpha13 switch I region alters the Galphabetagamma13-G protein-coupled receptor complex and inhibits Rho activation.

T. Voyno-Yasenetskaya, G. L. Le Breton, T. Kozasa, 2003, The Journal of biological chemistry.

Regulation of ATP-dependent surfactant secretion and activation of second-messenger systems in alveolar type II cells.

T. Voyno-Yasenetskaya, M. Williams, L. Dobbs, 1991, The American journal of physiology.

Constitutive activation of NF-kappa B and secretion of interleukin-8 induced by the G protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus involve G alpha(13) and RhoA.

T. Voyno-Yasenetskaya, P. Xie, M. Yang, 2001, The Journal of biological chemistry.

Vasodilator‐stimulated phosphoprotein deficiency potentiates PAR‐1‐induced increase in endothelial permeability in mouse lungs

U. Walter, J. Profirovic, T. Voyno-Yasenetskaya, 2011, Journal of cellular physiology.

Potent transforming activity of the G13 alpha subunit defines a novel family of oncogenes.

T. Voyno-Yasenetskaya, J. Gutkind, N. Xu, 1994, Biochemical and biophysical research communications.

Supporting Online Material Materials and Methods Fig. S1 References Movies S1 to S3

M. Hartman, T. Voyno-Yasenetskaya, P. Flevaris, 2022 .

Histamine and bradykinin stimulate the phosphoinositide turnover in human umbilical vein endothelial cells via different G‐proteins

T. Voyno-Yasenetskaya, V. Tkachuk, M. Panchenko, 1989, FEBS letters.

Gα12 Interaction with αSNAP Induces VE-cadherin Localization at Endothelial Junctions and Regulates Barrier Function*

J. Profirovic, R. Vaiskunaite, T. Voyno-Yasenetskaya, 2005, Journal of Biological Chemistry.

Conformational Activation of Radixin by G13 Protein α Subunit*

R. Vaiskunaite, T. Voyno-Yasenetskaya, A. Gudkov, 2000, The Journal of Biological Chemistry.

G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production.

J. Niu, J. Profirovic, Haiyun Pan, 2003, Circulation research.

Radixin Stimulates Rac1 and Ca2+/Calmodulin-dependent Kinase, CaMKII

T. Voyno-Yasenetskaya, Guoquan Liu, 2005, Journal of Biological Chemistry.

LIM Kinase 1 Coordinates Microtubule Stability and Actin Polymerization in Human Endothelial Cells*

J. Niu, J. Profirovic, T. Voyno-Yasenetskaya, 2005, Journal of Biological Chemistry.

G Protein (cid:1)(cid:2) Subunits Stimulate p114RhoGEF, a Guanine Nucleotide Exchange Factor for RhoA and Rac1 Regulation of Cell Shape and Reactive Oxygen Species Production

J. Niu, J. Profirovic, Haiyun Pan, 2003 .

Downregulation of LIM kinase 1 suppresses ocular inflammation and fibrosis

T. Voyno-Yasenetskaya, Zhengping Jia, B. Yue, 2008, Molecular vision.

LIM Kinase 1 Promotes Endothelial Barrier Disruption and Neutrophil Infiltration in Mouse Lungs

Haiyun Pan, T. Voyno-Yasenetskaya, Jingyan Han, 2009, Circulation research.

A Novel Mechanism of G Protein-dependent Phosphorylation of Vasodilator-stimulated Phosphoprotein*

J. Niu, J. Profirovic, T. Voyno-Yasenetskaya, 2004, Journal of Biological Chemistry.

Conformational activation of radixin by G13 protein alpha subunit.

R. Vaiskunaite, T. Voyno-Yasenetskaya, A. Gudkov, 2000, The Journal of biological chemistry.

A novel regulator of angiogenesis in endothelial cells: 5-hydroxytriptamine 4 receptor

R. Hen, J. Profirovic, T. Voyno-Yasenetskaya, 2012, Angiogenesis.

Galpha12 and Galpha13 regulate extracellular signal-regulated kinase and c-Jun kinase pathways by different mechanisms in COS-7 cells.

N. Ahn, H. Bourne, T. Voyno-Yasenetskaya, 1996, The Journal of biological chemistry.

Regulation of apoptosis signal-regulating kinase 1 degradation by G alpha13.

T. Voyno-Yasenetskaya, A. Andreeva, M. Kutuzov, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Regulation of Apoptosis Signal-regulating Kinase 1 (ASK1) by Polyamine Levels via Protein Phosphatase 5*

T. Voyno-Yasenetskaya, A. Andreeva, M. Kutuzov, 2005, Journal of Biological Chemistry.

G Protein Subunit G a 13 Binds to Integrin a IIb b 3 and Mediates Integrin “ Outside-In ” Signaling

T. Voyno-Yasenetskaya, P. Flevaris, Haixia Gong, 2010 .

Requirement of Gbetagamma and c-Src in D2 dopamine receptor-mediated nuclear factor-kappaB activation.

T. Voyno-Yasenetskaya, R. Ye, Ming Yang, 2003, Molecular pharmacology.

Galpha(q) and Gbetagamma regulate PAR-1 signaling of thrombin-induced NF-kappaB activation and ICAM-1 transcription in endothelial cells.

T. Voyno-Yasenetskaya, A. Malik, R. Ye, 2002, Circulation research.

G alpha12/G alpha13 subunits of heterotrimeric G proteins mediate parathyroid hormone activation of phospholipase D in UMR-106 osteoblastic cells.

T. Voyno-Yasenetskaya, P. Stern, A. Gilchrist, 2005, Endocrinology.

Zyxin is involved in thrombin signaling via interaction with PAR‐1 receptor

J. Niu, J. Profirovic, T. Voyno-Yasenetskaya, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The Role of Nitric Oxide in the Integrity of Endothelial Glycocalyx

T. Voyno-Yasenetskaya, D. Predescu, A. Malik, 2006, Microscopy and Microanalysis.

Ga12 Differentially Regulates Na-H Exchanger Isoforms*

D. Barber, T. Voyno-Yasenetskaya, Xia Lin, 1996 .