N. Ridgway

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Biochemistry of lipids, lipoproteins and membranes

N. Ridgway, R. McLeod, 2015 .

Regulation of Oxysterol-binding Protein Golgi Localization through Protein Kinase D–mediated Phosphorylation

John M. Asara, Michelle M. Ng, Xuemei Yang, 2010, Molecular biology of the cell.

Epidermal growth factor receptor (EGFR) in lung cancer: an overview and update.

N. Ridgway, Zhaolin Xu, G. Bethune, 2011, Journal of thoracic disease.

Molecular mechanisms and regulation of ceramide transport.

N. Ridgway, R. Perry, Neale D Ridgway, 2005, Biochimica et biophysica acta.

Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein.

N. Ridgway, R. Perry, 2006, Molecular biology of the cell.

Interactions between metabolism and intracellular distribution of cholesterol and sphingomyelin.

N. Ridgway, N D Ridgway, 2000, Biochimica et biophysica acta.

Lipid-associated PML structures assemble nuclear lipid droplets containing CCTα and Lipin1

N. Ridgway, G. Dellaire, J. Salsman, 2020, Life Science Alliance.

Lipid-associated PML domains regulate CCTα, Lipin1 and lipid homeostasis

N. Ridgway, G. Dellaire, J. Salsman, 2020, bioRxiv.

Oxysterol-binding proteins.

N. Ridgway, 2010, Sub-cellular biochemistry.

CTP:phosphocholine cytidylyltransferase α (CCTα) and lamins alter nuclear membrane structure without affecting phosphatidylcholine synthesis.

N. Ridgway, Karsten Gehrig, 2011, Biochimica et biophysica acta.

cDNA cloning and expression of oxysterol-binding protein, an oligomer with a potential leucine zipper.

C. Slaughter, P. Dawson, N. Ridgway, 1989, The Journal of biological chemistry.

The rate-limiting enzyme in phosphatidylcholine synthesis regulates proliferation of the nucleoplasmic reticulum.

N. Ridgway, Thomas A. Lagace, 2005, Molecular biology of the cell.

25-Hydroxycholesterol stimulates sphingomyelin synthesis in Chinese hamster ovary cells.

N. Ridgway, 1995, Journal of lipid research.

Brefeldin A Renders Chinese Hamster Ovary Cells Insensitive to Transcriptional Suppression by 25-Hydroxycholesterol (*)

N. Ridgway, Thomas A. Lagace, T. Lagace, 1995, The Journal of Biological Chemistry.

Phosphorylation of a serine/proline-rich motif in oxysterol binding protein-related protein 4L (ORP4L) regulates cholesterol and vimentin binding

N. Ridgway, A. Pietrangelo, 2019, PloS one.

Modulation of ceramide metabolism in T-leukemia cell lines potentiates apoptosis induced by the cationic antimicrobial peptide bovine lactoferricin.

N. Ridgway, D. Hoskin, S. Furlong, 2008, International journal of oncology.

Multisite phosphorylation of oxysterol-binding protein regulates sterol binding and activation of sphingomyelin synthesis

N. Ridgway, Xinwei Liu, C. Robinson, 2012, Molecular biology of the cell.

Metabolism of molecular species of phosphatidylethanolamine and phosphatidylcholine in rat hepatocytes during prolonged inhibition of phosphatidylethanolamine N-methyltransferase.

D. Vance, N. Ridgway, R. W. Samborski, 1993, Journal of lipid research.

Specificity of rat hepatic phosphatidylethanolamine N-methyltransferase for molecular species of diacyl phosphatidylethanolamine.

D. Vance, N. Ridgway, 1988, The Journal of biological chemistry.

Substrate channeling in the glycerol-3-phosphate pathway regulates the synthesis, storage and secretion of glycerolipids.

N. Ridgway, Jonghwa Lee, 2019, Biochimica et biophysica acta. Molecular and cell biology of lipids.

OSBP Negatively Regulates ABCA1 Protein Stability*

N. Ridgway, K. Bowden, 2008, Journal of Biological Chemistry.

U18666A Inhibits Intracellular Cholesterol Transport and Neurotransmitter Release in Human Neuroblastoma Cells

N. Ridgway, J. Carter, D. Byers, 2004, Neurochemical Research.

Regulation of Phosphatidylcholine Metabolism in Chinese Hamster Ovary Cells by the Sterol Regulatory Element-binding Protein (SREBP)/SREBP Cleavage-activating Protein Pathway*

N. Ridgway, M. K. Storey, Thomas A. Lagace, 2000, The Journal of Biological Chemistry.

Differential Effects of Sphingomyelin Hydrolysis and Cholesterol Transport on Oxysterol-binding Protein Phosphorylation and Golgi Localization*

N. Ridgway, D. Byers, H. W. Cook, 1998, The Journal of Biological Chemistry.

Golgi localization of oxysterol binding protein-related protein 4L (ORP4L) is regulated by ligand binding

N. Ridgway, A. Pietrangelo, 2018, Journal of Cell Science.

Inhibition of phosphorylation of the oxysterol binding protein by brefeldin A.

N. Ridgway, H. W. Cook, D. Byers, 1998, Biochimica et biophysica acta.

A 25-hydroxycholesterol-resistant cell line deficient in acyl-CoA: cholesterol acyltransferase.

P. Dawson, N. Ridgway, M. Brown, 1991, The Journal of biological chemistry.

Uncoupling Farnesol-induced Apoptosis from Its Inhibition of Phosphatidylcholine Synthesis*

N. Ridgway, C. McMaster, A. Henneberry, 2001, The Journal of Biological Chemistry.

Cholesterol regulates oxysterol binding protein (OSBP) phosphorylation and Golgi localization in Chinese hamster ovary cells: correlation with stimulation of sphingomyelin synthesis by 25-hydroxycholesterol.

N. Ridgway, H. W. Cook, D. Byers, 1998, The Biochemical journal.

Decreased phosphatidylcholine biosynthesis and abnormal distribution of CTP:phosphocholine cytidylyltransferase in cholesterol auxotrophic Chinese hamster ovary cells.

N. Ridgway, H. W. Cook, D. Byers, 1997, Journal of lipid research.

Genetic distinction between sterol-mediated transcriptional and posttranscriptional control of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

P. Dawson, N. Ridgway, M. Brown, 1991, The Journal of biological chemistry.

Oxysterol-binding protein-related protein 1 variants have opposing cholesterol transport activities from the endolysosomes

N. Ridgway, J. Foster, Kexin Zhao, 2020, Molecular biology of the cell.

19q13.12 microdeletion syndrome fibroblasts display abnormal storage of cholesterol and sphingolipids in the endo-lysosomal system.

N. Ridgway, S. Gale, D. Ory, 2018, Biochimica et biophysica acta. Molecular basis of disease.

Oxysterol-Binding Protein-Related Protein 1L Regulates Cholesterol Egress from the Endo-Lysosomal System.

N. Ridgway, Kexin Zhao, 2017, Cell reports.

Regulation of the CDP-choline pathway by sterol regulatory element binding proteins involves transcriptional and post-transcriptional mechanisms.

N. Ridgway, Thomas A. Lagace, 2003, The Biochemical journal.

Oxysterol‐binding protein recruitment and activity at the endoplasmic reticulum‐Golgi interface are independent of Sac1

N. Ridgway, M. Charman, Asako Goto, 2017, Traffic.

Cholesterol transfer at endosomal-organelle membrane contact sites

N. Ridgway, Kexin Zhao, 2018, Current opinion in lipidology.

Chinese hamster ovary cells overexpressing the oxysterol binding protein (OSBP) display enhanced synthesis of sphingomyelin in response to 25-hydroxycholesterol.

N. Ridgway, D. Byers, H. W. Cook, 1999, Journal of lipid research.

Global Proximity Interactome of the Human Macroautophagy Pathway

B. Raught, R. Vernon, N. Ridgway, 2021, Autophagy.

Oxysterol activation of phosphatidylcholine synthesis involves CTP:phosphocholine cytidylyltransferase alpha translocation to the nuclear envelope.

N. Ridgway, Karsten Gehrig, Thomas A. Lagace, 2009, The Biochemical journal.

Phosphatidylcholine synthesis influences the diacylglycerol homeostasis required for SEC14p-dependent Golgi function and cell growth.

N. Ridgway, C. McMaster, A. Henneberry, 2001, Molecular biology of the cell.

CTP:phosphocholine cytidylyltransferase: Function, regulation, and structure of an amphitropic enzyme required for membrane biogenesis.

N. Ridgway, R. Cornell, 2015, Progress in lipid research.

A mechanism for suppression of the CDP-choline pathway during apoptosis

N. Ridgway, Karsten Gehrig, Craig C Morton, 2013, Journal of Lipid Research.

ras-induced Up-regulation of CTP:Phosphocholine Cytidylyltransferase α Contributes to Malignant Transformation of Intestinal Epithelial Cells*

N. Ridgway, B. Yoo, K. Rosen, 2012, The Journal of Biological Chemistry.

Induction of apoptosis by lipophilic activators of CTP:phosphocholine cytidylyltransferase α (CCTα)

N. Ridgway, Thomas A. Lagace, 2005 .

Progesterone metabolism in human fibroblasts is independent of P-glycoprotein levels and Niemann–Pick type C disease

N. Ridgway, J. Sjövall, D. Byers, 1999, The Journal of Steroid Biochemistry and Molecular Biology.

Lipid and membrane recognition by the oxysterol binding protein and its phosphomimetic mutant using dual polarization interferometry.

N. Ridgway, J. Atkinson, P. Mukherjee, 2018, Biochimica et biophysica acta. Biomembranes.

Phosphatidylcholine synthesis regulates triglyceride storage and chylomicron secretion by Caco2 cells[S]

N. Ridgway, Jonghwa Lee, 2018, Journal of Lipid Research.

Resistance to UV-induced apoptosis in Chinese-hamster ovary cells overexpressing phosphatidylserine synthases.

N. Ridgway, C. McMaster, A. Yu, 2004, The Biochemical journal.

Stimulation of Phosphatidylserine Biosynthesis and Facilitation of UV-induced Apoptosis in Chinese Hamster Ovary Cells Overexpressing Phospholipid Scramblase 1*

N. Ridgway, C. McMaster, A. Yu, 2003, The Journal of Biological Chemistry.

Novel Role of CETP in Macrophages: Reduction of Mitochondrial Oxidants Production and Modulation of Cell Immune-Metabolic Profile

A. Vercesi, N. Ridgway, J. Morari, 2022, Antioxidants.

Differential dephosphorylation of CTP:phosphocholine cytidylyltransferase upon translocation to nuclear membranes and lipid droplets

N. Ridgway, S. Pelech, D. Winkler, 2020, Molecular biology of the cell.

Characterization of the Sterol and Phosphatidylinositol 4-Phosphate Binding Properties of Golgi-Associated OSBP-Related Protein 9 (ORP9)

N. Ridgway, Xinwei Liu, 2014, PloS one.

Induction of protein kinase C substrates, Myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein (MRP), by amyloid β-protein in mouse BV-2 microglial cells

N. Ridgway, C. McMaster, M. Sundaram, 2003, Neuroscience Letters.

The role of de novo ceramide synthesis in the mechanism of action of the tricyclic xanthate D609 Published, JLR Papers in Press, September 16, 2003. DOI 10.1194/jlr.M300300-JLR200

N. Ridgway, R. Perry, 2004, Journal of Lipid Research.

Characterization of the sterol-binding domain of oxysterol-binding protein (OSBP)-related protein 4 reveals a novel role in vimentin organization.

N. Ridgway, J. Wyles, R. Perry, 2007, Experimental cell research.

Effect of fumonisin B1 on phosphatidylethanolamine biosynthesis in Chinese hamster ovary cells.

N. Ridgway, H. W. Cook, D. Byers, 1996, Biochimica et biophysica acta.

Oxysterol-binding Protein Activation at Endoplasmic Reticulum-Golgi Contact Sites Reorganizes Phosphatidylinositol 4-Phosphate Pools*

N. Ridgway, M. Charman, Asako Goto, 2015, The Journal of Biological Chemistry.

Oxysterol-binding Protein (OSBP)-related Protein 4 (ORP4) Is Essential for Cell Proliferation and Survival*

N. Ridgway, L. Kreplak, M. Charman, 2014, The Journal of Biological Chemistry.

Phospholipid synthesis in mammalian cells

N. Ridgway, 2021, Biochemistry of Lipids, Lipoproteins and Membranes.

How CCTα puts a leash on phospholipid synthesis

N. Ridgway, 2018, The Journal of Biological Chemistry.

Metabolism of short-chain ceramide and dihydroceramide analogues in Chinese hamster ovary (CHO) cells.

N. Ridgway, D. Merriam, 1995, Biochimica et biophysica acta.

Lipoprotein lipase-mediated sequestration of long-chain polyunsaturated triacylglycerols in serum LDL from normal and hypothyroid rats.

N. Ridgway, P. Dolphin, 1984, Biochimica et biophysica acta.

Kinetic mechanism of phosphatidylethanolamine N-methyltransferase.

D. Vance, N. Ridgway, 1988, The Journal of biological chemistry.

The methylation of phosphatidylethanolamine.

D. Vance, N. Ridgway, D E Vance, 1988, Progress in lipid research.

The role of phosphatidylcholine and choline metabolites to cell proliferation and survival

N. Ridgway, 2013, Critical reviews in biochemistry and molecular biology.

Evidence that only newly made phosphatidylethanolamine is methylated to phosphatidylcholine and that phosphatidylethanolamine is not significantly deacylated-reacylated in rat hepatocytes.

D. Vance, N. Ridgway, R. W. Samborski, 1990, The Journal of biological chemistry.

Regulation of MARCKS and MARCKS‐related protein expression in BV‐2 microglial cells in response to lipopolysaccharide

N. Ridgway, D. Byers, H. W. Cook, 2001, Journal of neurochemistry.

Bridging the molecular and biological functions of the oxysterol-binding protein family

N. Ridgway, A. Pietrangelo, 2018, Cellular and Molecular Life Sciences.

Translocation of oxysterol binding protein to Golgi apparatus triggered by ligand binding

P. Dawson, N. Ridgway, M. Brown, 1992, The Journal of cell biology.

The Enzymes of Phosphatidylcholine Biosynthesis

D. Vance, N. Ridgway, J. Sanghera, 1986 .

Mechanisms by Which Probiotic Bacteria Attenuate the Risk of Hepatocellular Carcinoma

N. Ridgway, H. Rupasinghe, Wasitha P. D. W. Thilakarathna, 2021, International journal of molecular sciences.

Running ‘LAPS’ Around nLD: Nuclear Lipid Droplet Form and Function

N. Ridgway, G. Dellaire, J. Salsman, 2022, Frontiers in Cell and Developmental Biology.

The role of phospholipids in the biological activity and structure of the endoplasmic reticulum.

N. Ridgway, Thomas A Lagace, Neale D Ridgway, 2013, Biochimica et biophysica acta.

Expansion of the nucleoplasmic reticulum requires the coordinated activity of lamins and CTP:phosphocholine cytidylyltransferase alpha.

N. Ridgway, R. Cornell, Karsten Gehrig, 2008, Molecular biology of the cell.

Caspase Processing and Nuclear Export of CTP:Phosphocholine Cytidylyltransferase α during Farnesol-Induced Apoptosis

N. Ridgway, Jessica R. Miller, Thomas A. Lagace, 2002, Molecular and Cellular Biology.

Nuclear-localized CTP:phosphocholine cytidylyltransferase α regulates phosphatidylcholine synthesis required for lipid droplet biogenesis

N. Ridgway, Dan J Arsenault, Adam J Aitchison, 2015, Molecular biology of the cell.

A Lipid Transfer Protein Signaling Axis Exerts Dual Control of Cell-Cycle and Membrane Trafficking Systems.

B. Kennedy, K. Baetz, M. Polymenis, 2018, Developmental cell.

cDNA cloning of human oxysterol-binding protein and localization of the gene to human chromosome 11 and mouse chromosome 19.

U. Francke, P. Dawson, C. Hsieh, 1990, Genomics.

Inhibition of HCV Replication by Oxysterol-Binding Protein-Related Protein 4 (ORP4) through Interaction with HCV NS5B and Alteration of Lipid Droplet Formation

Ziqing Liu, In-Woo Park, Yahong Wen, 2013, PloS one.

Aromatic boronic acids as probes of the catalytic site of human plasma lecithin-cholesterol acyltransferase.

N. Ridgway, M. Jauhiainen, P. Dolphin, 1987, Biochimica et biophysica acta.

Staurosporines decrease ORMDL proteins and enhance sphingomyelin synthesis resulting in depletion of plasmalemmal phosphatidylserine

N. Ridgway, G. Fairn, Minhyoung Lee, 2016, Scientific Reports.

Purification of phosphatidylethanolamine N-methyltransferase from rat liver.

D. Vance, N. Ridgway, 1987, The Journal of biological chemistry.

Phosphatidylethanolamine levels and regulation of phosphatidylethanolamine N-methyltransferase.

D. Vance, N. Ridgway, Z. Yao, 1989, The Journal of biological chemistry.

Oxysterol Binding Protein-dependent Activation of Sphingomyelin Synthesis in the Golgi Apparatus Requires Phosphatidylinositol 4-Kinase IIα

N. Ridgway, Sangeeta Banerji, S. Minogue, 2010, Molecular biology of the cell.

Oxysterol binding protein-related Protein 9 (ORP9) is a cholesterol transfer protein that regulates Golgi structure and function.

N. Ridgway, Mike Ngo, Neale D Ridgway, 2009, Molecular biology of the cell.

Functional implications of sterol transport by the oxysterol-binding protein gene family.

N. Ridgway, Terry R Colbourne, Mike Ngo, 2010, The Biochemical journal.

Vesicle-associated Membrane Protein-associated Protein-A (VAP-A) Interacts with the Oxysterol-binding Protein to Modify Export from the Endoplasmic Reticulum*

N. Ridgway, C. McMaster, J. Wyles, 2002, The Journal of Biological Chemistry.

Oxysterol-binding protein-related protein (ORP) 9 is a PDK-2 substrate and regulates Akt phosphorylation.

N. Ridgway, M. Huber, M. Leitges, 2007, Cellular signalling.

Methylation of Phosphatidylethanolamine: Enzyme Characterization, Regulation and Physiological Function

D. Vance, N. Ridgway, 1986 .

Differential Expression of MARCKS and Other Calmodulin‐Binding Protein Kinase C Substrates in Cultured Neuroblastoma and Glioma Cells

N. Ridgway, F. Palmer, D. Byers, 1994, Journal of neurochemistry.

Inhibition of acyl-CoA:cholesterol acyltransferase in Chinese hamster ovary (CHO) cells by short-chain ceramide and dihydroceramide.

N. Ridgway, 1995, Biochimica et biophysica acta.

Curcumin-Induced Apoptosis in PC3 Prostate Carcinoma Cells Is Caspase-Independent and Involves Cellular Ceramide Accumulation and Damage to Mitochondria

C. Giacomantonio, N. Ridgway, D. Hoskin, 2010, Nutrition and cancer.

Phospholipase D Activities and Phosphatidylcholine Turnover are Differentially Related to Expression of Protein Kinase C Isoforms and Marcks in Control and Transfected Neural Cells

N. Ridgway, D. Byers, H. W. Cook, 1996 .

Differential alterations of ethanolamine and choline phosphoglyceride metabolism by clofibrate and retinoic acid in human fibroblasts are not mediated by phorbol ester-sensitive protein kinase C

N. Ridgway, D. Byers, H. W. Cook, 1996, Lipids.

Altered regulation of cholesterol and cholesteryl ester synthesis in Chinese-hamster ovary cells overexpressing the oxysterol-binding protein is dependent on the pleckstrin homology domain.

N. Ridgway, H. W. Cook, D. Byers, 1997, The Biochemical journal.

Protein kinase D1 and oxysterol‐binding protein form a regulatory complex independent of phosphorylation

N. Ridgway, M. Charman, Asako Goto, 2018, Traffic.

VAMP-associated protein-A regulates partitioning of oxysterol-binding protein-related protein-9 between the endoplasmic reticulum and Golgi apparatus.

N. Ridgway, J. Wyles, 2004, Experimental cell research.

Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and interacts with vimentin intermediate filaments.

N. Ridgway, L. JeBailey, Cheng Wang, 2002, The Biochemical journal.

Novel Members of the Human Oxysterol-binding Protein Family Bind Phospholipids and Regulate Vesicle Transport*

N. Ridgway, Yule Liu, C. McMaster, 2001, The Journal of Biological Chemistry.

In vitro phosphorylation of phosphatidylethanolamine N-methyltransferase by cAMP-dependent protein kinase: lack of in vivo phosphorylation in response to N6-2'-O-dibutryladenosine 3',5'-cyclic monophosphate.

D. Vance, N. Ridgway, 1989, Biochimica et biophysica acta.

Bridging the molecular and biological functions of the oxysterol-binding protein family

N. Ridgway, A. Pietrangelo, 2018, Cellular and Molecular Life Sciences.

Integration of phospholipid and sterol metabolism in mammalian cells.

N. Ridgway, H. W. Cook, D. Byers, 1999, Progress in lipid research.

Phosphatidylethanolamine N-methyltransferase from rat liver.

D. Vance, N. Ridgway, 1992, Methods in Enzymology.

Analysis of Sphingolipid Synthesis and Transport by Metabolic Labeling of Cultured Cells with [³H]Serine.

N. Ridgway, 2016, Methods in molecular biology.

Functional implications of sterol transport by the oxysterol-binding protein gene family.

N. Ridgway, Terry R Colbourne, Mike Ngo, 2010, The Biochemical journal.

Epidermal growth factor receptor (EGFR) in lung cancer: an overview and update.

N. Ridgway, Zhaolin Xu, G. Bethune, 2011, Journal of thoracic disease.

Exploring the Interactome of PML nuclear subdomains during fatty acid stress using APEX2-mediated proximity labeling

F. Boisvert, N. Ridgway, G. Dellaire, 2023, bioRxiv.