K. Rossman

发表

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

C. Der, K. Rossman, J. Sondek, 2005, Nature Reviews Molecular Cell Biology.

Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression

C. Der, K. Rossman, J. Sondek, 2007, Nature Structural &Molecular Biology.

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

J. Cherfils, C. Der, D. Vigil, 2010, Nature Reviews Cancer.

PH domain of ELMO functions in trans to regulate Rac activation via Dock180

Kodi S Ravichandran, John Sondek, M. Hengartner, 2004, Nature Structural &Molecular Biology.

Established and emerging fluorescence-based assays for G-protein function: Ras-superfamily GTPases.

K. Rossman, J. Sondek, D. Siderovski, 2003, Combinatorial chemistry & high throughput screening.

Substrate Trapping Proteomics Reveals Targets of the (cid:2) TrCP2/FBXW11 Ubiquitin Ligase

M. MacCoss, R. Moon, C. Der, 2014 .

Loss of PtdIns-3-P binding by the C-terminal Tiam-1 pleckstrin homology (PH) domain prevents in vivo Rac1 activation without affecting membrane targeting*

M. Chou, K. Rossman, J. Sondek, 2003 .

The Ras superfamily at a glance

Krister Wennerberg, K. Wennerberg, C. Der, 2005, Journal of Cell Science.

Development of a high-throughput TR-FRET screening assay for a fast-cycling KRAS mutant.

K. Pearce, K. Rossman, Xiaodong Wang, 2022, SLAS discovery : advancing life sciences R & D.

Signaling Interplay in Ras Superfamily Function

C. Der, K. Rossman, N. Mitin, 2005, Current Biology.

RAS isoforms and mutations in cancer at a glance

C. Der, K. Rossman, G. A. Hobbs, 2016, Journal of Cell Science.

The RalB Small GTPase Mediates Formation of Invadopodia through a GTPase-Activating Protein-Independent Function of the RalBP1/RLIP76 Effector

C. Der, J. Yeh, K. Rossman, 2012, Molecular and Cellular Biology.

Vav2 Is an Activator of Cdc42, Rac1, and RhoA*

C. Der, K. Rossman, S. Campbell, 2000, The Journal of Biological Chemistry.

Substrate Trapping Proteomics Reveals Targets of the βTrCP2/FBXW11 Ubiquitin Ligase

M. MacCoss, R. Moon, C. Der, 2014, Molecular and Cellular Biology.

A Steric-Inhibition Model for Regulation of Nucleotide Exchange via the Dock180 Family of GEFs

M. Hengartner, K. Rossman, J. Sondek, 2005, Current Biology.

Loss of Phosphatidylinositol 3-Phosphate Binding by the C-terminal Tiam-1 Pleckstrin Homology Domain Prevents in Vivo Rac1 Activation without Affecting Membrane Targeting*

M. Chou, K. Rossman, J. Sondek, 2003, The Journal of Biological Chemistry.

RhoGEF Specificity Mutants Implicate RhoA as a Target for Dbs Transforming Activity

K. Rossman, J. Sondek, D. Worthylake, 2002, Molecular and Cellular Biology.

Dbl family proteins.

C. Der, K. Rossman, I. Whitehead, 1997, Biochimica et biophysica acta.

P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils

C. Der, P. Hawkins, L. Stephens, 2014, Journal of Cell Science.

Increasing complexity of Ras signaling

Channing J Der, Roya Khosravi-Far, C. Der, 1998, Oncogene.

Discernment between candidate mechanisms for KRAS G13D colorectal cancer sensitivity to EGFR inhibitors

K. Rossman, T. McFall, E. Stites, 2020, Cell communication and signaling : CCS.

Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase-Activating Proteins in Basal-like Breast Cancers.

Nicole M. Baker, C. Fan, C. Perou, 2016, Cancer research.

Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease

C. Der, K. Rossman, D. R. Cook, 2014, Oncogene.

Role of the C-terminal SH3 domain and N-terminal tyrosine phosphorylation in regulation of Tim and related Dbl-family proteins.

K. Rossman, J. Sondek, M. Yohe, 2008, Biochemistry.

Auto-inhibition of the Dbl Family Protein Tim by an N-terminal Helical Motif*

C. Der, K. Rossman, J. Sondek, 2007, Journal of Biological Chemistry.

Requirement For C-terminal Sequences in Regulation of Ect2 Guanine Nucleotide Exchange Specificity and Transformation*

C. Der, K. Rossman, J. Sondek, 2004, Journal of Biological Chemistry.

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

K. Rossman, J. Sondek, D. Worthylake, 2000, Nature.

Increasing complexity of Ras signal transduction: involvement of Rho family proteins.

C. Der, K. Rossman, R. Khosravi‐Far, 1998, Advances in cancer research.

Dependence of Dbl and Dbs Transformation on MEK and NF-κB Activation

C. Der, K. Rossman, J. Trzăskos, 1999, Molecular and Cellular Biology.

Rho family proteins and Ras transformation: the RHOad less traveled gets congested

Channing J Der, Roya Khosravi-Far, C. Der, 1998, Oncogene.

Identification of a Novel Actin-Binding Domain within the Rho Guanine Nucleotide Exchange Factor TEM4

C. Der, K. Rossman, N. Mitin, 2012, PloS one.

The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity.

K. Rossman, J. Sondek, M. Lemmon, 2006, The Biochemical journal.

A crystallographic view of interactions between Dbs and Cdc42: PH domain‐assisted guanine nucleotide exchange

John Sondek, K. Rossman, J. Sondek, 2002, The EMBO journal.

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

C. Der, K. Rossman, J. Sondek, 2002, Nature Structural Biology.

Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins*

D P Siderovski, C. Der, K. Rossman, 2001, The Journal of Biological Chemistry.

Bacterial expressed DH and DH/PH domains.

K. Rossman, S. Campbell, Sharon L. Campbell, 2000, Methods in enzymology.

Molecular basis for Rac1 recognition by guanine nucleotide exchange factors

C. Der, K. Rossman, J. Sondek, 2001, Nature Structural Biology.

Crystal structure of the DH/PH fragment of Dbs without bound GTPase.

John Sondek, K. Rossman, J. Sondek, 2004, Structure.

Multifunctional Roles for the PH Domain of Dbs in Regulating Rho GTPase Activation*

John Sondek, K. Rossman, J. Sondek, 2003, The Journal of Biological Chemistry.

Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation.

C. Der, K. Rossman, J. Trzăskos, 1999, Molecular and cellular biology.

The RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin Contractility

C. Der, K. Rossman, N. Mitin, 2013, PloS one.

Tuba, a Novel Protein Containing Bin/Amphiphysin/Rvs and Dbl Homology Domains, Links Dynamin to Regulation of the Actin Cytoskeleton*

P. De Camilli, K. Rossman, J. Sondek, 2003, Journal of Biological Chemistry.

Discernment between candidate mechanisms for KRAS G13D colorectal cancer sensitivity to EGFR inhibitors

K. Rossman, T. McFall, E. Stites, 2020, Cell Communication and Signaling.

14-3-3 ζ Negatively Regulates Raf-1 Activity by Interactions with the Raf-1 Cysteine-rich Domain*

C. Der, K. Rossman, H. Fu, 1997, The Journal of Biological Chemistry.

Larger than Dbl: new structural insights into RhoA activation.

K. Rossman, J. Sondek, 2005, Trends in biochemical sciences.

Oncogenic Activity of Ect2 Is Regulated through Protein Kinase Cι-mediated Phosphorylation*

Channing J Der, C. Der, K. Rossman, 2010, The Journal of Biological Chemistry.

Structural Features of RhoGEFs

K. Rossman, J. Sondek, D. Worthylake, 2010 .

CHAPTER 246 – Structural Features of RhoGEFs

K. Rossman, J. Sondek, D. Worthylake, 2003 .

Functional Analysis of Cdc42 Residues Required for Guanine Nucleotide Exchange*

John Sondek, K. Rossman, J. Sondek, 2002, The Journal of Biological Chemistry.